Article
Cell Biology
Shuhei Fukuda, Masako Akiyama, Yuki Niki, Risa Kawatsura, Hiroyuki Harada, Ken-ichi Nakahama
Summary: The study revealed that miRNAs produced by normal cells can be transferred to cancer cells via connexin 43, inhibiting tumor migration and invasion.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yan-Jun Zong, Xiao-Zhou Liu, Lei Tu, Yu Sun
Summary: This review discusses the contribution of the connexin gene family to hearing loss, focusing on the GJB2, GJB6, and GJA1 genes. Mutations in these genes can lead to comprehensive or non-comprehensive genetic deafness in newborns. The precise regulation of connexin biosynthesis, structural composition, and degradation is crucial for proper functioning of gap junctions. This review provides insights into the etiological principles of connexin mutations and offers potential therapeutic strategies for hereditary deafness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Cai Qing, Zhao Xinyi, Yu Xuefei, Xue Xindong, Fu Jianhua
Summary: Bronchopulmonary dysplasia (BPD) is a common devastating pulmonary complication in preterm infants, characterized by alveolar maldevelopment associated with oxidative stress and excessive apoptosis. Gap26, a connexin 43-inhibiting peptide, has been shown to improve alveolar development by inhibiting intercellular communication in BPD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Xinyu Wang, Chuan Jiang, Chunli Lu, Longbing Ma, Yuxin Feng, Shengyu Cui, Qian Li, Kang Li, Xiang Wang, Fengzeng Jian
Summary: In this study, changes in the number and morphology of ependymal cilia in a syringomyelia rat model were investigated. The results showed a decline in cilia during the early stage of the disease, leading to disrupted intercellular communication. In the later stage, cilia were further reduced due to shear stress exposure, causing a potential mechanism of ependymal cilia decline in syringomyelia development.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Reproductive Biology
Yuxi Li, Hsun-Ming Chang, Yu-Wen Sung, Hua Zhu, Peter C. K. Leung, Ying-Pu Sun
Summary: In this study, it was found that the phosphorylation of connexin 43 (Cx43) is mediated by protein kinase C (PKC) signaling pathway, leading to a decline in gap junction intercellular communication (GJIC) and subsequent effects on oocyte meiotic resumption. This finding is crucial for understanding the molecular mechanisms of oocyte meiotic resumption.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Daniel Rodjakovic, Lilian Salm, Guido Beldi
Summary: Recent studies have shown that Connexin-43 plays important roles in macrophages, including migration, antigen-presentation, intercellular communication, electrochemical support, and immunomodulation. Dysregulation of Cx43 has been described in diseases such as inflammatory bowel disease, tumors, and HIV. However, its involvement in other macrophage functions and inflammatory processes requires further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Xiaoping Li, Yunshuo Xiao, Xiaoqi Wang, Ruihao Huang, Rui Wang, Yi Deng, Jun Rao, Qiangguo Gao, Shijie Yang, Xi Zhang
Summary: In this study, it was found that Cx43 deficiency exists in CML patients, and its expression is negatively correlated with HIF-1 alpha. Further experiments revealed that overexpression of Cx43 in BMSCs can increase apoptosis rate and block cell cycle in CML cells, while the opposite was observed in the absence of Cx43. Cx43 mediates gap junction intercellular communication (GJIC) through direct contact, and Ca2+ is the key factor mediating the downstream apoptotic pathway. Animal experiments confirmed the findings in vitro, suggesting that enhancing Cx43 expression and GJIC function in the HM may be a novel strategy to reverse drug resistance and promote IM efficacy.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cell Biology
Weiqi Zeng, Zhizhao Deng, Yingxin Gao, Guoliang Sun, Xianlong Li, Dongdong Yuan
Summary: Long-term exposure to Ang II significantly enhances the expression and function of Cx43-GJs in HUASMCs, leading to the accumulation of intracellular Ca2+ and the activation of downstream signaling pathways. However, propofol inhibits the function of Cx43-GJs in Ang II-pretreated HUASMCs, resulting in the inhibition of intracellular Ca2+ and its downstream signaling pathways and ultimately excessive relaxation of HUASMCs. This explains why patients with chronic hypertension experience more severe blood pressure fluctuations after propofol induction.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biology
Filippo Torrisi, Cristiana Alberghina, Debora Lo Furno, Agata Zappala, Samuel Valable, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti
Summary: Manipulating the sonic hedgehog pathway to affect connexin 43 expression can regulate cell migration and proliferation in glioblastoma, potentially offering a new therapeutic strategy.
