Article
Oncology
Yukiko Yamaguchi, Jackson Gibson, Kevin Ou, Lupita S. Lopez, Rachel H. Ng, Neena Leggett, Vanessa D. Jonsson, Jelani C. Zarif, Peter P. Lee, Xiuli Wang, Catalina Martinez, Tanya B. Dorff, Stephen J. Forman, Saul J. Priceman
Summary: This study reveals an alternative mechanism by which the combination of CAR T cells and immune checkpoint blockade modulates the immune landscape of solid tumors to enhance therapeutic efficacy of CAR T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Wenhui Shen, Peishang Shi, Qingyu Dong, Xiuman Zhou, Chunxia Chen, Xinghua Sui, Wentong Tian, Xueqin Zhu, Xiaoxi Wang, Shengzhe Jin, Yahong Wu, Guanyu Chen, Lu Qiu, Wenjie Zhai, Yanfeng Gao
Summary: A CD24/Siglec-10 blocking peptide (CSBP) was identified, which not only blocked the interaction of CD24/Siglec-10, but also PD-1/PD-L1. CSBP promoted the phagocytosis of tumor cells by macrophages and M-MDSCs, and elevated the activity of CD8(+) T cells. Furthermore, combination of CSBP and radiotherapy synergistically reduced tumor growth and altered the tumor microenvironment in both anti-PD-1-responsive MC38 and anti-PD-1-resistant 4T1 tumor models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Xiaolei Li, Xiao Su, Rui Liu, Yongsha Pan, Jiankai Fang, Lijuan Cao, Chao Feng, Qianwen Shang, Yongjing Chen, Changshun Shao, Yufang Shi
Summary: Pharmacological modulation of macrophage phenotype by HDAC inhibitors can reshape the tumor immune microenvironment, enhance anti-tumor immune responses, and improve the efficacy of immunotherapies in various tumors.
Article
Immunology
Fu-xue Huang, Jun-wan Wu, Xia-qin Cheng, Jiu-hong Wang, Xi-zhi Wen, Jing-jing Li, Qiong Zhang, Hang Jiang, Qiu-yue Ding, Xiao-feng Zhu, Xiao-shi Zhang, Ya Ding, Dan-dan Li
Summary: This study showed that high expression of HHLA2 is associated with better prognosis and improved response to immune checkpoint blockades in melanoma patients. The expression of HHLA2 is also positively correlated with the density of CD8(+) tumor infiltrating lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xianquan Feng, Zhenzhen Chen, Zhihong Liu, Xiaoling Fu, Hongtao Song, Qian Zhang
Summary: The combination of ATO, PpIX and stabilizer (ATO/PpIX NPs) was self-assembled and targeted to tumors for the first time. This combination induced immunogenic cell death, improved the tumor microenvironment, and enhanced the effectiveness of anti-PD-L1 immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Richard S. P. Huang, Brennan Decker, Karthikeyan Murugesan, Matthew Hiemenz, Douglas A. Mata, Gerald Li, James Creeden, Shakti H. Ramkissoon, Jeffrey S. Ross
Summary: The study found low prevalence of non-amplification short variants (SV) mutations in CD274, with mutation types and rates varying by tumor type. Specific mutation types may affect the expression level of PD-L1 protein and potentially function as resistance biomarkers in ICPI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Hao Zhang, Lin Liu, Jinbo Liu, Pengyuan Dang, Shengyun Hu, Weitang Yuan, Zhenqiang Sun, Yang Liu, Chengzeng Wang
Summary: In recent years, tumor immunotherapy, especially immune checkpoint inhibitors, has shown significant progress. However, these treatments are only effective for a small proportion of patients with solid cancers. Tumor-associated macrophages play a crucial role in the tumor microenvironment and have been shown to impact the therapeutic effect of PD-1/PD-L1 inhibitors.
