Article
Biochemistry & Molecular Biology
Lenny K. Hong, Shrinidhi Kadkol, Maria Sverdlov, Irida Kastrati, Mostafa Elhodaky, Ryan Deaton, Karen S. Sfanos, Heidi Wang, Li Liu, Alan M. Diamond
Summary: SELENOF is a selenoprotein involved in prostate cancer, with polymorphisms in the 3'-UTR region affecting the risk of prostate cancer mortality in African American men. Low levels of SELENOF in prostate cancer tissues may contribute to tumor progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qiwen Shi, Bei Hu, Chen Yang, Shufen Deng, Xiang Cheng, Jing Wu, Nan Qi
Summary: Chronic low-dose arsenic exposure upregulates ATF3, which inhibits inflammation and activation of downstream proteins, thus suppressing the transformation and acquisition of malignant characteristics, providing a new strategy for preventing carcinogen-induced lung cancer.
Article
Pharmacology & Pharmacy
Bandar Almutairy, Yao Fu, Zhuoyue Bi, Wenxuan Zhang, Priya Wadgaonkar, Yiran Qiu, Chitra Thakur, Fei Chen
Summary: Arsenic, a metalloid found abundantly in the environment, is associated with various human cancers. This study explored the mechanisms of arsenic-induced carcinogenesis and found that exposure to different concentrations and durations of arsenic can increase the risk of lung cancer. Long-term exposure to arsenic can promote malignant transformation and alter the expression of certain genes and microRNAs. These findings provide insights into the cellular transformation process caused by arsenic.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roseli da S. Soares, Talita de S. Laurentino, Camila T. da Silva, Jessica D. Goncalves, Antonio M. Lerario, Suely K. N. Marie, Sueli M. Oba-Shinjo, Miriam G. Jasiulionis
Summary: This study establishes a model of malignant astrocyte transformation by subjecting primary astrocytes from healthy adults to successive cycles of anchorage impediment. The transformed cells exhibit malignant characteristics and molecular analysis reveals the involvement of multiple signaling pathways and genes related to cell dedifferentiation. This model is significant for understanding glioblastoma treatment strategies and the underlying transformation mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Carmen S. Tellez, Marcie J. Grimes, Daniel E. Juri, Kieu Do, Randy Willink, Wendy W. Dye, Guodong Wu, Maria A. Picchi, Steven A. Belinsky
Summary: This study aimed to investigate whether exposure to e-liquid aerosols can induce cell transformation, potentially leading to pre-malignancy. The results showed that exposure to certain e-liquid aerosols can induce a pre-malignant phenotype in lung epithelial cells. Therefore, further studies are needed to evaluate the transformation potency of different e-liquid flavors to assess potential risks.
Article
Environmental Sciences
Luyao Li, Mei Zhou, Biyun Chen, Qin Wang, Shuya Pan, Yaxuan Hou, Jiamin Xia, Xue Zhou
Summary: This study revealed the mechanism of m6A modification in cadmium carcinogenesis, demonstrating that the ALKBH5 protein is involved in cell transformation by regulating the m6A level of PTEN mRNA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Jin Wang, Xin Tian, Jie Zhang, Lirong Tan, Nan Ouyang, Beibei Jia, Chunying Chen, Cuicui Ge, Jianxiang Li
Summary: Long-term pulmonary exposure to carbon nanotubes (CNTs) can induce carcinogenesis and tumor metastasis. A study on human lung cells exposed to single-walled carbon nanotubes (SWCNTs) showed that postchronic exposure led to increased migration and invasion abilities, irreversible malignant transformation, and promotion of carcinogenesis in vivo through DNA methylation and transcriptome dysregulation.
Article
Medicine, Research & Experimental
Hongyong Song, Xiaofeng Ye, Yueling Liao, Siwei Zhang, Dongliang Xu, Shuangshuang Zhong, Bo Jing, Tong Wang, Beibei Sun, Jianhua Xu, Wenzheng Guo, Kaimi Li, Min Hu, Yanbin Kuang, Jing Ling, Tuo Zhang, Yadi Wu, Jing Du, Feng Yao, Y. Eugene Chin, Qi Wang, Binhua P. Zhou, Jiong Deng
Summary: Chronic inflammation is closely associated with lung tumorigenesis, and NF-kappa B-mediated epigenetic regulation plays a critical role. NF-kappa B induces transcriptional repression of GPRC5A by forming a complex with retinoic acid receptor alpha/beta, and mediates epigenetic repression through suppression of H3K9ac.
