Article
Biochemistry & Molecular Biology
Miyu Watanabe, Kyoka Kawaguchi, Yusuke Nakamura, Kyoji Furuta, Hiroshi Takemori
Summary: The oxindole derivative GIF-2209 promotes melanogenesis and melanosome secretion by regulating multiple mechanisms, such as upregulating TYR expression, suppressing TYRP-1 protein levels, inducing lysosome expansion and redistribution, and accelerating autophagy.
Article
Pharmacology & Pharmacy
Chen Hong, Lili Yang, Yifan Zhang, Yiming Li, Huali Wu
Summary: This study demonstrates the potential pigmentation effect of Epimedium brevicornum Maxim., and elucidates its related molecular mechanisms and melanogenesis basis. Epimedium Folium extract (EFE) has been shown to exhibit repigmentation effects by promoting melanin synthesis and melanosome biogenesis/transfer. Six main flavonoid ingredients were identified among EFE, with epimedin B (EB) being confirmed as a high-content, low-toxicity, and effective melanogenic compound. These findings provide valuable insights into the pharmacology of Epimedium herb and may offer a novel therapeutic approach for hypopigmentation disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Min-Kyeong Lee, Heeyeon Ryu, Hyeon Hak Jeong, Bonggi Lee
Summary: Brassinin, a phytoalexin found in cabbage, has been shown to have anti-cancer and anti-inflammatory effects. This study demonstrated that brassinin can inhibit melanogenesis by reducing both the activity and mRNA expression levels of tyrosinase. These findings suggest that brassinin could be used in pharmaceutical or cosmetic products for depigmentation purposes.
Article
Biochemistry & Molecular Biology
Shilpi Goenka, Sanford R. Simon
Summary: Novel chemically modified curcumin analogs have shown inhibitory effects on melanin production by downregulating protein levels, suppressing phagocytosis of melanosome mimics, and inhibiting dendricity in human melanocytes. These analogs are more effective and less toxic than parent curcumin, suggesting their potential for skin depigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Caijing Han, Bingjie Lin, Xinyu Huang, Zhaojie Mao, Xiaoting Kong, Lei Fang, Peng Xue, Anning Wang, Fengxiang Zhang
Summary: In order to improve the treatment of pigmentation disorders, researchers are looking for natural and safe inhibitors of melanin synthesis. In this study, quinoa husk peptides were purified using 30% and 80% ethanol. The 80% ethanol fraction, known as QHP fraction, showed superior inhibitory effects on tyrosinase, scavenging of free radicals, reducing activity, and chelating capacity compared to the 30% fraction. Additionally, differentially expressed genes in the QHP fraction were primarily enriched in Akt-signaling pathways.
Review
Oncology
Jaewon You, Maftuna Yusupova, Jonathan H. Zippin
Summary: Melanin synthesis continues in melanoma cells even after the occurrence of melanomagenesis, although these cells are no longer involved in the tanning process. Melanin may have metabolic functions that benefit melanoma, aside from its role in blocking UV-induced DNA mutation. The mechanisms regulating melanin synthesis in melanoma cells outside the epidermis or hair follicle are currently unknown.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Analike Blom van Staden, Carel B. Oosthuizen, Namrita Lall
Summary: Pigmentation is a vital process in skin protection controlled by melanogenesis. This study evaluated Aspalathus linearis extract on melanogenesis stimulation and found compounds like aspalathin and catechin significantly increased enzymatic rate. Molecular docking analysis revealed interactions between compounds and the active site.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mason A. Baber, Cole M. Crist, Noah L. Devolve, James D. Patrone
Summary: Due to its crucial role in melanin biosynthesis, tyrosinase has become a vital target for inhibition in various fields, such as agriculture and cosmetics. Despite limited use of tyrosinase inhibitors in the cosmetics industry due to conflicting efficacy and potential toxicity, researchers have persistently pursued their development with varying degrees of success, resulting in a significant body of research. This review aims to provide an overview of the past twenty years (2003-2023) of tyrosinase inhibitor research by highlighting notable molecules and advancements.
Article
Biochemistry & Molecular Biology
Hui-hao Tang, Yi-fan Zhang, Li-li Yang, Chen Hong, Kai-xian Chen, Yi-ming Li, Hua-li Wu
Summary: The study examined the role and molecular mechanism of the 5-HT7 receptor in pigmentation in different models. It was found that the receptor could enhance melanin production and cell migration, suggesting it could be a therapeutic target for pigmentation disorders.
Article
Biochemistry & Molecular Biology
Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Sobarathne Senel Sanjaya, Kyoung Tae Lee, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Yung Hyun Choi, Sung-Pyo Hur, Gi-Young Kim
Summary: In this study, it was found that pinostrobin effectively inhibits melanogenesis in vitro and in vivo by regulating the cAMP-CREB-MITF axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kyoung Mi Moon, Ju-Hye Yang, Min-Kyeong Lee, Eun-Bin Kwon, Jiwon Baek, Taehyeok Hwang, Jae-Il Kim, Bonggi Lee
Summary: This study found that maclurin has inhibitory effects on melanogenesis and can be used as an anti-melanogenic agent.
Article
Food Science & Technology
Zizi Hu, Xiaomei Sha, Lu Zhang, Sheng Huang, Zongcai Tu
Summary: FTGML can inhibit melanin synthesis in B16F10 melanoma cells by reducing the involvement of reactive oxygen species and downregulating the cAMP-PI3K/Akt and MAPK pathways.
Article
Biochemistry & Molecular Biology
Sebastiano Masuri, Benedetta Era, Francesca Pintus, Enzo Cadoni, Maria Grazia Cabiddu, Antonella Fais, Tiziana Pivetta
Summary: The design of novel antityrosinase agents is important in medical and industrial sectors. Melanin irregular production is related to skin-related disorders and browning process of fruits and vegetables. Developing dual antioxidant and antityrosinase agents is advantageous. Two new bishydroxylated and two new monohydroxylated derivatives of (1E)-2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazine-1-carbothioamide (T1) were evaluated for their antioxidant and tyrosinase inhibition ability, showing stronger properties than the reference compound. The safety of these compounds has also been assessed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ting Chen, Wei-Chao Su, Yi-Ning Wu, Qing-Xi Chen, Qin Wang, Jing Song, Jiang-Xing Zhuang, Yan Shi
Summary: The study found that cardanol diene and crude extracted compound from cashew nut shell oil have both shown inhibitory effects on melanin production and transfer, potentially serving as promising candidates for new anti-melanin drugs in cosmetics and medicine.
PROCESS BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Huihao Tang, Lili Yang, Longlong Wu, Huimin Wang, Kaixian Chen, Huali Wu, Yiming Li
Summary: Kaempferol promotes melanogenesis and melanocyte growth by regulating dendritic growth and melanosome quantity, maturation, and transport in melanocytes via the P38/ERK MAPK and PI3K/AKT signaling pathways.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)