Article
Surgery
Georgios A. Margonis, Thomas Boerner, Jean-Baptiste Bachet, Stefan Buettner, Roberto Moretto, Nikolaos Andreatos, Andrea Sartore-Bianchi, Jane Wang, Carsten Kamphues, Johan Gagniere, Sara Lonardi, Inger M. Loes, Doris Wagner, Andrea Spallanzani, Kazunari Sasaki, Richard Burkhart, Filippo Pietrantonio, Emmanouil Pikoulis, Timothy M. Pawlik, Stephanie Truant, Armando Orlandi, Anastasia Pikouli, Nicoletta Pella, Katharina Beyer, George Poultsides, Hendrik Seeliger, Federico N. Aucejo, Peter Kornprat, Klaus Kaczirek, Per E. Lonning, Martin E. Kreis, Christopher L. Wolfgang, Matthew J. Weiss, Chiara Cremolini, Stephane Benoist, Michael D'Angelica
Summary: This study investigated the clinical implications of BRAF-mutated colorectal liver metastases. The results showed that BRAF V600E mutation was associated with shorter overall survival but not recurrence-free survival. Patients with MSS tumors had shorter recurrence-free survival compared with those with MSI-high tumors. Resection of converted disease resulted in encouraging survival. Second hepatectomy improved outcomes for patients with recurrence.
Article
Oncology
Francesco Cecere, Laura Pignata, Bruno Hay Mele, Abu Saadat, Emilia D'Angelo, Orazio Palumbo, Pietro Palumbo, Massimo Carella, Gioacchino Scarano, Giovanni Battista Rossi, Claudia Angelini, Angela Sparago, Flavia Cerrato, Andrea Riccio
Summary: This study reports a case of early-onset colorectal cancer (EO-CRC) in a 27-year-old woman with Beckwith-Wiedemann syndrome (BWSp). Genetic and epigenetic analysis revealed the presence of genetic and epigenetic variations that may be associated with the development of EO-CRC.
Article
Oncology
Maria Dobre, Alessandro Salvi, Iulia Andreea Pelisenco, Florina Vasilescu, Giuseppina De Petro, Vlad Herlea, Elena Milanesi
Summary: Colorectal cancer is characterized by mutations and abnormal DNA methylation in tumor suppressor and proto-oncogenes. This study identified nine genes with high methylation levels in tumor tissues compared to normal tissues. Molecular sub-classification based on mutations and epigenetic modifications may help identify epigenetic biomarkers for personalized treatment strategies to improve patient outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyoun Wook Lee, Boram Song, Kyungneun Kim
Summary: The presence of a residual adenoma component in colorectal cancer is associated with a high frequency of KRAS mutation and indolent clinicopathological features. The discordance in the incidence of KRAS mutation between the adenoma and carcinoma components emphasizes the need to document the adenoma component in the pathology report and avoid including it in molecular testing samples.
Review
Oncology
Hiroyuki Takeda, Yu Sunakawa
Summary: BRAF mutations are an important poor prognostic factor in mCRC, but greater understanding of patient characteristics through genomic classification allows for more ideal treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Koumarianou, Anastasios Ntavatzikos, David Symeonidis, Christos Vallilas, Maria Giannakakou, Georgios Papaxoinis, Spyridon Xynogalos, Ioannis Boukovinas, Stamatina Demiri, Katerina Kampoli, Georgios Oikonomopoulos, Epaminontas Samantas, Eleni Res, Nikolaos Androulakis, Georgia Vourli, Ioannis Souglakos, Michalis Karamouzis
Summary: This retrospective study examined the clinical characteristics and efficacy of FTD/TPI in patients with metastatic colorectal cancer. The results showed that FTD/TPI is effective as a third-line treatment, regardless of mutational status and tumor sidedness, by prolonging progression-free survival and overall survival.
Article
Oncology
Yuanyuan Wang, Zhi Zhao, Jing Zhuang, Xinxin Wu, Zhizhong Wang, Bing Zhang, Ge Gao, Yinping Zhang, Caili Guo, Qingxin Xia
Summary: The high expression of the LC3 protein in CRC patients is associated with prognosis, and LC3, MSI status, and KRAS mutations are essential considerations in selecting adjuvant therapy for CRC. It helps to identify high-risk patients and explore more effective treatment options.
