Article
Genetics & Heredity
Michael F. F. Neblett, Sarah C. C. Baumgarten, Samir N. N. Babayev, Chandra C. C. Shenoy
Summary: The study aimed to assess the efficacy of adjuvant dexamethasone during ovulation induction (OI) using letrozole in women with letrozole-resistant polycystic ovary syndrome (PCOS). The addition of dexamethasone increased ovulation rates and had similar pregnancy outcomes compared to prior studies, providing an effective and safe option for PCOS patients at risk for cycle cancelation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Obstetrics & Gynecology
Xiuxian Zhu, Yonglun Fu
Summary: This study aimed to evaluate whether extending letrozole (LE) treatment duration could induce ovulation in women with polycystic ovary syndrome (PCOS) who previously failed to ovulate after a 5-day regimen of 5 mg LE daily. The researchers found that extending LE treatment duration in a stepwise manner (2-step extended LE regimen) increased the ovulation rate without the occurrence of ovarian hyperstimulation syndrome.
FERTILITY AND STERILITY
(2023)
Article
Medicine, General & Internal
Wenyan Fu, Yanping Kuang
Summary: This retrospective study analyzed the effect of elevated luteinizing hormone (LH) on ovulation induction (OI) outcomes in polycystic ovary syndrome (PCOS) patients undergoing intrauterine insemination (IUI) with letrozole (LE) stimulation. The study found that dysregulated levels of LH did not negatively affect ovulation rate or reproductive outcomes. In addition, individuals with normal basal LH and high LH levels after letrozole administration had significantly higher rates of clinical pregnancy and live birth compared to those with normal basal LH and normal LH levels.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Andreas A. Vyrides, Essam El Mahdi, Konstantinos Giannakou
Summary: Anovulation is a common condition characterized by amenorrhea, oligomenorrhea, and abnormal uterine bleeding. The most common chronic disorder associated with anovulation is polycystic ovary syndrome (PCOS), which affects 6% to 10% of the global population. Ovulation induction (OI) techniques are used in women with PCOS who are unable to conceive naturally. This narrative review provides an overview of the current evidence and available techniques for OI in women with PCOS, discussing their performance and applicability.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Soumya Ranjan Panda, Vijayan Sharmila, Vinoth Kumar Kalidoss, Smrutismita Hota
Summary: The study evaluated the efficacy of combining letrozole and clomiphene citrate in inducing ovulation in infertile women with polycystic ovary syndrome. The combination treatment showed a higher ovulation rate compared to letrozole alone.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Lan Shi, Shujin Ye, Mengyun Gao, Yijie Chen, Xuejing Jin, Zhifen Zhang
Summary: This retrospective cohort study investigated the efficacy of oral letrozole starting on day 3 or 5 of the menstrual cycle in patients with polycystic ovary syndrome (PCOS). The study found that compared to starting on day 3, starting letrozole on day 5 was associated with higher ovulation and conception rates, and shorter time-to-pregnancy among infertile women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Xin Dai, Jingyi Li, Tian Fu, Xuefeng Long, Xiaoou Li, Ruiwen Weng, Yi Liu, Ling Zhang
Summary: This study aimed to compare the efficacy of sequential letrozole/HMG and letrozole alone in ovulation induction and pregnancy promotion among infertile women with PCOS. The results showed that the sequential treatment group had a higher ovulation rate and live birth rate compared to the letrozole group, with no significant adverse events.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Endocrinology & Metabolism
Zaixin Guo, Shuwen Chen, Zhiyan Chen, Pan Hu, Yanfang Hao, Qi Yu
Summary: This study evaluated the predictive value of initial screening characteristics for women with anovulatory polycystic ovary syndrome (PCOS) who did or did not respond to 2.5 mg letrozole (LET). Clinical and laboratory characteristics of PCOS patients undergoing LET treatment were assessed. The results showed that PCOS patients who responded to 2.5 mg LET had better outcomes compared to non-responders, and factors such as late menarche, increased anti-mullerian hormone (AMH), baseline luteinizing hormone (LH)/ follicle stimulating hormone (FSH), and free androgen index (FAI) were associated with a higher likelihood of no response to 2.5 mg LET.