Article
Biochemistry & Molecular Biology
Shuang Guo, Xinyue Wang, Hanxiao Zhou, Yue Gao, Peng Wang, Hui Zhi, Yue Sun, Yakun Zhang, Jing Gan, Yun Xiao, Shangwei Ning
Summary: Immune dysfunction and pro-oncogenic inflammation play critical roles in malignant progression and non-response to immunotherapy for hepatocellular carcinoma (HCC). In this study, the intercommunication between PD-L1 and the immunosuppressive tumor microenvironment (TME) and inflammatory response activity in HCC was investigated. Additionally, potential therapeutic drugs were predicted to improve the current therapeutic strategy for specific HCC patients.
Article
Oncology
Mathieu Larroquette, Jean-Philippe Guegan, Benjamin Besse, Sophie Cousin, Maxime Brunet, Sylvestre Le Moulec, Francois Le Loarer, Christophe Rey, Jean-Charles Soria, Fabrice Barlesi, Alban Bessede, Jean-Yves Scoazec, Isabelle Soubeyran, Antoine Italiano
Summary: This study investigated the predictive value of tumor-associated macrophages (TAMs) in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint blockers (ICBs) and characterized their transcriptomic profiles. The results showed that low intratumoral CD163+ cell infiltration was associated with longer progression-free survival (PFS) and overall survival (OS) under ICB treatment. The transcriptomic analyses identified potential targets to alter TAM recruitment/polarization and highlighted the complexity of the CSF1R pathway, which may not be a suitable target to improve ICB efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Xuan Zhao, Yulin Bao, Bi Meng, Zijian Xu, Sijin Li, Xu Wang, Rui Hou, Wen Ma, Dan Liu, Junnian Zheng, Ming Shi
Summary: Developing biomarkers for predicting the efficacy of immune checkpoint inhibitor therapies is important for avoiding side effects and economic burden. Current assays evaluating PD-L1 expression are imperfect, but recent studies are advancing the methodologies to improve accuracy. This includes standardization of immunohistochemistry tests and the use of novel in vivo probes and liquid biopsy. Considering PD-L1 expression on non-tumor cells and utilizing artificial intelligence can further enhance the predictive accuracy of PD-L1 as a biomarker.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Richard S. P. Huang, Karthikeyan Murugesan, Meagan Montesion, Dean C. Pavlick, Douglas A. Mata, Matthew C. Hiemenz, Brennan Decker, Garrett Frampton, Lee A. Albacker, Jeffrey S. Ross
Summary: The study analyzed a large cohort of solid tumor cases to investigate CD274 copy-number changes and their correlation with PD-L1 protein expression. The prevalence of CD274 copy-number changes varied across different tumor types and was found to be significantly associated with PD-L1 positivity in certain tumor types, indicating its potential as a biomarker for immune checkpoint inhibitor therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Junjie Liu, Haisu Tao, Tong Yuan, Jiang Li, Jian Li, Huifang Liang, Zhiyong Huang, Erlei Zhang
Summary: Anti-PD-1/PD-L1 therapy is an effective strategy for cancer treatment, but drug resistance is a challenge. Combining this therapy with regorafenib can enhance its efficacy. Regorafenib modifies the tumor microenvironment through various mechanisms and has immunomodulatory effects on immune cells and tumor cells. Studies on the synergistic mechanism of combination therapy can improve cancer treatment and patient selection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jiming Chen, Jie Yang, Wenhui Wang, Danfeng Guo, Chengyan Zhang, Shibo Wang, Xinliang Lu, Xiaofang Huang, Pingli Wang, Gensheng Zhang, Jing Zhang, Jianli Wang, Zhijian Cai
Summary: PD-L1(+) tumor-derived extracellular vesicles (TEVs) cause resistance to anti-PD-L1 antibody therapy by decoying the antibody and being cleared by macrophages, resulting in insufficient blockade of tumor PD-L1.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Zhenyu Zhao, Kongming Wu
