Article
Chemistry, Multidisciplinary
Yong-Dan Zhao, Hong-Wei An, Muhetaerjiang Mamuti, Xiang-Zhong Zeng, Rui Zheng, Jia Yang, Wei Zhou, Yuxin Liang, Gege Qin, Da-Yong Hou, Xiaolong Liu, Hao Wang, Yuliang Zhao, Xiaohong Fang
Summary: A nano material, nanoglycocluster, is reported to effectively penetrate tumors and repolarize hypoxic TAMs, which play a crucial role in immune escape. The nanoglycocluster self-assembles from mannose-containing precursor glycopeptides and engages with mannose receptors on TAMs, leading to efficient phenotype conversion. By accumulating in hypoxic areas through high diffusivity and weak affinity with TAMs, the nanoglycocluster achieves substantial repolarization of TAMs and shows promising therapeutic effects in mouse tumor models.
ADVANCED MATERIALS
(2023)
Review
Oncology
Iljin Kim, Sanga Choi, Seongkyeong Yoo, Mingyu Lee, In-San Kim
Summary: Cancers have regions of low oxygen concentration that activate hypoxia-related signaling pathways. Fibroblasts, one of the most abundant cellular components in the tumor stroma, are significantly affected by oxygen deprivation. This article summarizes the molecular and cellular mechanisms that regulate fibroblasts under hypoxic conditions and their impact on cancer development and progression. It also discusses potential therapeutic strategies targeting fibroblasts in the hypoxic tumor microenvironment.
Article
Chemistry, Multidisciplinary
Marie H. C. Boulet, Hannah R. Bolland, Ester M. Hammond, Adam C. Sedgwick
Summary: Platinum (IV) anticancer agents show potential to overcome limitations of commonly used Pt (II) chemotherapeutics and an improved understanding of their intracellular reduction is needed. Two fluorescence responsive oxaliplatin (IV) complexes, OxaliRes and OxaliNap, were synthesized and showed increased fluorescence emission intensity upon reduction by sodium ascorbate (NaAsc). Treatment with NaAsc increased fluorescence intensity in a dose-dependent manner in colorectal cancer cells. Hypoxia-induced reduction of OxPt (IV) complexes with <0.1% O-2 resulted in the greatest fluorescence signal and showed significant differences in toxicity compared to normoxia (21% O-2).
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Sophie Groux-Degroote, Philippe Delannoy
Summary: Aberrant expression of glycosphingolipids is closely linked with malignant properties of cancer cells, making them targets for immunotherapy. Various strategies, including monoclonal antibodies, vaccines, and immune effector-cell therapy, have shown promising results in targeting these tumor-associated gangliosides. Adoptive cellular therapy with engineered T cells expressing chimeric antigen receptors is a particularly focused approach in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Raefa Abou Khouzam, Mohak Sharda, Shyama Prasad Rao, Stephanie Maame Kyerewah-Kersi, Nagwa Ahmed Zeinelabdin, Ayda Shah Mahmood, Husam Nawafleh, Munazza Samar Khan, Goutham Hassan Venkatesh, Salem Chouaib
Summary: Hypoxia has a significant impact on the microenvironment of solid tumors, promoting malignancy. In this study, we investigated the effects of long-term hypoxia exposure on transcriptional remodeling, tumor mutational burden (TMB), and genomic instability in cancer cells categorized based on their sensitivity or resistance to hypoxia. Our findings demonstrate that chronic hypoxia leads to metabolic reprogramming, modulation of proliferation, and increased genomic instability in tumor cells. These adaptive responses can be targeted to inhibit the growth and survival of cancer cells in chronically hypoxic tumor areas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Isis Salviano Soares de Amorim, Isabelle Xavier Dias, Daphne Pinheiro, Simone Nunes de Carvalho, Pedro Nicolau-Neto, Juliana Alves Rodrigues, Priscyanne Barreto Siqueira, Matheus da Silva Oliveira, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
Summary: In breast cancer, hypoxia is associated with poor prognosis. The tumor suppressor SAV1 is downregulated in cancer cells, but its expression profile and importance in BC are limited. This study aimed to investigate SAV1 expression under normoxia and hypoxia, and its potential in BC prognosis. The results showed that SAV1 expression is lower in BC samples and tumor cell lines compared to normal samples. Lower levels of SAV1 were associated with worse survival curves and may be a risk factor for BC.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhiyong Liu, Mengsi Wu, Minbo Lan, Weian Zhang
Summary: The development of an oxygen-irrelevant radical nanogenerator, PI/FBC, offers a solution to overcome tumor hypoxia and enhance antitumor efficiency. Excited by NIR light, the nanogenerator generates ROS and toxic iodine radicals, providing a controllable and oxygen-insusceptible treatment option.
