Article
Nutrition & Dietetics
Shirelle X. Liu, Amanda K. Barks, Scott Lunos, Jonathan C. Gewirtz, Michael K. Georgieff, Phu Tran
Summary: Early-life iron deficiency leads to long-term gene dysregulation, including downregulation of JARID1B and BDNF genes in the rat hippocampus. Prenatal choline supplementation does not prevent the chromatin modifications induced by iron deficiency, but induces long-lasting repressive modifications in iron-sufficient rats, suggesting a separate mechanism for rescuing neural gene regulation. The negative epigenetic effects of choline supplementation in iron-sufficient rats warrant further investigation before considering it as an adjunctive therapeutic agent.
Article
Nutrition & Dietetics
Shirelle X. Liu, Tenille K. Fredrickson, Natalia Calixto Mancipe, Michael K. Georgieff, Phu V. Tran
Summary: Fetal-neonatal iron deficiency (ID) causes long-term neurocognitive and affective dysfunctions, with sex-specific effects that are poorly understood at the molecular level. In this study using a rat model, both ID and prenatal choline treatment induced sex-specific transcriptome alterations in the adult rat hippocampus. ID induced changes in gene networks related to enhanced neuroinflammation, while choline supplementation partially rescued ID-induced dysregulation and had both beneficial and adverse effects on hippocampal gene expression.
Article
Food Science & Technology
Katarzyna Skrypnik, Agnieszka Olejnik-Schmidt, Joanna Mikolajczyk-Stecyna, Marcin Schmidt, Joanna Suliburska
Summary: Supplementation with Lactobacillus plantarum and Lactobacillus curvatus increased serum ferroportin concentration in rats on a high-fat iron-deficient diet, and Lactobacillus curvatus enhanced liver expression of the Tfrc gene.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Hayarelis Moreno, Isabel de Brugada
Summary: Previous studies have shown that supplementing choline during the embryonic period can improve memory tasks in adulthood. This study aimed to investigate the effect of prenatal dietary choline supplementation on long-term memory development in rats. The results suggest that prenatal choline supplementation accelerates the development of long-term memory in rats.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Cristiana Pistono, Amandine Zimmermann, Chloe Morel, Karine Herbeaux, Celine Heraud, Stephanie Dumont-Kientzy, Paul Pevet, Marie-Paule Felder-Schmittbuhl, Chantal Mathis
Summary: The research findings suggest that MT2 plays a key role in mediating the beneficial effects of melatonin on long-term object recognition memory, while MT1 may contribute to the effects on object location memory.
HORMONES AND BEHAVIOR
(2021)
Article
Nutrition & Dietetics
Jessica A. Baker, Kristen R. Breit, Tamara S. Bodnar, Joanne Weinberg, Jennifer D. Thomas
Summary: Prenatal alcohol exposure can disrupt the development of the immune system, but choline supplementation can mitigate these effects. The study found that early choline supplementation can reduce the impact of alcohol exposure on hippocampal inflammation and improve hippocampal function.
Article
Behavioral Sciences
Joep Titulaer, Carl Bjorkholm, Kristin Feltmann, Torun Malmlof, Devesh Mishra, Carolina Bengtsson Gonzales, Bjorn Schilstrom, Asa Konradsson-Geuken
Summary: The study suggests that increased release of dopamine and norepinephrine in the rat ventral hippocampus plays a crucial role in recognition memory and signaling novelty. In a novel object recognition test, rats' responses to a new object led to increased dopamine and norepinephrine release in the ventral hippocampus, potentially aiding in the formation of long-term memory.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Kellie S. Gross, Randie L. Alf, Tiffany R. Polzin, Karyn M. Frick
Summary: The study found that 17β-estradiol enhances memory consolidation by regulating hippocampal TrkB signaling rather than mBDNF expression. This suggests that modulation of TrkB signaling by 17β-estradiol is essential for its beneficial effects on memory consolidation, providing further insights into how TrkB/BDNF signaling is regulated by 17β-estradiol in the hippocampus.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Food Science & Technology
Yaxing Man, Tiantian Xu, Benu Adhikari, Cunshan Zhou, Yuchuan Wang, Bo Wang
Summary: About one-third of the world population suffers from iron deficiency, and diet delivery of iron is an effective but potentially side-effect causing approach. Developing new iron-rich products with high bioavailability and stability is crucial. Common foods such as cereals and bakery products are still the best vehicles for iron fortification.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Marco Rinaudo, Francesca Natale, Francesco La Greca, Matteo Spinelli, Antonella Farsetti, Fabiola Paciello, Salvatore Fusco, Claudio Grassi
Summary: This study found that male mice are more susceptible to memory loss induced by retroactive interference than females. Estrogen signaling involving estrogen receptor alpha activation in the dorsal hippocampus mediates the resistance of female mice to retroactive interference. Female mice showed higher phosphorylation levels of ERK1/2 in the hippocampus following retroactive interference. Inhibition of ERK1/2 made female mice more prone to retroactive interference.