Summary: TGF-beta signaling has predictive value in cancer immunotherapy, and targeted therapies against TGF-beta are important strategies to overcome treatment resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Julie Lecuelle, Laure Favier, Clea Fraisse, Aurelie Lagrange, Coureche Kaderbhai, Romain Boidot, Sandy Chevrier, Philippe Joubert, Bertrand Routy, Caroline Truntzer, Francois Ghiringhelli
Summary: In patients with non-small cell lung cancer (NSCLC), high expression of endogenous retroviruses (ERVs) was associated with better treatment efficacy and immune response. This study found that high MER4 ERV expression was associated with improved progression-free survival (PFS) and overall survival (OS) in NSCLC patients receiving immune checkpoint inhibitors (ICI). Additionally, adding MER4 to existing transcriptomic signatures improved the predictive power for response to ICI.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Zhenfei Gao, Tiannan Wang, Zikun Rao, Hui Yan, Ran Zhang, Guosong Chen
Summary: Supra-amphiphilic compounds containing disaccharides and azobenzene ends were constructed via dynamic covalent bond. The slight structural difference of the disaccharides was found to significantly affect the self-assembled morphologies. Three kinds of azo-disaccharide supra-amphiphiles were found to assemble into different morphologies with only a difference in chemical structure. Molecular simulation revealed that the packing of molecules was influenced by the contribution from hydrogen bonds. This study highlights the importance of saccharide packing, particularly related hydrogen bonding, in determining the final morphology of assembled structures.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Rongying Liu, Long Li, Shuyu Chen, Zhiwei Yang, Zdravko Kochovski, Shilin Mei, Yan Lu, Lei Zhang, Guosong Chen
Summary: A protein assembly capable of switching interplay modes of multiple driving forces has been successfully achieved by leveraging ligand-ligand interaction and protein-protein interaction. This strategy not only provides a nanoscale understanding on the mechanism underlying the switch of interplay modes in the context of biomacromolecules, but also may enable the fabrication of diverse sophisticated biomacromolecular nanostructures that are historically inaccessible for conventional self-assembly strategies.
Article
Chemistry, Multidisciplinary
Cheng Gao, Cheryl H. T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang
Summary: Surface-engineered chlorella can be used as targeted drug carriers and sustainable oxygen suppliers to significantly improve sonodynamic therapy by alleviating hypoxia and inhibiting autophagy.
Review
Oncology
Si-yu Cao, Yu Fan, Yu-fei Zhang, Jia-ying Ruan, Yi Mu, Jin-ke Li
Summary: This study aimed to compare the effects of adjuvant chemoradiotherapy (ACR) and adjuvant chemotherapy (AC) on recurrence and survival in patients with stage III endometrial cancer after radical surgery. Data from relevant studies were analyzed, and the results showed that ACR significantly reduced the risk of local and total recurrence compared to AC. ACR was also associated with significantly better overall survival, progression-free survival, and disease-free survival.
Article
Chemistry, Multidisciplinary
Rui Sun, Siyang Dong, Jiekai Yang, Jing Xiong, Caihong Wang, Shengjun Lu, Yufei Zhang, Haosen Fan
Summary: Peony-like structured MoS2 with intercalation of polyaniline and crystal defects was prepared by a simple hydrothermal method. The defect-rich structure and broad interlayer distance effectively enhanced the ion diffusion rate. PA-MoS2 maintained a capacity of 157.7 mA h g(-1) at 0.1 A g(-1) after 80 cycles and 77.8 mA h g(-1) at 1 A g(-1) after 750 cycles in the charge-discharge cycling test.
