Article
Chemistry, Medicinal
Jingjing Zhang, Wenqiang Tan, Qing Li, Xiaorui Liu, Zhanyong Guo
Summary: The study successfully obtained a series of novel CTMCSG hydrogel films with good water stability, thermal stability, drug release capacity, and antibacterial property. The properties of the hydrogel films improved with an increase in the amount of the cross-linking agent, resulting in reduced water vapor permeability.
Review
Polymer Science
Karen Guillen-Carvajal, Benjamin Valdez-Salas, Ernesto Beltran-Partida, Jorge Salomon-Carlos, Nelson Cheng
Summary: Hydrogels are versatile biomaterials with three-dimensional, cross-linked, highly hydrated polymeric networks. They have a variety of biochemical and biophysical properties, allowing for diffusion of diverse molecules and control of cellular interactions. Hydrogels can be molded into different structures resembling surrounding tissues and bone defects. Their application in bone tissue engineering has garnered significant attention due to the beneficial bone improvement results achieved. Synthetic polymers have played a key role, but there is a trend towards using biological precursors like chitosan, collagen, and gelatin for their high biocompatibility, degradability, and mechanical control.
Article
Chemistry, Multidisciplinary
Nechikkottil Sivadasan Sumitha, Prabha Prakash, Balagopal N. Nair, Gopalakrishnanchettiar Sivakamiammal Sailaja
Summary: Glyoxal cross-linked porous magnetic chitosan microspheres (GMS) were synthesized using a water-in-oil emulsion technique for controlled delivery of doxorubicin (DOX) with prolonged chemotherapeutic effects. GMS exhibited superparamagnetism and excellent cytocompatibility, with a release mechanism involving diffusion-inspired release through the swollen polymer network and regulated degradation release.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Polymer Science
Sana Afzal, Kashif Barkat, Muhammad Umer Ashraf, Ikrima Khalid, Yasir Mehmood, Nisar Hussain Shah, Syed Faisal Badshah, Saba Naeem, Saeed Ahmad Khan, Mohsin Kazi
Summary: The study aimed to develop bacitracin zinc-loaded patches as a new therapeutic agent for wound healing. The results showed that the polymeric network can accelerate wound healing and treatment of minor skin injuries by enhancing drug deposition.
Article
Chemistry, Applied
Huong Thi Hoang, Trung Thang Vu, Viswanathan Karthika, Sung-Han Jo, Yi-Jun Jo, Jeong-Woo Seo, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim
Summary: A physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate was developed for the delivery of ketoprofen. The hydrogel showed outstanding hydrophobic drug loading and sustained release, as well as pH responsiveness, making it a potential candidate for hydrophobic drug delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Marcel Jakubowski, Aleksandra Domke, Maria Ratajczak, Joanna Szczuka, Tomasz Buchwald, Adam Voelkel, Mariusz Sandomierski
Summary: Osteoporosis is a widespread disease. Bisphosphonates are commonly used drugs for its treatment, but they have limitations. This paper focuses on the development of a hydrogel material modified with lanthanum for sustained and slow release of Zoledronate. The research found that the hydrogel is capable of long-term release, making it suitable for implantable hydrogel or coating for local drug delivery on titanium implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Xiaochun Yin, Meixia Du, Zhongming Sun, Hai Zhu, Pei Xu, Huiyao Wang
Summary: Keratin/chitosan hybrid hydrogels were developed by integrating keratin with chitosan through alkaline freeze-thaw cycles. The resulting hydrogels exhibited honeycomb-like structures and excellent mechanical properties. Hydrogel C, with a keratin/chitosan ratio of 3/2, showed the highest compressive stress and strain. It also demonstrated effective controlled release profiles for different drugs at varying pH and temperatures.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Chung-Kai Sun, Cherng-Jyh Ke, Yi-Wen Lin, Feng-Huei Lin, Tung-Hu Tsai, Jui-Sheng Sun
Summary: The study aims to establish an effective antibiotic slow-release system and evaluate its efficacy in preventing implant-related infections through an animal model experiment.
Article
Polymer Science
Lili Deng, Kangkang Ou, Jiaxin Shen, Baoxiu Wang, Shiyan Chen, Huaping Wang, Song Gu
Summary: A natural self-healing hydrogel based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) was developed in this study. The hydrogel showed good self-healing properties and cytocompatibility, indicating its potential in wound healing and tissue repair.