Review
Nutrition & Dietetics
Ana M. Puga, Maria de Lourdes Samaniego-Vaesken, Ana Montero-Bravo, Mar Ruperto, Teresa Partearroyo, Gregorio Varela-Moreiras
Summary: Gut microbiota plays a crucial role in human health, and both diet and iron supplementation have an impact on it. Iron supplementation can potentially harm the gut microbiota, therefore it should be used with caution and recommended only to individuals with confirmed iron deficiency or iron-deficiency anemia. Further population studies are needed to confirm these findings.
Review
Microbiology
Arista Nienaber, Mary A. Uyoga, Robin C. Dolman-Macleod, Linda Malan
Summary: Tuberculosis (TB) is characterized by chronic non-resolving inflammation, which leads to anaemia of infection and iron deficiency anaemia (IDA) in TB patients. Although anaemia in TB patients is associated with poor clinical outcomes, managing anaemia is complicated due to the bacteria's reliance on iron. Anaemia of infection is likely to resolve with correct TB drug treatment, while IDA may require iron supplementation. This review provides insights into iron metabolism in TB, its contribution to iron deficiency and anaemia, and the association between iron status and clinical outcomes, as well as the available trials on iron supplementation in TB.
Article
Cell Biology
Jessica A. Baker, Tamara S. Bodnar, Kristen R. Breit, Joanne Weinberg, Jennifer D. Thomas
Summary: Alcohol exposure during pregnancy can have negative effects on development, including cognitive and behavioral dysfunction. It has been found that alcohol-induced changes in cytokine levels in the hippocampus can contribute to abnormal outcomes. Nutritional intervention with choline may improve behavioral impairments and influence neuroimmune function.
Article
Psychiatry
Emily E. Noble, Christine A. Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B. Jones, Claire de la Serre, Xia Yang, Elaine Y. Hsiao, Scott E. Kanoski
Summary: Research indicates that excessive early life consumption of sugar negatively impacts memory function in rats during adulthood, affecting hippocampal-dependent memory function and altering the gut microbiome, including the abundance of specific Parabacteroides species. Enrichment of these bacterial taxa during adolescence impairs hippocampal-dependent memory in adulthood, while early life sugar consumption and Parabacteroides microbial enrichment lead to alterations in gene expression related to intracellular kinase, neurotransmitter signaling, metabolic function, neurodegenerative disease, and dopaminergic signaling pathways.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Chang Cao, Miguel A. Prado, Liang Sun, Shira Rockowitz, Piotr Sliz, Joao A. Paulo, Daniel Finley, Mark D. Fleming
Summary: Maternal iron deficiency has limited impact on placental gene expression in mice during mid-gestation, mainly mediated by IRE coordination of iron gene expression. Interestingly, sexually dimorphic effects of maternal iron deficiency on placental gene expression were observed, with more alterations in male mouse placentas.
JOURNAL OF NUTRITION
(2021)
Article
Neurosciences
Phu V. Tran
Review
Pediatrics
Amanda Barks, Anne M. Hall, Phu V. Tran, Michael K. Georgieff
PEDIATRIC RESEARCH
(2019)
Article
Nutrition & Dietetics
Yu-Chin Lien, David E. Condon, Michael K. Georgie, Rebecca A. Simmons, Phu V. Tran
Article
Nutrition & Dietetics
Paulina S. Marell, Sharon E. Blohowiak, Michael D. Evans, Michael K. Georgieff, Pamela J. Kling, Phu Tran
Article
Nutrition & Dietetics
Luke N. Erber, Ang Luo, Yao Gong, Montana Beeson, Maolin Tu, Phu Tran, Yue Chen
Summary: Iron deficiency in neuronal cells leads to alterations in key metabolic and epigenetic pathways, impacting the phosphorylation of essential proteins. Specifically, iron deficiency increases the phosphorylation of GFPT1, reducing its enzymatic activity and subsequently lowering global O-GlcNAc modification in neuronal cells. This adaptive cellular response highlights the importance of post-translational modifications in intracellular signaling and epigenetic programming.
