Article
Oncology
Jing-Jin Yang, Wei-Xia Peng, Mei-Biao Zhang
Summary: This study investigated the role of lncRNA KCNQ1OT1 in osteogenic differentiation of bone marrow mesenchymal stem cells. The results showed that KCNQ1OT1 can upregulate the expression of RICTOR by inhibiting miR-205-5p, thus promoting osteogenesis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Respiratory System
Xiaolong Zhu, Ling He, Xueqin Li, Weiya Pei, Hui Yang, Min Zhong, Mengying Zhang, Kun Lv, Yingying Zhang
Summary: This study reveals that miR-125b-5p is highly expressed in asthma and plays a role in modulating macrophage polarization. By suppressing the expression of miR-125b-5p, allergic airway inflammation in mice can be attenuated. These findings may present a potential therapeutic and diagnostic target for asthma.
BMC PULMONARY MEDICINE
(2023)
Article
Pathology
Ping Chen, Li-Sha Sun, Hao-Ming Shen, Bin Qu
Summary: KCNQ1OT1 is highly expressed while miR-125b-5p is lowly expressed in ovarian cancer (OC). KCNQ1OT1 promotes OC cell proliferation and metastasis by binding to miR-125b-5p. MiR-125b-5p targets CD147, and its expression is negatively correlated with that of miR-125b-5p in OC specimens. KCNQ1OT1 is positively correlated with CD147 in OC specimens, and it accelerates OC progression through the miR-125b-5p/CD147 axis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Xiuyun Shen, Fengnan Zhi, Chunpeng Shi, Jincheng Xu, Yuqiu Chao, Juan Xu, Yunlong Bai, Yanan Jiang, Baofeng Yang
Summary: The lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway is involved in ATO-induced cardiotoxicity. Propranolol can attenuate ATO-induced cardiotoxicity at least partially through the lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Yijun Liu, Ding Zhao, Xue Wang, Ying Dong, Fupeng Ding
Summary: The study found that KCNQ1OT1 upregulated PIK3C2A to reduce chondrocyte dysfunction by targeting miR-218-5p, shedding new light on the pathogenesis of osteoarthritis.
CELL AND TISSUE RESEARCH
(2021)
Article
Endocrinology & Metabolism
Li Zhao, Huaqian Chen, Lin Wu, Zhengdong Li, Ren Zhang, Yan Zeng, Tao Yang, Hualing Ruan
Summary: This study revealed that upregulated KCNQ1OT1 in DN patients and cell models inhibited cell proliferation and fibrosis while inducing apoptosis. It was found that miR-93-5p is a direct target of KCNQ1OT1, and targeting ROCK2, miR-93-5p overexpression can suppress cell proliferation and fibrosis. KCNQ1OT1 regulates ROCK2 expression by binding to miR-93-5p, providing potential value for DN treatment.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Oncology
Qilin Gong, Huaying Li, Jintian Song, Chang Lin
Summary: The study found that lncRNA LINC01569 is highly expressed in tumor-associated macrophages (TAMs) of hypopharyngeal carcinoma. LINC01569 inhibits the polarization of M2 macrophages through the miR-193a-5p/FADS1 signaling pathway, promoting the occurrence and development of hypopharyngeal carcinoma.
Article
Cardiac & Cardiovascular Systems
Jinbei Li, Yalin Tong, Yanjun Zhou, Zhanying Han, Xule Wang, Tongbin Ding, Yongsheng Qu, Zhiliang Zhang, Chao Chang, Xiaoli Zhang, Chunguang Qiu
Summary: The study revealed that KCNQ1OT1 is involved in the regulation of autophagy and apoptosis of cardiomyocytes in myocardial infarction patients, affecting cell survival through the miR-26a-5p/ATG12 pathway. Inhibition of KCNQ1OT1 may be a potential therapeutic option to protect cardiomyocytes from damage caused by MI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Yebao Wang, Ling Liu, Jianmin Li
Summary: This study revealed that KCNQ1OT1 expression was upregulated and miR-145-5p was downregulated in atherosclerotic plaques of AS mice and ox-LDL-treated THP-1 cells. Attenuation of lipid metabolic disorders and inflammation was observed in vivo and in vitro by either KCNQ1OT1 knockdown or miR-145-5p overexpression. Furthermore, KCNQ1OT1 acted as a molecular sponge of miR-145-5p, influencing AS progression.
MICROVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yibo Zhuang, Hongxue Zheng, Yong Yang, Huiping Ni
Summary: The study revealed the association between diabetic kidney disease and the polarization of macrophages, as well as the anti-inflammatory effects of GABA regulating the direction of macrophage polarization. GABA alleviated podocyte injury by reversing the polarization of macrophages and regulating the expression of miR-21a-5p-Tnpo1/miR-25-3p-ATXN3 axis in macrophage-derived exosomes under high glucose conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Furong Wang, Fucai Zhang, Feng Zheng
Summary: The study demonstrated that Kcnq1ot1 promotes bone formation by inhibiting miR-98-5p and upregulating Tbx5, suggesting their potential as therapeutic targets for osteoporosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Oncology
Qing Wei, Guoman Liu, Zihua Huang, Yanyan Huang, Lizheng Huang, Zheng Huang, Xianjian Wu, Huamei Wei, Jian Pu
Summary: Hepatocellular carcinoma (HCC) is a common form of liver cancer, and tumor-associated macrophages (TAMs) play a crucial role in tumor growth and metastasis. The long non-coding RNA MEG3 has been found to inhibit HCC development. However, its role in macrophage phenotypic polarization in HCC is still unclear.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Biotechnology & Applied Microbiology
Kun Liu, Xin Luo, Zhao-Yong Lv, Yu-Jue Zhang, Zhen Meng, Jun Li, Chun-Xiu Meng, Hui-Fen Qiang, Cai-Yao Hou, Lei Hou, Feng-Zhen Liu, Bin Zhang
Summary: The effective healing of bone defects relies on the coordination between inflammatory and bone-forming cells. This study investigated the interaction between polarized macrophages and bone mesenchymal stem cells (BMSCs), as well as their effects on osteogenesis. The results showed that exosomes from both pro-inflammatory M1 and anti-inflammatory M2 macrophages can promote the osteogenesis of BMSCs, especially M1 macrophage-derived exosomes through microRNA-21a-5p in the early stage of inflammation. This research helps us understand the complex interactions between BMSCs and macrophages, and provides insights for improving bone healing and other regenerative processes through the release of exosomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Ma, Li Chen, Xiang Zhu, Qing Li, Liqun Hu, Hongqi Li
Summary: The study demonstrated that MSC-derived exosomes promote M2 polarization of macrophages, reduce plaque area, and decrease macrophage infiltration, thereby attenuating the development of atherosclerosis (AS). This effect is achieved by targeting KLF6 and ERK1/2 signaling pathways, offering a promising treatment option for AS.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)