期刊
BEHAVIORAL NEUROSCIENCE
卷 132, 期 5, 页码 388-395出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/bne0000223
关键词
retrosplenial cortex; context memory; local field potential; NMDA; muscarinic
资金
- NIMH [MH078064]
This work summarizes evidence for the role of RSC in processing fear-inducing context memories. Specifically, we discuss molecular, cellular, and network mechanisms by which RSC might contribute the processing of contextual fear memories. We focus on glutamatergic and cholinergic mechanisms underlying encoding, retrieval, and extinction of context-dependent fear. RSC mechanisms underlying retrieval of recently and remotely acquired memories are compared to memory mechanisms of anterior cortices. Due to the strong connectivity between hippocampus and RSC, we also compare the extent to which their mechanisms of encoding, retrieval, and extinction show overlap. At a theoretical level, we discuss the role of RSC in the framework of systems consolidation as well as retrieval-induced memory modulation. Lastly, we emphasize the implication of these findings for psychopathologies associated with neurological and psychiatric disorders.
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