Article
Cell Biology
Weilin Pu, Fei Qian, Jing Liu, Keke Shao, Feng Xiao, Qin Jin, Qingmei Liu, Shuai Jiang, Rui Zhang, Jun Zhang, Shicheng Guo, Jianfeng Zhang, Yanyun Ma, Shaoqing Ju, Weifeng Ding
Summary: The study suggests that ESR1 and ZNF132 may have better predictive capabilities for early diagnosis of CRC compared to SEPT9, especially in CRC patients with KRAS mutations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Muhammad G. Kibriya, Maruf Raza, Anthony Quinn, Mohammed Kamal, Habibul Ahsan, Farzana Jasmine
Summary: There are differences in clinical and molecular characteristics between EOCRC and LOCRC, including differential expression of cancer-related pathways and differences in DNA damage repair capacity. Additionally, a higher degree of methylation in growth factor receptor genes in LOCRC may impact treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jihoon E. Joo, Mark Clendenning, Ee Ming Wong, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Ingrid M. Winship, Susan G. Preston, Aung Ko Win, Pierre-Antoine Dugue, Harindra Jayasekara, Dallas English, Finlay A. Macrae, John L. Hopper, Mark A. Jenkins, Roger L. Milne, Graham G. Giles, Melissa C. Southey, Daniel D. Buchanan
Summary: This study identified unique DNA methylation changes in early-onset colorectal cancer (EOCRC) at 234 loci. CpGs associated with ageing-related methylation drift were significantly altered in EOCRC, with evidence of accelerated ageing in normal mucosa. The findings suggest that EOCRC acquires distinct DNAm alterations, contributing to its earlier onset compared to intermediate- and late-onset CRC.
Article
Oncology
Alice Talbot, Emily O'Donovan, Eileen Berkley, Carmel Nolan, Roisin Clarke, David Gallagher
Summary: Lynch syndrome (LS) is responsible for 2-4% of hereditary colorectal cancers and is characterized by mismatch repair protein deficiency. A retrospective review in Ireland found that LS patients most commonly had colorectal cancer, followed by breast and endometrial cancer. The study also identified significant differences in cancer type based on the specific gene involved in LS.
Article
Oncology
Valentina Condelli, Giovanni Calice, Alessandra Cassano, Michele Basso, Maria Grazia Rodriquenz, Angela Zupa, Francesca Maddalena, Fabiana Crispo, Michele Pietrafesa, Michele Aieta, Alessandro Sgambato, Giampaolo Tortora, Pietro Zoppoli, Matteo Landriscina
Summary: This study identified and validated a novel epigenetic eight-gene signature, with hypermethylation of the promoter regions, that can predict poor outcomes for a subgroup of metastatic colorectal carcinomas. The study showed that methylation events were enriched in genes located on specific chromosomal regions associated with adenoma-to-carcinoma progression, providing prognostic information for identifying metastatic colorectal carcinomas with poor prognosis.
Article
Oncology
Susanti Susanti, Satrio Wibowo, Gilang Akbariani, Naomi Yoshuantari, Didik Setyo Heriyanto, Asep Muhamad Ridwanuloh, Hariyatun Hariyatun, Adeodatus Yuda Handaya, Johan Kurnianda, Susanna Hilda Hutajulu, Mohammad Ilyas
Summary: This study revealed a potentially higher frequency of Lynch Syndrome among CRC patients in Indonesia, which may partially explain the higher incidence of early onset colorectal cancer in the country compared to the West.
Article
Oncology
Takuro Hirano, Eri Arai, Mao Fujimoto, Yuji Nakayama, Ying Tian, Nanako Ito, Takeshi Makabe, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki, Yae Kanai
Summary: This study identified genes associated with recurrence risk in endometrial cancer through genome-wide DNA methylation analysis, and established DNA methylation diagnostic criteria for predicting recurrence risk in patients aged 40 years or less.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Virology
XuSha Zhou, Jing Zhao, Jian V. Zhang, Yinglin Wu, Lei Wang, Xiaoqing Chen, Dongmei Ji, Grace Guoying Zhou
Summary: This study demonstrated that MEK inhibitor Trametinib can enhance oncolytic virus activity in BRAF V600E-mutated tumor cells, and combination therapy with oHSV and MEKi Trametinib can improve virus replication and show synergistic therapeutic efficacy in vivo for BRAF or KRAS-mutated tumors, providing new insights for clinical development.
Article
Endocrinology & Metabolism
Francesca Terracciano, Alessia Capone, Andrea Montori, Maria Rinzivillo, Stefano Partelli, Francesco Panzuto, Emanuela Pilozzi, Paolo Giorgio Arcidiacono, Claudio Sette, Gabriele Capurso
Summary: The dysregulation of mTORC1-dependent pathways in PanNENs leads to the introduction of the mTORC1 inhibitor everolimus. Although effective in increasing progression-free survival, many patients develop secondary resistance to the drug. MYC overexpression is identified as a key factor in the development of resistance, and its inhibition with dinaciclib shows promise in overcoming secondary resistance to everolimus in PanNENs.
NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
M. Rinzivillo, D. Prosperi, F. Mazzuca, L. Magi, E. Iannicelli, E. Pilozzi, G. Franchi, A. Laghi, B. Annibale, A. Signore, F. Panzuto
Summary: This study aimed to investigate the correlation between FDG-PET findings and responses to everolimus therapy in patients with neuroendocrine neoplasia, and identify predictors of long-term efficacy. The results showed that everolimus is a valid therapeutic option for well-differentiated NEN, even in patients with positive FDG-PET findings.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Giovanni Maria Garbarino, Giulia Canali, Giulia Tarantino, Gianluca Costa, Mario Ferri, Genoveffa Balducci, Emanuela Pilozzi, Giammauro Berardi, Paolo Mercantini
Summary: The study demonstrates that laparoscopic rectal cancer surgery is associated with comparable short-term outcomes in terms of operative time and postoperative morbidity to open surgery, with the added benefit of a faster recovery. Additionally, there were no significant differences observed between laparoscopic and open surgery in terms of oncological adequateness of the surgical specimen and long-term survival rates.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
Valentina Panzeri, Isabella Manni, Alessia Capone, Chiara Naro, Andrea Sacconi, Silvia Di Agostino, Luisa de Latouliere, Andrea Montori, Emanuela Pilozzi, Giulia Piaggio, Gabriele Capurso, Claudio Sette
Summary: The research revealed that MEX3A plays a significant role in the acquisition and maintenance of chemoresistance by PDAC cells, suggesting it may represent a novel therapeutic target for PDAC.
MOLECULAR ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Gloria Galli, Marilia Carabotti, Emanuela Pilozzi, Edith Lahner, Bruno Annibale, Laura Conti
Summary: The study found that approximately 36.3% of celiac disease patients continue to experience persistent gastrointestinal symptoms and/or malabsorption signs despite being on a gluten-free diet. This persistence is associated with a longer duration of symptoms before CD diagnosis (>= 5 years) and the presence of constipation at the time of CD diagnosis. Other variables, including age at CD diagnosis, sex, duration of GFD, comorbidities, CD serology positivity, and severity of duodenal damage, were not found to have an association with the persistence of symptoms/signs. The relationship between symptoms/signs and histological findings remains unclear in CD management.
Article
Surgery
Edoardo Virgilio, Gian Luca Rampioni, Mariangela Lombardi, Genoveffa Balducci, Emanuela Pilozzi, Marco Cavallini
Summary: Clear cell gastric cancer (CCGC) is an extremely rare variant of adenocarcinoma of the stomach that can be mistaken for metastatic lesions from other anatomical parts. More studies are needed to understand its adverse prognostic significance and standardize management and treatment.
ACTA CHIRURGICA BELGICA
(2021)
Article
Gastroenterology & Hepatology
Gianluca Esposito, Emanuele Dilaghi, Maria Cazzato, Emanuela Pilozzi, Laura Conti, Marilia Carabotti, Emilio Di Giulio, Bruno Annibale, Edith Lahner
Summary: This longitudinal cohort study investigated the occurrence of gastric neoplastic lesions at the 3-year follow-up in patients with autoimmune and multifocal atrophic gastritis. The study found that 16% of patients presented gastric neoplastic lesions, primarily gastric cancer, low-grade dysplasia, and type-1 neuroendocrine tumors. Patients over 70 years of age had a significantly higher risk of developing gastric epithelial neoplastic lesions.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
M. Cazzato, G. Esposito, G. Galli, E. Pilozzi, E. Lahner, V. D. Corleto, A. Zullo, E. Di Giulio, B. Annibale
Summary: EndoFaster (R) is a promising tool for diagnosing corpus atrophic gastritis during gastroscopy, with high accuracy compared to histological evaluation. NBI endoscopy can accurately detect and perform target biopsies in areas of intestinal metaplasia, aiding in the diagnosis of corpus atrophic gastritis.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2021)
Article
Biology
Michela Relucenti, Federica Francescangeli, Maria Laura De Angelis, Vito D'Andrea, Selenia Miglietta, Emanuela Pilozzi, Xiaobo Li, Alessandra Boe, Rui Chen, Ann Zeuner, Giuseppe Familiari
Summary: The study found that patient-derived colorectal cancer spheroids and mouse xenografts contain the same types of cancer cells but in different ratios, reflecting the influence of in vitro and in vivo microenvironments on cancer cells. Spheroids were enriched in cells with a stem-like phenotype, while xenografts had more cells containing lipid droplets. These differences need to be considered when designing innovative models for personalized drug testing.
Article
Chemistry, Multidisciplinary
Giovanni Maria Garbarino, Marta Zerunian, Eva Berardi, Federico Mainardi, Emanuela Pilozzi, Michela Polici, Gisella Guido, Carlotta Rucci, Tiziano Polidori, Mariarita Tarallo, Giovanni Guglielmo Laracca, Elsa Iannicelli, Paolo Mercantini, Bruno Annibale, Andrea Laghi, Damiano Caruso
Summary: The study confirms the importance of CT radiomics in the radiologic evaluation of advanced gastric cancer patients and demonstrates the ability to differentiate patients who respond to perioperative chemotherapy from those who do not. Analysis of radiomic features can provide valuable predictive information for early response to p-ChT in gastric cancer patients.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell Biology
Christian Barbato, Paola Frisone, Laura Braccini, Simona D'Aguanno, Luisa Pieroni, Maria Teresa Ciotti, Caterina Catalanotto, Carlo Cogoni, Francesca Ruberti
Summary: RNA-binding proteins play important roles in miRNA-mediated gene silencing. This study discovered that SERBP1 is a partner protein of Argonaute2, and it participates in miR-92-mediated gene silencing by regulating the 3' UTR of KCC2. These findings advance our understanding of KCC2 translational regulation in neuronal cells and highlight the key role of SERBP1 in this gene regulation.
Article
Medicine, General & Internal
Giulia Pivetta, Chiara Coluccio, Emanuele Dilaghi, Edith Lahner, Emanuela Pilozzi, Marilia Carabotti, Vito Domenico Corleto
Summary: Iron-deficiency anemia in the elderly may be caused by various gastrointestinal conditions. The use of routine duodenal biopsies for diagnostic purposes in elderly patients is debated. A cross-sectional study analyzing 7968 gastroscopies was conducted to determine the diagnostic value of routine duodenal biopsies in adult and elderly patients with no bleeding anemia. The study found limited diagnostic yield of routine duodenal biopsies in this population.
Article
Biochemistry & Molecular Biology
Andrea Montori, Aldo Germani, Mario Ferri, Annalisa Milano, Teresa Valentina Ranalli, Maria Piane, Emanuela Pilozzi
Summary: This study conducted a mutational analysis of genes involved in the DNA damage response pathway in LARC patients who had undergone neoadjuvant chemo-radiotherapy. The results showed rare mutations in genes associated with the Homologous Recombination pathway in LARC patients. However, a missense mutation in RAD50 was identified in one case of pathological complete response, suggesting its potential role as a biomarker in larger series.
Meeting Abstract
Endocrinology & Metabolism
D. Orlando, M. Rinzivillo, L. Magi, S. Angeletti, E. Pilozzi, E. di Giulio, B. Annibale, F. Panzuto
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Oncology
Paola Visconti, Federica Parodi, Barbara Parodi, Lucia Casarino, Paolo Romano, Mariachiara Buccarelli, Roberto Pallini, Quintino Giorgio D'Alessandris, Andrea Montori, Emanuela Pilozzi, Lucia Ricci-Vitiani
Summary: Colorectal and glioblastoma cancer stem-like cells are crucial for translational research, and their authentication through STR profiling ensures research reproducibility. This study provides a reference dataset for a panel of CSCs, allowing comparison with a large number of tumor cell lines, along with clinical data and mutation information. The STR profiles and information of CSCs are available in databases for further research.
INTERNATIONAL JOURNAL OF CANCER
(2021)