Editorial Material
Cell Biology
Hongming Pan, Yuting Jian, Feijie Wang, Shaokun Yu, Jiannan Guo, Juntao Kan, Wei Guo
Summary: This article discusses the crucial role of the NLRP3 inflammasome in maintaining gut microbiota homeostasis, gut health, and immune system stability.
Article
Fisheries
Ramya Kumar, Mei-Ying Huang, Chih-Ling Chen, Han-Ching Wang, Hsiao-Pei Lu
Summary: In order to face the recurring outbreaks of bacterial and viral shrimp diseases, shrimp gut microbiota research and probiotic intervention have shown promising results in improving shrimp gut health and controlling disease in shrimp aquaculture. This review summarizes the current understanding of the shrimp gastrointestinal tract, the role of microbiota in disease, and the effects of probiotics based on studies on acute hepatopancreatic necrosis disease and white spot disease. The concept of microbiota resilience and strategies for restoring shrimp gut health through probiotics are also discussed.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Clelia Altieri, Barbara Speranza, Maria Rosaria Corbo, Milena Sinigaglia, Antonio Bevilacqua
Summary: Many scientific studies have found a significant link between human intestinal microbiota, eating habits, and the development of chronic-degenerative diseases. The composition and function of microbiota can affect chronic inflammatory mechanisms. This paper focuses on the changes in the gut microbiota of MS patients, its implications for health and disease, and the variables that influence it. It also discusses the role of microbiota in modulating immune responses in both the intestine and the brain, as well as the potential of microbiota modulation as a therapeutic approach for MS. Additionally, a case study evaluates the significance of gastrointestinal pains indirectly related to dysbiosis and the willingness of MS patients to use probiotics to modulate gut microbiota.
Review
Microbiology
Jinghang Xu, Qiao Zhan, Yanan Fan, Emily Kwun Kwan Lo, Fangfei Zhang, Yanyan Yu, Hani El-Nezami, Zheng Zeng
Summary: Liver cancer, especially hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths globally. The emerging importance of gut homeostasis in HCC pathogenesis, patterns of dysbiosis in HCC patients, and potential role in diagnosis highlight the potential for improving treatment and prevention. Although clinical studies are lacking, animal models suggest that modulation of gut microbiota by probiotics could be a new approach to treat or prevent HCC development.
Review
Medicine, General & Internal
Pasquale Napolitano, Mariaelena Filippelli, Sergio Davinelli, Silvia Bartollino, Roberto dell'Omo, Ciro Costagliola
Summary: The microbiota plays a crucial role in host health, with alterations in the intestinal microbiota potentially contributing to the pathogenesis of common diseases. There is evidence of a gut-eye axis, indicating that gut dysbiosis may influence the onset and progression of various ocular diseases. Supplementation with pre- and probiotics is a promising approach to restore gut microbiota and prevent eye pathologies.
ANNALS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bharati Kadamb Patel, Kadamb Haribhai Patel, Ryan Yuki Huang, Chuen Neng Lee, Shabbir M. Moochhala
Summary: Diabetic foot ulcers are a growing concern worldwide and can pose complications in diagnosis and treatment. The interaction of bacteria on the skin surface plays a vital role in the pathophysiology of these ulcers. Commensal microbiota interacts with skin cells involved in wound healing and enhances barrier regeneration. The gut-skin axis shows the connection between the gut and skin health through immunological and metabolic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Infectious Diseases
Stefano Musumeci, Matteo Coen, Antonio Leidi, Jacques Schrenzel
Summary: The mycobiome in the human gut microbiota plays a significant role in both health and disease, with Candida albicans as a key component potentially influencing various pathological processes. Further research and understanding of the mycobiome could lead to advancements in clinical practice and disease management.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, Research & Experimental
Jiaxing Tan, Lingqiu Dong, Zheng Jiang, Li Tan, Xinyao Luo, Gaiqin Pei, Aiya Qin, Zhengxia Zhong, Xiang Liu, Yi Tang, Wei Qin
Summary: This study found that both IgAN patients and mice exhibited gut microbiota dysbiosis, with a decrease in Bifidobacterium levels, which were negatively correlated with IgAN severity. Probiotic treatment containing Bifidobacterium could effectively alleviate gut dysbiosis and attenuate IgAN clinicopathological manifestations by inhibiting the NLRP3/ASC/Caspase 1 signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Anjana, Santosh Kumar Tiwari
Summary: Lactic acid bacteria can cure diseases and modulate gut microbiota by producing bacteriocins, making them effective in treating various human disorders.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Oncology
Himani Pandey, Daryl W. T. Tang, Sunny H. H. Wong, Devi Lal
Summary: Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. Gut microbiota play a significant role in promoting inflammation and tumor progression in CRC. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the role of gut microbiota in CRC development and its potential applications in diagnosis, prevention, and treatment.
Review
Immunology
Yaxuan Xing, Longmei Yan, Xiaoya Li, Zhijie Xu, Xianyu Wu, Huirong Gao, Yiduo Chen, Xiaojuan Ma, Jiangang Liu, Jingchun Zhang
Summary: This review discusses the interconnection between NLRP3 inflammasomes and gut microbiota in the development of atrial fibrillation, and explores the potential value of pharmacological and dietary induction in managing AF through the association between NLRP3 inflammasomes and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ding Yang, Zixu Wang, Yaoxing Chen, Qingyun Guo, Yulan Dong
Summary: The role of the gut-brain axis in maintaining homeostasis of the brain and gut has been recognized. The NLRP3 inflammasome plays a crucial role in coordinating host physiology and immunity. More research is needed to determine the causal link between gut microbiota structure and NLRP3 activation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Nutrition & Dietetics
Yuan Zhang, Wanpeng Yu, Christopher Flynn, Wenguang Chang, Lei Zhang, Man Wang, Wanhong Zheng, Peifeng Li
Summary: The pathophysiological process of intracerebral hemorrhage (ICH) involves complex mechanisms such as apoptosis, oxidative stress, and inflammation. Inflammatory response, as a key factor, plays a crucial role in the pathological process of acute brain injury and is associated with patient prognosis. Abnormal or dysregulated inflammatory responses can worsen cellular damage in the injured brain tissue. The NLRP3 inflammasome, a multiprotein complex in the cytosol, is activated after ICH, leading to neuroinflammation and aggravated brain edema. Additionally, the gut microbiota has been found to be essential in NLRP3 inflammasome activation. Changes in gut microbiota diversity and species influence neuroinflammation through NLRP3 inflammasome activation and the release of inflammatory cytokines. Conversely, the composition of the gut microbiota can be influenced by NLRP3 inflammasome activation. Therefore, targeting the microbe-gut-brain axis via NLRP3 inflammasome regulation could be a novel approach to protect against secondary brain injury in ICH patients.
Article
Microbiology
J. Elijah Powell, Zac Carver, Sean P. Leonard, Nancy A. Moran
Summary: The use of antibiotic tylosin in honey bee hives reduces gut microbiota diversity and beneficial bacteria, leading to decreased resistance to bacterial pathogens. However, probiotic treatment with native gut bacteria can enhance bees' survival following pathogen challenges and mitigate the negative effects of antibiotic exposure.
MICROBIOLOGY SPECTRUM
(2021)
Review
Pharmacology & Pharmacy
Diren Beyoglu, Jeffrey R. Idle
Summary: Hepatocellular carcinoma (HCC) is a major complication of liver cirrhosis, causing over 2 million deaths globally each year. There are limited treatment options for liver cirrhosis and HCC, emphasizing the importance of early intervention. This article proposes dietary and therapeutic solutions that involve the gut microbiota and its consequences. Dysbiosis, the imbalance of gut microbiota, can be induced by various lifestyle factors and produce metabolites that may contribute to HCC development. The activation of toll-like receptor 4 (TLR4) by gram-negative bacteria in the liver can also contribute to HCC initiation and progression. To prevent HCC, maintaining a healthy gut microbiota through the use of probiotic supplements and prebiotic plant fibers is suggested. Additionally, the development of TLR4 antagonists and further nutrigenomic studies are deemed urgent to counteract dysbiosis and understand the effects of diet on the gut microbiota and liver.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jia Zhang, Yanjun Hou, Xue-liang Du, Dan Chen, Guangzhi Sui, Yong Qi, Julio Licinio, Ma-Li Wong, Yunlei Yang
Summary: Understanding the interaction between brain and adipocytes is crucial for regulating energy and glucose homeostasis. Central ADORA(1) signaling reduces body weight and induces adipose tissue lipolysis, while peripheral ADORA(1) signaling may contribute to obesity. This study proposes a novel mechanism where central and peripheral ADORA(1) signaling play opposite roles in modulating diet-induced obesity.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Chaodong Ding, Chunling Zhang, Richard Kopp, Liz Kuney, Qingtuan Meng, Le Wang, Yan Xia, Yi Jiang, Rujia Dai, Shishi Min, Wei-Dong Yao, Ma-Li Wong, Hongyu Ruan, Chunyu Liu, Chao Chen
Summary: POU3F2 regulates the expression of SCZ-related gene TRIM8 through a specific SNP, influencing neural development and synaptic function, potentially playing a key role in the etiology of schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Shi-Yu Peng, Zhe Shi, Dong-Sheng Zhou, Xin-Yue Wang, Xing-Xing Li, Xiao-Li Liu, Wei-Di Wang, Guan-Ning Lin, Bing-Xing Pan, Valerie Voon, Anthony A. Grace, Markus Heilig, Ma-Li Wong, Ti-Fei Yuan
Summary: Chronic alcohol exposure leads to significant alterations in cortical GABA(B) receptor function, resulting in weakened cortical inhibition mediated by GABA receptors. These changes may be attributed to the modulation of phosphorylation status of GABA(B) receptor subunits.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Philip W. Gold, Ma-Li Wong
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Tuanjie Huang, Fangxia Guan, Julio Licinio, Ma-Li Wong, Yunlei Yang
Summary: This study reveals that the neuropeptide oxytocin increases anxiety by activating OXTr neurons in the septal region of the brain, which project inhibitory GABA inputs to the horizontal diagonal band of Broca (HDB). The activation of these pathways induces anxiety-like behaviors, shedding light on the complex role of oxytocin in modulating emotions.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Andrew P. Shoubridge, Jocelyn M. Choo, Alyce M. Martin, Damien J. Keating, Ma-Li Wong, Julio Licinio, Geraint B. Rogers
Summary: The gut microbiome has a significant influence on human neurophysiology and mental health, playing a role in the development of psychiatric conditions and the effectiveness of common therapies. With an increasing acceptance of its role, research is now shifting towards using this knowledge to improve clinical outcomes and understanding the mechanisms of gut microbiome-brain interactions.
MOLECULAR PSYCHIATRY
(2022)
Review
Public, Environmental & Occupational Health
Seth W. Perry, Jacob C. Rainey, Stephen Allison, Tarun Bastiampillai, Ma-Li Wong, Julio Licinio, Steven S. Sharfstein, Holly C. Wilcox
Summary: Suicide rates in the US show disparities based on age, sex, race/ethnicity, geography, and other factors. Untreated or unidentified depression and access to firearms are identified as major risk factors for suicide. Firearm suicides are increasing in rural areas, while suicides by falls decrease. To reduce suicide death disparities and achieve health equity, emphasis should be placed on policies and universal programs to reduce suicidal behaviors and improving strategies for depression and firearm prevention.
Article
Medicine, Research & Experimental
Eunice Wm Chin, Qi Ma, Hongyu Ruan, Camille Chin, Aditya Somasundaram, Chunling Zhang, Chunyu Liu, Martin D. Lewis, Melissa White, Tracey L. Smith, Malcolm Battersby, Wei-Dong Yao, Xin-Yun Lu, Wadih Arap, Julio Licinio, Ma-Li Wong
Summary: Synaptic dysfunction is a manifestation of various disorders. This study focuses on the role of PHD finger protein 21B (Phf21b) in synaptic processes and identifies Phf21b as an important regulator of synaptic plasticity-related genes. The Phf21b-deficient mouse model exhibits impaired social memory and reduced expression of synaptic proteins, providing insights into potential therapeutic targets for neurobehavioral dysfunction.
Article
Clinical Neurology
Yifan Li, Hanping Zhang, Peng Zheng, Jian Yang, Jing Wu, Yu Huang, Xi Hu, Xunmin Tan, Jiajia Duan, Tingjia Chai, Jingjing Zhou, Zuoli Sun, Min Liu, Jianbo Lai, Tingting Huang, Yanli Du, Peifen Zhang, Wenjuan Sun, Yun Ding, Chun Luo, Jianhua Zhao, Seth W. Perry, Ma-Li Wong, Julio Licinio, Shaohua Hu, Peng Xie, Gang Wang
Summary: This study explored the gender specificity of gut microbiome in patients with unipolar and bipolar depression disorder. Specific microbial changes were found in both disorders, and a gender-specific biomarker panel was identified with good diagnostic performance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Julio Licinio, Ma-Li Wong
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Rachel E. H. Sager, Adam K. Walker, Frank A. Middleton, Kate Robinson, Maree J. Webster, Karen Gentile, Ma-Li Wong, Cynthia Shannon Weickert
Summary: Cytokines play important roles in brain development, affecting neural cell generation, differentiation, maturation, and survival. This study investigates the changes in mRNA and protein levels of key cytokines and cytokine receptors during postnatal development of the human prefrontal cortex. The results show that cytokine expression levels vary at different developmental stages, with increases during the toddler/preschool period and adolescence/young adult maturation.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Health Care Sciences & Services
Michael Musker, Alexa McArthur, Zachary Munn, Ma-Li Wong
Summary: The study aims to evaluate circulating levels of leptin in individuals diagnosed with myalgic encephalomyelitis chronic fatigue syndrome or fibromyalgia syndrome compared to healthy controls. The conditions are characterized by symptoms such as fatigue, post-exertional malaise, and widespread unexplained pain, with the association with leptin suggesting a potential impact on pro-inflammatory cytokines and symptom severity.
JBI EVIDENCE SYNTHESIS
(2021)
Article
Clinical Neurology
Ma-Li Wong, Mauricio Arcos-Burgos, Sha Liu, Alice W. Licinio, Chenglong Yu, Eunice W. M. Chin, Wei-Dong Yao, Xin-Yun Lu, Stefan R. Bornstein, Julio Licinio
Summary: Rare functional variants were identified in antidepressant drug response, serving as potential genetic markers for predicting drug response. Limitations include small sample size and inability to use antidepressant blood level as a covariate. Further studies with larger cohorts are warranted.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
