Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

Tumor Necrosis Factor-α Induced Apoptosis in U937 Cells Promotes Cathepsin D-Independent Stefin B Degradation

(2017) Katja Bidovec et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cathepsin B expression in colorectal cancer in a Middle East population: Potential value as a tumor biomarker for late disease stages

(2017) Maha-Hamadien Abdulla et al.   ONCOLOGY REPORTS

Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization

(2017) Long-Xian Lv et al.   Oncotarget

Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells

(2017) Lu Liu et al.   Scientific Reports

Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer

(2017) Patricia Dauer et al.   Scientific Reports

Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer

(2016) Hong Li et al.   ACS Applied Materials & Interfaces

Lysosomal cell death mechanisms in aging

(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

A Review on Novel Breast Cancer Therapies: Photodynamic Therapy and Plant Derived Agent Induced Cell Death Mechanisms

(2016) Blassan Plackal Adimuriyil George et al.   Anti-Cancer Agents in Medicinal Chemistry

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure

(2016) Elisabeth Corcelle-Termeau et al.   Autophagy

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of mTORC1 by lysosomal calcium and calmodulin

(2016) Ruo-Jing Li et al.   eLife

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

(2016) Anne-Marie Ellegaard et al.   EBioMedicine

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

(2015) Ana Serrano-Puebla et al.   Annals of the New York Academy of Sciences

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal “metastability” in primary hepatocytes determining in vitro cell survival

(2015) Margit A. Krenn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium

(2015) Kimberly A. Toops et al.   MOLECULAR BIOLOGY OF THE CELL

Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection

(2015) Wenhan Zhu et al.   PLoS Pathogens

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer

(2014) Andrew Poklepovic et al.   Autophagy

Combined autophagy and HDAC inhibition

(2014) Devalingam Mahalingam et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Proteinase 3–dependent caspase-3 cleavage modulates neutrophil death and inflammation

(2014) Fabien Loison et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

SRT1720 Induces Lysosomal-Dependent Cell Death of Breast Cancer Cells

(2014) T. J. Lahusen et al.   MOLECULAR CANCER THERAPEUTICS

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Host-derived, pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection

(2014) Y. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

(2014) M. A. Bewley et al.   mBio

Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2

(2013) Gloria E. Villalpando Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

(2013) Wei-Ting Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review

(2013) Tetsumori Yamashima   PROGRESS IN NEUROBIOLOGY

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes

(2013) M Hafner Česen et al.   Cell Death & Disease

Lysosomal Iron, Iron Chelation, and Cell Death

(2012) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage

(2012) David H. Kessel et al.   Autophagy

Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization

(2012) T Arnandis et al.   CELL DEATH AND DIFFERENTIATION

Cathepsin D Primes Caspase-8 Activation by Multiple Intra-chain Proteolysis

(2012) Sébastien Conus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism

(2012) Salvador Mena et al.   PLoS One

Identification of Cytoskeleton-Associated Proteins Essential for Lysosomal Stability and Survival of Human Cancer Cells

(2012) Line Groth-Pedersen et al.   PLoS One

A Cytotoxic Type III Secretion Effector of Vibrio parahaemolyticus Targets Vacuolar H+-ATPase Subunit c and Ruptures Host Cell Lysosomes

(2012) Shigeaki Matsuda et al.   PLoS Pathogens

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

Chelation of Lysosomal Iron Protects Dopaminergic SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide Toxicity by Precluding Autophagy and Akt Dephosphorylation

(2011) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

Lysosomal membrane permeabilization in Parkinson disease

(2010) Miquel Vila et al.   Autophagy

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

(2010) Shunya Sahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

(2010) Nikolaj H.T. Petersen et al.   CELL CYCLE

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

(2010) Kai Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

TRB3 links ER stress to autophagy in cannabinoid antitumoral action

(2009) María Salazar et al.   Autophagy

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of lysosomal rupture in neuronal death

(2009) Tetsumori Yamashima et al.   PROGRESS IN NEUROBIOLOGY

Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-Bax activation loop

(2008) Roberta Castino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE