Article
Computer Science, Artificial Intelligence
Humayun Kayesh, Md Saiful Islam, Junhu Wang, Ryoma Ohira, Zhe Wang
Summary: This paper proposes a novel approach for detecting ADRs in Tweets by exploiting cause-effect relationships. By splitting Tweets into different segments, extracting causal features, and applying multi-head self-attention mechanism, ADRs can be effectively detected. Extensive experiments demonstrate the effectiveness of the proposed approach.
Review
Biochemistry & Molecular Biology
Ramon Cacabelos, Vinogran Naidoo, Lola Corzo, Natalia Cacabelos, Juan C. Carril
Summary: Pharmacogenomics plays a crucial role in optimizing drug efficacy and safety in preventing adverse drug reactions, but its application in ADR prevention is hindered by limitations such as lack of education and training, unspecific biomarkers, cost-effectiveness issues, administrative challenges, and insufficient regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Jaesub Park, Sangyeon Lee, Kwansoo Kim, Jaegyun Jung, Doheon Lee
Summary: In this study, a computational approach called LAPINE is proposed for large-scale prediction of ADR-related proteins. The results show that LAPINE is capable of predicting ADR-related proteins with high reliability, providing insights into the mechanism of ADRs and aiding in prevention. The source code of LAPINE is available on GitHub and Figshare.
Review
Pharmacology & Pharmacy
Kanoot Jaruthamsophon, Paul J. Thomson, Chonlaphat Sukasem, Dean J. Naisbitt, Munir Pirmohamed
Summary: This review explores the translational progress of using HLA as a key susceptibility factor for immune ADRs and highlights gaps in our knowledge. Additionally, it covers relevant findings of HLA-mediated drug-specific T cell activation.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Genetics & Heredity
Zhichong Wu, Kenneth Guangpu Yang, Tsz-Ping Lam, Jack Chun Yiu Cheng, Zezhang Zhu, Wayne Yuk-Wai Lee
Summary: This study identified causal proteins and druggable targets for osteoporosis using GWAS summary statistics and estimated bone mineral density. Several proteins associated with bone density and fracture risk were found and validated. Enrichment analysis highlighted the role of collagen binding and extracellular matrix in osteoporosis development.
FRONTIERS IN GENETICS
(2023)
Article
Computer Science, Artificial Intelligence
Antonino Aparo, Pietro Sala, Vincenzo Bonnici, Rosalba Giugno
Summary: Computational approaches for detecting signals of adverse drug reactions are powerful tools in monitoring unattended effects reported by users, aiming to prevent serious injuries and deaths by early detection of adverse reactions. The methodology allows for a greater number of true signals to be detected without significantly increasing false positives.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hongqun Yang, Lanlan Chen, Yahui Liu
Summary: Using Mendelian randomization analysis, this study identified and validated 13 plasma proteins associated with hypothyroidism. Some of these proteins could explain the association between the coagulation system and hypothyroidism. These proteins have the potential to be used as early screening biomarkers for hypothyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Xuyan Wang, Donghong Yin, Yang Tang, Feng Xiao, Shuyun Wang
Summary: The development of non-selective multi-kinase inhibitors (MKIs) has improved the survival outcomes of patients with cancers. However, psychiatric disorders as adverse events of MKIs are a particular concern. This study analyzed the psychiatric adverse events related to various non-selective RET MKIs using a public database, aiming to provide evidence for optimizing drug administration in the clinic.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chuang-Wei Wang, Ivan Arni C. Preclaro, Wei-Hsiang Lin, Wen-Hung Chung
Summary: This mini review article summarizes the current knowledge of pharmacogenomics of severe adverse drug reactions (ADR) and discusses the potential clinical use of genetic markers in avoiding ADR.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Jingwei Zhang, Jie Wen, Xin Wan, Peng Luo
Summary: The study suggests that exposure to heavy air pollution increases the risk of obesity and COVID-19. Moreover, obesity itself increases the susceptibility to COVID-19. It is important to monitor weight status in populations exposed to heavy air pollution as they are more vulnerable to COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Pan Luo, Jiawen Xu, Shiqiang Cheng, Ke Xu, Wensen Jing, Feng Zhang, Peng Xu
Summary: This study used genetic correlation analysis and Mendelian randomization (MR) analysis to identify the correlation and potential causal relationship between blood metabolites and deep vein thrombosis (DVT). The findings suggest that hydroxytryptophan may be causally related to DVT. These results provide new insights into the pathogenesis and diagnosis of DVT.
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
Bin Guo, Chao Wang, Yong Zhu, Zhi Liu, Haitao Long, Zhe Ruan, Zhangyuan Lin, Zhihua Fan, Yusheng Li, Shushan Zhao
Summary: This study aimed to investigate the causal associations between brain structure and bone mineral density (BMD). Through genetic correlation analysis and linkage disequilibrium score regression, it was found that a part of brain structure had strong associations with BMD, providing important perspectives for the prevention of osteoporosis and valuable insights for further research on the brain-bone axis.
