Article
Endocrinology & Metabolism
Hao Yang, Qingzhuang Liang, Jian Zhang, Jinkun Liu, Hao Wei, Haibo Chen, Wei Wei, Dong Chen, Yongsheng Zhao
Summary: Papillary thyroid cancer (PTC) is a common malignancy with increasing morbidity and mortality. Traditional culture methods lack tissue structure and fail to reflect tumor heterogeneity. Mouse models are time-consuming and inefficient for large-scale application. Clinical relevant patient-derived organoids have been successfully established from PTC clinical specimens, showing high consistency with parental tumors in histopathological and genome analysis. A detailed method for deriving PTC organoids from clinical specimens is presented, with a success rate of 77.6% (38/49) so far.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Dong Chen, Yawen Tan, Zhichao Li, Wujiao Li, Lei Yu, Wei Chen, Yuchen Liu, Lisa Liu, Liangfeng Guo, Weiren Huang, Yongsheng Zhao
Summary: Researchers established patient-derived PTC organoids as a promising new preclinical model for personalized therapy, demonstrating preservation of biological characteristics and genomic heterogeneity from the originating tumors and patient-specific drug responses.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Jingyao Chen, Siqi Dai, Lei Zhao, Yiman Peng, Chongen Sun, Hongling Peng, Qian Zhong, Yuan Quan, Yue Li, Xuelan Chen, Xiangyu Pan, Ailing Zhong, Manli Wang, Mengsha Zhang, Shengyong Yang, You Lu, Zhong Lian, Yu Liu, Shengtao Zhou, Zhengyu Li, Feifei Na, Chong Chen
Summary: A strategy based on organoids and genome editing was used to generate primary, orthotopic, and driver-defined endometrial cancer (EC) models in mice. These models faithfully recapitulate the molecular and pathohistological characteristics of human EC. Using these models, it was shown that Pik3ca and Pik3r1 mutations cooperate with Pten loss to promote endometrial adenocarcinoma, while Kras G12D mutation leads to endometrial squamous cell carcinoma.
Article
Medicine, Research & Experimental
Dong Chen, Xi Su, Lizhang Zhu, Hao Jia, Bin Han, Haibo Chen, Qingzhuang Liang, Chenchen Hu, Hao Yang, Lisa Liu, Peng Li, Wei Wei, Yongsheng Zhao
Summary: This study established patient-derived papillary thyroid cancer (PTC) organoid models to investigate tumor biology and drug responsiveness. These organoids closely recapitulated the histological architectures and mutational landscapes of the primary tumors. The drug sensitivity assays demonstrated distinct drug responses among patients and showed improved efficacy of combination therapy compared to BRAF inhibition alone.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Veronica Veschi, Alice Turdo, Chiara Modica, Francesco Verona, Simone Di Franco, Miriam Gaggianesi, Elena Tirro, Sebastiano Di Bella, Melania Lo Iacono, Vincenzo Davide Pantina, Gaetana Porcelli, Laura Rosa Mangiapane, Paola Bianca, Aroldo Rizzo, Elisabetta Sciacca, Irene Pillitteri, Veronica Vella, Antonino Belfiore, Maria Rita Bongiorno, Giuseppe Pistone, Lorenzo Memeo, Lorenzo Colarossi, Dario Giuffrida, Cristina Colarossi, Paolo Vigneri, Matilde Todaro, Giorgio Stassi
Summary: In this study, the authors demonstrated the ability of hESCs to recapitulate different histotypes of thyroid carcinoma (TC) through specific genomic alterations using CRISPR-Cas9. They identified KISS1R and TIMP1 targeting as a potential therapeutic adjuvant option for undifferentiated TCs.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Andrew J. H. Sedlack, Samual J. Hatfield, Suresh Kumar, Yasuhiro Arakawa, Nitin Roper, Nai-Yun Sun, Naris Nilubol, Katja Kiseljak-Vassiliades, Chuong D. Hoang, Emily K. Bergsland, Jonathan M. Hernandez, Yves Pommier, Jaydira del Rivero
Summary: Adrenocortical cancer is a rare and aggressive endocrine malignancy with a low survival rate. Due to limited clinical data, the development of drugs and understanding of mechanisms heavily rely on preclinical models. In recent years, significant progress has been made in generating new in vitro and in vivo models for adrenocortical cancer research. These models include cell lines, spheroids, organoids, xenograft, and genetically engineered mouse models.
