Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, John A. Rathmacher, Keith T. Wilson
Summary: This study found that isolevuglandins (isoLGs), formed from lipid peroxidation, covalently bind with amine-containing macromolecules in colonic epithelial cells of colorectal cancer (CRC) patients. The natural compound 2-hydroxybenzylamine (2-HOBA), a scavenger of electrophiles, was shown to reduce isoLG adduct levels, tumorigenesis, and oncogenic NRF2 activation in CRC models. In addition, 2-HOBA attenuated the growth of human CRC cells in animal models.
Article
Environmental Sciences
Sakshi Verma, Smriti Batoye, Rajinder Jindal
Summary: This study investigated the protective role of naringenin (NG) against cadmium chloride (CdCl2) toxicity in Labeo rohita. Exposure to CdCl2 for 15 and 30 days induced adaptive mechanisms, but on the 60th day, oxidative damage was observed. Oral administration of NG restored altered levels of antioxidants and enzymes, suggesting a protective role against Cd-induced oxidative insult.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Qiuhui Yang, Xiangyang Chen, Ziqi Zhang, Jingru Han, Neng Wu, Canchao Yang
Summary: Birds often clean their nests and reject foreign eggs to ensure the survival of their own eggs. The study suggests that nest sanitation in barn swallows may be an evolutionary precursor to egg rejection. Both male and female barn swallows engage in nest sanitation and egg rejection, but females invest more time. This provides evidence for the evolutionary relationship between nest sanitation and egg rejection behaviors in barn swallows.
Article
Biochemistry & Molecular Biology
S. Shehna Mahim, V. R. Anjali, V. S. Remya, S. Reshmi, C. Aruna Devi
Summary: The study investigates the effects of Bisphenol S(BPS) on fish and finds that sublethal exposure to BPS significantly influences the biomarker activities and leads to oxidative stress in fish. This indicates that BPS has oxidative potential.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Samukelisiwe C. Shabalala, Rabia Johnson, Albertus K. Basson, Khanyisani Ziqubu, Nokulunga Hlengwa, Sinenhlanhla X. H. Mthembu, Sihle E. Mabhida, Sithandiwe E. Mazibuko-Mbeje, Sidney Hanser, Ilenia Cirilli, Luca Tiano, Phiwayinkosi Dludla
Summary: This review investigates the pathological relevance of elevated lipid peroxidation products in type 2 diabetes (T2D), highlighting their potential role as biomarkers and therapeutic targets. It also briefly explains the significance of antioxidant enzymes/factors involved in blocking lipid peroxidation.
Article
Biochemistry & Molecular Biology
Michal Biernacki, Anna Jastrzab, Elzbieta Skrzydlewska
Summary: The study shows that topical application of CBD can regulate liver antioxidants and phospholipid metabolism to counteract oxidative stress and inflammation caused by UV radiation.
Article
Agriculture, Multidisciplinary
Boris Rabkin, Oren Tirosh, Joseph Kanner
Summary: The stomach acts as a bioreactor and plays a crucial role in biochemical reactions that impact human health. The oxidation of meat lipids in the stomach generates malondialdehyde (MDA), which is then absorbed into the bloodstream and modifies low-density lipoprotein (LDL) to MDA-LDL. The study found that vitamin E exhibits strong antioxidant activity against meat lipid oxidation in the stomach, especially at pH 3.0. The antioxidant activity of vitamin E at pH 3.0 is 20 times higher than that of catechin. Additionally, when combined with metmyoglobin (MbFe(+3)), vitamin E acts synergistically as a peroxidase/antioxidant couple, surpassing the antioxidant effect achieved by MbFe(+3)/catechin 150-fold. The continuous addition of low concentrations of vitamin E, catechin, and vitamin C helps maintain the meat's antioxidant activity, preventing lipid oxidation, reactive aldehyde generation, and loss of vitamin E.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Muhammad Arslan Ashraf, Arslan Hafeez, Rizwan Rasheed, Iqbal Hussain, Umer Farooq, Muhammad Rizwan, Shafaqat Ali
Summary: Salt toxicity is a major limitation for crop growth and yield. Screening for salt-tolerant wheat cultivars is important for sustainable wheat production. In this experiment, ten wheat cultivars were evaluated for salt tolerance. Salt stress reduced growth, physiological, and biochemical traits in all cultivars. Salt-sensitive cultivars showed higher oxidative stress and higher accumulation of Na, while salt-tolerant cultivars exhibited better growth and antioxidant systems, as well as higher accumulation of osmolytes. These physiological and biochemical markers could be useful for screening salt-tolerant wheat cultivars.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Biology
Valeria Marasco, Manrico Sebastiano, David Costantini, Gianni Pola, Leonida Fusani
Summary: The emergence of the migratory phenotype in birds is associated with changes in oxidative status, including higher levels of TBARS in the liver, lower levels of SOD in red blood cells and liver, and higher levels of GPx in the pectoral muscle. Despite higher food intake in migratory birds, there is no link between food intake and markers of oxidative status. The increase in body mass is positively correlated with muscle GPx activity during pre-migratory fattening, suggesting strategic displacement of oxidative costs to safeguard muscles for successful migration.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Sport Sciences
Karlee M. Quinn, Amanda J. Cox, Llion A. Roberts, David Briskey, Clare Minahan
Summary: This study found that the use of Free Oxygen Radical Test (FORT) and Free Oxygen Radical Defence (FORD) can reliably measure changes in redox homeostasis in athletes. Although there is a significant correlation between these point-of-care tests and laboratory measures pre- and post-exercise, the FORD test showed variable changes during exercise. Further research is needed to assess the ability of point-of-care tests in detecting redox perturbations induced by exercise.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Ecology
Devin Kirk, Megan Greischar, Nicole Mideo, Martin Krkosek
Summary: The costs of immune response can lead to trade-offs with other physiological functions such as reproduction, and these trade-offs are influenced by environmental variability. Higher environmental variability results in increased investment in the immune system at the cost of decreased reproduction, showing that optimal strategies are contingent on environmental conditions. This has implications for various aspects of infectious disease dynamics and evolution.
