Review
Cell Biology
Lincheng Zhang, Ludi Yang, Shuheng Jiang, Minhao Yu
Summary: Nerves play a pivotal role in tumorigenesis and cancer progression, especially in neurotrophic cancers. Perineural invasion in colorectal cancer has been recognized as a strong predictor of prognosis. Nerves can shield and nurture tumor cells, and their precise role and interaction pattern with CRC cells have not been fully revealed yet.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aishwarya S. S. Iyer, Mohammed Rifat Shaik, Jean-Pierre Raufman, Guofeng Xie
Summary: Despite the high mortality rate of colorectal cancer worldwide, effective treatments for advanced disease are limited. The development of colorectal cancer involves epigenetic modifications of gene expression and function, resulting in altered cell signaling and cell cycle regulation. Zinc finger proteins, as important transcriptional regulators, play crucial roles in the cellular mechanisms underlying colorectal tumorigenesis, impacting cell differentiation, proliferation, apoptosis, and stemness. This review focuses on the oncogenic and tumor suppressor roles of zinc finger proteins in colorectal cancer, aiming to identify potential therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing Ji, Jinyu Lv, Mingxiao Lv, Aixin Jing, Menghan Xu, Qing Yuan, Xinhui Ma, Qilan Qian, Weiling Wang, Ting Geng, Yuanyuan Ding, Jingting Qin, Yuanyuan Liu, Jiayan Yang, Jiaojiao Zhou, Ling Ma, Yasong Wang, Lingyi Zuo, XiuJun Wang, Shaojie Ma, Bin Liu
Summary: The deubiquitinating enzyme USP14 is a crucial regulator in various diseases by stabilizing its substrate proteins. Our study identified new potential substrate proteins for USP14 and demonstrated its key role in heme metabolism and tumor invasion through stabilizing BACH1 protein. The NRF2-USP14-BACH1 axis was found to be important in regulating ovarian cancer cell invasion and heme metabolism, suggesting its potential as a therapeutic target in related diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jia-Ren Lin, Shu Wang, Shannon Coy, Yu -An Chen, Clarence Yapp, Madison Tyler, Maulik K. Nariya, Cody N. Heiser, Ken S. Lau, Sandro Santagata, Peter K. Sorger
Summary: We used advanced imaging techniques, 3D reconstruction, spatial statistics, and machine learning to identify cell types and states associated with diagnostic and prognostic features in colorectal cancer. We found that at the tumor invasive margin, T cell suppression involves multiple cell types and that seemingly localized features such as tertiary lymphoid structures are interconnected and have graded molecular properties. These findings challenge the notion that discrete changes in tumor state are most important, demonstrating the presence of large-scale morphological and molecular gradients.
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pathology
Doerthe Jechorek, Inken Haeusler-Pliske, Frank Meyer, Albert Roessner
Summary: SDC4 plays a crucial role in the progression of colorectal cancer, with high expression associated with aggressive pathological features and reduced survival rates. Research on its impact on patient prognosis may offer clinical utility, identifying potential therapeutic targets in the diagnosis and treatment of CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Tianwei Chen, Xilin Zhang, Xufen Ding, Jing Feng, Xueli Zhang, Dong Xie, Xiang Wang
Summary: Based on bioinformatic analysis, this study found that the expression of RyR2 was upregulated in KRAS-mutant colorectal cancer patients and promoted cancer cell metastasis. The approved drug S107 can inhibit the release of calcium from RyR2 and thus inhibit metastasis. High expression of RyR2 is associated with poor prognosis. RyR2 regulates cellular ROS levels and activates the accumulation of the transcription factor BACH1, which may be a potential intervention target for CRC metastasis.
MOLECULAR ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Muhammad Tufail, Changxin Wu
Summary: The WNT5A pathway, a member of the Wnt signaling pathway, is crucial in cancer. It activates non-canonical Wnt signaling pathways by binding to Frizzled (FZD) and Receptor Tyrosine Kinase-Like Orphan Receptor (ROR) family members. WNT5A pathway is involved in various cellular processes and its abnormal activation or inhibition in colorectal cancer (CRC) can have both oncogenic and antitumor effects. WNT5A is also associated with inflammation, metastasis, and altered metabolism in cancer cells.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2023)
Article
Oncology
Bin Zhang, Yanyun Lin, Chao Wang, Zexian Chen, Tianze Huang, Hao Chen, Guannan Wang, Ping Lan, Xiaowen He, Xiaosheng He
Summary: This study found that perineural invasion has significant prognostic value in colorectal cancer, not limited to stage II. Patients with stage II combined with perineural invasion have similar survival rates to those with stage III. Therefore, perineural invasion is an important prognostic factor in colorectal cancer.