Article
Plant Sciences
Zu-Jun Que, Yun Yang, Hai-Tao Liu, Wen-Ji Shang-Guan, Pan Yu, Li-Hua Zhu, He-Gen Li, Huai-Min Liu, Jian-Hui Tian
Summary: The study aimed to investigate the anti-metastatic mechanism of Jinfukang in lung cancer by intervening in circulating tumor cells (CTCs). Results showed that Jinfukang inhibited the proliferation, migration, and invasion of CTCs, as well as inducing anoikis through suppression of the integrin/Src pathway. This suggests that Jinfukang may exert its anti-metastatic effects in lung cancer through anoikis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Yu Heng Yi, Guo Hua Qi, Feng Yan, Cheng Wei, Wang Yan
Summary: This study investigated the role of exosomes from bronchial epithelial cells in promoting lung cancer metastasis induced by PM2.5. The results showed that exosomes derived from PM2.5-treated bronchial epithelial cells promoted the migration, invasion, and epithelial-to-mesenchymal transition of lung cancer cells through activation of c-Jun N-terminal kinase. These findings provide new insights into the cancer-promoting mechanisms of environmental pollutants.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Environmental Sciences
Mei Zhou, Luyao Li, Biyun Chen, Shuya Pan, Wei Tu, Yaxuan Hou, Panpan Chen, Rodolfo Rochin Hernandez, Xue Zhou
Summary: In this study, we found that circ-SHPRH plays a crucial role in cadmium-induced carcinogenesis by regulating miR-224-5p to impact QKI expression, thereby inhibiting the transformation of BEAS-2B cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Margherita De Marzio, Ayse Kilic, Enrico Maiorino, Jennifer Mitchel, Chimwemwe Mwase, Michael J. O'Sullivan, Maureen McGill, Robert Chase, Jeffrey J. Fredberg, Jin-Ah Park, Kimberly Glass, Scott T. Weiss
Summary: By conducting compression experiments on bronchial epithelial cells, the genome-wide analysis of UJT revealed different activation stages of intracellular and extracellular molecular networks induced by compression. Furthermore, the study found common genomic patterns associated with ECM remodeling in nonasthmatic and asthmatic bronchial epithelial cells.
Article
Medicine, Research & Experimental
Youngran Park, Jin-Gyoung Jung, Zheng-Cheng Yu, Ryoichi Asaka, Wenjing Shen, Yeh Wang, Wei-Hung Jung, Alicja Tomaszewski, Geoff Shimberg, Yun Chen, Vamsi Parimi, Stephanie Gaillard, Ie-Ming Shih, Tian-Li Wang
Summary: The study introduces a new human endometrial epithelial cell line, hEM3, which is non-transformed, capable of stable in vitro growth, and can serve as a model for studying the pathogenesis of endometrium-related diseases.
LABORATORY INVESTIGATION
(2021)
Article
Cell Biology
Kuan-Yuan Chen, Chien-Hua Tseng, Po-Hao Feng, Wei-Lun Sun, Shu-Chuan Ho, Cheng-Wei Lin, Nguyen Van Hiep, Ching-Shan Luo, Yen-Han Tseng, Tzu-Tao Chen, Wen-Te Liu, Kang-Yun Lee, Sheng-Ming Wu
Summary: Chronic exposure of human lung epithelial cells to 3-NBA leads to malignant transformation, in which the EREG signaling pathway plays a pivotal mediating role.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miroslav Machala, Josef Slavik, Ondrej Kovac, Jirina Prochazkova, Katerina Pencikova, Martina Parenicova, Nicol Strakova, Jan Kotoucek, Pavel Kulich, Steen Mollerup, Jan Vondracek, Martina Hyzdalova
Summary: The study identified significant alterations in the SL and GSL profile in transformed cells and their exosomes, with a majority of SLs and GSLs transported by exosomes in a similar relative pattern as in the cells of origin. The exceptions included decreased contents of certain substances and increased levels of others. These changes might contribute to cancer progression in recipient cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Donna R. Edwards, Krzysztof Moroz, Haitao Zhang, David Mulholland, Asim B. Abdel-Mageed, Debasis Mondal
