期刊
FEMS YEAST RESEARCH
卷 15, 期 4, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsyr/fov026
关键词
crosstalk; Snf1; signaling pathways; systems biology
资金
- European Commission via the Marie Curie-Network for Initial training ISOLATE [289995]
The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways occurs to integrate different internal and external stimuli and adjust cellular metabolism, growth and proliferation to altered environmental conditions. The main glucose repression pathway, Snf1/Mig1, plays an essential role in adaptation to glucose limitation. However, the Snf1 protein kinase is also involved in regulation of many other cellular processes. We summarize evidence that Snf1 is part of a network of communicating pathways, and we suggest research directions that may help elucidating signal flow within this network.
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