Article
Biochemistry & Molecular Biology
Xiufeng Hu, Yu Mu, Jiaojie Wang, Yanqiu Zhao
Summary: This study demonstrates that TDRG1 is significantly overexpressed in NSCLC, and interacts with miR-873-5p to positively regulate the expression of ZEB1, thereby facilitating the progression of NSCLC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Jiawei Yan, Hongyan Xu
Summary: This study demonstrated that circANKS1B is highly expressed in OSCC tissues and cells, positively correlated with TGF-beta 1 expression, and regulates cell invasion, migration, and cisplatin resistance by sponging miR-515-5p to modulate TGF-beta 1. CircANKS1B may serve as a potential therapeutic target for overcoming chemoresistance in OSCC.
Article
Oncology
Kai Guo, Di Qi, Bo Huang
Summary: The study revealed that lncRNA MEG8 plays a critical role in the development of NSCLC by modulating the miR-15a/b-5p/PSAT1 axis, indicating that lncRNA MEG8, miR-15a-5p, miR-15b-5p, and PSAT1 may serve as potential targets for NSCLC therapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jinpeng Hu, Guoqing Zhang, Yongfeng Wang, Kai Xu, Lian Chen, Gang Luo, Jinkun Xu, Hao Li, Dongmei Pei, Xiang Zhao, Zhengting Guo, Xinqiao Li, Shengliang Zong, Yang Jiang, Zhitao Jing
Summary: This study identifies a novel circular RNA, circGNB1, which is upregulated in glioma and closely associated with poor prognosis. Functional assays reveal that circGNB1 overexpression promotes the viability, proliferation, invasion, and neurosphere formation of glioma stem cells. Mechanistically, circGNB1 upregulates the expression of oncogene XPR1 by sponging miR-515-5p and miR-582-3p. XPR1, in turn, promotes the malignant phenotype of glioma stem cells through upregulating IL6 expression and activating JAK2/STAT3 signaling. Additionally, the RNA binding protein IGF2BP3 binds to and stabilizes circGNB1, thus enhancing its effects on glioma stem cells. This study uncovers the crucial role of circGNB1 in tumorigenesis and malignant progression of glioma, providing a promising cancer biomarker.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Pengxu Shi, Yueting Li, Qingsheng Guo
Summary: The study identified the critical role of circular RNA circPIP5K1A in the stemness of osteosarcoma cells, with enhanced expression in clinical tissues. Knockdown of circPIP5K1A inhibited cell viabilities, induced apoptosis, and reduced invasion and migration capabilities. Mechanistically, circPIP5K1A enhanced YAP expression by targeting miR-515-5p, affecting the stemness of osteosarcoma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Rilei Jiang, Bing Lu, Fanchao Feng, Qian Li, Xiaolei Chen, Shibing Cao, Zhaoxia Pan, Zhengming Deng, Yufei Zhou, Ping Liu, Jiatuo Xu
Summary: The study indicated that a derivative of Houttuynia cordata (SNH) promoted pyroptosis in non-small cell lung cancer (NSCLC) cells by up-regulating a novel lncRNA (TCONS-14036) and activating the TCONS-14036/miR-1228-5p/PRKCDBP pathway. This finding offers a potential therapeutic target for NSCLC.
CELL PROLIFERATION
(2023)
Article
Oncology
Julija Simiene, Daiva Dabkeviciene, Diana Stanciute, Rimvile Prokarenkaite, Valerija Jablonskiene, Renatas Askinis, Kamile Normantaite, Saulius Cicenas, Kestutis Suziedelis
Summary: This study investigated the expression levels of miR-181a-5p and miR-630 in NSCLC tumor tissue and plasma samples, and their association with treatment response and disease prognosis in NSCLC patients. It was found that the expression levels of miR-181a-5p and miR-630 were significantly decreased in NSCLC samples, and were associated with treatment response and disease prognosis.
Article
Cell Biology
Misa Nunode, Masami Hayashi, Yoko Nagayasu, Masami Sawada, Mayumi Nakamura, Takumi Sano, Daisuke Fujita, Masahide Ohmichi
Summary: This study reveals that miR-515-5p is significantly upregulated in maternal serum from preeclampsia patients, and it may play critical roles in the pathogenesis of preeclampsia through suppression of XIAP. Serum miR-515-5p could potentially serve as a biomarker for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Peng Wu, Chunxiang Li, Dong mei Ye, Kenan Yu, Yuxuan Li, Hailin Tang, Gaoshen Xu, Shuijing Yi, Zhiwei Zhan
Summary: In this study, circEPSTI1 was found to be significantly upregulated in cervical cancer and shown to impact cell ferroptosis. The circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis was identified to affect proliferation in cervical cancer through the ceRNA mechanism and was linked to ferroptosis. The findings suggest circEPSTI1 as a potential new biomarker for monitoring and targeting treatment in cervical cancer.
Article
Biotechnology & Applied Microbiology
Guoliang Mao, Bing Zhou, Wuqin Xu, Nanlin Jiao, Zhihao Wu, Jiajia Li, Yinhua Liu
Summary: In CRC, circ_0040809 and DNMT1 expression are increased while miR-515-5p expression is decreased. circ_0040809 facilitates CRC cell proliferation and migration, and inhibits apoptosis through modulating the miR-515-5p/DNMT1 axis. Targeting circ_0040809 may be a potential therapeutic strategy for CRC treatment.
JOURNAL OF GENE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hallgeir Selven, Sigve Andersen, Mona Pedersen, Ana Paola Giometti Lombardi, Lill-Tove Rasmussen Busund, Thomas Karsten Kilvaer
Summary: This study investigated the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. The results showed that high expression of both miR-17-5p and miR-20a-5p is associated with a favorable prognosis and inhibits cell migration.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Pan He, Feng Liu, Zhijun Wang, Haoli Gong, Meilan Zhang, Zhen Jia, Xiaohui Zhai
Summary: This study identifies the biological significance of the circKIF4A-miR-515-5p-SLC7A11 axis in osteosarcoma cell proliferation and metastasis, which is important for monitoring and treatment of osteosarcoma.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Xu Zhao, Jizhao Wang, Rui Zhu, Jing Zhang, Yunfeng Zhang
Summary: DLX6-AS1 regulates cisplatin sensitivity of lung squamous cell carcinoma cells through the miR-181a-5p/miR-382-5p/CELF1 axis, playing a key role in promoting secondary cisplatin resistance. Targeting DLX6-AS1 may be a novel approach to overcome cisplatin resistance in lung squamous cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Shuai Zhang, Yuan Lu, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, Shi Zhou
Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.
CELL DEATH & DISEASE
(2021)
Article
Andrology
Guangwen Wang, Haiyang Zhao, Xiaohong Duan, Zhiqiang Ren
Summary: The abundance of circular RNA circ-PAPPA is increased in prostate cancer cells, leading to elevated malignant phenotypes by negatively regulating miR-515-5p and modulating the expression of FKBP1A.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