Article
Substance Abuse
Shirelle X. Liu, Mari S. Gades, Yayi Swain, Aarthi Ramakrishnan, Andrew C. Harris, Phu Tran, Jonathan C. Gewirtz
Summary: Repeated morphine exposure induces changes in neural activity and gene expression in male and female rats, leading to behavioral abnormalities. The majority of differentially expressed genes are involved in synaptic signaling and neuroplasticity, with commonalities and some differences observed between sexes.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Developmental Biology
Amanda Barks, Montana M. Beeson, Timothy C. Hallstrom, Michael K. Georgieff, Phu Tran
Summary: Iron deficiency during neurodevelopment can lead to long-lasting cognitive and socioemotional deficits, as well as increased risk for neuropsychiatric disease. This study investigated the mechanism by which iron deficiency affects gene regulation in the brain. The researchers found that the epigenetic modification of 5-hydroxymethylcytosine (5hmC), or DNA hydroxymethylation, plays a role in these neurophenotypical changes. Additionally, they discovered that iron treatment can partially reverse these changes in the developing brain.
DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Luke Erber, Shirelle Liu, Yao Gong, Phu Tran, Yue Chen
Summary: Iron and oxygen deficiencies are common in pathophysiological conditions. Adaptive responses to these deficiencies include repression of mitochondrial respiration, promotion of angiogenesis, and cell cycle control. This study used a proteomics analysis to identify global proteomic changes caused by hypoxia and iron deficiency in neuronal cells.
Article
Pediatrics
Garima Singh, Diana J. Wallin, Juan E. Abrahante Llorens, Phu Tran, Henry A. Feldman, Michael K. Georgieff, Tate Gisslen
Summary: Phlebotomy-induced anemia in neonatal mice leads to altered hippocampal transcriptome, with changes severity depending on the degree of anemia and sex of the neonatal mice. This study provides insights into sex-specific outcomes in preterm infants and may inform sex-based treatment strategies for neonatal anemia. The findings suggest that the consequences of PIA may be linked to sex-specific transcriptomic alterations and could also be relevant for other causes of neonatal anemia affecting term infants.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Shirelle X. Liu, Amanda K. Barks, Scott Lunos, Jonathan C. Gewirtz, Michael K. Georgieff, Phu Tran
Summary: Early-life iron deficiency leads to long-term gene dysregulation, including downregulation of JARID1B and BDNF genes in the rat hippocampus. Prenatal choline supplementation does not prevent the chromatin modifications induced by iron deficiency, but induces long-lasting repressive modifications in iron-sufficient rats, suggesting a separate mechanism for rescuing neural gene regulation. The negative epigenetic effects of choline supplementation in iron-sufficient rats warrant further investigation before considering it as an adjunctive therapeutic agent.
Review
Nutrition & Dietetics
Amanda K. Barks, Shirelle X. Liu, Michael K. Georgieff, Timothy C. Hallstrom, Phu V. Tran
Summary: Iron deficiency anemia is a major global micronutrient deficiency, affecting pregnant women and young children. Iron deficiency during prenatal and early postnatal periods can have long-term effects on neurodevelopment, such as cognitive impairment and increased risk for neuropsychiatric disorders. In animal models, developmental iron deficiency can lead to abnormal gene regulation, potentially causing lifelong deficits. Iron-dependent epigenetic modifications may play a role in the direct impact of iron deficiency on gene regulation.
Article
Nutrition & Dietetics
Shirelle X. Liu, Tenille K. Fredrickson, Natalia Calixto Mancipe, Michael K. Georgieff, Phu V. Tran
Summary: Fetal-neonatal iron deficiency (ID) causes long-term neurocognitive and affective dysfunctions, with sex-specific effects that are poorly understood at the molecular level. In this study using a rat model, both ID and prenatal choline treatment induced sex-specific transcriptome alterations in the adult rat hippocampus. ID induced changes in gene networks related to enhanced neuroinflammation, while choline supplementation partially rescued ID-induced dysregulation and had both beneficial and adverse effects on hippocampal gene expression.
Article
Developmental Biology
Amanda K. Barks, Montana M. Beeson, Tatyana Matveeva, Jonathan J. Gale, Raghavendra Rao, Phu V. Tran
DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Psychology, Developmental
Michael K. Georgieff, Phu V. Tran, Erik S. Carlson
DEVELOPMENT AND PSYCHOPATHOLOGY
(2018)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)