Overcoming differences: The catalytic mechanism of metallo-β-lactamases

Conformational dynamics of metallo-β-lactamase CcrA during catalysis investigated by using DEER spectroscopy

(2015) Mahesh Aitha et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

(2015) Jürgen Brem et al.   Chemical Science

Mechanism of Meropenem Hydrolysis by New Delhi Metallo β-Lactamase

(2015) Ravi Tripathi et al.   ACS Catalysis

Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-β-lactamase VIM-2

(2014) Mahesh Aitha et al.   BIOCHEMISTRY

Dilution of dipolar interactions in a spin-labeled, multimeric metalloenzyme for DEER studies

(2014) Mahesh Aitha et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-β-lactamase NDM-1

(2014) Hao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins

(2014) Han Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibiotic resistance: An infectious arms race

(2014) Karyn Hede   NATURE

Solution structures of theBacillus cereusmetallo-β-lactamase BcII and its complex with the broad spectrum inhibitorR-thiomandelic acid

(2013) Andreas Ioannis Karsisiotis et al.   BIOCHEMICAL JOURNAL

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

(2013) Alan P. Johnson et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Genetic and Biochemical Characterization of an Acquired Subgroup B3 Metallo-β-Lactamase Gene,blaAIM-1, and Its Unique Genetic Context in Pseudomonas aeruginosa from Australia

(2012) Dongeun Yong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanistic and Spectroscopic Studies of Metallo-β-lactamase NDM-1

(2012) Hao Yang et al.   BIOCHEMISTRY

Catalytic mechanisms for phosphotriesterases

(2012) Andrew N. Bigley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

(2012) Dustin T. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallo-β-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions

(2012) Javier M González et al.   Nature Chemical Biology

Biochemical Characterization of Sfh-I, a Subclass B2 Metallo-β-Lactamase from Serratia fonticola UTAD54

(2011) Fátima Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural and Kinetic Studies on Metallo-β-lactamase IMP-1

(2011) Dionne H. Griffin et al.   BIOCHEMISTRY

IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons

(2011) Wei-Hua Zhao et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

(2011) HongMin Zhang et al.   FASEB JOURNAL

Crystal Structure of Serratia fonticola Sfh-I: Activation of the Nucleophile in Mono-Zinc Metallo-β-Lactamases

(2011) Fátima Fonseca et al.   JOURNAL OF MOLECULAR BIOLOGY

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study

(2011) Timothy R Walsh et al.   LANCET INFECTIOUS DISEASES

Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

(2011) Dustin King et al.   PROTEIN SCIENCE

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

(2010) J.-D. Docquier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Reaction Mechanism of the Trinuclear Zinc Enzyme Phospholipase C: A Density Functional Theory Study

(2010) Rong-Zhen Liao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Structure of the Dizinc Subclass B2 Metallo- -Lactamase CphA Reveals that the Second Inhibitory Zinc Ion Binds in the Histidine Site

(2009) C. Bebrone et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of a New Metallo- -Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

(2009) D. Yong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Catalytic Role of the Metal Ion in the Metallo-β-lactamase GOB

(2009) María-Natalia Lisa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motion of the Zinc Ions in Catalysis by a Dizinc Metallo-β-Lactamase

(2009) Robert M. Breece et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential Binding of Co(II) and Zn(II) to Metallo-β-Lactamase Bla2 fromBacillus anthracis

(2009) Megan J. Hawk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-β-lactamase fromAeromonas hydrophila

(2008) Carine Bebrone et al.   BIOCHEMICAL JOURNAL

Loss of enzyme activity during turnover of the Bacillus cereus β-lactamase catalysed hydrolysis of β-lactams due to loss of zinc ion

(2008) Adriana Badarau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Role of the Zn1and Zn2sites in Metallo-β-lactamase L1

(2008) Zhenxin Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal Content and Localization during Turnover inB. cereusMetallo-β-lactamase

(2008) Leticia I. Llarrull et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping and Characterization of a Reaction Intermediate in Carbapenem Hydrolysis byB. cereusMetallo-β-lactamase

(2008) Mariana F. Tioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility

(2008) P. E. Tomatis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Design of Inhibitors for the L1 Metallo-β-lactamase from Stenotrophomonas maltophilia

(2007) L. Nauton et al.   JOURNAL OF MOLECULAR BIOLOGY

The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form

(2007) I. Garcia-Saez et al.   JOURNAL OF MOLECULAR BIOLOGY