Article
Chemistry, Multidisciplinary
Yinxian Yang, Xiuhong Li, Jiaxuan Song, Lingxiao Li, Qing Ye, Shiyi Zuo, Tian Liu, Fudan Dong, Xiaohong Liu, Zhonggui He, Bingjun Sun, Jin Sun
Summary: Albumin has been used as a versatile drug carrier, and researchers have synthesized acid-labile DOX prodrugs using different fatty acids as albumin-binding motifs. These prodrugs assembled albumin nanoparticles with ultrahigh drug loading, and their colloidal stability depended on the saturation of fatty acids, impacting their in vivo pharmacokinetics, tumor accumulation, and antitumor efficacy. The hydrazone bond-bridged prodrugs could release DOX in the acidic tumor environment, resulting in improved antitumor efficacy and safety.
Article
Biotechnology & Applied Microbiology
Jie Lv, Shuangling Wang, Duo Qiao, Yulong Lin, Shuyang Hu, Meng Li
Summary: By combining photodynamic therapy, photothermal therapy, and hypoxia-activated chemotherapy, this study developed a mitochondrial targeted nanoplatform that can synergistically treat tumors and maximize the therapeutic window.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Xiaokang Jin, Huang Yang, Zhengwei Mao, Bing Wang
Summary: Using a multifunctional peptide coating on gold nanorods, this study addressed the poor tumor recognition issue in cancer therapy, enhancing therapeutic effects and reducing side effects. In vitro and in vivo results demonstrated the excellent treatment efficacy of the nanoplatform, promoting effective near-infrared light-triggered subcellular hyperthermia therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Xinyu Lou, Dong Zhang, Hao Ling, Zhonggui He, Jin Sun, Mengchi Sun, Dongchun Liu
Summary: This study presents an albumin-bound tumor redox-responsive paclitaxel prodrugs nano-delivery strategy, which enhances drug accumulation in tumor regions and improves the selectivity of cytotoxicity between cancer cells through rapid disintegration of prodrug nanoparticles in vivo.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Multidisciplinary
Young Seok Cho, Gui Chul Kim, Hye Min Lee, Byoungmo Kim, Ha Rin Kim, Seung Woo Chung, Hyo Won Chang, Yoon Gun Ko, Yoon Se Lee, Seong Who Kim, Youngro Byun, Sang Yoon Kim
Summary: This study reports a novel strategy to treat pan-KRAS mutant cancers by utilizing enhanced albumin metabolism to deliver a cytotoxic agent. The researchers found that increased albumin metabolism in KRAS mutant cancer cells induced apoptosis via the uptake of albumin-bound MPD1, resulting in bystander killing of neighboring cancer cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Hamid Rashidzadeh, Seyed Jamal Tabatabaei Rezaei, Hossein Danafar, Ali Ramazani
Summary: A pH-responsive nanogel has been designed and fabricated for smart delivery of antimalarial and anticancer drugs. The nanogel showed efficient drug release in acidic environments and exhibited great antimalarial activity. Furthermore, it completely eradicated parasites in vivo.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Cheng Ma, Mingjun Wu, Weifen Ye, Zhengwei Huang, Xiangyu Ma, Wenhao Wang, Wenhua Wang, Ying Huang, Xin Pan, Chuanbin Wu
Summary: A mannose-modified macrophage-targeting solid lipid nanoparticle loaded with a pH-sensitive prodrug of isoniazid was designed to treat latent tuberculosis infection, demonstrating a promising platform for the disease.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Ahmed Aziz, Yahya Sefidbakht, Shokouh Rezaei, Hasan Kouchakzadeh, Vuk Uskokovic
Summary: This study investigates the physicochemical and biological effects of supplementing albumin nanoparticles to improve cancer treatment. It finds that the supplementation of albumin nanoparticles with doxorubicin can enhance drug release and targeting of cancer cells.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Takeshi Matsumoto, Takashi Komori, Yuta Yoshino, Tadaaki Ioroi, Tsukasa Kitahashi, Hiromu Kitahara, Kohei Ono, Tamami Higuchi, Masayo Sakabe, Hiroshi Kori, Masahiro Kano, Ritsuko Hori, Yukio Kato, Shinji Hagiwara
Summary: The study characterized the stability, tumor targeting, and payload release of liposome-encapsulated gemcitabine, FF-10832, in mouse models of pancreatic cancer. Results showed that FF-10832 had superior pharmacokinetic properties and better antitumor activity and tolerability compared to unencapsulated gemcitabine. This suggests that FF-10832 is a promising candidate for the treatment of pancreatic cancer.
