Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Chih-Cheng Wu, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Summary: Elevation of intracellular cAMP levels through inhibition of phosphodiesterase using dipyridamole has shown to inhibit glioma cell proliferation, migration, and invasion. Dipyridamole induces apoptosis through Noxa-guided endoplasmic reticulum (ER) stress and impairs autophagic flux. YAP1 plays a role in the communication between ER stress and autophagy, promoting autophagy and protecting glioma cells from dipyridamole-induced apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sahib Zada, Trang Minh Pham, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Omar Elashkar, Jung-Hwan Kim, Dong Hee Kim, Deok Ryong Kim
Summary: The study demonstrates that chlorogenic acid (CGA) protects human chondrocytes against H2O2-induced apoptosis by decreasing apoptosis markers, increasing anti-apoptotic markers, and activating antioxidant response proteins through autophagy induction.
Article
Environmental Sciences
Hai Jia, Ning Liu, Yunchang Zhang, Chao Wang, Ying Yang, Zhenlong Wu
Summary: This study demonstrated that exposure to 3-acetyldeoxynivalenol (3-Ac-DON) resulted in oxidative damage, cell death, and immune cell infiltration in the liver, with activation of endoplasmic reticulum stress. Inhibiting endoplasmic reticulum stress may be a preventive strategy to mitigate the detrimental effects of 3-Ac-DON on liver health.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Rita Dreier, Thomas Ising, Markus Ramroth, Yvonne Rellmann
Summary: Gender differences in osteoarthritis (OA) may be attributed to the differential response of males and females to endoplasmic reticulum (ER) stress in articular chondrocytes. This study demonstrates that the female sex hormone estradiol can reduce ER stress and ER stress-induced apoptosis in articular chondrocytes, thus minimizing critical events favoring osteoarthritic cartilage degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yvonne Rellmann, Elco Eidhof, Uwe Hansen, Lutz Fleischhauer, Jonas Vogel, Hauke Clausen-Schaumann, Attila Aszodi, Rita Dreier
Summary: Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum of chondrocytes, leading to the development of knee osteoarthritis. This study found that ER stress in chondrocytes results in the degeneration and apoptosis of knee cartilage, with young mice being less susceptible to OA. The findings suggest that inhibiting ER stress may be an attractive therapeutic target for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhiguang Chang, Minghui Yang, Hong Ji
Summary: The research revealed that the AIF gene in grass carp is widely expressed in various tissues and is involved in palmitic acid-induced lipoapoptosis. Treatment with PA increased CiAIF expression, induced ER stress, and apoptosis. CiAIF may play a key role in regulating physiological functions such as protein translation.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zilin Liu, Jun Huang, Xuezhong Wang, Shuang Deng, Jianlin Zhou, Ziheng Gong, Xuyang Li, Yanjie Wang, Jian Yang, Yong Hu
Summary: The study demonstrated that dapagliflozin can attenuate endoplasmic reticulum (ER) stress-induced apoptosis in chondrocytes by activating Sirt1, and it has anti-inflammatory and cartilage degeneration-improving effects in an osteoarthritis (OA) rat model.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Research & Experimental
Jihang Dai, Yaxin Zhang, Deng Chen, Duoyun Chen, Xiaolei Li, Jingcheng Wang, Yu Sun
Summary: This study found that Glabridin can increase the expression of extracellular matrix related genes and significantly reduce oxidative stress levels, decreasing apoptosis of chondrocytes. In animal experiments, Glabridin was observed to alleviate the progression of osteoarthritis and protect chondrocytes from apoptosis.
Article
Biochemistry & Molecular Biology
Wenfeng Gou, Na Luo, Bing Yu, Hongying Wu, Shaohua Wu, Chen Tian, Jianghong Guo, Hongxin Ning, Changfen Bi, Huiqiang Wei, Wenbin Hou, Yiliang Li
Summary: UA232, a derivative of ursolic acid, demonstrates anti-tumor effects against breast and cervical cancer cells by inducing apoptosis and promoting autophagy. The compound exerts its pharmacological effects through triggering endoplasmic reticulum stress and lysosomal dysfunction, making it a promising candidate for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Miaoran Li, Gang Liu, Li-Xia Yuan, Jing Yang, Jing Liu, Zhijie Li, Chuanbin Yang, Jigang Wang
Summary: In this study, using normal hepatocyte AML12 cells as a model, we uncovered the cellular mechanisms of triphenyl phosphate (TPP)-induced apoptosis in mouse hepatocytes. ER stress and autophagy flux inhibition induced by TPP were key factors contributing to cell death.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Junyan Qu, Cheng Zeng, Tingting Zou, Xu Chen, Xiaolong Yang, Zhenghong Lin
Summary: Trichodermic acid (TDA) demonstrates anticancer effects on colorectal cancer cells by inducing endoplasmic reticulum stress and autophagy-mediated apoptosis, suggesting a potential effective strategy for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jie Sun, Kangsen Mai, Qinghui Ai
Summary: Endoplasmic reticulum (ER) homeostasis is important for cell physiological functions and disruption of ER homeostasis can lead to ER stress and inflammation. Glucose-regulated protein 78 (GRP78), an ER chaperone, is crucial for maintaining cellular homeostasis, but its effects on ER stress and inflammation in fish are not fully understood. In this study, ER stress and inflammation were induced in macrophages of large yellow croakers by tunicamycin (TM) or palmitic acid (PA), and the effects of GRP78 agonist/inhibitor were examined. The results showed that the TM/PA treatment induced ER stress and inflammation, which were reduced by GRP78 agonist treatment, while GRP78 inhibitor treatment further induced ER stress and inflammation. These findings provide novel insights into the relationship between GRP78 and TM/PA-induced ER stress or inflammation in large yellow croakers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Jingtao Wu, Heng Yu, Yangcan Jin, Jingquan Wang, Liwen Zhou, Teng Cheng, Zhao Zhang, Binghao Lin, Jiansen Miao, Zhongke Lin
Summary: Ajugol has been found to activate autophagy and attenuate ER stress-induced cell death and ECM degradation, suggesting its potential as a therapeutic agent for modulating OA.
Article
Marine & Freshwater Biology
Ye Zhao, Huiling Wang, Priscilla Agyemang Duah, Vladimir Retyunskiy, Yizheng Liu, Guoguang Chen
Summary: This study investigates the embryonic toxicogenomic responses induced by Zinc pyrithione (ZPT) in zebrafish. The results show that ZPT treatment causes embryogenesis toxicity, including irregular cell division and rearrangement, delayed differentiations of eyes and notochords, and defects in epiboly and germ ring formation and somite segmentation. ZPT exposure also alters gene expression during early embryonic development, leading to morphological abnormalities and metabolic dysfunctions. Additionally, ZPT induces oxidative stress, apoptosis, endoplasmic reticulum (ER) stress, and autophagy.
AQUATIC TOXICOLOGY
(2022)
Article
Oncology
Lone A. A. Nazir, Naikoo H. H. Shahid, Kumar Amit, Sheikh A. A. Umar, Sharma Rajni, Sandip Bharate, Pyare L. L. Sangwan, Sheikh Abdullah Tasduq
Summary: NPC-402, a derivative of glycyrrhtinic acid, has shown anti-melanoma effects by inducing oxidative stress and apoptosis in melanoma cells. In vivo studies have demonstrated that NPC-402 significantly inhibited angiogenesis and reduced tumor growth without causing toxicity, suggesting its potential as a chemotherapeutic agent for melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)