Article
Chemistry, Multidisciplinary
Luntao Liu, Qingqing Li, Lanlan Chen, Lihong Song, Xueqiang Zhang, Hongqi Huo, Zhixin You, Ying Wu, Zongsheng Wu, Jiamin Ye, Qinrui Fu, Lichao Su, Xuan Zhang, Huanghao Yang, Jibin Song
Summary: In this study, multifunctional photocatalysis-powered nanomotors were developed for synergistically enhanced cancer radiotherapy. The nanomotors showed superior motility and efficient accumulation in tumor due to the catalytic generation of hydrogen. The nanomotors also exhibited a high radiation dose deposition, leading to enhanced therapeutic efficacy.
Article
Oncology
Qi-Hua Peng, Chun-Hua Wang, Hong-Min Chen, Rong-Xin Zhang, Zhi-Zhong Pan, Zhen-Hai Lu, Gao-Yuan Wang, Xin Yue, Wenlin Huang, Ran-Yi Liu
Summary: CMTM6 is upregulated in colorectal cancer and is associated with lower pT stage, increased CD4(+)/CD8(+) tumor-infiltrating lymphocytes, and a favorable prognosis. PD-L1 is expressed at a low level in tumor tissues, and PD-L1 positivity in tumor stroma is associated with increased CD4(+) TIL density and a favorable prognosis. The coexpression status of CMTM6 and PD-L1 can stratify patients with CRC into different risk groups and may be especially useful for patients undergoing adjuvant chemotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Chemistry, Multidisciplinary
Yi Pan, Longcai Liu, Xiaozhou Mou, Yu Cai
Summary: Cancer is a major disease with complex pathological processes that greatly affect human welfare. Hypoxia, caused by an imbalance between oxygen supply and consumption, is a natural characteristic of most solid tumors and a significant obstacle for cancer therapy. Various strategies have been developed to exploit tumor hypoxia, including alleviating hypoxia and utilizing it for targeted delivery and diagnostic imaging. Nanomedicine strategies have shown promising progress in both conquering and utilizing hypoxia to combat cancer, and the development of emerging nanomaterials holds potential for future clinical translation.
Review
Immunology
Raefa Abou Khouzam, Rania Faouzi Zaarour, Klaudia Brodaczewska, Bilal Azakir, Goutham Hassan Venkatesh, Jerome Thiery, Stephane Terry, Salem Chouaib
Summary: Hypoxia is an environmental stressor that affects tumor microenvironment and immune cell functions, and may have an impact on the effectiveness of immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jianfeng Ding, Xiaobo He, Xiao Cheng, Guodong Cao, Bo Chen, Sihan Chen, Maoming Xiong
Summary: The study established a hypoxia risk model using mRNA expression profiles from TCGA and GEO databases, which could be used to predict prognosis and demonstrate the immune microenvironment in PAC. The higher hypoxia risk score was associated with poorer prognosis and an immunosuppressive microenvironment in PAC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Immunology
Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim
Summary: IL-32 plays a contradictory role in cancer development, with its high expression typically associated with tumor proliferation and progression. However, different isoforms of IL-32 may have different effects in cancer, such as IL-32 beta promoting cancer expansion and IL-32 theta inhibiting epithelial-mesenchymal transition. Further research is needed to understand the role of IL-32 in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Abhisek Sarkar, Sounak Banerjee, Kaushik Biswas
Summary: Gangliosides play important roles in various cancers, but their structural complexity and heterogeneity pose challenges in research. The selective expression of O-acetylated gangliosides in cancer tissues suggests their potential as better targets. Engineering antibodies for targeted ganglioside therapy is an emerging field.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Raefa Abou Khouzam, Shyama Prasad Rao, Goutham Hassan Venkatesh, Nagwa Ahmed Zeinelabdin, Stephanie Buart, Maxime Meylan, Manjunath Nimmakayalu, Stephane Terry, Salem Chouaib
Summary: An eight-gene hypoxia signature identified in this study showed significant association with overall survival in pancreatic ductal adenocarcinoma (PDA), indicating its potential prognostic value. Tumors with high hypoxia were found to have less immune cell infiltration and lower expression of cytokines and inflammatory markers, suggesting a potential role of the signature in identifying an immune cold, hypoxic tumor microenvironment. The combination of the hypoxia signature with an immune metric revealed worse survival outcomes in patients with high hypoxia and low immune reactivity, highlighting the possible utility of this approach in refining survival estimates.
