Article
Biochemistry & Molecular Biology
Chunxiu Chen, Lingli Liu, Ying Zhong, Miaoran Wang, Yanbiao Ai, Yi Hou, Hong Chen, Xiaojing Lin, Yunqi Zhang, Min Ding, Ting Luo, Jibin Li, Xinyu Li, Xiaoqiu Xiao
Summary: DIR mice exhibit improved metabolic profile through brown adipose tissue (BAT) activation and decreased levels of unconjugated bile acids (BAs). The composition of gut flora differs greatly between DIR and DOR, and fecal microbiota transplants from DIR mice show potential in reducing adiposity and improving glucose tolerance in recipient mice. The activation of the FXR/TGR5 pathway and induction of GLP-1 by T-beta-MCA may play a role in inhibiting ceramide synthesis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Wuling Zhong, Hui Wang, Yale Yang, Yali Zhang, Hejin Lai, Yalan Cheng, Huimin Yu, Ning Feng, Rui Huang, Shen Liu, Sheng Yang, Tongyang Hao, Baoyu Zhang, Hao Ying, Fang Zhang, Feifan Guo, Qiwei Zhai
Summary: Post-dieting fat mass increase is caused by enhanced intestinal lipid absorption, which is influenced by the increase in intestinal Lactobacillus. Inhibiting the growth of intestinal Lactobacillus through a high-protein diet or antibiotics can prevent fat accumulation.
Article
Nutrition & Dietetics
Lin Song, Jiaqi Cui, Shuyuan Hu, Rui Wang, Hongbao Li, Bo Sun
Summary: A maternal high-fat diet has long-term adverse effects on offspring, but these effects can be ameliorated by maternal metformin treatment. This study found that maternal high-fat diet caused dysbiosis of gut microbiota, leading to colonic inflammation and gut barrier disruption. However, maternal metformin treatment reversed this dysbiosis and improved the metabolic phenotype of the offspring.
Article
Nutrition & Dietetics
Dianzhi Hou, Qingyu Zhao, Laraib Yousaf, Yong Xue, Qun Shen
Summary: The study found that supplementation of MBC significantly reduced HFD-induced adiposity, fat accumulation, serum lipid levels, endotoxin, and proinflammatory cytokines concentrations, along with improvements in hepatic steatosis and adipocyte size. Additionally, MBC supplementation also significantly improved elevated fasting blood glucose and insulin resistance. Furthermore, MBC was able to normalize HFD-induced gut microbiota dysbiosis and promote the bloom of beneficial bacteria while restoring several HFD-dependent taxa back to normal status.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Food Science & Technology
Ou-yang Jian, Xiu-ping Li, Chang-wei Liu, Ou-yang Jie, Jing-yi Tang, Qi Liu, Jian-an Huang, Zhonghua Liu
Summary: Moringa-Fu brick tea extract (MFTE) has anti-obesity effects by reducing weight gain, adipose tissue accumulation, visceral adiposity index, oxidative stress, and inflammation. It can also regulate gut microbiota diversity and improve bile acid metabolism. These findings suggest that MFTE could serve as a functional food for prevention of obesity and hyperlipidemia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Bartosz Fotschki, Katarzyna Ognik, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Kamil Myszczynski, Magdalena Krauze, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of supplementation with chromium nanoparticles (Cr-NPs) on the gut microenvironment in rats fed a high-fat diet. The results showed that Cr-NPs mainly acted by altering the activity of gut microbiota, leading to decreased concentration of short-chain fatty acids and increased level of cecal lithocholic acid. Switching to a low-fat diet had a more significant impact on obesity-related disorders, improving microbial activity, composition, and the production of short-chain fatty acids.
Article
Nutrition & Dietetics
Fusheng Xu, Zhiming Yu, Yaru Liu, Ting Du, Leilei Yu, Fengwei Tian, Wei Chen, Qixiao Zhai
Summary: Patients with post-cholecystectomy often experience adverse gastrointestinal conditions, and an epidemiological survey suggests that the risk of cholecystectomy is associated with high-fat and high-cholesterol dietary intake. Mounting evidence shows that cholecystectomy is associated with disrupted gut microbial homeostasis and dysregulated bile acids metabolism. However, the effect of an HFHC diet on gastrointestinal complications after cholecystectomy has not been elucidated.
