Article
Medicine, Research & Experimental
Xuguang Yuan, Yanan Jing, Mengkai Guang, Junfei Zhu, Ji Wang, Yang Wang, Ye Zhang
Summary: In oral squamous cell carcinoma, the expression level of GAS5 is closely related to the survival rate. Overexpression of GAS5 can restore chemosensitivity by downregulating miR-196a to alleviate chemoresistance.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Xiaobo Shi, Xiaoxiao Liu, Shan Huang, Yu Hao, Shupei Pan, Yue Ke, Wei Guo, Yuchen Wang, Hongbing Ma
Summary: In this study, miR-4443 was found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, providing a new perspective and clue to alleviate radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Article
Oncology
Min Su, Jinming Tang, Baihua Zhang, Desong Yang, Zhining Wu, Jie Wu, Yong Zhou, Qianjin Liao, Hui Wang, Wenxiang Wang, Yuhang Xiao
Summary: This study demonstrates that GACAT3 acts as an oncogene in ESCC by interacting with miR-149 to promote tumor progression, and also functions as a ceRNA to modulate FOXM1 expression. These findings suggest that GACAT3 may serve as a potential therapeutic target in ESCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui, Qiang Wang
Summary: The study found that miR-137 was down-regulated in ESCC cells. Upregulation of miR-137 inhibited proliferation, migration, invasion, and EMT of ESCC cells. CTCF activated miR-137 transcription and its downstream targets included EZH2 and PXN.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Dan Song, Ziqi Ye, Fangyu Chen, Liangliang Zhan, Xinchen Sun
Summary: This study reveals that circFNDC3B is upregulated in ESCC and promotes ESCC progression by regulating the miR-370-3p/miR-136-5p/MYO5A signaling pathway. circFNDC3B could potentially serve as a diagnostic marker for ESCC.
Article
Oncology
Yi He, Rong Hua, Yang Yang, Bin Li, Xufeng Guo, Zhigang Li
Summary: This study found that LncRNA JPX is highly expressed in esophageal squamous cell carcinoma (ESCC) and promotes ESCC cell proliferation, migration, and invasion through the miR-516b-5p/VEGFA pathway. This highlights the potential of JPX as a biomarker and therapeutic target for ESCC.
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yu-Cheng Lee, Cheng-Han Lin, Wei-Lun Chang, Wen-Der Lin, Jhih-Kai Pan, Wei-Jan Wang, Bor-Chyuan Su, Hsien-Hui Chung, Chen-Hsun Tsai, Forn-Chia Lin, Wen-Ching Wang, Pei-Jung Lu
Summary: This study found that miR-200b and miR-200c can regulate the epithelial-mesenchymal transition in esophageal squamous cell carcinoma, thereby affecting the response of cells to concurrent chemoradiotherapy. These findings contribute to the development of new treatment strategies to improve the therapeutic efficacy for esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Wei Zhang, Xiaowen Yang, Jianping Lv, Shichang An
Summary: miR-196a is highly expressed in CSCC and is closely related to the progression and prognosis of the disease.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Environmental Sciences
Han Gao, Mingjun Sun, Zhikui Gao, Jing Song, Derong Tang, Ran Liu
Summary: This study identified a highly expressed circRNA, hsa_circ_0001707, in ESCC and found that overexpression of hsa_circ_0001707 significantly promoted tumor proliferation, metastasis, and invasion. Through functioning as a ceRNA to regulate the activity of miR-203a-3p and Snail2 gene, hsa_circ_0001707 enhanced the endothelial-mesenchymal transition process in ESCC. This research revealed the crucial role of hsa_circ_0001707 in the pathogenesis of ESCC and its potential as a biomarker for diagnostics and targeted therapy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Ying Zhang, Weiqing Lu, Yelong Chen, Youbin Lin, Xia Yang, Hu Wang, Zhaoyong Liu
Summary: Esophageal squamous cell carcinoma (ESCC) is a challenging malignancy worldwide. The downregulation of MAP2K3 in ESCC is associated with poor clinical outcomes, and it inhibits proliferation and invasion of ESCC cells. The miR-19b-3p-MAP2K3-STAT3 feedback loop plays a crucial role in regulating ESCC tumorigenesis.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Mei-Ling Xu, Tian-Cheng Liu, Feng-Xiang Dong, Ling-Xin Meng, Ai-Xia Ling, Shan Liu
Summary: This study found that exosomal LINC01711 promoted the proliferation, migration, and invasion of esophageal cancer cells by up-regulating FSCN1 and down-regulating miR-326, thus improving the occurrence and development of ESCC.
Article
Oncology
Yunfeng Niu, Yanli Guo, Yan Li, Supeng Shen, Jia Liang, Wei Guo, Zhiming Dong
Summary: This study revealed that GATA2-AS1, expressed at low levels in ESCC, plays a crucial role in the progression of ESCC by targeting the miR-940/PTPN12 axis. These findings contribute to a better understanding of the molecular mechanisms underlying ESCC and provide a potential therapeutic target for the treatment of ESCC patients.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)