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Urology & Nephrology
Daniel J. Heidenberg, Nora M. Haney, Bashir M. Rezk, Sudha Talwar, Samuel C. Okpechi, Sudesh K. Srivastav, Matthew Honda, Bryant Song, Kevin Swan, Salah Awadallah, James Anaissie, Taylor Peak, Kenneth J. DeLay, Phillip J. Kadowitz, Suresh C. Sikka, Asim B. Abdel Mageed, Wayne J. G. Hellstrom
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2019)
Article
Urology & Nephrology
Nora M. Haney, Sudha Talwar, Prasad K. Akula, Amit G. Reddy, Geoffroy Sanga Pema, Thien V. Ninh, Bashir M. Rezk, Zahra Heidari, Mostafa T. Bouljihad, Suresh C. Sikka, Vijay John, Asim B. Abdel-Mageed, Wayne J. G. Hellstrom
JOURNAL OF SEXUAL MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Saumya Das, K. Mark Ansel, Markus Bitzer, Xandra O. Breakefield, Alain Charest, David J. Galas, Mark B. Gerstein, Mihir Gupta, Aleksandar Milosavljevic, Michael T. McManus, Tushar Patel, Robert L. Raffai, Joel Rozowsky, Matthew E. Roth, Julie A. Saugstad, Kendall Van Keuren-Jensen, Alissa M. Weaver, Louise C. Laurent, Asim B. Abdel-Mageed, Catherine Adamidi, P. David Adelson, Kemal M. Akat, Eric Alsop, Jorge Arango, Neil Aronin, Seda Kilinc Avsaroglu, Azadeh Azizian, Leonora Balaj, Iddo Z. Ben-Dov, Karl Bertram, Robert Blelloch, Kimberly A. Bogardus, Xandra Owens Breakefield, George A. Calin, Bob S. Carter, Al Charest, Clark C. Chen, Tanuja Chitnis, Robert J. Coffey, Amanda Courtright-Lim, Amrita Datta, Peter DeHoff, Thomas G. Diacovo, David J. Erle, Alton Etheridge, Marc Ferrer, Jeffrey L. Franklin, Jane E. Freedman, Timur Galeev, Roopali Gandhi, Aitor Garcia, Mark Bender Gerstein, Vikas Ghai, Ionita Calin Ghiran, Maria D. Giraldez, Andrei Goga, Tasos Gogakos, Beatrice Goilav, Stephen J. Gould, Peixuan Guo, Fred Hochberg, Bo Huang, Matt Huentelman, Craig Hunter, Elizabeth Hutchins, Andrew R. Jackson, M. Yashar S. Kalani, Pinar Kanlikilicer, Reka Agnes Karaszti, Anastasia Khvorova, Yong Kim, Hogyoung Kim, Taek Kyun Kim, Robert Kitchen, Richard P. Kraig, Anna M. Krichevsky, Raymond Y. Kwong, Minyoung Lee, Noelle L'Etoile, Shawn E. Levy, Feng Li, Jenny Li, Xin Li, Gabriel Lopez-Berestein, Rocco Lucero, Bogdan Mateescu, A. C. Matin, Klaas E. A. Max, Thorsten R. Mempel, Cindy Meyer, Debasis Mondal, Kenneth Jay Mukamal, Oscar D. Murillo, Thangamani Muthukumar, Deborah A. Nickerson, Christopher J. O'Donnell, Dinshaw J. Patel, James G. Patton, Anu Paul, Elaine R. Peskind, Mitch A. Phelps, Chaim Putterman, Peter J. Quesenberry, Joseph F. Quinn, Saritha Ranabothu, Shannon Jiang Rao, Cristian Rodriguez-Aguayo, Anthony Rosenzweig, Marc S. Sabatine, Nikita A. Sakhanenko, Julie Anne Saugstad, Thomas D. Schmittgen, Neethu Shah, Ravi Shah, Kerby Shedden, Jian Shi, Anil K. Sood, Anuoluwapo Sopeyin, Ryan M. Spengler, Robert Spetzler, Srimeenakshi Srinivasan, Sai Lakshmi Subramanian, Manikkam Suthanthiran, Kahraman Tanriverdi, Yun Teng, Muneesh Tewari, William Thistlethwaite, Thomas Tuschl, Karolina Kaczor Urbanowicz, Kasey C. Vickers, Olivier Voinnet, Kai Wang, Zhiyun Wei, Howard L. Weiner, Zachary R. Weiss, Zev Williams, David T. W. Wong, Prescott G. Woodruff, Xinshu Xiao, Irene K. Yan, Ashish Yeri, Bing Zhang, Huang-Ge Zhang
Article
Endocrinology & Metabolism
Serap Gur, Laith Alzweri, Didem Yilmaz-Oral, Ecem Kaya-Sezginer, Asim B. Abdel-Mageed, Suresh C. Sikka, Wayne J. G. Hellstrom
Article
Surgery
Emmanuelle M. L. Ruiz, Tianhua Niu, Mourad Zerfaoui, Muthusamy Kunnimalaiyaan, Paul L. Friedlander, Asim B. Abdel-Mageed, Emad Kandil
Article
Biochemistry & Molecular Biology
Namrata Khurana, Partha K. Chandra, Hogyoung Kim, Asim B. Abdel-Mageed, Debasis Mondal, Suresh C. Sikka
Article
Endocrinology & Metabolism