Article
Engineering, Environmental
Zhiyuan Meng, Sen Yan, Wei Sun, Jin Yan, Miaomiao Teng, Ming Jia, Sinuo Tian, Zhiqiang Zhou, Wentao Zhu
Summary: This study found that chlorothalonil (CHI), the most commonly used organochlorine pesticide nowadays, can induce obesity in mice based on ADI level, and also causes an imbalance in the gut microbiota of the mice. Furthermore, the study discovered that CHI disturbs the bile acids metabolism in mice, causing glycolipid metabolism disorders and obesity through the FXR signaling pathway. This study provides evidence linking gut microbiota and pesticide exposure with the progression of obesity, highlighting the importance of gut microbiota in the toxic effects of pesticides.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Lin Zhu, Cheng Ye, Baifei Hu, Hui Xia, Qinglai Bian, Yang Liu, Mingwang Kong, Shuhan Zhou, Hongtao Liu
Summary: In this study, Poria cocos oligosaccharides (PCO) were found to improve glucose intolerance and insulin resistance, reduce blood glucose and insulin levels, suppress fatty acid synthesis regulators and pro-inflammatory cytokines, alleviate intestinal barrier damage, and restore the balance of gut microbiota and their metabolites. The results suggest that PCO may be used as a novel prebiotic in the treatment of glucolipid disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Jingyue Sun, Jiemin Fan, Tingting Li, Xiaoxue Yan, Yihong Jiang
Summary: Nuciferine (NF) has a mitigating effect on non-alcoholic fatty liver disease (NAFLD) by reinforcing intestinal barrier functions, regulating lipid metabolism, improving inflammation, modulating bile acid (BA) metabolism, and regulating gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jiamiao Hu, Peiying Zheng, Jinhui Qiu, Qingyan Chen, Shaoxiao Zeng, Yi Zhang, Shaoling Lin, Baodong Zheng
Summary: High-amylose corn starch, as a resistant starch, can regulate gut microbiota and circulating bile acids, which may be the underlying mechanisms of its anti-obesity activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Elaine Soares, Aruanna C. Soares, Patricia Leticia Trindade, Elisa B. Monteiro, Fabiane F. Martins, Andrew J. Forgie, Kim O. P. Inada, Graziele F. de Bem, Angela Resende, Daniel Perrone, Vanessa Souza-Mello, Francisco Tomas-Barberan, Benjamin P. Willing, Mariana Monteiro, Julio B. Daleprane
Summary: The study showed that polyphenol-rich jaboticaba peel and seed powder improved non-alcoholic fatty liver disease induced by a high-fat diet, through ameliorating gut microbial community structure and reducing symptoms of metabolic syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Akari Nishida, Yuna Ando, Ikuo Kimura, Junki Miyamoto
Summary: This article reviews the association between diet, gut microbiota, and host energy homeostasis, with a focus on the risks of obesity and metabolic disorders and the impact of gut microbiota on host energy balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shun-ichiro Asahara, Hiroyuki Inoue, Hitoshi Watanabe, Yoshiaki Kido
Summary: Pancreatic beta-cells are the only cells that can control glycemic levels through insulin secretion. Studies have found that mTOR plays a significant role in the function of beta-cells and the progression of diabetes.
Article
Multidisciplinary Sciences
Fukie Yaoita, Keita Watanabe, Ikuo Kimura, Masayuki Miyazawa, Shinobu Tsuchiya, Makoto Kanzaki, Masahiro Tsuchiya, Koichi Tan-No
Summary: The gut environment, including the microbiota and its metabolites, is crucial for maintaining health. This study suggests that habitual mastication and feeding powdered diets can impact the gut microbiota and environment. The findings reveal that powdered diet feeding leads to changes in the gut microbiota, constipation-like symptoms, and suppressed colonic motility, which can be improved by masticatory activity.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sawako Tomioka, Natsumi Seki, Yuki Sugiura, Masahiro Akiyama, Jun Uchiyama, Genki Yamaguchi, Kyosukuke Yakabe, Ryuta Eijima, Kouya Hattori, Tatsuki Kimizuka, Yumiko Fujimura, Hiroki Sato, Monica Gondo, Satoru Ozaki, Yoshiko Honme, Makoto Suematsu, Ikuo Kimura, Naohir Inohara, Gabriel Nunez, Koji Hase, Yun-Gi Kim
Summary: This study found that L-arabinose and sucrose interact with gut microbiota and have anti-obesogenic effects. L-arabinose inhibits diet-induced obesity in the presence of sucrose and this effect is abolished in mice lacking SCFA receptors.
Article
Biochemistry & Molecular Biology
Yujie Ma, Eunyoung Lee, Hayato Yoshikawa, Tomoe Noda, Junki Miyamoto, Ikuo Kimura, Ryo Hatano, Takashi Miki
Summary: Phloretin suppresses maltose/miglitol-induced GLP-1 secretion through inhibiting SCFAs produced by microbiome. GLUT2 is not essential for glucose/phloridzin-induced GLP-1 secretion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Takumi Kitamoto, Yun-Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili
Summary: Genetic or chemical inhibition of FoxO1 gene in mice successfully induced the conversion of gut cells into insulin-secreting β cells, showing promising potential for future clinical applications and therapies.
