Article
Agriculture, Dairy & Animal Science
Adel R. Moawad, Ali Salama, Magdy R. Badr, Mohamed Fathi
Summary: Supplementation of L-Carnitine (LC) during in vitro maturation (IVM) of canine oocytes improves maturation, fertilization, and preimplantation embryo development rates following IVF and in vitro culture (IVC).
Article
Medicine, Research & Experimental
Jianhua Li, Jing Chen, Tiecheng Sun, Shuiwen Zhang, Tingting Jiao, Ri-Cheng Chian, Youzhu Li, Ye Xu
Summary: In vitro oocyte maturation (IVM) does not affect the quality of embryos and the aneuploidy rate of embryos. The aneuploidy rate of embryos increases with maternal age, especially over 35 years old, whether in IVF or IVM group. Embryos with poor quality, especially grade III embryos, are recommended to be tested by PGS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Huaxing Zhao, Yazheng Dong, Yuxing Zhang, Xiao Wu, Xianjun Zhang, Yalin Liang, Yanan Li, Fang Zeng, Junsong Shi, Rong Zhou, Linjun Hong, Gengyuan Cai, Zhenfang Wu, Zicong Li
Summary: The addition of 20 ng/mL SDF1 during pig oocyte IVM improves the maturation rate of oocytes and the cleavage and blastocyst rates of resulting embryos. SDF1 supplementation decreases oxidative stress, enhances mitochondrial function, and influences gene expression related to apoptosis in pig oocytes.
Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Reproductive Biology
You Li, Leizhen Xia, Zengming Li, Ziyu Zhang, Ru Jiang
Summary: This study retrospectively analyzed 1380 PCOS patients who received IVF/ICSI-ET and found significant correlations between CLBR and factors such as duration of infertility, infertility type, stimulation protocols, starting dose of gonadotrophins, and oocyte retrieved numbers. Using the prolonged GnRH-agonist protocol, starting dose of gonadotrophins between 100u-112.5u, and obtaining 11-15 or 16-20 oocytes significantly increased the CLBR of PCOS patients after the first oocyte collection.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lixia Zhu, Qiyu Yang, Huizi Jin, Juepu Zhou, Meng Wang, Liu Yang, Zhou Li, Kun Qian, Lei Jin
Summary: This study identified different phenotypes in patients with oocyte maturation arrest (OMA), and found that clinical outcomes were associated with the presence of gene mutations and the classification of oocyte phenotypes. A triage system was proposed to optimize resource allocation and maximize patient benefit.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Houjin Dongye, Yizheng Tian, Dan Qi, Yanbo Du, Lei Yan
Summary: The influence of endometrioma on oocyte and embryo competence is inconclusive, and the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and explore whether surgery could improve oocyte and embryo competence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Xueqian Ma, Long Cui, Lin Chen, Jun Zhang, Xiaohui Zhang, Quanmin Kang, Fan Jin, Yinghui Ye
Summary: This study found that maternal plasma concentrations of perfluorooctanoic acid (PFOA) were negatively associated with the numbers of retrieved oocytes, mature oocytes, 2 PN zygotes, and good-quality embryos, while higher paternal plasma PFOA concentrations were significantly associated with reduced numbers of 2 PN zygotes. However, none of the maternal or paternal PFAS were significantly associated with the probability of implantation, clinical pregnancy, or live birth.
ENVIRONMENTAL POLLUTION
(2021)
Article
Genetics & Heredity
Aalaap Naigaonkar, Roshan Dadachanji, Indira Hinduja, Srabani Mukherjee
Summary: Women with PCOS undergoing IVF have disrupted redox balance in follicular fluid, potentially impacting oocyte/embryo quality. Granulosa cells may play a crucial role in maintaining follicular redox balance. The glutathione system and paraoxonase1 could be further explored as surrogate markers for IVF prognosis/outcome.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Robert B. Gilchrist, Johan Smitz
Summary: Oocyte in vitro maturation (IVM) is a minimally invasive technique involving the collection and culture of immature oocytes to maturity outside the body. It is now classified as nonexperimental and is primarily indicated for patients with a high antral follicle count and for fertility preservation in cancer patients. Significant advances in IVM culture methods have been made based on animal studies and a simplified patient treatment protocol, leading to its routine practice in specialized centers worldwide.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Yong-Jie Lu, Qin Li, Li-Xue Chen, Tian Tian, Jia Kang, Yong-Xiu Hao, Jian-Suo Zhou, Yuan-Yuan Wang, Li-Ying Yan, Rong Li, Liang Chang, Jie Qiao
Summary: This study reveals the impact of maternal MTHFR C677T/A1298C combination polymorphisms on oocyte maturation potential and embryo quality. The findings indicate that a reduction in maternal MTHFR activity leads to a decrease in oocyte maturation potential, while women with intermediate MTHFR activity have worse embryo quality.
HUMAN REPRODUCTION OPEN
(2022)
Article
Endocrinology & Metabolism
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Celal Kaloglu, Ahmed M. Isa, Hooria Younas, Rachel Ziders, Yousaf Latif Khan, Zahira Hassan, Bilgun Ozturk Turhan, Aysegul Yildiz, Hikmet Hakan Aydin, Ender Yalcinkaya Kalyan
Summary: The study demonstrated the differential expression of miR-7-5p, miR-378-3p, miR-224, and miR-212-3p in normo-androgenic PCOS patients compared to NOR patients, while miRNA-320a showed significance in predicting embryo quality.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Shaoyuan Xu, Ying Zhang, Cancan Qiang, Changjun Zhang
Summary: The serum TSH level of PCOS patients is higher than that of the general female population, and it has a negative impact on the outcomes of in vitro fertilization.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Edgardo Somigliana, Letizia Li Piani, Alessio Paffoni, Noemi Salmeri, Michele Orsi, Laura Benaglia, Paolo Vercellini, Paola Vigano'
Summary: Apart from the negative effect of surgical excision of endometriomas on ovarian reserve, endometriosis does not significantly affect IVF outcomes. Ovarian response, oocyte quality, and embryonic development remain largely unaffected.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rong Luo, Jiahui Wang, Yu Yang, Cen Xu, Minyan Yang, Dandan Zhu, Jia Wang, Ping Zhang, Hongshan Ge
Summary: This study aimed to assess the impact of vitamin D levels on embryo quality and pregnancy outcomes in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle. The findings suggest that serum vitamin D level is not associated with embryo quality and pregnancy outcomes for these patients. Further studies are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)