Article
Dentistry, Oral Surgery & Medicine
Werner E. G. Mueller, Meik Neufurth, Hiroshi Ushijima, Rafael Munoz-Espi, Lena-Katharina Mueller, Shunfeng Wang, Heinz C. Schroeder, Xiaohong Wang
Summary: The study shows that polyphosphate can prevent the transition from amorphous CaP to crystalline CaP, and this effect can be reversed by alkaline phosphatase.
Article
Medicine, Research & Experimental
Daan F. Boreel, Paul N. Span, Annemarie Kip, Milou Boswinkel, Johannes P. W. Peters, Gosse J. Adema, Johan Bussink, Sandra Heskamp
Summary: Limited oxygen diffusion and increased oxygen consumption in solid malignancies lead to chronic hypoxia, which induces radioresistance and an immunosuppressive microenvironment. This study aimed to develop a radiolabeled antibody to visualize chronic hypoxia and study immune cell populations in these hypoxic areas. The results showed that the radiotracer binds to CAIX-expressing cells in vitro and accumulates in CAIX+ areas in vivo. The technique can quantitatively distinguish between tumor models with varying CAIX+ fractions and identified less infiltration of immune cells in the CAIX+ areas.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Utpal K. Mondal, Kate Doroba, Ahmed M. Shabana, Rachel Adelberg, Md. Raqibul Alam, Claudiu T. Supuran, Marc A. Ilies
Summary: The study identified a series of PEGylated CA inhibitors that effectively suppressed the growth and proliferation of tumor cells by attaching to different lengths of PEG backbones. In experimental models, PEGylated CA inhibitors with short to medium PEG backbones were found to have higher anticancer effects under both normoxic and hypoxic conditions, as well as in tumor spheroid models. The findings confirmed that PEGylated CA inhibitors did not affect the cell viability of CA IX-negative NCI-H23 tumor spheroids, indicating a potential CA IX-mediated cell killing for these anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Gustavo Provensi, Alessia Costa, Barbara Rani, Maria Vittoria Becagli, Fabio Vaiano, Maria Beatrice Passani, Damiano Tanini, Antonella Capperucci, Simone Carradori, Jacobus P. Petzer, Anel Petzer, Daniela Vullo, Gabriele Costantino, Patrizio Blandina, Andrea Angeli, Claudiu T. Supuran
Summary: This study reported the synthesis of β-arylchalcogeno amines with structural similarity to amphetamine, which showed good activation properties for certain enzymes in the brain. In vivo evaluation demonstrated the procognitive effects of these compounds without causing unwanted side effects. These findings suggest the potential utility of these compounds for improving cognitive decline associated with neurodegenerative and psychiatric diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ozlem Akgul, Srishti Singh, Jacob T. Andring, Robert McKenna, Silvia Selleri, Fabrizio Carta, Andrea Angeli, Claudiu T. Supuran
Summary: A series of taurine substituted sulfonamide derivatives with ureido moiety at the tail section were synthesized as selective inhibitors of tumor associated human Carbonic Anhydrase (CA) IX and XII. These derivatives showed a strong dependence on the presence of ureido moiety and demonstrated highly stabilized ligand-protein complex with specific amino acid residues in both hCA II and hCA IX-mimic.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zhuang Hu, Ruihan Li, Xinyue Cui, Changjun Hu, Zilin Chen
Summary: Osteosarcoma (OS) is a common and deadly carcinoma of the skeletal system. Detecting the tumor early and implementing effective interventional therapies can improve limb salvage and overall survival rates. Carbonic anhydrase IX (CA IX) is an important functional protein in tumor acidification and is considered a potential biomarker. This study developed a pH-sensitive near-infrared imaging probe called ABSi-783 by combining the CA IX inhibitor ABSi with IR783. The probe has high selectivity for osteosarcoma imaging, can detect pH changes in vitro, and has demonstrated potential for targeted diagnosis and surgical treatment monitoring of osteosarcoma.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Oncology
Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek
Summary: Hypoxia in the tumor microenvironment is a major factor in cancer progression, and low levels of oxygen may indicate treatment failure. Carbonic anhydrase IX (CA IX) is a precise target in hypoxic tumors, and its presence contributes to the failure of standard therapy. Humanized antibodies against CA IX show promise as suitable therapies for hypoxic tumors, with the ability to modulate the tumor microenvironment, induce an immune response, and block metastasis formation.
CANCER & METABOLISM
(2022)
Review
Energy & Fuels
Shumin Ni, Weifeng Lv, Zemin Ji, Kai Wang, Pal ostebo Andersen
Summary: This paper comprehensively explores the research and prospective advancements in CO2 mineralization sequestration within Chinese oil and gas reservoirs, providing a detailed review of the mechanisms involved in CO2 mineralization and sequestration. Special emphasis is placed on microbial metabolic activities and the presence of carbonic anhydrase within oil and gas reservoirs, which drive the front of carbon dioxide mineralization. The pivotal role of carbonic anhydrase in catalyzing carbon dioxide hydration, promoting carbonate mineralization, and facilitating efficient, stable sequestration is analyzed in-depth.