Sen Liu, Fengli Liu, Bing Zhang, Peng Yan, Brian G. Rowan, Asim B. Abdel-Mageed, Chad Steele, S. Michal Jazwinski, Krzysztof Moroz, Elizabeth B. Norton, Alun Wang, Leann Myers, Oliver Sartor, Qiuyang Zhang
Article
Andrology
Serap Gur, Laith Alzweri, Didem Yilmaz-Oral, Ecem Kaya-Sezginer, Asim Abdel-Mageed, Brian Dick, Suresh C. Sikka, Cetin Volkan Oztekin, Wayne J. G. Hellstrom
Article
Neurosciences
Partha K. Chandra, Ibolya Rutkai, Hogyoung Kim, Stephen E. Braun, Asim B. Abdel-Mageed, Debasis Mondal, David W. Busija
Summary: Damage to the cerebral vascular endothelium is a critical initiating event in the development of HIV-1-associated neurocognitive disorders. Exosomes isolated from HIV-infected cells accelerate dysfunction in brain microvascular endothelial cells by inducing mitochondrial hyperfusion and reducing nitric oxide synthase expression. These exosomes, containing viral proteins, reduce mitochondrial function and accelerate brain endothelial dysfunction.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jacob W. Greenberg, Hogyoung Kim, Ahmed A. Moustafa, Amrita Datta, Pedro C. Barata, A. Hamid Boulares, Asim B. Abdel-Mageed, Louis S. Krane
Summary: Recent studies suggest that ketoconazole (KTZ) may impact clear cell renal cell carcinoma (ccRCC) by inhibiting exosome biogenesis and secretion, enhancing the efficacy of current therapies for RCC.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sen Liu, Bing Zhang, Brian G. Rowan, S. Michal Jazwinski, Asim B. Abdel-Mageed, Chad Steele, Alun R. Wang, Oliver Sartor, Tianhua Niu, Qiuyang Zhang
Summary: The study investigated the impact of age on prostate cancer using an experimental model with Pten conditional knockout mice at different ages. Results showed that aged mice exhibited accelerated PI3K/AKT/mTOR signaling and increased prostate cancer onset and progression compared to young mice. This model could be useful for further research on cancer related to aging.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Jacob W. Greenberg, Hogyoung Kim, Miae Ahn, Ahmed A. Moustafa, He Zhou, Pedro C. Barata, A. Hamid Boulares, Asim B. Abdel-Mageed, Louis S. Krane
Summary: Exosomes play a significant role in the resistance of metastatic renal cell carcinoma. The combination of Tipifarnib with standard therapy reduces tumor growth through an exosome-mediated mechanism. Tipifarnib also directly inhibits PD-L1 protein expression in chemo-sensitive and resistant cell lines.
Article
Biochemical Research Methods
Joshua A. Welsh, Bryce Killingsworth, Julia Kepley, Tim Traynor, Sean Cook, Jason Savage, Jenn Marte, Min-Jung Lee, Hoyoung M. Maeng, Michelle L. Pleet, Setty Magana, Andre Gorgens, Cecile L. Maire, Katrin Lamszus, Franz L. Ricklefs, Maria J. Merino, W. Marston Linehan, Tim Greten, Tomer Cooks, Curtis C. Harris, Andrea Apolo, Asim Abdel-Mageed, Alexander R. Ivanov, Jane B. Trepel, Matthew Roth, Mercedes Tkach, Aleksandar Milosavljevic, Clotilde Thery, Amy LeBlanc, Jay A. Berzofsky, Eytan Ruppin, Kenneth Aldape, Kevin Camphausen, James L. Gulley, Ionita Ghiran, Steve Jacobson, Jennifer C. Jones
Summary: Extracellular vesicles (EVs) carry various types of proteins and nucleic acids, and can provide a retrospective snapshot of cell state through liquid biopsies. Multiplex assays for high-parameter EV protein detection are still being developed. To facilitate EV repertoire studies, we developed MPAPASS software for stitched multiplex analysis, EV database-compatible reporting, and visualization of EV repertoires.
CELL REPORTS METHODS
(2022)
Review
Urology & Nephrology
Nora M. Haney, Hoang M. T. Nguyen, Matthew Honda, Asim B. Abdel-Mageed, Wayne J. G. Hellstrom
SEXUAL MEDICINE REVIEWS
(2018)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)