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Nutrition & Dietetics
Farhad Gholami, Jose Antonio, Cassandra Evans, Khadijeh Cheraghi, Leila Rahmani, Fatemeh Amirnezhad
Summary: The study found that tomato powder can enhance antioxidant capacity and reduce exercise-induced lipid peroxidation, possibly due to a synergistic interaction of lycopene with other bioactive nutrients.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Karol Tejchman, Katarzyna Kotfis, Jerzy Sienko
Summary: Oxidative stress, caused by imbalance between pro- and antioxidants, can lead to cellular damage and functional impairment. The close relationship between oxidative stress, inflammation, and functional impairment may result in various diseases affecting the entire human body. Research on oxidative damage, stress, and ROS is ongoing, with promising data on modifying cellular responses at different levels, including gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Laura Patras, Aura Elena Ionescu, Cristian Munteanu, Renata Hajdu, Andreea Kosa, Alina Porfire, Emilia Licarete, Valentin Florian Rauca, Alina Sesarman, Lavinia Luput, Paul Bulzu, Paul Chiroi, Rares Andrei Tranca, Marta-Szilvia Meszaros, Giorgiana Negrea, Lucian Barbu-Tudoran, Monica Potara, Stefan Szedlacsek, Manuela Banciu
Summary: Tailoring EVs as targeted drug delivery systems offers superior advantage over liposomal therapies for enhancing therapeutic efficacy. PEGylated EVs loaded with DOX showed promising potential as Trojan horses to deliver drugs to solid tumors, with superior antitumor activity compared to liposomal DOX in melanoma models. EV-based therapy also demonstrated reduced NF-kappa B activation and increased BAX expression, indicating better prognosis than traditional liposomal DOX treatment.
CANCER BIOLOGY & THERAPY
(2022)
Article
Ecology
Orsolya Vincze, Csongor Vagasi, Janka Penzes, Krisztian Szabo, Nora M. Magonyi, Gabor A. Czirjak, Peter L. Pap
Summary: Sex-specific physiology in wild birds was investigated in this study. Results showed that higher female immune indices were most common, while oxidative physiology showed no general sex bias and packed cell volume was generally male-biased. Contrary to predictions based on sexual selection, male-biased sexual size dimorphism was associated with male-biased immune measures. Factors such as sexual dichromatism, mating system and parental roles had no effect on sex-specificity in physiology. Importantly, female-biased immunity remained after accounting for sexual selection indices, suggesting alternative explanations should be explored for cross-species differences in physiological sex bias.
Article
Pharmacology & Pharmacy
Giorgiana Negrea, Valentin-Florian Rauca, Marta Szilvia Meszaros, Laura Patras, Lavinia Luput, Emilia Licarete, Vlad-Alexandru Toma, Alina Porfire, Dana Muntean, Alina Sesarman, Manuela Banciu
Summary: This study proposes a novel combination therapy that selectively targets both tumor-associated macrophages and melanoma cells, leading to strong inhibition of tumor growth and modulation of the tumor-immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ecology
Attila Marton, Csongor Vagasi, Orsolya Vincze, Veronika Bokony, Peter L. Pap, Laura Patras, Janka Penzes, Lorinc Barbos, Attila Fulop, Gergely Osvath, Simon Ducatez, Mathieu Giraudeau
Summary: The mechanistic link between avian oxidative physiology and plumage coloration has been the focus of attention in recent decades. This study investigated the relationship between oxidative physiology and plumage coloration at the interspecific level and found that plasma level of reactive oxygen metabolites was related to melanin coloration, but not to antioxidant glutathione. Furthermore, carotenoid scores were unrelated to oxidative physiology parameters, suggesting that pigmentation differences in birds do not influence their oxidative state.
ECOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Attila Fulop, Zoltan Nemeth, Bianka Kocsis, Bettina Deak-Molnar, Timea Bozsoky, Gabriella Csoppu, Zoltan Barta
Summary: This study examined the relationship between exploratory behavior and fighting ability in Eurasian tree sparrows during winter competition for food. The results showed no direct correlation between exploratory behavior and fighting ability. However, there was a positive correlation between bib size and probability of winning in females, indicating a potential signaling role of the bib in females as well.
