期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 41, 期 7, 页码 979-984出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b18-00166
关键词
transthyretin; crystal structure; amyloidosis; natural product; stabilizer; amyloid fibril disrupter
资金
- Amyloidosis Research Committee from the Ministry of Health, Labour, and Welfare, Japan
- JSPS KAKENHI [16K08193]
- JSPS Core-to-Core Program
- Grants-in-Aid for Scientific Research [16K08193] Funding Source: KAKEN
Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural products and synthetic compounds that have been shown to inhibit the amyloidogenesis of TTR. The stabilizers and/or the amyloid fibril disrupters isolated from natural sources may become lead compounds for the treatment of TTR-related amyloidosis.
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