PHARMACEUTICAL RESEARCH
(2021)
Article
Oncology
Keisuke Oyama, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Tadafumi Asaoka, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: Insufficient cancer treatment can lead to the formation of senescent cancer cells and treatment resistance. This study analyzed the properties of these senescent cancer cells and their relationship with the prognosis of PDAC. The findings suggest that cellular senescence may contribute to treatment resistance in PDAC, and targeting GLS1 in these cells may improve therapeutic outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Inorganic & Nuclear
Weinan Han, Weiyu He, Yutong Song, Jian Zhao, Zhiheng Song, Yi Shan, Wuyang Hua, Yanyan Sun
Summary: A multifunctional platinum(IV) compound with tumor-targeting ability and simultaneous targeting of DNA and histone deacetylase (HDAC) has been designed and prepared. In vitro experiments showed that the compound exhibited higher cytotoxicity against cancer cell lines and lower toxicity against normal cells compared to cisplatin.
DALTON TRANSACTIONS
(2022)
Article
Oncology
Adam R. Wolfe, Ryan Robb, Ahmad Hegazi, Laith Abushahin, Linlin Yang, Duan-Liang Shyu, Jose G. Trevino, Zobeida Cruz-Monserrate, John R. Jacob, Kamalakannan Palanichamy, Arnab Chakravarti, Terence M. Williams
Summary: The study showed that pretreatment with gemcitabine significantly increased nab-paclitaxel uptake, improved treatment efficacy and survival benefits, justifying further testing of this altered scheduling combination in preclinical and clinical settings.
CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yuxin Chen, Lulu Han, Xiaoyan Qiu, Meng Wang, Zheng Chen, Ying Cai, Yong Xin, Yanfang Lv, Ankang Hu, Dafei Chai, Liantao Li, Huizhong Li, Junnian Zheng, Gang Wang
Summary: This study demonstrated that neutrophil-mediated targeting drug delivery can improve the therapeutic efficacy of albumin-bound paclitaxel (abPTX) and mitigate its side effects.
Article
Oncology
Xiangzi Jin, Jie Yu, Meijiao Yin, Amit Sinha, Guangming Jin
Summary: The study found that Tf-PEG-DANPS has a greater ability to inhibit tumor growth and induce apoptosis compared to other drug-giving groups, while in vivo experiments showed that US+Tf-PEG-DANPS effectively inhibited tumor growth, reduced metastasis, and had fewer toxic side effects on mice.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Mostafa A. Askar, Noura M. Thabet, Gharieb S. El-Sayyad, Ahmed El-Batal, Mohamed Abd Elkodous, Omama E. El Shawi, Hamed Helal, Mohamed K. Abdel-Rafei
Summary: This study developed multi-functional dual drug-loaded nanoparticles targeting CD44 and folate receptors to enhance localized chemo-radiotherapy for more effective breast cancer treatment. The nanoparticles exhibited sustained drug release properties in bio-relevant media and played a crucial inhibitory role in the glycolytic and OXPHOS pathways.
Article
Chemistry, Physical
Fudan Dong, Qikun Jiang, Lingxiao Li, Tian Liu, Shiyi Zuo, Lin Gao, Mengna Fang, Yanlin Gao, Bingjun Sun, Cong Luo, Zhonggui He, Jin Sun
Summary: Mitochondrial bioenergy plays a vital role in cancer occurrence and development. The study presents a cancer cell membrane camouflaged nano-inhibitor that can block two different energy pathways and exhibit precision tumor-targeting. Under laser irradiation, the nano-inhibitor inhibits oxidative phosphorylation and reduces tumor energy, significantly suppressing tumor growth.
