Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi, Naoya Oishi
Summary: This study found that NRs in the hippocampal CA3 are crucial for supporting hippocampal functions, such as pattern completion and reverberatory association of sensory inputs. Previous research showed that synchronous activation of distinct cell populations in CA3 could result in the artificial association of independent events, indicating the role of NRs in mediating memory event association in CA3. However, it is still unclear whether NRs in CA3 are essential for the artificial association of memory events stored in CA3 ensembles.
Article
Engineering, Environmental
Ying Hao, Li Meng, Yan Zhang, Aixin Chen, Ye Zhao, Kaoqi Lian, Xiangfei Guo, Xinhao Wang, Yuru Du, Xi Wang, Xuzi Li, Li Song, Yun Shi, Xi Yin, Miao Gong, Haishui Shi
Summary: The study revealed that chronic exposure to TCS can reduce social dominance in mice, decrease social interaction, impair memory formation, alter the relative abundance of gut microbiota, and induce ultrastructural damage to hippocampal neurons and synapses. These findings suggest that TCS exposure may impact social behaviors through changes in gut microbiota and impaired plasticity of hippocampal neurons and synapses.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Biochemistry & Molecular Biology
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Summary: Acute hippocampal slice preparations have been commonly used in studying the anti-amnesic properties of drug candidates on long-term potentiation (LTP). Genetic background is crucial in experimental design, considering the availability of various transgenic mouse models. In this study, LTP was compared between inbred and outbred mice, showing reduced LTP magnitude in outbred mice due to lower responsiveness to theta-frequency during conditioning stimuli. Overall, this study highlights the importance of considering animal models in electrophysiological experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marlene F. Pereira, Ines M. Amaral, Catia Lopes, Catarina Leitao, Daniela Madeira, Joao P. Lopes, Francisco Q. Goncalves, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study shows that L-alpha-aminoadipate (L-AA) affects astrocytes differently and impairs synaptic plasticity and memory. Injection of L-AA negatively impacts hippocampal long-term potentiation (LTP) and hippocampal-dependent memory in mice. D-serine administration can partially rescue the reduction in hippocampal LTP induced by L-AA exposure.
Article
Neurosciences
Rachel Humphries, Jack R. Mellor, Cian O'Donnell
Summary: Acetylcholine enhances dendritic excitability and facilitates NMDA spike generation by inhibiting potassium channels. Distal SLM dendrites have a lower threshold for NMDA spike generation compared to SR dendrites. These results reveal the role of acetylcholine in promoting synaptic integration and NMDA spike generation in selected CA3 dendrites.
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Neurosciences
Qinghu Yang, Da Song, Zhen Xie, Guiqiong He, Juan Zhao, Zhe Wang, Zhifang Dong, Heao Zhang, Liang Yang, Ming Jiang, Yili Wu, Qing Shi, Junjie Li, Jun Yang, Zhantao Bai, Zhenzhen Quan, Hong Qing
Summary: This study reveals the role of optogenetic activation of CA3 pyramidal neurons in restoring the spatial memory of APP/PS1 mice. The stimulation enhances synaptic density/strength, synaptic plasticity, and activates astrocytes. Inhibiting the activity of CA3 astrocytes disrupts this restoration effect, resulting in reduced synaptic density/strength and cognitive impairments in the mice.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu
Summary: We found that exogenous AMPA can dose-dependently inhibit carbachol-induced oscillation in the CA3 area of rat hippocampal slices, but the underlying mechanism is unclear. Our results suggest that CP-AMPAR and CaMKK negatively modulate the formation of oscillation, and AMPA downregulation of oscillation may be related to the reduced recurrent excitation within the CA3 local neuronal network.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Lacy K. Goode, Allison R. Fusilier, Natalie Remiszewski, Jacob M. Reeves, Kavitha Abiraman, Matthew Defenderfer, Jodi R. Paul, Lori L. McMahon, Karen L. Gamble
Summary: This study investigated the influence of sex and time-of-day on hippocampal neurophysiology and memory in mice. The results showed that both time-of-day and sex had an impact on memory performance and hippocampal synaptic activity. The study emphasizes the importance of understanding how sex and circadian rhythms affect hippocampal physiology, which can improve the relevance of treatments and inform the timing of therapy.