BMC ENDOCRINE DISORDERS
(2023)
Article
Obstetrics & Gynecology
Shavina Bansal, Manu Goyal, Charu Sharma, Shashank Shekhar
Summary: In women with polycystic ovarian syndrome, letrozole may be a better option for ovulation induction compared to clomiphene citrate, as it results in higher pregnancy rates, shorter time to pregnancy, and lower chances of multiple pregnancies due to higher monofollicular development.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Jennifer J. Yland, Yu-Han Chiu, Paolo Rinaudo, John Hsu, Miguel A. Hernan, Sonia Hernandez-Diaz
Summary: For women with PCOS, letrozole was associated with higher risks of pregnancy, livebirth, and neonatal outcomes compared to clomiphene. In women with unexplained infertility, the two treatments resulted in comparable outcomes.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Sushila Arya, Karl R. Hansen, Jennifer D. Peck, Robert A. Wild
Summary: This study aimed to investigate the impact of metabolic syndrome on fertility success and pregnancy complications in obese women with polycystic ovary syndrome undergoing ovulation induction. The results showed that metabolic syndrome was associated with lower rates of live birth and clinical pregnancy, as well as an increased risk of pregnancy complications, particularly gestational diabetes and macrosomia. Additionally, the type of medication used for ovulation induction also affected outcomes, with letrozole showing higher live birth rates compared to clomiphene in the presence of metabolic syndrome.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Yufan Song, Mingmin Zhang
Summary: The study aimed to evaluate the effect of letrozole and clomiphene citrate on women with infertility and polycystic ovarian syndrome (PCOS). A total of 29 randomized controlled trials (RCTs) were included, involving 3,952 women and 7,633 ovulation induction cycles. The pooled analysis showed that letrozole had superior outcomes in terms of ovulation rate, clinical pregnancy rate, and live-birth rate compared to clomiphene citrate. Therefore, letrozole is recommended as an ovulation induction drug in women with infertility and PCOS.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Amy Kaing, Eleni A. Jaswa, Michael P. Diamond, Richard S. Legro, Marcelle I. Cedars, Heather G. Huddleston
Summary: The study suggests that women with PCOS and high AMH levels who conceived after ovulation induction represent a high-risk group for preterm delivery. Data indicate that closer monitoring in the third trimester of pregnancies in PCOS patients with early first-trimester AMH levels above 9.3 ng/mL may be warranted.
FERTILITY AND STERILITY
(2021)
Article
Multidisciplinary Sciences
Warda Salah Elkhalifa, Hayat Mohamed Suliman, Iman H. Abdoon, Walaa Mohamed, Bashier Osman
Summary: PCOS is a complex condition characterized by metabolic, hormonal, and environmental factors, along with infertility in women of reproductive age. This study compared letrozole and clomiphene citrate as ovulation inducers in infertile Sudanese patients with PCOS. The results showed comparable rates of positive pregnancy tests and similar effects on compacting ovarian cysts between letrozole and clomiphene citrate. However, letrozole had a lesser impact on follicle maturation and resulted in increased endometrial thickness compared to clomiphene citrate.
Article
Biochemistry & Molecular Biology
Kok-Min Seow, Pin-Shiou Liu, Kuo-Hu Chen, Chien-Wei Chen, Luen-Kui Chen, Chi-Hong Ho, Jiann-Loung Hwang, Peng-Hui Wang, Chi-Chang Juan
Summary: This study investigated the mechanisms of polycystic ovary syndrome (PCOS) and the effects of letrozole on reproductive and metabolic disorders using a mouse model. Letrozole treatment resulted in disrupted estrous cycle, hormonal imbalances, formation of cystic follicles, glucose intolerance, and insulin resistance. Additionally, the expression of CCR5 and CCL5 in the perigonadal white adipose tissue was significantly higher in the letrozole-treated mice compared with the control group, and correlated with insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Lucy Kate Goodman, Lucy Rebecca Prentice, Rebecca Chanati, Cynthia Farquhar
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2020)
Review
Health Care Sciences & Services
Thomas Timmers, Loes Janssen, Rudolf B. Kool, Jan A. M. Kremer
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Obstetrics & Gynecology
Elizabeth Joan Glanville, Christos Venetis, Clare Anne Boothroyd, Cynthia Farquhar, Mary Louise Hull
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2020)
Article
Obstetrics & Gynecology
Sarah Lensen, Sheng Chen, Lucy Goodman, Luk Rombauts, Cindy Farquhar, Karin Hammarberg
Summary: The study found widespread advertising of IVF add-ons on clinic websites in Australasia, with most claims of benefit not quantified and lacking scientific publications support. None of the add-ons were supported by high-quality evidence for improving pregnancy or live birth rates.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2021)
Article
Medicine, General & Internal
Emily Aspasia Karanges, Conrad Nangla, Lisa Parker, Alice Fabbri, Cynthia Farquhar, Lisa Bero
Summary: The study investigated pharmaceutical industry payments related to fertility and assisted reproduction in Australia, revealing that pharmaceutical companies sponsored a range of fertility clinicians and organizations, potentially contributing to the overuse of fertility services.