MOLECULAR METABOLISM
(2022)
Review
Endocrinology & Metabolism
Domenico Accili, Wen Du, Takumi Kitamoto, Taiyi Kuo, Wendy McKimpson, Yasutaka Miyachi, Maria Mukhanova, Jinsook Son, Liheng Wang, Hitoshi Watanabe
Summary: Research on the etiology and treatment of diabetes has made significant progress. However, the number of patients achieving glycemic control targets has not increased, mainly due to the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. This review aims to integrate research advances in transcriptional regulation of insulin action and the pathophysiology of beta cell dedifferentiation, exploring the potential impact on prospects of a durable cure for patients suffering from type 2 diabetes.
DIABETOLOGY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Yu Oshima, Kohsuke Tsuchiya, Shin Murai, Chiaki Takahashi, Michihiro Matsumoto, Shigetaka Kitajima, Yasuhiko Yamamoto, Masao Honda, Shun-ichiro Asahara, Kim Ravnskjaer, Shin-ichi Horike, Shuichi Kaneko, Masato Kasuga, Hiroyasu Nakano, Kenichi Harada, Hiroshi Inoue
Summary: Aggravation of liver steatosis shifts the mode of hepatocellular death from apoptosis to necroptosis, and the transcription factor ATF3 regulates this shift through the induction of RIPK3. ATF3 acts as a master regulator in this shift by inducing RIPK3 expression. The frequency of hepatocytes expressing ATF3 or RIPK3 is correlated with hepatocellular damage in non-alcoholic steatohepatitis (NASH).
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Miki Igarashi, Kensuke Iwasa, Tetsuhiko Hayakawa, Tsuyoshi Tsuduki, Ikuo Kimura, Kei Maruyama, Keisuke Yoshikawa
Summary: In this study, it was found that dietary oleic acid (OA) is an important molecule in inducing satiety by reducing food intake. This effect is mediated through the signaling of oleoylethanolamide (OEA).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Junki Miyamoto, Hidenori Shimizu, Keiko Hisa, Chiaki Matsuzaki, Shinsuke Inuki, Yuna Ando, Akari Nishida, Ayano Izumi, Mayu Yamano, Chihiro Ushiroda, Junichiro Irie, Takane Katayama, Hiroaki Ohno, Hiroshi Itoh, Kenji Yamamoto, Ikuo Kimura
Summary: Fermented foods have health benefits due to probiotic bacteria or microproducts produced by bacterial fermentation. Prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) show significant metabolic benefits. EPS-derived gut microbial short-chain fatty acids improve glucose metabolism and energy homeostasis, and alter gut microbial composition.
Article
Endocrinology & Metabolism
Miki Igarashi, Tetsuhiko Hayakawa, Haruka Tanabe, Keita Watanabe, Akari Nishida, Ikuo Kimura
Summary: In this study, Gpr119 knockout mice were generated using CRISPR-Cas9 gene-editing technology. The results showed that Gpr119-deficient mice exhibited lower blood glucose levels and greater weight loss under food deprivation conditions. Further experiments revealed that elevated levels of OEA in the cecum were associated with satiety control and energy metabolism.
MOLECULAR METABOLISM
(2023)
Article
Cell Biology
Hitoshi Watanabe, Wen Du, Jinsook Son, Lina Sui, Shun-ichiro Asahara, Irwin J. Kurland, Taiyi Kuo, Takumi Kitamoto, Yasutaka Miyachi, Rafael de Cabo, Domenico Accili
Summary: Sulfonylureas are effective and affordable antidiabetic drugs, but chronic use leads to secondary failure. Cytochrome b5 reductase 3 (Cyb5r3) down-regulation is identified as a mechanism of secondary SU failure and can be successfully reversed. Cyb5r3 activators can rescue secondary SU failure and potentially rehabilitate SU use in diabetes.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Megumi Urakawa, Tao Zhuang, Hidetoshi Sato, Satoru Takanashi, Kozue Yoshimura, Yuma Endo, Teppei Katsura, Tsuyoshi Umino, Koutaro Tanaka, Hitoshi Watanabe, Hiroko Kobayashi, Naokazu Takada, Tomoyuki Kozutsumi, Hiroaki Kumagai, Takafumi Asano, Kohko Sazawa, Nobuhisa Ashida, Guoqi Zhao, Michael T. Rose, Haruki Kitazawa, Hitoshi Shirakawa, Kouichi Watanabe, Tomonori Nochi, Takehiko Nakamura, Hisashi Aso
Summary: Probiotics have the potential to prevent mastitis and reduce the risk of antibiotic resistant bacteria.
ANIMAL SCIENCE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)