期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 14, 期 -, 页码 1554-1562出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.14.132
关键词
antimicrobial; HCV; lanyamycin; macrolide; Sorangium cellulosum
资金
- German Ministry for Education and Research (BMBF) [16GW0105]
- National Commission for Science, Technology and Innovation-Kenya (DAAD-NACOSTI) Scholarship [57139945 (91530969)]
- Deutscher Akademischer Austauschdienst (DAAD) [57342738 (91654821)]
- Deutscher Akademischer Austauschdienst
Lanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configuration of their macrolactone ring was assigned based on NOE and vicinal H-1 NMR coupling constants and by calculation of a 3D model. Lanyamycin inhibited HCV infection into mammalian liver cells with an IC50 value of 11.8 mu M, and exhibited a moderate cytotoxic activity against the mouse fibroblast cell line L929 and the human nasopharyngeal cell line KB3 with IC50 values of 3.1 and 1.5 mu M, respectively, and also suppressed the growth of the Gram-positive bacterium Micrococcus luteus.
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