Article
Health Care Sciences & Services
Thomas Timmers, Manouk Keijsers, Jan A. M. Kremer, Loes Janssen, Jesper Smeenk
Summary: This study demonstrates that using an app can increase IVF patients' satisfaction with treatment information and their knowledge about the procedures. Patients are willing to use electronic health applications as part of their treatment.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Health Care Sciences & Services
Eva W. Verkerk, Ester A. Rake, Didi D. M. Braat, Willianne L. D. M. Nelen, Johanna W. M. Aarts, Jan A. M. Kremer
Summary: This study developed a clinical tool that provides insight into the values and preferences of individual patients, aiming to facilitate person-centred fertility care. The tool has been tested and proven feasible, highlighting important issues and personal contexts of individual patients.
HEALTH EXPECTATIONS
(2022)
Article
Health Care Sciences & Services
Thomas Timmers, Walter van Der Weegen, Loes Janssen, Jan Kremer, Rudolf Bertijn Kool
Summary: This study explores the added value of patient involvement in developing the content for an eHealth app, as well as the patients' suggestions for improvement. The results of the study demonstrate that patients have many valuable suggestions for improving the content of eHealth interventions, and even a relatively small group of patients can contribute to improving app content from the patient's perspective.
JMIR FORMATIVE RESEARCH
(2022)
Article
Medicine, General & Internal
Marian Showell, Cynthia M. Farquhar, Grace Greenwood, Vanessa M. B. Jordan
Summary: This study evaluated the reporting of results from projects and programmes funded by the Health Research Council (HRC) New Zealand. It found that 13% of the projects from 2006 to 2014 did not publish or report any research output.
Article
Health Care Sciences & Services
Erik Wackers, Simone van Dulmen, Bart Berden, Jan Kremer, Niek Stadhouders, Patrick Jeurissen
Summary: This study evaluated the effectiveness of two Dutch hospitals' strategies aimed at increasing healthcare quality and reducing costs. The findings showed that both strategies led to a decrease in the volume of care provided by the hospitals, while maintaining the quality of care. However, one hospital failed to sufficiently reduce operating costs, resulting in declining profit margins. Overall, these strategies have shifted the focus of hospitals from production to quality-driven care.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Article
Medicine, General & Internal
Sarah C. Armstrong, Emily Vaughan, Sarah Lensen, Lucy Caughey, Cynthia M. Farquhar, Allan Pacey, Adam H. Balen, Michelle Peate, Elaine Wainwright
Summary: This study investigates the decision-making process and concerns surrounding IVF add-ons. Patients often prioritize hope over safety, efficacy, and cost, while professionals prioritize patient outcomes and avoiding wasteful spending. Applying available evidence to individual circumstances is challenging for both groups.
Article
Health Care Sciences & Services
Hilde Grens, Jan Peter de Bruin, Aleida Huppelschoten, Jan A. M. Kremer
Summary: Video consultation is a promising remote healthcare solution that provides high levels of patient centeredness and shared decision making. However, attention should be paid to mitigate the more impersonal setting of video consultation compared to face-to-face consultation.
JMIR FORMATIVE RESEARCH
(2022)
Article
Medicine, General & Internal
Sarah C. Armstrong, Sarah Lensen, Emily Vaughan, Elaine Wainwright, Michelle Peate, Adam H. Balen, Cynthia M. Farquhar, Allan Pacey
Summary: This study aims to investigate the types and costs of add-ons offered by IVF clinics in the UK, explore the opinions and beliefs of patients, clinicians, and embryologists on add-ons through qualitative interviews, and review the interpretation of the HFEA traffic light system to improve decision-making information for IVF stakeholders.
Article
Obstetrics & Gynecology
Lucy Prentice, Lynn Sadler, Sarah Lensen, Melissa Vercoe, Jack Wilkinson, Richard Edlin, Georgina M. Chambers, Cynthia M. Farquhar
HUMAN REPRODUCTION OPEN
(2020)
Letter
Medicine, General & Internal
Cynthia Farquhar
BMJ EVIDENCE-BASED MEDICINE
(2019)