Article
Polymer Science
Nadia G. Kandile, Mansoura I. Mohamed, Howida T. Zaky, Abir S. Nasr, Yassmin G. Ali
Summary: Chitosan was chemically modified to prepare novel hydrogels with excellent antibacterial activity and drug release performance, as well as potent efficiency in metal ion uptake.
Review
Biochemistry & Molecular Biology
Yuhan Xia, Zhiyuan Ma, Xuechen Wu, Huidan Wei, Han Zhang, Guang Li, Yuqi Qian, Mina Shahriari-Khalaji, Kai Hou, Ran Cao, Meifang Zhu
Summary: Sustainable and controllable drug transport is an efficient method for disease treatment. Chitosan hydrogel, characterized by high biocompatibility, good biodegradability, and low costs, has been widely used in biomedical fields. The abundant amino and hydroxyl groups in chitosan hydrogel allow it to interact with human tissues and enable drugs to pass through biological barriers. The multi-responsive nature of chitosan hydrogel, including pH, temperature, ions strength, and magnetic field, makes precise drug release possible. This review summarizes the synthesis methods, modification strategies, stimuli-responsive mechanisms, and recent progress of chitosan-based hydrogels in drug delivery, focusing on subcutaneous, oral, and facial administration. The challenges towards clinical application and future prospects are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Hamid Amiri, Gilles J. Guillemin, Vijai Kumar Gupta, Ahmad Rajaei, Yadong Yang, Wanxi Peng, Junting Pan, Mortaza Aghbashlo, Meisam Tabatabaei
Summary: The article introduces the importance of chitosan and its derivative chitin in biomaterials, particularly in terms of their antimicrobial, antioxidant, and anticancer activities. The article also points out some drawbacks in the structure of chitosan and discusses a modification method using lactose and galactose as main raw materials to prepare soluble branched chitosan.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
V Muthulakshmi, G. R. Rajarajeswari
Summary: Drug-loaded biopolymeric films with pectin-chitosan blends showed enhanced thermal stability, mechanical strength, and antibacterial properties. Among the prepared films, PC4/CC1.5 demonstrated optimal performance and was effective in wound dressing applications with superior wound healing ability in in vivo studies. The curcumin-loaded film holds great potential for further clinical studies.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Najma Rehman, Muhammad Rizwan Dilshad, Atif Islam, Nafisa Gull, Tabinda Riaz, Shahzad Maqsood Khan, Rafi Ullah Khan
Summary: A novel graphene oxide loaded sodium alginate hydrogel was prepared and characterized for its suitability in biomedical applications. The hydrogel containing 10 mg of graphene oxide showed the best performance in terms of swelling and cytotoxicity, making it a promising candidate for controlled drug release.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Tomas Cordero-Lanzac, Cristina Martinez, Andres T. Aguayo, Pedro Castano, Javier Bilbao, Avelino Corma
Summary: This study investigates the synergies between oxygenates (especially dimethyl ether) and n-pentane at low OX/nC(5) ratios, enhancing n-pentane conversion while reducing catalyst coking rate. The analysis of used catalysts reveals that dimethyl ether exhibits higher reactivity than methanol in forming coke structures.
Article
Chemistry, Applied
Cristina Martinez, Alejandro Vidal-Moya, Bilge Yilmaz, C. P. Kelkar, Avelino Corma
Summary: Fluidized Catalytic cracking (FCC) is a main conversion process in refineries, using Y zeolite as the main source of activity and selectivity. A new Y zeolite catalyst, Phinesse(TM), based on partial substitution of RE by P, has been developed and shown to have similar performance to the conventional RE stabilized counterpart. The hydrothermal stability of different USYs with different dealumination degrees, containing P or La alone or a combination of both stabilizing elements, was compared. The results provide insights into the benefits of P-La stabilization observed in the commercial PhinesseTM catalyst.
Review
Chemistry, Multidisciplinary
Lichen Liu, Avelino Corma
Summary: This review discusses the structure, synthesis, and catalytic applications of heterogeneous bimetallic catalysts, including binuclear sites, nanoclusters, and nanoparticles. Recent progress in the field of bimetallic catalysts is highlighted, along with the future research directions and prospects in both fundamental and practical aspects of heterogeneous catalysis.