Article
Biotechnology & Applied Microbiology
Jian Zhao, Hao Ye, Qi Lu, Kaiyuan Wang, Xiaofeng Chen, Jiaxuan Song, Helin Wang, Yutong Lu, Maosheng Cheng, Zhonggui He, Yinglei Zhai, Haotian Zhang, Jin Sun
Summary: In this study, a bioresponsive gel combined with chemoimmunotherapeutic agents was developed to effectively inhibit both local tumor recurrence and metastasis. The gel promoted tumor immunogenic cell death and induced a strong antitumor immune response. The concurrent release of an anti-PD-L1 antibody impaired the PD-1/PD-L1 pathway and improved the tumor-killing effect of cytotoxic T cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhiqiang Zhao, Xuanbo Zhang, Hongyuan Zhang, Xinzhu Shan, Meiyu Bai, Zhe Wang, Fujun Yang, Haotian Zhang, Qiming Kan, Bingjun Sun, Jin Sun, Zhonggui He, Cong Luo
Summary: This study proposes a method of using photothermal therapy to overcome the challenges of conventional thrombolytic treatments, achieving thrombus-targeted delivery through nanoscale assembly, and demonstrating high therapeutic efficacy.
Article
Chemistry, Physical
Chang Li, Qiu Wang, Dan Li, Yubo Liu, Baichun Hu, Yao Feng, Haotian Zhang, Zhonggui He, Cong Luo, Jin Sun
Summary: This study presents a novel molecular co-assembly nanoplatform for efficient co-delivery of hydrophilic and hydrophobic drugs. Through supramolecular co-assembly, a reduction-sensitive prodrug is synthesized and readily co-assembles with another drug, resulting in high drug loading rate and satisfactory therapeutic effects in vivo.
NANOSCALE HORIZONS
(2022)
Article
Engineering, Biomedical
Jianhuan Guan, Xiao Tan, Jian Jiao, Shuang Lai, Haotian Zhang, Qiming Kan, Zhonggui He, Mengchi Sun, Jin Sun
Summary: This study developed metal iron-coordinated carrier-free supramolecular co-nanoadssemblies with high drug loading capacity for enhanced tumor regression through DNA damage. PEGylated co-nanoadssemblies showed superior therapeutic efficacy and reduced systemic toxicity, while also activating antitumor immune response.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Shenwu Zhang, Jing Wang, Zhiqiang Kong, Xinxin Sun, Zhonggui He, Bingjun Sun, Cong Luo, Jin Sun
Summary: Immunotherapy is a promising cancer treatment, but its efficacy for immune-cold tumors is not satisfactory. Photodynamic therapy can effectively induce immunogenic cell death, and the use of nanotechnology enhances the effectiveness of cancer immunotherapy. This article reviews recent advances in photodynamic therapy, nanotechnology, and immunogenic cell death, and discusses the prospects and challenges in this field.
Review
Engineering, Environmental
Yao Chen, Tongyao Zhao, Meiyu Bai, Tianrui Gu, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: Cancer is not a single disease, but a complex adaptive system involving inflammation, metabolism, and immunization. Combining multiple antineoplastic drugs offers advantages over monotherapy, but precise co-delivery into tumors remains challenging. Carrier-free nanoassemblies, engineered by small molecules, have emerged as a promising platform for co-delivery of anticancer drugs. This article provides an overview of the latest developments in this field, summarizing trends in nanomedicines, analyzing assembly mechanisms and drug release characteristics, and highlighting the prospects and challenges in clinical translation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Shenwu Zhang, Xinxin Sun, Ziyue Wang, Jin Sun, Zhonggui He, Bingjun Sun, Cong Luo
Summary: A novel three-in-one photodynamic therapy nanoamplifier is developed to address the challenges of tumor hypoxia and short half-life of singlet oxygen. The nanoamplifier facilitates the assembly of materials and amplifies the photodynamic therapy effect through the production of lipid reactive oxygen species. It exhibits potent antitumor activity in a mouse tumor model.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Danping Wang, Chaoying Du, Shuo Wang, Lingxiao Li, Tian Liu, Jiaxuan Song, Zhonggui He, Yinglei Zhai, Bingjun Sun, Jin Sun
Summary: The connecting bonds and modifying chains play a vital role in the rational design of prodrug nanoassemblies and have significant impact on their characteristics and anticancer effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yixin Sun, Simeng Wang, Yaqi Li, Danping Wang, Yu Zhang, Haotian Zhang, Hongrui Lei, Xiaohong Liu, Jin Sun, Bingjun Sun, Zhonggui He
Summary: Prodrug-based nanoassemblies, combining prodrug technology and nanocarriers, show great promise in cancer treatment. The chemical structure of prodrugs is closely related to their antitumor efficacy and safety, and the relationship between them needs further exploration.
ACTA BIOMATERIALIA
(2023)
Article
Medicine, Research & Experimental
Chutong Tian, Jin Sun, Mingyang Zhang, Chunlin Guo, Yifan Miao, Zhonggui He
Summary: In this study, a lipophilic disulfide-bridged linoleic prodrug (PTX-S-S-LA) was synthesized and efficiently incorporated into a self-microemulsifying drug delivery system (SMEDDS) to facilitate the oral absorption of paclitaxel (PTX). The prodrug SMEDDS showed higher drug loading efficiency and stability compared to parent PTX, and significantly increased drug partition in the intestinal micellar aqueous phase. Moreover, SMEDDS enhanced gastrointestinal biological adhesion and lymphatic transport, resulting in improved antitumor efficiency without significant gastrointestinal toxicity. Overall, the combination of PTX-S-S-LA and SMEDDS provides a promising approach for effective oral delivery of PTX.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Xiaoyuan Fan, Kaiyuan Wang, Qi Lu, Yutong Lu, Jin Sun
Summary: Immunotherapy aims to activate the immune system to treat cancer, but its effectiveness in clinical applications is still limited. Cell-based drug delivery systems have the potential to enhance the efficacy of cancer immunotherapy and play important roles.
Article
Medicine, Research & Experimental
Ximing Zhang, Fangxue Zhao, Jing Feng, Cong Chen, Zhonggui He, Mengchi Sun, Jin Sun
Summary: In this study, an ionizable PTX prodrug (PTXP) was designed to achieve remote loading of liposomal formulations. Compared to marketable PTX liposomes, PTXP liposomes showed higher loading efficiency and encapsulation efficiency, as well as demonstrated stability, prolonged circulation time, high tumor site accumulation, potent anti-tumor effects, and safety in vitro and in vivo.
MOLECULAR PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Yi-fan Miao, Qing Ye, Ming-yang Zhang, Lin Gao, Xi-yan Wang, Wen-xin Zhong, Zi-xuan Wang, Zhong-gui He, Chu-tong Tian, Jin Sun
Summary: Due to the serious side effects of intravenous Taxol, the development of an oral chemotherapeutic strategy for paclitaxel (PTX) delivery is highly anticipated. This study explores a series of triglyceride-mimetic prodrugs of PTX with different fatty acid structures to enhance oral antitumor effect and guide the design of similar prodrugs. The results show that the length of fatty acids plays a significant role in in vitro intestinal digestion behavior, lymph transport efficiency, and plasma pharmacokinetics, while the degree of unsaturation has a negligible impact. These findings provide a theoretical basis for the rational design of TG-like PTX prodrugs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xiaofeng Chen, Kaiyuan Wang, Fangming Liang, Ruiqi Jiang, Jin Sun
Summary: Exosomes, as potential drug delivery systems, show promising prospects in cancer treatment. Researchers are exploring different modification strategies to improve the targeting ability of exosomes and enhance their therapeutic effect while reducing toxicity to normal cells.
PROGRESS IN CHEMISTRY
(2022)