Article
Medicine, Research & Experimental
Huiqin Wang, Xueying Yang, Huaqing Lai, Yang Sun, Xu Yan, Qidi Ai, Meiyu Lin, Songwei Yang, Yantao Yang, Shifeng Chu, Zhenzhen Wang, Naihong Chen
Summary: Hypericin repaired the dysfunction of gap junctions in the chronic unpredictable stress (CUS) rat model of depression. While hypericin showed potential for treating depression in in vivo experiments, it failed to demonstrate antidepressant benefits in cell experiments. This study suggests that gap junctional function may be a novel therapeutic target for hypericin in the treatment of depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kaat Leroy, Alanah Pieters, Axelle Cooreman, Raf Van Campenhout, Bruno Cogliati, Mathieu Vinken
Summary: The study found that both genotoxic and non-genotoxic carcinogenic compounds negatively affect connexin32 expression, but no specific effects related to chemical type were observed at the gap junction or connexin hemichannel functionality level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Aya Yamada, Keigo Yoshizaki, Masaki Ishikawa, Kan Saito, Yuta Chiba, Emiko Fukumoto, Ryoko Hino, Seira Hoshikawa, Mitsuki Chiba, Takashi Nakamura, Tsutomu Iwamoto, Satoshi Fukumoto
Summary: Connexin 43 (Cx43) is an integral membrane protein that plays a crucial role in tooth development, regulating intercellular communication through gap junction activity by modulating TGF-beta 1-mediated ERK signaling and enamel formation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Jeremy Gingrich, Yong Pu, Brad L. Upham, Madeline Hulse, Sarah Pearl, Denny Martin, Anita Avery, Almudena Veiga-Lopez
Summary: Gap junction intercellular communication (GJIC) is crucial for ovarian function and can be modulated by chemicals like bisphenol S, which may enhance GJIC in ovine and human theca cells through signal pathway regulation. Upregulation of GJIC could lead to the hyperplasia of the theca cell layer or hinder ovulation by maintaining the oocyte in meiotic arrest.
Article
Hematology
Laura Beth Payne, Bhanu P. Tewari, Logan Dunkenberger, Samantha Bond, Alyssa Savelli, Jordan Darden, Huaning Zhao, Caroline Willi, Ronak Kanodia, Rosalie Gude, Michael D. Powell, Kenneth J. Oestreich, Harald Sontheimer, Sophie Dal-Pra, John C. Chappell
Summary: This study found that a distinct lineage of pericytes emerges alongside vasculogenesis and directly communicates with nascent endothelial cells via Cx43. Loss of Cx43/Gja1 in pericyte progenitors can cause embryonic vessel dysmorphogenesis, but other connexin isoforms may compensate.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Immunology
Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Summary: This study reveals a novel mechanism of the GJ-Cx43-mediated astrocytic network involved in isoflurane-induced neuroinflammation and cognitive impairments, which provides new mechanistic insight into the pathogenesis of POCD and identifies potential targets for its treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Letter
Chemistry, Multidisciplinary
Chandan Raychaudhury, Debnath Pal
JOURNAL OF MATHEMATICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Aditi Garg, Debnath Pal
Summary: This study introduces a method to improve metal-binding site prediction using the Geometric Hashing algorithm. By screening metal-specific amino acids in the structure ensemble, the residues for Ca2+, Zn2+, Mg2+, Cu2+, and Fe3+ binding sites can be predicted with superior performance compared to existing methods.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2021)
Article
Chemistry, Physical
Dibyajyoti Maity, Debnath Pal
Summary: Through molecular dynamics studies, it was found that fibrils of hemoglobin in sickle cell anemia disintegrate upon oxygenation, primarily due to the presence of specific residues leading to stability. Additionally, conformational changes associated with the transition from tense to relaxed states were identified as potentially involving quaternary changes.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Abantika Pal, Debnath Pal, Pralay Mitra
Summary: A computational framework was developed for modeling functionally related protein-complex structures, achieving a success rate of 83%. The framework can handle protein sequence and structure information, combining rigid-body docking and template-based modeling techniques.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Swati Gupta, Debnath Pal
Summary: By predicting and validating RNA hairpins, the study identified 87% of ITT sites in bacteria, with hairpins forming clusters near the stop codon, indicating their significant role in transcriptional control.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Rajnandani Kashyap, Naga Veera Yerra, Joachyutharayalu Oja, Sandeepchowdary Bala, Gal Reddy Potuganti, Jagadeshwar Reddy Thota, Manjula Alla, Debnath Pal, Anthony Addlagatta
Summary: Two natural enzymes, PyrI4 and AbnU, have been shown to catalyze stereospecific intermolecular Diels-Alder reactions on non-natural substrates. AbnU catalyzes a single exo-stereoisomer by 32-fold higher than the background, while PyrI4 catalyzes the same stereoisomer as a major component (>50%).Structural, biochemical and fluorescence studies indicate that the dienophile enters first into the beta-barrel of the enzymes followed by the 1,3-diene, yielding a stereospecific product.