Article
Multidisciplinary Sciences
Pau Ferri, Chengeng Li, Daniel Schwalbe-Koda, Mingrou Xie, Manuel Moliner, Rafael Gomez-Bombarelli, Mercedes Boronat, Avelino Corma
Summary: Approaching the level of molecular recognition of enzymes with solid catalysts is a challenging goal, achieved in this work for the competing transalkylation and disproportionation of diethylbenzene catalyzed by acid zeolites. The key diaryl intermediates for the two competing reactions only differ in the number of ethyl substituents in the aromatic rings, and therefore finding a selective zeolite able to recognize this subtle difference requires an accurate balance of the stabilization of reaction intermediates and transition states inside the zeolite microporous voids.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Barbara Sanchez-Dengra, Elena Garcia-Montoya, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez
Summary: The aim of this study was to create and validate a new in vitro model capable of predicting the permeability across the blood-brain barrier in the presence of glioblastoma. The results showed that the co-culture model of MDCK and MDCK-MDR1 with U87-MG had high predictability in drug access to the central nervous system.
Article
Chemistry, Multidisciplinary
Risheng Bai, Guangyuan He, Lin Li, Tianjun Zhang, Junyan Li, Xingxing Wang, Xiumei Wang, Yongcun Zou, Donghai Mei, Avelino Corma, Jihong Yu
Summary: In this work, a carbonization-reduction method was used to create palladium carbide subnanometric species within pure silicate MFI zeolite. The developed catalyst showed superior performance in the selective hydrogenation of alkynes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Francisco Gonell, Miriam Rodenes, Santiago Martin, Mercedes Boronat, Ivan Sorribes, Avelino Corma
Summary: Developing precious-metal-free electrocatalysts for the hydrogen evolution reaction (HER) is crucial. Amorphous molybdenum sulfide-based materials provide highly active HER electrocatalysts by introducing active sites at both the edge positions and the typically inactive basal planes. The bottom-up synthesis using molecular complexes with Mo3S4 and Mo3S7 cluster cores enhances the HER activity and allows the modification of the derived materials with atomic-scale precision.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Miriam Rodenes, Frederic Dhaeyere, Santiago Martin, Patricia Concepcion, Avelino Corma, Ivan Sorribes
Summary: A defect-engineered molybdenum sulfide catalyst is used to establish straightforward synthetic processes using alcohols. Developing tandem catalytic strategies based on readily available, stable, and renewable feedstocks is crucial for sustainable chemical industries. The catalyst, defect-engineered basal planes of a molybdenum sulfide nanomaterial ({Mo3S4}( n )), enables one-pot single-step synthesis and facilitates various coupling reactions involving alcohol dehydrogenation and hydrogen activation processes.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Lichen Liu, Avelino Corma
Summary: Heterogeneous bimetallic catalysts are widely used in industrial processes, but understanding the active sites in these catalysts at the atomic and molecular level is challenging due to their structural complexity. Comparing the structural features and catalytic performances of different bimetallic entities can aid in developing a unified understanding of the structure-reactivity relationships and improving current bimetallic catalysts. This review discusses the geometric and electronic structures of three representative types of bimetallic catalysts, as well as the synthesis methods, characterization techniques, and catalytic applications of these catalysts.
Article
Chemistry, Physical
Risheng Bai, Yue Song, Ge Tian, Fei Wang, Avelino Corma, Jihong Yu
Summary: The synthesis of highly efficient nano-sized Ti-rich TS-1 zeolites with controllable titanium species is crucial in zeolite catalytic reactions. A new method was developed using tetrabutyl orthotitanate tetramer as the titanium source, which slowed down the zeolite crystallization process and prevented the formation of anatase species. The Ti-rich TS-1 zeolite prepared with this method exhibited enriched active titanium species, enlarged external surface area, and superior catalytic performance in oxidative desulfurization reactions.
GREEN ENERGY & ENVIRONMENT
(2023)
Review
Chemistry, Multidisciplinary
Alexandra Velty, Avelino Corma
Summary: For many years, capturing, storing or sequestering CO2 from emission sources has been an effective method for reducing atmospheric CO2. The chemical conversion of CO2 into valuable chemicals has gained much attention due to CO2's abundance and renewable nature. Catalysts, particularly zeolite and ordered mesoporous materials, play a critical role in the conversion of CO2. By studying the reactions involving these catalysts, this review aims to explore the potential opportunities for using them to convert CO2 into essential chemicals and fuels.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Barbara Sanchez-Dengra, Maria Alfonso, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Ramon Martinez-Manez
Summary: The two types of nanoparticles loaded with ponatinib have been proven to be non-toxic to blood-brain barrier cells and have shown improved drug delivery to the brain compared to the free drug when administered intranasally. This research is significant for the treatment of brain cancer.