CHEMICAL COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Shunzhang You, Dao-Sheng Liu, Minghui Ye, Yufei Zhang, Yongchao Tang, Xiaoqing Liu, Cheng Chao Li
Summary: Aqueous zinc-ion batteries (ZIBs) face challenges such as dendritic growth and corrosion of zinc anodes, as well as hydrogen release. To address these issues, MoCl5-GICs are used as interface layers to protect zinc anodes and improve the Coulombic efficiency (CE) of ZIBs. The Zn@MGs cell with MoCl5-GICs coating shows uniform deposition and transmission of zinc ions, leading to excellent cycling stability and long lifespan. When paired with a NVO cathode, the Zn@MGs parallel to NVO full cell demonstrates remarkable capacity retention. Therefore, constructing multi-functional interface layers is a valuable method for the development of ZIBs.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Civil
Chi Chiu Lam, Yufei Zhang, Jiaming Gu, Jingming Cai
Summary: This paper investigates the reinforcing strategies of carbon fiber reinforced polymer (CFRP) plates for coped steel beams. Experimental results show that CFRP plates can effectively improve the load carrying capacity and resist local web buckling of coped beams. The reinforcing effect is more prominent with more layers of CFRP plates, and CFRP plates with inclined pasting angles can also provide higher post-peak ductility. The research findings provide reference for the design of single coped beams in practical engineering.
ENGINEERING STRUCTURES
(2023)
Editorial Material
Chemistry, Physical
Christine Aikens, Damien Alloyeau, Hakim Amara, Vincenzo Amendola, Catherine Amiens, Pascale Andreazza, Francesca Baletto, Stephan Barcikowski, Michael Bowker, Florent Calvo, Fuyi Chen, Emmanuel Cottancin, Wolfgang E. Ernst, Riccardo Farris, Riccardo Ferrando, Georg Daniel Forster, Alessandro Fortunelli, Alexis Front, Didier Grandjean, Hazar Guesmi, Graham J. Hutchings, Ewald Janssens, Miguel Jose Yacaman, Christian Kuttner, Eric Marceau, Marcelo M. Mariscal, Jette K. Mathiesen, John McGrady, Trang Nguyen, Pinkie Ntola, Cameron J. Owen, Charlie Paris, Micha Polak, Rasmus Svensson, Swathi Swaminathan, Mona Treguer-Delapierre, Jonathan Quinson, Yufei Zhang
FARADAY DISCUSSIONS
(2023)
Article
Plant Sciences
Xuehui Xu, Meiying Liu, Yufei Zhang, Yuexin Zhang
Summary: Although research on the toxic effects of PBDEs on animals has made progress, their phytotoxicity to plants, particularly low and medium brominated PBDE congeners, has been overlooked. This study found that PBDEs inhibited seed germination, root and shoot elongation, and seedling biomass of maize in a dose-dependent manner, with the highest inhibition rate occurring at 15 mg L-1. PBDE exposure induced lipid peroxidation and DNA damage in maize roots, as evidenced by increased levels of MDA and g-H2AX. Additionally, PBDEs increased the production of reactive oxygen species and the activity of antioxidant enzymes in the roots, with BDE-99 causing the most severe damage and ROS generation.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Chemistry, Physical
Yufei Zhang, Jiejing Chen, Jin Xia
Summary: This study investigated the mechanical and durability properties of slag/metakaolin-based ultra-high performance geopolymer concrete (UHPGC) reinforced with steel fibers. The results showed that increasing the steel fiber dosage and alkali concentration improved the compressive strength, with a maximum strength exceeding 140 MPa. The rapid chloride migration test indicated a moderate chloride penetration resistance, with chloride migration coefficients ranging from 6.5 x 10(-12) m(2)/s to 14.1 x 10(-12) m(2)/s. The addition of steel fibers slightly increased the chloride penetration depth, while higher sodium hydroxide solution concentration improved the chloride penetration resistance. These findings highlight the importance of considering the durability issues of steel fiber reinforced slag/metakaolin-based geopolymer concrete.