COMMUNICATIONS CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Thangaraj Sindhu, Pal Debnath
Summary: The cytochrome bc1-aa3 supercomplex is crucial for the respiratory system of Mycobacterium Tuberculosis and is a major target for developing new antibiotics. The recent cryo-EM structure provides new insights for understanding its structure and function and developing more effective therapeutics against pulmonary tuberculosis.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Saleem Iqbal, Md Zubbair Malik, Debnath Pal
Summary: System medicine approaches have successfully identified novel disease networks in miRNA research, particularly in Alzheimer's Disease. The study revealed two highly expressed novel miRNAs in the brain region associated with LGMN. In addition, the research identified 10 transcription factors linked to LGMN and found high and continuous expression of LGMN in various brain regions, especially in the frontal cortex. The in silico analysis led to the discovery of Oprea1 as a potential therapeutic target for AD treatment.
Review
Neurosciences
Fareeha Saadi, Debnath Pal, Jayasri Das Sarma
Summary: This article focuses on the function of the S protein of Coronaviruses and its role in mediating membrane fusion, spread, tropism, and associated pathogenesis, with an emphasis on therapeutic strategies derived from studies on a murine beta-Coronavirus and its disease process.
ANNALS OF NEUROSCIENCES
(2021)
Article
Biochemical Research Methods
Dibyajyoti Maity, Debnath Pal
Summary: MD DaVis is a python package developed to facilitate quick comparative analysis of MD trajectories of proteins, improving productivity and saving time by creating interactive visualizations with a few simple steps.
Article
Biology
Swathy Babu, Yuki Takeuchi, Ichiro Masai, Katharina Schlacher
Summary: Banp plays crucial roles in DNA damage response and chromosome segregation, especially during embryonic development. It regulates cell cycle progression and cell survival by controlling DNA replication and DNA damage repair.
Article
Biochemistry & Molecular Biology
Niladri R. Das, Kunal N. Chaudhury, Debnath Pal
Summary: Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to understand the conformational states of proteins in physiological conditions. However, the limited availability of NMR data for proteins with high degrees of freedom can lead to structural artifacts in the generated models. In this study, we propose a novel graph-based modeling approach that combines NMR-derived distance-geometry constraints to build the core structure and uses a hybrid method to model the remaining molecule with insufficient data. Our approach overcomes the challenges of building large and sparse data systems by partitioning the problem in a data-driven bottom-up manner. Comparative analysis with state-of-the-art methods shows the accuracy of our models in the secondary structure regions, which is further confirmed by NMR data. Benchmarking on a wide range of protein folds demonstrates the minimal violation of experimental constraints and adherence to other important structure quality parameters. Comparative molecular dynamics (MD) studies reveal distinct conformational dynamics in our models, providing insights into protein structure-function relationships. Overall, our work contributes to the development of improved NMR-evidence-based models that capture the contextual variations in protein structure during experimentation and expand the scope of functional inference.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Umesha Katrahalli, Govindaswamy Shanker, Debnath Pal, Manjunatha Devagondanahalli Hadagali
Summary: This study investigated the binding characteristics of the water-soluble thiadicarbocyanine dye DTC with BSA using spectroscopic techniques and molecular docking methods. The experimental results showed that DTC quenched the fluorescence intensity of BSA and altered its secondary structure. The binding was found to be driven by hydrophobic forces. Molecular docking validated the experimental findings and revealed a free binding energy release of -7.37 kcal/mol. This research provides insights into the interaction between water-soluble DTC dye and biological molecules.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Swati Gupta, Namrata Padmashali, Debnath Pal
Summary: The study identified a group of hairpins called cluster hairpins, which are located within 15 nucleotides of each other and can work together to cause intrinsic transcription termination (ITT). The INTERPIN database is the largest collection of in silico inferred ITT hairpins in bacteria, covering 12745 bacterial genomes. It provides detailed information on operons, individual clusters, and single ITT hairpins, as well as software for visualizing hairpin structures in the genomic context.
Article
Biochemistry & Molecular Biology
Subhankar Sahu, Raja Banerjee, Debnath Pal
Summary: The presence of L-state torsion facilitates the concavity and ligand binding potential of the Nest motif in protein. Molecular dynamics simulations of 35 peptides reveal that 60% of them initially adopt the L-state and maintain it for a significant portion of the trajectory. These findings provide insights into the crucial role of L-state conformation in stabilizing the Nest motif and have implications for designing therapeutics.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)