Article
Engineering, Biomedical
Yong Hun Jung, Dong-Hee Choi, Kyungwon Park, Sat-Byol Lee, Jonghun Kim, Hyunho Kim, Hyun-Woo Jeong, Ji Hun Yang, Jin-A Kim, Seok Chung, Byung Soh Min
Summary: This study demonstrates a scalable organoid production platform that can produce functionally complex and uniform organoids. Hydro-organoids produced on the new platform show better consistency in drug screening and have the potential to be used in high-throughput assays and predicting clinical outcomes.
Review
Biochemistry & Molecular Biology
Cristina Romei, Rossella Elisei
Summary: Thyroid carcinoma is a diverse group of cancers with distinct genetic alterations, which play a critical role in determining the biological behavior and guiding treatment strategies. Understanding these genetic events is essential for personalized and effective management of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Lei Li, Qixuan Sheng, Huajin Zeng, Wei Li, Qiang Wang, Guanjun Ma, Ming Qiu, Wei Zhang, Chengxiang Shan
Summary: This paper comprehensively describes thyroid regenerative medicine and highlights the promising therapeutic potential of transplanting engineered functional thyroid tissue to restore optimal hormonal balance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Zhen Fang, Peijuan Li, Fengying Du, Liang Shang, Leping Li
Summary: Organoids are established through in vitro 3D culture and have the ability to mimic the structure and physiological functions of organs or tissues in vivo. They have gained significant attention and are considered reliable platforms for cancer research and treatment. Organoids have great potential in areas such as new drug development, drug screening, tumor mechanism research, and precision medicine. This review primarily focuses on recent advances in the application of organoids in cancer research and discusses the opportunities and challenges they face, aiming to provide insights for their future development.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Arielle Katcher, Brian Yueh, Kadir Ozler, Aaron Nizam, Ariel Kredentser, Charlie Chung, Marina Frimer, Gary L. Goldberg, Semir Beyaz
Summary: Endometrial cancer is the most common gynecologic malignancy in the United States with increasing incidence and mortality rate over the last decade. Current research models are inadequate in replicating the essential characteristics of this heterogeneous disease. Patient-derived organoids provide a long-term and versatile culture system that can capture patient-specific characteristics, facilitating the understanding and treatment of endometrial cancer. This study establishes and banks endometrial cancer organoids, enabling downstream histological and genomic characterization as well as functional assays.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Biochemical Research Methods
Madhura Mukhopadhyay
Summary: Human cervical organoids successfully replicate the dynamics of cancer and sexually transmitted infections.
Review
Oncology
Ruobing Zhang, Tiantian Guo, Lulin Ji, Yirui Yin, Shuitu Feng, Weihong Lu, Fei Zhang, Maoshu Zhu, Shugang Liu, Jinhua Jiang, Fanwei Zeng
Summary: Human gastrointestinal cancer poses a significant challenge to public health globally, with surgery and postoperative chemotherapy only effective for early-stage cases. The emergence of patient-derived cancer organoid technology offers new opportunities for modeling gastrointestinal cancers and advancing personalized treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Carolin Kastner, Anne Hendricks, Hanna Deinlein, Mohammed Hankir, Christoph-Thomas Germer, Stefanie Schmidt, Armin Wiegering
Summary: Despite advancements in multimodal therapy, cancer remains a leading cause of death in industrial nations. Organoids, a 3D ex vivo culture system, have been developed and show great potential in personalized drug investigations. They retain genetic, functional, and phenotypic characteristics of original tissue, making them valuable tools in studying a wide range of physiological and pathophysiological processes.
Review
Endocrinology & Metabolism
Hilda Samimi, Rasha Atlasi, Somayeh Parichehreh-Dizaji, Samaneh Khazaei, Mahshid Akhavan Rahnama, Soroush Seifirad, Vahid Haghpanah
Summary: Although there are limitations and controversies in the study of thyroid, organoid technology offers a wide range of potential applications, accurately modeling thyroid in health and diseases, and providing an excellent preclinical in vitro platform.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Russell G. Witt, Yuki Hirata, Laura R. Prakash, Timothy E. Newhook, Jessica E. Maxwell, Michael P. Kim, Hop S. Tran Cao, Jeffrey E. Lee, Jean-Nicolas Vauthey, Matthew H. G. Katz, Ching-Wei D. Tzeng, Naruhiko Ikoma
Summary: Compared to traditional open PD, patients undergoing robotic PD required less opioid use during hospitalization while maintaining similar pain scores. Despite a shorter length of stay, a higher percentage of robotic PD patients tapered off opioids prior to discharge. These results provide a rationale for choosing robotic PD when feasible to minimize opioid use.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yibo Fan, Yuan Li, Xiaodan Yao, Jiangkang Jin, Ailing Scott, Bovey Liu, Shan Wang, Longfei Huo, Ying Wang, Ruiping Wang, Melissa Pool Pizzi, Lang Ma, Shan Shao, Matheus Sewastjanow-Silva, Rebecca Waters, Deyali Chatterjee, Bin Liu, Namita Shanbhag, Guang Peng, George Adrian Calin, Pawel Karol Mazur, Samir M. Hanash, Jo Ishizawa, Yuki Hirata, Osamu Nagano, Zhenning Wang, Linghua Wang, Wa Xian, Frank McKeon, Jaffer A. Ajani, Shumei Song
Summary: SOX9 plays a critical role in suppressing CD8(+) T cell responses and modifying macrophage function in GAC through the paracrine factor LIF. Targeting both LIF/LIFR and CSF1R has potential for combination therapy against advanced GAC, targeting SOX9-mediated cancer stemness, T cell immunosuppression, and metastasis.