Article
Neurosciences
Fang-Fei Tao, Zi-Yu Wang, Ying Wang, Qian-Ru Lv, Peng-Peng Cai, Hai-Wen Min, Jian-Wei Ge, Chun-Yu Yin, Rui Cheng
Summary: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), but the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood. Inhibition of CDK5 overactivation can improve cognitive deficits, neuronal apoptosis, and synaptic plasticity disorders in BPD mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Biology
Vincent Robert, Ludivine Therreau, Vivien Chevaleyre, Eude Lepicard, Cecile Viollet, Julie Cognet, Arthur J. Y. Huang, Roman Boehringer, Denis Polygalov, Thomas J. McHugh, Rebecca Ann Piskorowski
Summary: The study reveals that the hypothalamic supramammillary nucleus (SuM) influences the hippocampal area CA2 through a mix of excitatory and inhibitory responses. The inhibitory effect of SuM input is mediated largely by parvalbumin-expressing basket cells, enhancing the precision of action potential firing in CA2 pyramidal neurons and modulating CA1 activity. Synchronized output from CA2 drives pulsed inhibition in CA1, laying the foundation for understanding how SuM activity contributes to social memory encoding in the local hippocampal circuit.
Article
Neurosciences
Anupratap Tomar, Denis Polygalov, Sumantra Chattarji, Thomas J. McHugh
Summary: Chronic stress can lead to anxiety, depression, and memory deficits, some of which are mediated by impaired hippocampal function. Research shows that stress results in an increase in neuronal synchrony in the CA1 region of mice, specifically during sharp-wave ripples, potentially affecting memory consolidation. These alterations may persist even after the stress is removed, offering new insights into how chronic stress can interfere with subsequent information processing.
NEUROBIOLOGY OF STRESS
(2021)
Article
Biochemistry & Molecular Biology
Kazuo Nakajima, Mizuho Ishiwata, Adam Z. Weitemier, Hirotaka Shoji, Hiromu Monai, Hiroyuki Miyamoto, Kazuhiro Yamakawa, Tsuyoshi Miyakawa, Thomas J. McHugh, Tadafumi Kato
Summary: A report on a family with Darier's disease and mood disorders highlighted the key role of ATP2A2 gene in influencing risk of neuropsychiatric disorders. Mutations in ATP2A2 may lead to prolonged cytosolic Ca2 transients and enhanced dopamine signaling in the brain, contributing to mood disorders and schizophrenia vulnerability.
HUMAN MOLECULAR GENETICS
(2021)
Article
Neurosciences
Hongshen He, Roman Boehringer, Arthur J. Y. Huang, Eric T. N. Overton, Denis Polygalov, Kazuo Okanoya, Thomas J. McHugh
Summary: Research suggests that CA2 activity plays a crucial role in the fidelity of experience-dependent hippocampal replay. By temporarily silencing CA2 pyramidal cells, it was observed that the reactivation of CA1 pyramidal cell ensembles within sharp-wave ripples events lost both temporal and informational precision.
Article
Cell Biology
Chihiro Yoshihara, Kenichi Tokita, Teppo Maruyama, Misato Kaneko, Yousuke Tsuneoka, Kansai Fukumitsu, Eri Miyazawa, Kazutaka Shinozuka, Arthur J. Huang, Katsuhiko Nishimori, Thomas J. McHugh, Minoru Tanaka, Shigeyoshi Itohara, Kazushige Touhara, Kazunari Miyamichi, Kumi O. Kuroda
Summary: Maternal mammals exhibit heightened motivation to care for offspring, and this behavior is at least partially mediated by upregulation of amylin-Calcr signaling in distinct neuronal populations of the medial preoptic area. These Calcr+ MPOA neurons are required for both maternal and allomaternal nurturing behaviors, with modified connectomics postpartum potentially influencing risk-taking maternal care.
Article
Behavioral Sciences
Anupratap Tomar, Denis Polygalov, Thomas J. McHugh
Summary: This study found that acute and chronic stress have different effects on neural activity in the hippocampus. Acute stress can improve spatial information encoding in the hippocampus, while chronic stress may result in poorer spatial tuning.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Olga Tyurikova, Pei-Yu Shih, Yulia Dembitskaya, Leonid P. Savtchenko, Thomas J. McHugh, Dmitri A. Rusakov, Alexey Semyanov
Summary: Glutamatergic transmission through postsynaptic NMDA receptors induces K+ efflux, which enhances glutamate release in astrocytes and reduces glutamate uptake, forming a feedback loop.
Review
Neurosciences
Anupratap Tomar, Thomas J. McHugh
Summary: This article reviews studies on the effects of stress on hippocampal spatial coding. The findings suggest that chronic stress disrupts the accuracy and specificity of CA1 spatial coding and alters hippocampal oscillations, while acute stress may have a facilitatory impact on spatial representations.