Review
Behavioral Sciences
Zoltan Radai, Johanna Kiss, Nikoletta A. Nagy, Anna Agnes Somogyi, Attila Fulop, Zsofia Toth, Melinda Alexane Babits, Zoltan Nemeth
Summary: This article reviews the relationship between personality and physiological parameters in arthropods, highlighting the significance of metabolic rate, thermal physiology, immunophysiology, endocrine regulation, and exogenous agents in shaping arthropod personality. The study suggests that a more comprehensive integration of physiological parameters with condition is necessary for a better understanding of the importance of state in animal personality. It also points out the knowledge gap regarding the association between metabolic rate, hormonal regulation, and their combined effects on personality in arthropods.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2022)
Article
Ecology
Tamara Szentivanyi, Orsolya Vincze
Summary: The occurrence of nasal toad myiasis in the European toad was documented using public photo repositories. The distribution of the disease was found to be limited to certain regions, despite the wide distribution of the host. The use of community science platforms provides a useful tool for long-term surveillance and monitoring of wildlife diseases.
EUROPEAN JOURNAL OF WILDLIFE RESEARCH
(2022)
Article
Ecology
Renata Urgyan, Balazs A. Lukacs, Reka Fekete, Attila Molnar, Andras Nagy, Orsolya Vincze, Andy J. Green, Adam Lovas-Kiss
Summary: This study aimed to investigate how endozoochory rates change throughout the annual cycle for migratory waterfowl and how it relates to plant life-form and phenology. The results showed that migratory waterfowl endozoochory is a strong driver of plant distributions and is underestimated in its importance.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2023)
Review
Oncology
Laura Patras, Lee Shaashua, Irina Matei, David Lyden
Summary: Primary tumors actively induce immunosuppression in the pre-metastatic niche (PMN), the future sites of metastasis, to prepare for disseminated tumor cell arrival. This article discusses recent advances in understanding the tumor immune microenvironment and provides a comprehensive overview of the immune determinants of PMN's spatiotemporal evolution. The authors also outline emerging therapeutic approaches to alter PMN formation and reverse immunosuppression programs.
Article
Zoology
Andras Attila Nagy, Nandor Eros, Istvan Imecs, Gabor Bone, Attila Fulop, Peter Laszlo Pap
Summary: Freshwater fishes are facing a serious decline worldwide, becoming one of the most threatened groups of vertebrates. Although Transylvania has a rich diversity of freshwater fishes, there has been a lack of systematic survey in the region for the past 50 years. This study provides data on the occurrence and distribution of fishes and lampreys in Transylvania, recording 65 fish species and three lamprey species, with additional nine fish species reported based on information from experts. The importance of the study in conservation planning, such as the designation of new protected areas and the compilation of the Romanian Red List of fishes, is discussed.
Review
Oncology
Laura Patras, Doru Paul, Irina R. Matei
Summary: The discovery of the pre-metastatic niche (PMN) formation, where primary tumors condition distant organ sites for future metastasis, has revolutionized our understanding of cancer progression and provided new avenues for therapeutic interventions. The remodeling of the extracellular matrix (ECM) in the distal organ is the initiating event in PMN development, facilitated by primary tumor-secreted factors and orchestrated through crosstalk between various resident and recruited cells. This review explores the ECM changes, cellular effectors, and mechanisms of ECM remodeling in PMN progression, highlighting the clinical implications and therapeutic opportunities for targeting the ECM to hinder PMN formation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Ecology
Adam Lovas-Kiss, Maria J. Navarro-Ramos, Orsolya Vincze, Viktor Loeki, Renata Urgyan, Felicia Paller-Kapusi, Casper H. A. Van Leeuwen, Andy J. Green, Balazs Andras Lukacs
Summary: This study investigates the potential of alien plant seeds to disperse through ingestion, transport, and egestion in waterfowl. By comparing the endozoochorous dispersal ability of alien and native wetland plant species in a feeding experiment with mallards, it is found that alien species have higher passage rates and slower germination, while native species have shorter retention times and higher germinability. These findings suggest that alien species may have traits that facilitate successful endozoochory and enable rapid expansions in new environments.
FRESHWATER BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Katalin Ozogany, Viola Kerekes, Attila Fueloep, Zoltan Barta, Mate Nagy
Summary: Using drones, researchers tracked the movement of individual Przewalski's horses and linked their behavior to long-term population monitoring, revealing the structure of their society. The study shows how collective movements in the herd are related to kinship and familiarity among horses, and how movement patterns can predict future dynamics of the group.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Kristof Süveges, Orsolya Vincze, Viktor Löki, Adam Lovas-Kiss, Attila Takacs, Reka Fekete, Julia Tüdosne Budai, V. Attila Molnar
Summary: This study conducted a botanical survey of poplar plantations in central Europe and found that these monocultures harbor a rich plant diversity, including terrestrial orchids. The results highlight the importance of recognizing the biodiversity of poplar plantations and recommend delaying or partial harvest to increase their conservation potential.