Article
Oncology
Yuki Hirata, Annamaria Agnes, Laura R. Prakash, Paul Mansfield, Brian D. Badgwell, Naruhiko Ikoma
Summary: This study aimed to investigate the relationship between Borrmann type and response to preoperative therapy in advanced gastric cancer. The results showed that patients with Borrmann type 3/4 had a lower likelihood of achieving pCR after preoperative therapy, suggesting the need for careful treatment selection.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Gastroenterology & Hepatology
Ryo Seishima, Koji Okabayashi, Hiroki Ikeuchi, Motoi Uchino, Kitaro Futami, Tatsuki Noguchi, Hiroki Ohge, Yasuhito Iseki, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yuji Toiyama, Takayuki Ogino, Masafumi Nakamura, Kazutaka Yamada, Toshifumi Wakai, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Fumio Ishida, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Seiichiro Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Junya Arakaki, Koji Komori, Yoshito Akagi, Dai Shida, Shigeki Yamaguchi, Keiji Matsuda, Kiyoshi Maeda, Toshihiro Noake, Riichiro Nezu, Shin Sasaki, Junichi Hasegawa, Eiji Sunami, Yukihide Kanemitsu, Kenji Katsumata, Kei Uehara, Tomomichi Kiyomatsu, Takeshi Suto, Shinsuke Kazama, Takeshi Yamada, Takenori Goi, Soichiro Ishihara, Yoichi Ajioka, Kenichi Sugihara
Summary: This study aimed to evaluate the impact of biologics on the risk of advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer. The results showed that in patients with Crohn's disease (CD), no drugs were significantly associated with cancer stage. However, in patients with ulcerative colitis (UC), less use of biologics, 5-aminosalicylic acid, and immunomodulators was significantly associated with advanced cancer stage. Multivariate analysis demonstrated that biologic use was significantly associated with a lower risk of advanced-stage disease.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Editorial Material
Oncology
Yuki Hirata, Paul Mansfield, Naruhiko Ikoma
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Kiyoaki Sugiura, Yuki Seo, Yuki Tajima, Hiroto Kikuchi, Akira Hirata, Jumpei Nakadai, Hideo Baba, Takayuki Kondo, Akitsugu Makino, Yujin Kato, Shimpei Matsui, Ryo Seishima, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa
Summary: This study investigates the necessity of lymph node dissection during colon cancer surgery and finds that main lymph node metastasis (MLNM) has a significant impact on the prognosis of colon cancer patients. Adding the MLNM status to the TNM staging system can enhance prognostic evaluation and the clinical efficacy of adjuvant therapy.
WORLD JOURNAL OF SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Nahoko Ono, Ryo Seishima, Koji Okabayashi, Hiroaki Imai, Syuji Fujii, Yuya Oaki
Summary: This study presents a sponge device that utilizes two stimuli-responsive materials to image and measure compression stresses. The device successfully achieves imaging and measurement of compression stresses in the kPa range, and can be applied to various fields.
Article
Oncology
Yuki Hirata, Annamaria Agnes, Jeannelyn S. Estrella, Mariela Blum Murphy, Prajnan Das, Bruce D. Minsky, Jaffer A. Ajani, Brian D. Badgwell, Paul Mansfield, Naruhiko Ikoma
Summary: Microscopically positive (R1) surgical margins after gastrectomy increase gastric cancer recurrence risk, and this study aimed to explore the impact of R1 margins on recurrence patterns and survival. The results showed that patients with R1 margins had aggressive clinicopathologic features and a significantly lower 5-year overall survival rate. Most patients with R1 margins experienced peritoneal recurrence, and the time to peritoneal dissemination recurrence was relatively short.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Yuki Hirata, Jessica E. Maxwell, Michael P. Kim, Ching-Wei D. Tzeng, Matthew H. G. Katz, Naruhiko Ikoma
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kyoko Sakamoto, Koji Okabayashi, Shunsuke Matsumoto, Shimpei Matsui, Ryo Seishima, Kohei Shigeta, Yuko Kitagawa
Summary: This study investigates the flow pattern of the splenic flexure vein (SFV) and its positional relationship with the accessory middle colic artery (AMCA). The results show that the SFV mostly returns to the inferior mesenteric vein, followed by the superior mesenteric vein and splenic vein. The AMCA is present in many cases and is mainly connected to the superior mesenteric artery or its branches.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Yuki Hirata, Annamaria Agnes, Elsa M. Arvide, Kristen A. Robinson, Connie To, Heather L. Griffith, Madison D. LaRose, Kathryn M. Munder, Paul Mansfield, Brian D. Badgwell, Naruhiko Ikoma
Summary: This study aimed to compare the benefits of open gastrectomy (OG) and robotic gastrectomy (RG) in gastric cancer patients. The results showed that RG had longer surgery time, smaller blood loss volume, shorter recovery time compared to OG, but there was no significant difference in postoperative complication rates between the two groups. Overall, RG was found to be a safe option for gastric cancer patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Yoshiyuki Saito, Natsuko Watanabe, Nami Suzuki, Naoko Saito, Hiroto Narimatsu, Hiroshi Takami, Kaori Kameyama, Kana Yoshioka, Chie Masaki, Junko Akaishi, Kiyomi Yamada Hames, Masako Matsumoto, Miho Fukushita, Ai Yoshihara, Ritsuko Okamura, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Wataru Kitagawa, Mitsuji Nagahama, Jaeduk Yoshimura Noh, Kiminori Sugino, Koichi Ito
Summary: This study aimed to establish an appropriate staging system and evaluate the role of surgery and radiation therapy in primary thyroid MALT lymphoma. The modified staging system allows discrimination between stage IE and IIE MALT lymphoma. Surgery provides good prognosis, avoids complications, shortens painful periods, and simplifies follow-up.
Article
Gastroenterology & Hepatology
Masashi Takeuchi, Hideki Endo, Taizo Hibi, Ryo Seishima, Yutaka Nakano, Hiroyuki Yamamoto, Hiroaki Miyata, Hiromichi Maeda, Kazuhiro Hanazaki, Akinobu Taketomi, Yoshihiro Kakeji, Yasuyuki Seto, Hideki Ueno, Masaki Mori, Yuko Kitagawa
Summary: This study investigated the impact of COVID-19 on the incidence of postoperative complications in gastric cancer patients. The results showed that although the number of surgeries decreased during the COVID-19 pandemic, the rates of ICU admissions, mortality, and critical morbidity did not worsen. This suggests that surgical management was conducted adequately even with limited medical resources and staff during the pandemic.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Surgery
Hirochika Kato, Ryo Seishima, Kimihiko Nakamura, Shimpei Matsui, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa
Summary: It is more challenging to predict the risk of postoperative complications in late-onset ulcerative colitis patients compared to early-onset patients using nutritional status. The prognostic nutritional index (PNI) may be a useful marker for both late-onset and early-onset UC patients.
WORLD JOURNAL OF SURGERY
(2023)
Article
Medicine, Research & Experimental
Fumimasa Kitamura, Takashi Semba, Noriko Yasuda-Yoshihara, Kosuke Yamada, Akiho Nishimura, Juntaro Yamasaki, Osamu Nagano, Tadahito Yasuda, Atsuko Yonemura, Yilin Tong, Huaitao Wang, Takahiko Akiyama, Kazuki Matsumura, Norio Uemura, Rumi Itoyama, Luke Bu, Lingfeng Fu, Xichen Hu, Feng Wei, Kosuke Mima, Katsunori Imai, Hiromitsu Hayashi, Yo-ichi Yamashita, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto
Summary: Glycolysis is increased in pancreatic ductal adenocarcinoma (PDAC) cells, resulting in glucose restrictions on nontumor cells in the tumor microenvironment. Cancer-associated fibroblasts (CAFs) with restricted glucose availability utilize lactate as a fuel and exhibit immunosuppressive activity in the PDAC microenvironment. Coculture experiments revealed that glucose is mainly consumed by tumor cells, while CAFs consume lactate through monocarboxylate transporter 1 to enhance proliferation. Lactate-stimulated CAFs upregulate IL-6 expression and synergistically suppress cytotoxic immune cell activity with lactate. Inhibiting lactate dehydrogenase A (LDHA) reduces tumor growth and improves antitumor immunity in CAF-rich PDAC tumors.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