Review
Oncology
Hao Wang, Ruixue Huo, Kexin He, Li Cheng, Shan Zhang, Minhao Yu, Wei Zhao, Hui Li, Junli Xue
Summary: In recent years, the importance of the nervous system in the tumor microenvironment has been recognized. The bidirectional communication between nerves and cancer cells is crucial for tumor initiation and progression. Perineural invasion (PNI) is a common feature in various malignancies and is associated with tumor invasion, metastasis, cancer-related pain, and unfavorable clinical outcomes. It is essential to investigate the role of nerves in colorectal cancer (CRC) and understand the mechanisms of PNI in order to impede tumor progression and improve patient survival.
Article
Pathology
Mahmoud A. Elrebehy, Tamer M. Abdelghany, Mostafa M. Elshafey, Maher H. Gomaa, Ahmed S. Doghish
Summary: This study evaluated the expression of miR-509-5p in colorectal cancer (CRC) cell lines and tissues and found a significant reduction compared to normal tissues. Upregulation of miR-509-5p inhibited cell viability and suppressed the expression of SLC7A11. Overexpression of miR-509-5p also increased levels of MDA and iron, suggesting its role in promoting ferroptosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Anatomy & Morphology
Reyhaneh Afshar-Khamseh, Arash Javeri, Masoumeh Fakhr Taha
Summary: CXCR4 plays a crucial role in colorectal cancer development and metastasis, and the downregulation of CXCR4 by miR-146a affects proliferation, apoptosis, and migration of CRC cells. While the overexpression of miR-146a leads to cell cycle arrest and decreased apoptosis, it may not universally suppress tumor growth in all CRC cells.
Review
Oncology
Nayden G. Naydenov, Susana Lechuga, Emina H. Huang, Andrei I. Ivanov
Summary: Colorectal cancer (CRC) is a deadly disease that often presents at an advanced stage, with few interventions available. Myosins, a family of actin motor proteins, play crucial roles in regulating cell proliferation, differentiation, and motility. Altered expression or mutations of myosins have been documented in CRC, but their specific roles in cancer development remain poorly understood.
Review
Biochemistry & Molecular Biology
Zhuomin Tan, Wenyan Sun, Ya Li, Xingmeng Jiao, Mingliang Zhu, Junfei Zhang, Chen Qing, Yinnong Jia
Summary: This article reviews the current status of CRC with metastasis, the studies of EMT, the possible relationship of EMT with CRC, as well as the potential targeted therapy.
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Article
Oncology
Feng Liu, Rui Zhou, Funeng Jiang, Guolong Liu, Kangbao Li, Guodong Zhu
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Guodong Zhu, Bei Zhang, Funeng Jiang, Luqian Zhao, Feng Liu
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Xu-Guang Guo, Ya-Ru Zhuang, Jin-Zhou Wen, Tian-Ao Xie, Ye-Ling Liu, Guo-Dong Zhu, Yong Xia
BIOSCIENCE REPORTS
(2019)
Article
Cell Biology
Guo-dong Zhu, Jing Yu, Zheng-yu Sun, Yan Chen, Hong-mei Zheng, Mei-lan Lin, Shi Ou-yang, Guo-long Liu, Jie-wen Zhang, Feng-min Shao
Summary: CARHSP1 is identified as a critical driver for radioresistance in glioblastomas, potentially mediating radioresistance by activating the inflammatory signaling pathway. Patients with high levels of CARHSP1 have poorer survival when treated with radiotherapy.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Hongmei Zheng, Guodong Zhu, Qing Guan, Wei Fan, Xiang Li, Mancheng Yu, Juan Xu, Xinhong Wu
Summary: This study compared three different methods for immediate breast reconstruction and found that MIPLD, MWLD, and BCSPLD all achieved good outcomes and aesthetic effects, with high surgical success rates and no major complications. The 5-year distant metastasis-free survival rate was 94.2%, and patients showed good arm and back function postoperatively, with excellent or good cosmetic outcomes in terms of breast satisfaction according to the BREAST-Q score.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Guo-Dong Zhu, Xun-Jie Cao, Ya-Ping Li, Jia-Xin Li, Zi-Jian Leng, Li-Min Xie, Xu-Guang Guo
Summary: By analyzing the RNA transcription profiles of different tissues infected with Chlamydia trachomatis, key genes in conjunctival and reproductive tract infections were identified. These genes may have potential applications in future clinical treatments and diagnosis.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)