Review
Chemistry, Medicinal
Shubham Kumar, Sandeep Rulhania, Shalini Jaswal, Vikramdeep Monga
Summary: Carbonic anhydrase is an important enzyme involved in various physiological and pathological processes, with 16 different isoforms in humans. Inhibitors targeting different isoforms of carbonic anhydrase have clinical applications in treating various diseases, but current drugs lack selectivity leading to undesired side effects. Efforts are being made to develop novel isoform-selective inhibitors of carbonic anhydrase for therapeutic implications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Wen Zhou, Chunping Wang, Bin Zhang, Shaohua Gou
Summary: In order to effectively attenuate myocardial injury caused by hypoxic and inflammatory injury, researchers designed and synthesized a kind of anti-inflammatory compounds by coupling cyclooxygenase and carbonic anhydrase inhibitors. The compounds were found to be structurally stable and had two enzymatic inhibition activities. By inhibiting the overexpression of carbonic anhydrase under hypoxia, the compounds can regulate the acidic microenvironment to inhibit hypoxic injury and improve the anti-inflammatory effect of the cyclooxygenase inhibitor. This study provides a new strategy for the treatment of cardiac inflammation accompanied by hypoxia.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Victor Marchenkov, Natalya Ryabova, Vitaly Balobanov, Anatoly Glukhov, Nelly Ilyina, Natalya Katina
Summary: The study reveals that bovine carbonic anhydrase B forms amyloid fibrils under acidic pH and elevated temperature conditions. Prior to amyloid formation, BCAB undergoes fragmentation by acid hydrolysis to give peptides, with associated peptides containing a pronounced secondary structure acting as the main precursor of amyloid fibrils.
Article
Chemistry, Multidisciplinary
Ji Hyeon Kim, Peter Verwilst, Miae Won, Junhyoung Lee, Jonathan L. Sessler, Jiyou Han, Jong Seung Kim
Summary: Breast cancer stem cells (BCSCs) are a major contributor to the unfavorable outcomes seen in many breast cancer patients, as they are more prevalent in hypoxic environments and refractory to traditional chemotherapy. A small molecule construct named AzCDF has been developed to target BCSCs effectively in the hypoxic tumor environment, reducing tumor growth and migration. This is the first time a CSC-targeting small molecule has been shown to prevent tumorigenesis in an animal model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Wagdy M. Eldehna, Mahmoud A. El Hassab, Nahla A. Abdelshafi, Rana A. Eissa, Nadeen H. Diab, Ekram H. Mohamed, Mamdouh A. Oraby, Sara T. Al-Rashood, Rana G. Eissa, Zainab M. Elsayed, Alessio Nocentini, Claudiu T. Supuran, Mahmoud Elsabahy, Noura G. Eissa
Summary: In this study, a selective inhibitor for human CA isoforms IX and XII was incorporated into nanosized niosomes to enhance its antitumor activity. In a mice model of Ehrlich ascites solid tumor, administration of the niosomes loaded with the inhibitor exhibited superior antitumor activity compared to the free drug, as evidenced by reduced tumor weight and volume, decreased activity of CA IX and XII, and suppression of HIF-1 alpha and MMP-2. Furthermore, there was an increase in caspase 3 activity and a decrease in VEGF immune expression in the treated animals.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Marta Meneghello, Ana Rita Oliveira, Aurore Jacq-Bailly, Ines A. C. Pereira, Christophe Leger, Vincent Fourmond
Summary: Mo/W formate dehydrogenases catalyze the reversible reduction of CO2 to formate, and it has been definitively demonstrated through an electrochemical method that the substrate is indeed CO2, not a hydrated species like HCO3-.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Xiaojing Huang, Daniel Winter, Dominic. J. J. Glover, Claudiu. T. T. Supuran, William. A. A. Donald
Summary: Carbonic anhydrases (CAs) are metalloenzymes that play important roles in cellular processes and have been implicated in various diseases. Phosphorylation, a common post-translational modification of CAs, can significantly impact their catalytic activity and drug-binding capabilities. This study highlights the potential regulatory role of phosphorylation in CA activity and its effect on small molecule drug binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Baofeng Zhang, Chuguo Zhang, Wei Yuan, Ou Yang, Yuebo Liu, Lixia He, Yuexiao Hu, Linglin Zhou, Jie Wang, Zhong Lin Wang
Summary: This study proposes a self-charging marine power system that utilizes a conductive polymer with hollow morphology and seawater to achieve stable high power density and energy density, overcoming the challenges of corrosion and environmental friendliness.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jiajia Han, Yawei Feng, Pengfei Chen, Xi Liang, Hao Pang, Tao Jiang, Zhong Lin Wang
Summary: Wind energy is seen as a renewable and sustainable source, and an improved rotary triboelectric nanogenerator using rabbit fur-based soft-contact has been designed to harvest low-speed wind energy. The generator has shown potential in addressing energy consumption and environmental deterioration issues.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Wenjie Yan, Yuan Liu, Pengfei Chen, Leo N. Y. Cao, Jie An, Tao Jiang, Wei Tang, Baodong Chen, Zhong Lin Wang
Summary: A flexible film-discharge-switch (FDS) is developed as a key component in the power management system (PMS) of Triboelectric nanogenerators (TENGs), enabling enhanced charging for all four operation modes of TENG. The FDS exhibits high flexibility, stability, and self-driven design, making it suitable for versatile applications.