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Biochemistry & Molecular Biology
Paula A. Bousquet, Joe Alexander Sandvik, Nina F. Jeppesen Edin, Ute Krengel
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Albert Serrano, Jessica L. Guyette, Joel B. Heim, Michael Taylor, Patrick Cherubin, Ute Krengel, Ken Teter, Suren A. Tatulian
Summary: This study found that protein disulfide isomerase (PDI) disassembles cholera toxin (CT) more efficiently, providing a possible explanation for the greater potency of CT compared to heat-labile enterotoxin (LT). Furthermore, the analysis of geometrical positioning highlighted structural differences between CT and LT, leading to distinct modes of PDI-toxin interactions.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Delmon Arous, Stefan Schrunner, Ingunn Hanson, Nina Frederike Jeppesen Edin, Eirik Malinen
Summary: This article presents a machine learning procedure for automatic identification and segmentation of cell colonies, addressing challenges in image processing. The proposed algorithm achieves high accuracy and outperforms state-of-the-art methods on two tested datasets.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Biochemistry & Molecular Biology
Ingunn Hanson, Kathinka E. Pitman, Ursula Altanerova, Cestmir Altaner, Eirik Malinen, Nina F. J. Edin
Summary: This study aimed to elucidate the mechanism of transforming growth factor beta 3 (TGF-beta 3) activation and receptor binding in low dose rate (LDR) irradiated cells. The results showed that small extracellular vesicles (sEVs) from LDR primed cells could remove hyper-radiosensitivity (HRS), and inhibition of the matrix metalloproteinase (MMP) family prevented the removal of HRS. Additionally, functional interaction between TGF-beta 3 and activin receptor like kinase 1 (ALK1) was demonstrated in the removal of HRS, independent of ALK5 and TGF-beta RII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Inga Solgard Juvkam, Olga Zlygosteva, Delmon Arous, Hilde Kanli Galtung, Eirik Malinen, Tine Merete Soland, Nina Jeppesen Edin
Summary: This study investigated the early effects of radiotherapy for head and neck cancer and established a preclinical model to evaluate normal tissue responses. The study found that radiation dermatitis and oral mucositis were common side effects, and radiotherapy led to reduced saliva production.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Helen V. Thorbjornsrud, Luca Bressan, Tamjidmaa Khatanbaatar, Manuel Carrer, Kathrin Wurth-Roderer, Gabriele Cordara, Peter Kast, Michele Cascella, Ute Krengel
Summary: Unlike typical chorismate mutases, the enzyme from Mycobacterium tuberculosis (MtCM) has low activity, but its catalytic efficiency can be significantly increased by forming a complex with a partner enzyme. Through molecular dynamics simulations and kinetic investigations, we have studied the structure and functional changes of this enzyme. Our findings show that key residues in artificially evolved enzyme variants contribute to enhancing catalysis by preorganizing and stabilizing the active site loop.