Review
Chemistry, Medicinal
Carlo Maria Bellanca, Egle Augello, Anna Flavia Cantone, Rosaria Di Mauro, Giuseppe Antonino Attaguile, Vincenza Di Giovanni, Guido Attilio Condorelli, Giulia Di Benedetto, Giuseppina Cantarella, Renato Bernardini
Summary: ADR has a significant impact on morbidity and mortality, particularly among older adults. Preventive measures such as accurate prescriptions and appropriate medication management, as well as digital health interventions, offer valuable solutions to alleviate the burden of ADRs.
Article
Computer Science, Artificial Intelligence
Tongxuan Zhang, Hongfei Lin, Yuqi Ren, Zhihao Yang, Jian Wang, Shaowu Zhang, Bo Xu, Xiaodong Duan
Summary: The importance of drug safety issues related to adverse drug reactions (ADRs) is increasing, as patients share their reactions on social media for support. However, available social media datasets are rare, and the informality of social media text poses a challenge for ADR identification. Introducing PubMed datasets can improve ADR identification in social media. The proposed adversarial transfer framework and dynamic weight method show promising results in enhancing ADR identification performance on social media.
APPLIED SOFT COMPUTING
(2021)
Article
Pharmacology & Pharmacy
Nontaya Nakkam, Parinya Konyoung, Warayuwadee Amornpinyo, Niwat Saksit, Somsak Tiamkao, Usanee Khunarkornsiri, Kanyarat Khaeso, Oranuch Pattanacheewapull, Teekayu Plangkoon Jorns, Pansu Chumworathayi, Wichittra Tassaneeyakul
Summary: The study found significant associations between the HLA-B*15:02 and HLA-B75 alleles and CBZ-induced SJS/TEN, serving as strong genetic markers for predicting SCARs caused by CBZ in the Thai population.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pediatrics
Zulfan Zazuli, Catharina J. P. Op 't Hoog, Susanne J. H. Vijverberg, Rosalinde Masereeuw, Shahrad Rod Rassekh, Mara Medeiros, Rodolfo Rivas-Ruiz, Anke H. van der Zee, Bruce C. Carleton
Summary: This study evaluated the incidence of kidney injury in children who received cisplatin using different definitions. The Alt-AKI criteria detected more cases of nephrotoxicity compared to pRIFLE and KDIGO criteria. pRIFLE was more sensitive at detecting actual kidney injury and patients at risk, while KDIGO was better at detecting clinically significant kidney injury.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Kelly R. McMahon, Asaf Lebel, Shahrad Rod Rassekh, Kirk R. Schultz, Tom D. Blydt-Hansen, Geoffrey D. E. Cuvelier, Cherry Mammen, Maury Pinsk, Bruce C. Carleton, Ross T. Tsuyuki, Colin J. D. Ross, Louis Huynh, Mariya Yordanova, Frederik Crepeau-Hubert, Stella Wang, Ana Palijan, Jasmine Lee, Debbie Boyko, Michael Zappitelli
Summary: This study examines the burden of acute kidney injury (AKI) and kidney outcomes in pediatric patients receiving cisplatin therapy. Severe electrolyte abnormalities were found to be associated with kidney outcomes, highlighting the need for dose optimization and follow-up guidelines in post-cisplatin care.
PEDIATRIC NEPHROLOGY
(2023)
Review
Health Care Sciences & Services
Angela Siemens, Spencer J. Anderson, S. Rod Rassekh, Colin J. D. Ross, Bruce C. Carleton
Summary: Polygenic models can be used to predict complex traits and drug outcomes, but there are challenges in constructing and validating these models, such as the heterogeneity of performance measures and comparison with clinical predictors.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Khalid Taha, Atul Sharma, Kristine Kroeker, Colin Ross, Bruce Carleton, David Wishart, Mara Medeiros, Tom D. D. Blydt-Hansen
Summary: This study aims to develop a novel urine test based on metabolomics to estimate the exposure of mycophenolate in pediatric renal transplantation. The urine samples were analyzed for 133 unique metabolites, and a top 10 urinary metabolite classifier was developed to estimate MPA exposure. The test was validated and showed correlation with allograft inflammation and eGFR ratio.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Jafar S. Hasbullah, Erika N. Scott, Amit P. Bhavsar, Erandika P. Gunaretnam, Fudan Miao, Hesham Soliman, Bruce C. Carleton, Colin J. D. Ross
Summary: This study explores the effects of activating the retinoic acid pathway using all-trans retinoic acid (ATRA) on anthracycline-induced cardiotoxicity (ACT). The findings demonstrate that ATRA can reduce the toxicity of anthracyclines on human cardiomyocytes by regulating gene expression and enhancing cell survival. In a mouse model, ATRA treatment improves heart function and reduces pathological changes associated with ACT.
Article
Medical Laboratory Technology
Angela Siemens, Shahrad Rod Rassekh, Colin J. D. Ross, Bruce C. Carleton
Summary: This study aimed to examine how the pharmacogenetic effects of SLC28A3, UGT1A6, and RARG are modulated by cumulative anthracycline doses in the development of cardiotoxicity. The findings suggest that the SLC28A3 variant provides more significant protection for patients receiving higher anthracycline doses, while the UGT1A6 and RARG risk variants significantly increase the risk of cardiotoxicity at low anthracycline doses.
THERAPEUTIC DRUG MONITORING
(2023)
Letter
Pharmacology & Pharmacy
Mahyar Etminan, Mohit Sodhi, Bruce Carleton
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Si-Yue Yu, Tiffany Carlaw, Tyler Thomson, Alexandra Birkenshaw, Genc Basha, Daniel Kurek, Cassie Huang, Jayesh Kulkarni, Lin-Hua Zhang, Colin J. D. Ross
Summary: The development of CRISPR genome editing technology has potential for treating genetic diseases, but delivering genome editors to affected tissues is challenging. In this study, a luminescent ABE (LumA) mouse model was developed, which showed restoration of luciferase activity through A-to-G correction. The model was validated using FDA-approved lipid nanoparticle formulations and demonstrated successful restoration of luciferase activity in treated mice. This model can be used to evaluate the efficacy and safety of genome editors and delivery systems for optimizing genome editing therapeutics.
Letter
Pediatrics
Victoria E. Cook, Michael Seear, Bruce Carleton, Connie L. Yang
PEDIATRIC PULMONOLOGY
(2023)
Article
Medical Laboratory Technology
Angela Siemens, Beth Brooks, S. Rod Rassekh, Annelot J. M. Meijer, Mary M. van den Heuvel-Eibrink, Wei Xu, Catrina M. Loucks, Colin J. D. Ross, Bruce C. Carleton
Summary: This study found a close relationship between cisplatin dose intensity and the risk of ototoxicity in children, and this risk is further increased by the presence of TPMT-risk alleles.
THERAPEUTIC DRUG MONITORING
(2023)
Review
Immunology
Matthew Z. Dudley, Jennifer E. Gerber, Haley Budigan Ni, Madeleine Blunt, Taylor A. Holroyd, Bruce C. Carleton, Gregory A. Poland, Daniel A. Salmon
Summary: This scoping review examines the associations between human genetics and vaccine immunogenicity and safety. The study found numerous genetic determinants associated with the immunogenicity of hepatitis B, measles, rubella, and influenza vaccines. Additionally, genetic associations were reported with adverse events following influenza and measles vaccinations.
Article
Oncology
Peng Xia, Jingrui Chen, Yadav Sapkota, Erika N. Scott, Yuening Liu, Melissa M. Hudson, Shahrad R. Rassekh, Bruce C. Carleton, Colin J. D. Ross, Eric J. Chow, Zhaokang Cheng
Summary: This study found that RBL2 is an endogenous CDK2 inhibitor in the heart, which can inhibit FOXO1-mediated pro-apoptotic gene expression. Loss of RBL2 increases sensitivity to DOX-induced cardiotoxicity. These findings suggest that RBL2 could be used as a biomarker to predict the risk of cardiotoxicity before the initiation of anthracycline-based chemotherapy.
JACC: CARDIOONCOLOGY
(2023)
Article
Pediatrics
Hayton Y. Chui, Kelly R. McMahon, Shahrad Rod Rassekh, Kirk R. Schultz, Tom D. Blydt-Hansen, Cherry Mammen, Maury Pinsk, Geoffrey D. E. Cuvelier, Bruce C. Carleton, Ross T. Tsuyuki, Colin J. D. Ross, Prasad Devarajan, Louis L. Huynh, Mariya Yordanova, Frederik G. Crepeau-Hubert, Stella Wang, Vedran Cockovski, Ana Palijan, Michael Zappitelli
Summary: In this study, it was found that urine TIMP-2 and IGFBP-7 may serve as biomarkers for early detection of cisplatin-induced AKI in pediatric patients. The concentrations of these biomarkers were associated with the occurrence of AKI during cisplatin treatment.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Samina Ali, Katie Gourlay, Aran Yukseloglu, Rhonda J. Rosychuk, Silvia Ortiz, Rick Watts, David W. Johnson, Bruce Carleton, Sylvie Le May, Amy L. Drendel
Summary: The study aimed to compare the frequency and intensity of adverse events in children using ibuprofen versus oxycodone for pain management following acute fractures, with oxycodone associated with more frequent and intense AEs. Additionally, lower extremity fractures were found to result in more functional limitations. Clinicians should take these differences into consideration when providing fracture pain care for children.
BMJ PAEDIATRICS OPEN
(2022)