ADVANCED ENERGY MATERIALS
(2022)
Article
Energy & Fuels
Ou Yang, Chuguo Zhang, Baofeng Zhang, Lixia He, Wei Yuan, Yuebo Liu, Xinyuan Li, Linglin Zhou, Zhihao Zhao, Jie Wang, Zhong Lin Wang
Summary: In this study, an energy harvesting device was designed to improve the energy harvesting efficiency by coupling an adaptive rotating triboelectric nanogenerator (AR-TENG) with a thermoelectric generator (ThEG). The results showed that the energy storage velocity of the whole device charging supercapacitor was improved by almost 28 times.
Article
Chemistry, Multidisciplinary
Kaveh Barri, Qianyun Zhang, Isaac Swink, Yashar Aucie, Kyle Holmberg, Ryan Sauber, Daniel T. Altman, Boyle C. Cheng, Zhong Lin Wang, Amir H. Alavi
Summary: This paper discusses the unmet need for smart medical implants and proposes the concept of self-aware implants to create a new generation of multifunctional metamaterial implantable devices. The integration of nano energy harvesting and mechanical metamaterial design paradigms enables these implants to respond to their environment, empower themselves, and self-monitor their condition.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Yang Jiang, Jie An, Fei Liang, Guoyu Zuo, Jia Yi, Chuan Ning, Hong Zhang, Kai Dong, Zhong Lin Wang
Summary: This paper presents a self-powered sitting position monitoring vest based on triboelectric nanogenerators (TENGs) that achieve accurate real-time posture recognition. The vest utilizes a knitted structure and sensor arrays to recognize different sitting postures and provide feedback, while ensuring comfortability during long-term wearing.
Article
Polymer Science
Lamis Ahmed Aboelmagd, Emad Tolba, Zeinab Ahmed AbdelAziz
Summary: Functional cotton fabrics with silver-based nanoparticles (AgNPs) have been developed using chitosan and chitosan-organosilica solutions as adhesives. The cotton fabrics treated with chitosan-organosilica/AgNPs solution showed good stability against washing and maintained high antimicrobial activity even after multiple laundering cycles.
Article
Materials Science, Multidisciplinary
Werner E. G. Mueller, Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Veronica Ferrucci, Massimo Zollo, Rongwei Tan, Heinz C. Schroeder, Xiaohong Wang
Summary: The polyP hydrogel formulation can accelerate the healing of chronic wounds and provide more metabolic energy by encapsulating and killing bacteria.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mousa AlTarabeen, Qosay Al-Balas, Amgad Albohy, Werner Ernst Georg Mueller, Peter Proksch
Summary: Manzamines are a group of compounds extracted from Acanthostrongylophora ingens species. We have identified and characterized seven compounds. Based on previous screening work by Mayer et al., who suggested that manzamine A could be an inhibitor of RSK1 kinase, our work focused on targeting the RSK1 N-terminal kinase domain. Docking using Autodock Vina software showed that Manzamine A N-oxide (5) exhibited the highest activity with an IC50 value of 3.1 μM.
Article
Pharmacology & Pharmacy
Shunfeng Wang, Meik Neufurth, Hadrian Schepler, Rongwei Tan, Zhending She, Bilal Al-Nawas, Xiaohong Wang, Heinz C. Schroeder, Werner E. G. Mueller
Summary: Amorphous calcium carbonate (ACC) precipitated in the presence of inorganic polyphosphate (polyP) has shown potential as a material for bone regeneration. ACC center dot PP particles, stabilized by polyP, have enzymatic activity that promotes the transformation of ACC into crystalline polymorphs. In experiments conducted in vitro and in vivo, ACC center dot PP was found to stimulate cell migration and accelerate wound healing, particularly in chronic wounds.
Article
Polymer Science
Ahmed Salama, Safaa Saleh, Ragab E. Abou-Zeid, Engy M. Akl, Emad Tolba
Summary: Biocompatible polymers are used to manufacture surgical implants that can degrade in the body without requiring additional removal surgery. In this study, flaxseed mucilage was used to prepare composite scaffolds made of calcium phosphate embedded in the mucilage matrix. The scaffolds were characterized and found to consist of mucilage/dicalcium phosphate dihydrate and mucilage/hydroxyapatite phases. Cell viability tests showed that the hybrids formed at different pH conditions were non-cytotoxic, indicating the potential of the developed composite as a bone graft substitute material.
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.