Dynamics, flexibility, and allostery in molecular chaperonins

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Structures of the Gβ-CCT and PhLP1–Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

(2015) Rebecca L. Plimpton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form

(2014) X. Fei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of the ATP hydrolysis asymmetry of the CCT chaperonin complex

(2014) Mónica Chagoyen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin

(2014) Moses Kasembeli et al.   PLOS BIOLOGY

Visualizing GroEL/ES in the Act of Encapsulating a Folding Protein

(2013) Dong-Hua Chen et al.   CELL

Chaperonin-mediated Protein Folding

(2013) Arthur L. Horwich   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate protein switches GroE chaperonins from asymmetric to symmetric cycling by catalyzing nucleotide exchange

(2013) X. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structures of the Eukaryotic Chaperonin CCT Reveal Its Functional Partitioning

(2013) Nir Kalisman et al.   STRUCTURE

Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

(2012) Krishanu Mukherjee et al.   BMC EVOLUTIONARY BIOLOGY

ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the GroEL Chaperonin

(2012) Daniel K. Clare et al.   CELL

Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling

(2012) N. Kalisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dynamic model of long-range conformational adaptations triggered by nucleotide binding in GroEL-GroES

(2012) Lars Skjaerven et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

(2012) F. Herzog et al.   SCIENCE

The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT

(2012) Alexander Leitner et al.   STRUCTURE

A Gradient of ATP Affinities Generates an Asymmetric Power Stroke Driving the Chaperonin TRIC/CCT Folding Cycle

(2012) Stefanie Reissmann et al.   Cell Reports

Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

(2011) Nicholai R. Douglas et al.   CELL

Mechanism of nucleotide sensing in group II chaperonins

(2011) Jose H Pereira et al.   EMBO JOURNAL

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

(2011) Carien Dekker et al.   EMBO JOURNAL

Dynamics, flexibility and ligand-induced conformational changes in biological macromolecules: a computational approach

(2011) Lars Skjærven et al.   Future Medicinal Chemistry

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Cryo-EM Structure of a Group II Chaperonin in the Prehydrolysis ATP-Bound State Leading to Lid Closure

(2011) Junjie Zhang et al.   STRUCTURE

Chaperonins: two rings for folding

(2011) Hugo Yébenes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations

(2011) Lars Skjaerven et al.   PLoS Computational Biology

Denatured proteins facilitate the formation of the football-shaped GroEL–(GroES)2complex

(2010) Tomoya Sameshima et al.   BIOCHEMICAL JOURNAL

Crystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding Cycle

(2010) Jose H. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Two-step Mechanism for the Folding of Actin by the Yeast Cytosolic Chaperonin

(2010) Sarah F. Stuart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Equivalent Mutations in the Eight Subunits of the Chaperonin CCT Produce Dramatically Different Cellular and Gene Expression Phenotypes

(2010) Maya Amit et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of folding chamber closure in a group II chaperonin

(2010) Junjie Zhang et al.   NATURE

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

(2010) Inés G Muñoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement

(2010) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation among HSP60 sequences in relation to structure, function, and evolution

(2010) Luciano Brocchieri et al.   PROTEIN SCIENCE

On the evolutionary origin of the chaperonins

(2010) Carien Dekker et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal Structure of Group II Chaperonin in the Open State

(2010) Yanwu Huo et al.   STRUCTURE

The GroEL/GroES cis cavity as a passive anti-aggregation device

(2009) Arthur L. Horwich et al.   FEBS LETTERS

Differential substrate specificity of group I and group II chaperonins in the archaeonMethanosarcina mazei

(2009) Angela M. Hirtreiter et al.   MOLECULAR MICROBIOLOGY

Chaperonin complex with a newly folded protein encapsulated in the folding chamber

(2009) D. K. Clare et al.   NATURE

GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state

(2009) N. K. Tyagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM Structure of the Native GroEL-GroES Complex from Thermus thermophilus Encapsulating Substrate Inside the Cavity

(2009) Ryo Kanno et al.   STRUCTURE

Chaperonins: The hunt for the Group II mechanism

(2008) Maria Giulia Bigotti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Small molecule inhibition of a Group II chaperonin: Pinpointing a loop region within the equatorial domain as necessary for protein refolding

(2008) Lisa M. Bergeron et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effect of the C-terminal Truncation on the Functional Cycle of Chaperonin GroEL

(2008) Mihoko Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Action of ATP-dependent Subunit Conformational Change and Interaction between Helical Protrusions in the Closure of the Built-in Lid of Group II Chaperonins

(2008) Taro Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-Induced Allostery in the Eukaryotic Chaperonin CCT Is Abolished by the Mutation G345D in CCT4 that Renders Yeast Temperature-Sensitive for Growth

(2008) Liat Shimon et al.   JOURNAL OF MOLECULAR BIOLOGY

The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin

(2008) Jorge Cuéllar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GroEL stimulates protein folding through forced unfolding

(2008) Zong Lin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Setting the chaperonin timer: A two-stroke, two-speed, protein machine

(2008) J. P. Grason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery and cooperativity revisited

(2008) Qiang Cui et al.   PROTEIN SCIENCE

Asymmetry of the GroEL-GroES Complex under Physiological Conditions as Revealed by Small-Angle X-Ray Scattering

(2007) Tomonao Inobe et al.   BIOPHYSICAL JOURNAL