Article
Energy & Fuels
Yufei Zhang, Huanran Wang, Ruixiong Li, Zhuangjie Wang, Lanning Ling, Peng Jin, Haiyang Wang
Summary: In this study, an electro-hydrogen cogeneration system combining compressed air energy storage (CAES) and methanol cracking reaction (MCR) was proposed to solve the issues of insufficient utilization of compression heat in CAES and the need for supplementary heat in MCR for hydrogen production. The system utilizes the heat generated from adiabatic compression to preheat methanol, and the carbon monoxide produced from methanol cracking to supplement the heat in the cracker and the energy release module of the CAES system. By constructing a thermodynamic model, the system's performance was investigated, with energy efficiency and exergy efficiency reaching 85.71% and 80.94% respectively.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Engineering, Chemical
Yufei Zhang, Junjie Zheng, Jiejie Nan, Chengjie Gai, Qian Shao, Vignesh Murugadoss, Srihari Maganti, Nithesh Naik, Hassan Algadi, Mina Huang, Ben Bin Xu, Zhanhu Guo
Summary: ZnFe-layered double oxide (LDO)/cobalt(II,III) oxide (Co3O4) composites were prepared by calcining Co loaded ZnFe-LDO obtained through hydrothermal and microwave hydrothermal methods. The composites exhibited a flower-like structure composed of Co(3)O(4) nanowires and ZnFe-LDO nanosheets. The ZnFe-LDO/Co3O4 composite showed a high degradation efficiency of 93.3% for methylene blue (MB) under visible light and 1.0 V voltage after 3 hours, indicating its potential for organic pollutant removal.
Article
Polymer Science
Shuyu Chen, Xuyang Xu, Yufei Zhang, Linfei Ye, Lei Zhang, Long Li, Guosong Chen
Summary: Based on rational design, biepitope nanovaccines were developed by integrating CD4+ and CD8+ T cell epitopes. These amphiphilic peptides, composed of biepitope and hydrophilic amino acids, formed well-defined nanostructures and effectively enhanced endocytosis in dendritic cells. The designed biepitopes further stimulated the maturation of dendritic cells and demonstrated potential to prime T cells and induce specific cellular immunity. In murine colon cancer, the rationally designed biepitope nanovaccines efficiently triggered immune activation and potentiated antitumor immunity, providing an alternative strategy for neoantigen vaccines.
Article
Polymer Science
Xuyang Xu, Long Li, Linfei Ye, Xiaomei Liu, Yingle Feng, Guosong Chen
Summary: This article reports two classes of stereoisomeric glycolipid amphiphiles based on d-N-acetylgalactosamine (GalNAc), which can aggregate into ribbon-like structures in aqueous solution and obtain glycocalyx-mimicking supramolecular materials. The different molecular packing in self-assembled structures is determined by the subtle distinction in glycoside configuration of GalNAc-α-SSA and GalNAc-β-SSA. By blending the glycolipid epimers, the ribbon-like architectures transform into spherical nanostructures. The resulting spherical micelles fabricated by blending glycolipid epimers can enhance the immune responses mediated by macrophages and dendritic cells in vitro. These glycolipid epimers pave the way to create glycocalyx-mimicking immune modulators by incorporating stereochemistry into supramolecular self-assembly.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Xuefeng Pan, Rongying Liu, Zhilong Yu, Benedikt Haas, Zdravko Kochovski, Sijia Cao, Radwan M. Sarhan, Guosong Chen, Yan Lu
Summary: This study reports a facile and green approach for the fabrication of metal/CNT composites using a versatile glycopeptide (GP) as a stabilizer for CNTs in water and as a reducing agent for noble metal ions. The abundant hydrogen bonds in GP endow the formed GP-CNTs with excellent plasticity, enabling the availability of polymorphic CNT species from dispersion to viscous paste, gel, and even to dough by increasing their concentration. The GP molecules can reduce metal precursors at room temperature without additional reducing agents, enabling the in situ immobilization of metal nanoparticles (e.g. Au, Ag, Pt, and Pd) on the CNT surface. The Pd/CNT composite, which combines the excellent catalytic properties of Pd particles with the photothermal conversion capability of CNTs, shows promise as a catalyst for the fast degradation of organic pollutants.