Article
Biotechnology & Applied Microbiology
Xiujuan Huang, Hongxia Dong, Yang Liu, Fen Yu, Shunshi Yang, Zhen Chen, Jueying Li
Summary: In this study, MB-mediated let-7b-5p inhibitor showed a higher transfection efficiency and more significant inhibitory effects on ovarian cancer cells compared to let-7b-5p inhibitor alone. The downregulation of DDX19A reversed the inhibitory effects of MB-let-7b-5p inhibitor on ovarian cancer cells, suggesting a potential therapeutic target for ovarian cancer treatment.
Review
Oncology
Fengzhi Li, Christos Fountzilas, Igor Puzanov, Kristopher M. Attwood, Carl Morrison, Xiang Ling
Summary: DDX5, a multifunctional DEAD-box RNA helicase, has been recognized as both a potential biomarker and therapeutic target for various cancer types. While some studies have found it to be oncogenic target, others suggest it may act as a tumor suppressor, highlighting its complexity in cancer biology. Further research and discussion are needed to fully understand DDX5's role in cancer therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shaheda Tabassum, Malini Basu, Mrinal K. Ghosh
Summary: This study reveals a novel mechanism of alliance between DDX5 (p68) and the Wnt/β-catenin pathway in regulating FOXM1 gene expression and driving colon carcinogenesis, providing a new mechanistic basis for colorectal cancer research.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Respiratory System
Mudan He, Guoqing Zhang, Fang Shen, Xingjing Li
Summary: In this study, the effect of caspase inhibitors, Z-VAD and Ac-DEVD, on airway inflammation and mucus secretion in mice exposed to cigarette smoke was investigated. The results showed that Z-VAD relieved airway inflammation and emphysema, and decreased IL-1 beta and IL-8 levels in serum. Ac-DEVD reduced airway inflammation, serum IL-1 beta and IL-8 levels, and Muc5ac levels in BALF.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Oncology
Yantao Wang, Xuan Huang, Panpan Wang, Yi Zeng, Guozhi Zhou
Summary: In this study, the important hsa_circ_0007396-miR-767-3p-CHD4 axis associated with gastric cancer (GC) proliferation and carcinogenesis was identified. CHD4 may represent a promising therapeutic target for the future cure of GC.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Biophysics
Jan Philip Wurm
Summary: DEAD-box helicases are important regulators of RNA-dependent cellular processes, with DbpA playing a role in ribosome maturation. By studying conformational changes of DbpA, researchers aim to better understand the ATP-dependent RNA unwinding process catalyzed by DEAD-box helicases. Initial NMR studies have provided insight into the structural dynamics of DbpA during its catalytic cycle.
BIOMOLECULAR NMR ASSIGNMENTS
(2021)
Article
Mathematical & Computational Biology
Hao Zhang, Yanpu Li, Yuanning Liu, Haiming Liu, Hongyu Wang, Wen Jin, Yanmei Zhang, Chao Zhang, Dong Xu
BMC SYSTEMS BIOLOGY
(2016)
Article
Genetics & Heredity
Zhang Xiangyuan, Dong Jiaqiang, He Yan, Zhao Ming, Liu Zhen, Wang Na, Jiang Mingzuo, Zhang Zhe, Liu Gang, Liu Haiming, Nie Yongzhan, Fan Daiming, Tie Jun
Article
Biochemistry & Molecular Biology
Yi Chu, Mingzuo Jiang, Feng Du, Di Chen, Tao Ye, Bing Xu, Xiaowei Li, Weijie Wang, Zhaoyan Qiu, Haiming Liu, Yongzhan Nie, Jie Liang, Daiming Fan
Article
Genetics & Heredity
Haiming Liu, Zhe Zhang, Nan Wu, Hao Guo, Hao Zhang, Daiming Fan, Yongzhan Nie, Yuanning Liu
Article
Cell Biology
Nan Wu, Mingzuo Jiang, Yuying Han, Haiming Liu, Yi Chu, Hao Liu, Jiayi Cao, Qiuqiu Hou, Yu Zhao, Bing Xu, Xin Xie
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Genetics & Heredity
Haiming Liu, Nan Wu, Zhe Zhang, XiaoDan Zhong, Hao Zhang, Hao Guo, Yongzhan Nie, Yuanning Liu
FRONTIERS IN GENETICS
(2019)
Article
Genetics & Heredity
Xiaodan Zhong, Yuanning Liu, Haiming Liu, Yutong Zhang, Linyu Wang, Hao Zhang
FRONTIERS IN GENETICS
(2018)
Article
Genetics & Heredity
Linyu Wang, Yuanning Liu, Xiaodan Zhong, Haiming Liu, Chao Lu, Cong Li, Hao Zhang
FRONTIERS IN GENETICS
(2019)
Article
Cell Biology
Yuying Han, Nan Wu, Mingzuo Jiang, Yi Chu, Zhiyang Wang, Hao Liu, Jiayi Cao, Hanming Liu, Bing Xu, Xin Xie
CELL PROLIFERATION
(2019)
Article
Biochemistry & Molecular Biology
Mingfu Tong, Haiming Liu, Jianyu Hao, Daiming Fan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Xiaodan Zhong, Yutong Zhang, Linyu Wang, Hao Zhang, Haiming Liu, Yuanning Liu
Article
Biochemistry & Molecular Biology
Nan Wu, Mingzuo Jiang, Haiming Liu, Yi Chu, Dan Wang, Jiayi Cao, Zhiyang Wang, Xin Xie, Yuying Han, Bing Xu
Summary: LINC00941 plays a crucial role in metastatic colorectal cancer by activating the TGF-beta/SMAD2/3 pathway to promote metastasis and invasion.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Medicine, Research & Experimental
Yi Chu, Mingzuo Jiang, Nan Wu, Bing Xu, Wenjiao Li, Haiming Liu, Song Su, Yanting Shi, Hao Liu, Xiaoliang Gao, Xin Fu, Di Chen, Xiaowei Li, Weijie Wang, Jie Liang, Yongzhan Nie, Daiming Fan
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)