期刊
AUTOPHAGY
卷 14, 期 10, 页码 1665-1673出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2018.1466014
关键词
Disease; innate immunity; mitophagy; pathogenesis; virus
类别
资金
- National Natural Science Foundation of China (NSFC) [81471939, 31630086]
- natural science foundation of hubei province innovation group [2017CFA022]
Viral infection causes many physiological alterations in the host cell, and many of these alterations can affect the host mitochondrial network, including mitophagy induction. A substantial amount of literature has been generated that advances our understanding of the relationship between mitophagy and several viruses. Some viruses trigger mitophagy directly, and indirectly and control the mitophagic process via different strategies. This enables viruses to promote persistent infection and attenuate the innate immune responses. In this review, we discuss the events of virus-regulated mitophagy and the functional relevance of mitophagy in the pathogenesis of viral infection and disease.
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