期刊
BASIC RESEARCH IN CARDIOLOGY
卷 113, 期 4, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-018-0684-z
关键词
Remote ischaemic conditioning; Cardioprotection; Neuroprotection
资金
- NIHR Biomedical Research Council
- British Heart Foundation [PG/15/52/31598]
- Hatter Foundation
- British Heart Foundation [PG/15/52/31598] Funding Source: researchfish
Remote ischaemic conditioning (RIC) is a promising method of cardioprotection, with numerous clinical studies having demonstrated its ability to reduce myocardial infarct size and improve prognosis. On the other hand, there are several clinical trials, in particular those conducted in the setting of elective cardiac surgery, that have failed to show any benefit of RIC. These contradictory data indicate that there is insufficient understanding of the mechanisms underlying RIC. RIC is now known to signal indiscriminately, protecting not only the heart, but also other organs. In particular, experimental studies have demonstrated that it is able to reduce infarct size in an acute ischaemic stroke model. However, the mechanisms underlying RIC-induced neuroprotection are even less well understood than for cardioprotection. The existence of bidirectional feedback interactions between the heart and the brain suggests that the mechanisms of RIC-induced neuroprotection and cardioprotection should be studied as a whole. This review, therefore, addresses the topic of the neural component of the RIC mechanism.
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