A family of DNA aptamers with varied duplex region length that forms complexes with thrombin and prothrombin

HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase.

(2015) Colin A. Kretz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of weak affinity chromatography and surface plasmon resonance in determining affinity of small molecules

(2014) Minh-Dao Duong-Thi et al.   ANALYTICAL BIOCHEMISTRY

Duplex–quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer

(2013) Irene Russo Krauss et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

(2012) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

Characteristics of a New DNA Aptamer, Direct Inhibitor of Thrombin

(2011) A. V. Mazurov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Studies of the binding mechanism between aptamers and thrombin by circular dichroism, surface plasmon resonance and isothermal titration calorimetry

(2011) Po-Hsun Lin et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Thrombin–aptamer recognition: a revealed ambiguity

(2011) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

Correlation between the composition of multivalent antibody conjugates with colloidal gold nanoparticles and their affinity

(2010) Irina V. Safenkova et al.   JOURNAL OF IMMUNOLOGICAL METHODS

HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions

(2009) C. A. Kretz et al.   THROMBOSIS AND HAEMOSTASIS

Effect of the immobilisation of DNA aptamers on the detection of thrombin by means of surface plasmon resonance

(2008) Veronika Ostatná et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY