Article
Biochemistry & Molecular Biology
Fangqin Song, Siqi Li, Chuanhao Sun, Ying Ji, Yan Zhang
Summary: The study developed ROS-responsive drug carrier nanoparticles PS@AQ4N/mPEG-b-PSe NPs, which combined a photosensitizer with a hypoxia-activated prodrug to enhance ROS generation efficiency, showing potential in antitumor therapy based on cell experiments.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Die Jia, Xianbin Ma, Yi Lu, Xinyi Li, Shengxin Hou, Yuan Gao, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: Cyclodextrin is widely used for constructing CD-based nanoplatforms due to its special spatial structure and good biological safety. The study designed a highly sensitive ROS-responsive polymer PCP encapsulating doxorubicin (DOX) and purpurin 18 (P18) for synergistic photodynamic and chemotherapy effects. The micelles showed enhanced anti-cancer activity through the release of drugs triggered by ROS in the tumor microenvironment.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Hui Zhou, Yuqin Liao, Xiangfei Han, Dean Shuailin Chen, Xuechuan Hong, Kun Zhou, Xingya Jiang, Yuling Xiao, Jinjun Shi
Summary: This study reports a reactive oxygen species (ROS)-responsive polymeric nanoparticle (NP) platform for the first time, enabling co-delivery of mRNA and a photosensitizer for effective cancer treatment. The ROS-triggered disassembly of the NPs promoted mRNA translation efficiency, leading to p53 expression-induced apoptosis of lung tumor cells. Meanwhile, the released photosensitizer induced photodynamic therapy under 808 nm laser irradiation. The co-delivery of mRNA and the photosensitizer demonstrated an effective and safe anti-tumor effect in a lung cancer model.
Article
Medicine, Research & Experimental
Islam Zmerli, Nada Ibrahim, Paul Cressey, Stephanie Denis, Ali Makky
Summary: Polydopamine nanoparticles have been considered for their multifunctional properties including photothermal and photodynamic activities. In this study, PDA NPs were modified with SH-PEG polymers bearing a reactive oxygen species-cleavable linker coupled to trisulfonatedtetraphenylporphyrin for PDT applications. The efficient grafting of PS-conjugated PEG on PDA was demonstrated in situ and the photoinduced release of PS was confirmed by H-1 NMR. In vitro experiments on human esophageal cells showed the strong synergistic effect of combining PTT and PDT within this nanoplatform.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang, Jie Liu
Summary: A novel combined chemo/photodynamic therapy has been developed using pH/ROS/MMP-2 triple-responsive drug nanocarriers for efficient treatment of solid tumors. The nanoparticles can effectively accumulate in tumors, release drugs in response to intracellular pH and ROS levels, and amplify ROS generation with external laser irradiation to achieve extraordinary therapeutic efficacy. The treatment showed substantial tumor shrinkage and eradication with low toxicity in major organs, indicating great potential for tumor therapy.
Article
Chemistry, Applied
Zulal Ozdemir, Mengyao Yang, Gyoungmi Kim, Uladzimir Bildziukevich, David Saman, Xingshu Li, Juyoung Yoon, Zdenek Wimmer
Summary: The redox-responsive nanoparticle is designed to produce singlet oxygen and release anticancer drug in response to GSH-triggered disassembly, making it a promising candidate for photodynamic therapy.
Article
Engineering, Biomedical
Yu Zhang, Xiyou Du, Shangui Liu, Huixian Yan, Jianbo Ji, Yanwei Xi, Xiaoye Yang, Guangxi Zhai
Summary: The CPIM nanoplatform combines size-transforming and transcytosis strategies to enhance tumor penetration and drug delivery, resulting in significant effects on tumor penetration, drug transport, and anti-tumor immunity.
Article
Chemistry, Physical
Shiliang Zhu, Ke Li, Shuai Qin, Jianguo Lin, Ling Qiu
Summary: Traditional photodynamic therapy (PDT) using external light source has poor tissue penetration. Cerenkov radiation (CR) can serve as an internal light source to activate photosensitizers. However, the outcomes of CR-induced PDT (CR-PDT) are limited by the weakness of CR emission. This study presents a new strategy using a ROS-responsive Chemo-PDT agent to improve the outcomes of CR-PDT.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qian An, Shengze Su, Wei Hu, Yanying Wang, Tao Liang, Xianghong Li, Chunya Li
Summary: Combining photothermal therapy (PTT) with photodynamic therapy (PDT) and other therapeutic tools can significantly enhance tumor-killing ability. Copper sulfide nanoparticle (CuS NP) photothermal reagents, when combined with PDT photosensitizers, can effectively construct a PTT/PDT combination therapeutic platform. The CuS@COF nanosheets prepared with a dual-ligand assistant strategy exhibit excellent photothermal conversion performance, high singlet oxygen yield, and high photothermal conversion efficiency.
Article
Biochemistry & Molecular Biology
Xiuhan Guo, Haoze Yu, Wanjie Shen, Rui Cai, Yueqing Li, Guangzhe Li, Weijie Zhao, Shisheng Wang
Summary: Researchers found that the PS-NO photosensitizers containing NO donors have stronger antitumor activity compared to chlorin e6, and can increase the levels of NO and ROS in cells. Additionally, the addition of the ferroptosis inhibitor Ferrostatin-1 significantly reduces the photodynamic activity of PS-NO and the levels of NO and ROS in cells.
BIOORGANIC CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Xiaoxiang Ren, Han Liu, Xianmin Wu, Weizong Weng, Xiuhui Wang, Jiacan Su
Summary: Reactive oxygen species (ROS) play a crucial role in the bone microenvironment and excessive accumulation of ROS can lead to bone metabolic diseases. Therefore, ROS-responsive biomaterials are considered promising strategies for treating bone-related diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nnamdi Nwahara, Garth Abrahams, John Mack, Earl Prinsloo, Tebello Nyokong
Summary: This study presents a liposome loaded-silicon (IV) phthalocyanine (SiPc) with naphthoquinone axial ligands as hypoxia-responsive prodrug-like moieties (Prodrug-SiPc). Computational methods were used to assess the photophysical, photochemical and electrochemical redox properties of Prodrug-SiPc, revealing the relationship between material structure and properties. The liposomal encapsulation of Prodrug-SiPc resulted in potential photodynamic therapy (PDT) drug candidates, which took advantage of the hypoxic microenvironment of tumors to enhance therapeutic efficacy compared to typical PDT.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fang-Zhou Xu, Cheng-Yun Wang, Qi Wang, Jian-Wei Zou, Yi-Jie Qiao, Zhi-Qian Guo, Weijun Zhao, Wei-Hong Zhu
Summary: In this study, several AIEgens with excellent properties were designed and synthesized for wash-free off-on mitochondrial imaging and photodynamic therapy of HeLa cells.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Hao Hu, Hua Wang, Yuchong Yang, Jiang-Fei Xu, Xi Zhang
Summary: In this study, a cationic porphyrin derivative TMPyP was developed that could be used for specific bacteria-responsive antimicrobial treatment through adaptable photodynamic/photothermal therapy processes. The results showed that TMPyP exhibited strong antimicrobial activity (>99%) through photothermal therapy in hypoxic environments where facultative anaerobes with a strong reducing ability, such as E. coli and S. typhimurium, could reduce TMPyP to phlorin. In aerobic environments with aerobic bacteria, TMPyP functioned as a typical photosensitizer that effectively killed bacteria (>99.9%) through photodynamic therapy. The biocompatibility of TMPyP was significantly improved by forming a host-guest complex with cucurbit[7]uril. This bacteria-responsive porphyrin demonstrates specificity and adaptability in antimicrobial treatment and holds potential in non-invasive treatments of bacterial infections.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
Chaozhou Li, Hui Tan, Ruitao Lu, Sainan Qin, Xiangying Meng, Han Zhang, Zhongjian Xie
Summary: Photodynamic therapy (PDT) is a promising anticancer method, but its development is hindered by tissue penetration limitations and dependence on oxygen concentration for reactive oxygen species (ROS) formation. This study introduces electrotherapy to generate oxygen and alleviate tumor hypoxia, thus enhancing the efficacy of PDT.