Article
Engineering, Biomedical
Delmon Arous, Jacob Larsen Lie, Bjorg Varli Haland, Magnus Borsting, Nina Frederike Jeppesen Edin, Eirik Malinen
Summary: Spatially fractionated radiation therapy (SFRT or GRID) is an approach to deliver high local radiation doses in an on-off' pattern. In this study, a framework was developed to link local radiation dose to clonogenic survival. A novel image segmentation method was used to locate surviving colonies, and dosimetry and simulations were employed to map the dose at each colony centroid. The findings showed that GRID irradiation resulted in lower survival rates in peak regions compared to open field configuration.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ingunn Hanson, Kathinka E. Pitman, Nina F. J. Edin
Summary: TGF-beta 3 is a multifunctional cytokine involved in various physiological and pathological processes. It has the potential to mitigate radiation- and chemotherapy-induced toxicity in healthy tissue through cellular signaling pathways, cell cycle regulation, and anti-fibrotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga Zlygosteva, Inga Solgard Juvkam, Hans Christian D. Aass, Hilde K. Galtung, Tine M. Soland, Eirik Malinen, Nina F. J. Edin
Summary: This study aimed to investigate the effect of locally fractionated radiotherapy on fibrosis and hyposalivation by monitoring cytokine levels. The results showed significant fibrosis in the submandibular salivary gland and reduced saliva production after irradiation. Pro-inflammatory cytokines IL-1 alpha, TNF, TIMP1, G-CSF, KC, and MIP-1 alpha were found to have increased levels in saliva and a strong correlation with late endpoints. Cytokine expression in saliva, particularly IL-1 alpha, was identified as a good biomarker for assessing salivary gland damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Instruments & Instrumentation
Ravikumar Nattudurai, Delmon Arous, Nina F. J. Edin, Anant Pandey, Eirik Malinen
Summary: The TL properties of BaSO4: Eu nanophosphors were studied after irradiation with low dose γ- and X-rays. The highest radiation sensitivity was observed for an Eu concentration of 0.5 mol%. The optimized BaSO4: Eu displayed a major TL peak at around 220°C and showed a linear response with absorbed dose.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2023)
Article
Multidisciplinary Sciences
Fatemeh Askarian, Chih-Ming Tsai, Gabriele Cordara, Raymond H. Zurich, Elisabet Bjanes, Ole Golten, Henrik Vinther Sorensen, Armin Kousha, Angela Meier, Elvis Chikwati, Jack-Ansgar Bruun, Judith Anita Ludviksen, Biswa Choudhury, Desmond Trieu, Stanley Davis, Per Kristian Thoren Edvardsen, Tom Eirik Mollnes, George Y. Liu, Ute Krengel, Douglas J. Conrad, Gustav Vaaje-Kolstad, Victor Nizet
Summary: The study reveals the virulence role of Pseudomonas aeruginosa (PA) CbpD in PA pneumonia, which is related to the impairment of the host complement function and opsonophagocytic clearance. The research shows that a PAΔCbpD mutant is more easily cleared and causes less mortality compared to the wild-type strain. Furthermore, the study provides insights into the structure and immunogenicity of CbpD, laying the foundation for the development of novel and effective vaccine antigens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Physical
Ravikumar Nattudurai, Delmon Arous, Nina F. J. Edin, Anant Pandey, Eirik Malinen
Summary: Accurate dosimetry of ionizing radiation requires consideration of the absorption properties of the dosimeter material. This study investigates the energy dependence of the nanophosphor BaSO4: Eu for orthovoltage X-rays and low energy protons. The results show that BaSO4 exhibits a linear relationship between signal and absorbed dose for both radiation types, with a higher energy dependence observed for X-rays.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
H. V. Sorensen, Mateu Montserrat-Canals, Jennifer S. M. Loose, S. Zoe Fisher, Martine Moulin, Matthew P. Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel
Summary: Demonstrating the feasibility of neutron-based techniques for studying LPMOs proteins using N-acetylglucosamine-binding protein A (GbpA) as a target.
Article
Dentistry, Oral Surgery & Medicine
Lisa Printzell, Janne Elin Reseland, Nina Frederike Jeppesen Edin, Jan Eirik Ellingsen, Hanna Tiainen
Summary: The influence of radiation backscatter from titanium on DNA damage and migration capacity of human osteoblasts and mesenchymal stem cells was investigated. Higher doses of radiation and backscatter from titanium increased DNA damage, with mesenchymal stem cells being more affected. High doses of radiation inhibited cell migration on titanium, while low doses did not affect migration capacity.
CLINICAL ORAL INVESTIGATIONS
(2023)
Meeting Abstract
Oncology
R. Nattudurai, D. Arous, N. F. J. Edin, A. Pandey, E. Malinen
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)