期刊
FEBS LETTERS
卷 589, 期 13, 页码 1437-1443出版社
WILEY
DOI: 10.1016/j.febslet.2015.04.032
关键词
Hepatocyte growth factor receptor; Receptor-type tyrosine-protein phosphatase zeta; Fusion gene; Expression level; Dimerization; Phosphorylation
资金
- biological medicine department, Beijing Municipal Science & Technology Commission [Z141100000214009]
- National High Technology Research and Development Program [2012AA02A508]
- International Science and Technology Cooperation Program [2012DFA30470]
- National Natural Science Foundation of China [91229121]
PTPRZ1-MET (ZM) proteins are a group of fusion proteins identified in human gliomas by high-throughput transcriptome sequencing. ZM fusions are associated with poor prognosis in afflicted glioma patients and mediate oncogenic effects in assays. In this study, we show that ZM-carrying patients have increased hepatocyte growth factor receptor (MET) mRNA expression levels induced by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1). Furthermore, ZM fusions preserve fundamental properties of wild-type MET with respect to processing and dimerization, and enhance phosphorylation in an hepatocyte growth factor (HGF)-dependent and independent manner. Our findings suggest that ZM induces gliomas through elevated expression and phosphorylation of the MET oncoprotein. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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