TRENDS IN NEUROSCIENCES
(2022)
Article
Multidisciplinary Sciences
Hefei Guan, Steven J. Middleton, Takafumi Inoue, Thomas J. McHugh
Summary: The bilateral projection from CA3 plays a key role in coordinating CA1 spatial coding across hemispheres. Blocking synaptic transmission at CA3 terminals leads to decreased ripple synchronization between left and right CA1, and results in less coordinated neuronal ensemble activity across hemispheres during exploration and rest.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kansai Fukumitsu, Misato Kaneko, Teppo Maruyama, Chihiro Yoshihara, Arthur J. Huang, Thomas J. McHugh, Shigeyoshi Itohara, Minoru Tanaka, Kumi O. Kuroda
Summary: Social animals experience stress upon isolation and actively engage in contact with conspecifics. This study demonstrates that amylin-calcitonin receptor signaling in the medial preoptic area mediates affiliative social contacts among adult female mice. Isolation leads to active contact-seeking behavior and depressive-like behavior, along with a decrease in Amylin mRNA expression. Reuniting with peers induces physical contacts and a recovery of Amylin mRNA expression.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Chia-Wen Lin, Dian E. Septyaningtrias, Hsu-Wen Chao, Mikiko Konda, Koji Atarashi, Kozue Takeshita, Kota Tamada, Jun Nomura, Yohei Sasagawa, Kaori Tanaka, Itoshi Nikaido, Kenya Honda, Thomas J. McHugh, Toru Takumi
Summary: This study traces the developmental origins of immune dysregulation in a mouse model of idiopathic autism using single-cell RNA sequencing. The findings reveal that dysregulation of HDAC1-mediated epigenetic machinery during embryogenesis leads to immune system dysregulation, resulting in gut dysbiosis and hyperactive microglia in the brain. Furthermore, the study identifies specific microbiota composition associated with dysregulated immune profiles.
MOLECULAR PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Alexandra Gros, Amos W. H. Lim, Victoria Hohendorf, Nicole White, Michael Eckert, Thomas John McHugh, Szu-Han Wang
Summary: The study found that in young rats, neuronal assemblies activated by memory encoding were also partially activated by novelty, especially in the distal CA1 and proximal CA3 subregions. In early aging, both encoding- and novelty-triggered neuronal populations were significantly reduced, with a more profound effect in encoding neurons.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Chinnakkaruppan Adaikkan, Jun Wang, Karim Abdelaal, Steven J. Middleton, P. Lorenzo Bozzelli, Ian R. Wickersham, Thomas J. McHugh, Li-Huei Tsai
Summary: A reduction in white matter and correlated activity is observed in neurodegenerative diseases, but the underlying mechanisms and cognitive relevance are unclear. This study reveals a novel circuit connecting the two cerebral hemispheres in the visual cortex, which plays a role in novelty discrimination behavior. Impairment of this circuit is observed in mouse models of neurodegeneration.
Article
Neurosciences
Hongshen He, Yi Wang, Thomas J. McHugh
Summary: Dynamic interactions between the subregions of the hippocampus are necessary for memory encoding and consolidation. This study focuses on understanding the role of the CA2 region in hippocampal dynamics. By using chemogenetics to silence CA2 pyramidal cells, the researchers found that CA2 influences hippocampal synchronization and network activity during rest and new learning. The findings also suggest that CA2 is important for the excitability of CA1 pyramidal cells during pausing. Overall, these results provide novel insights into the distinct contributions of CA2 in regulating hippocampal dynamics.
Article
Biochemistry & Molecular Biology
Chia-Wen Lin, Jacob Ellegood, Kota Tamada, Ikuo Miura, Mikiko Konda, Kozue Takeshita, Koji Atarashi, Jason P. Lerch, Shigeharu Wakana, Thomas J. McHugh, Toru Takumi
Summary: The BTBR T(+)Itpr3(tf)/J (BTBR/J) strain is a valuable model for studying idiopathic autism and understanding its complexity. Another strain, BTBR TF/ArtRbrc (BTBR/R), exhibits more prominent autism core symptoms but relatively normal hippocampus-dependent memory, resembling autism in the high functioning spectrum. The disrupted epigenetic silencing mechanism leads to increased activity of endogenous retrovirus (ERV), which in turn increases copy number variations (CNV) formation in the BTBR strains, making it an evolving multiple-loci model for higher susceptibility to ASD. Moreover, the active ERV evades the host defense response and manipulates transcriptional machinery during embryonic development in the BTBR strains. These findings suggest that ERV plays dual roles in the pathogenesis of ASD, influencing host genome evolution and cellular pathways in response to viral infection, with immediate effects on embryonic development. Additionally, the wild-type Draxin expression in BTBR/R makes it a more precise model for investigating the core etiology of autism without the interference of impaired forebrain bundles observed in BTBR/J.
MOLECULAR PSYCHIATRY
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)