Article
Genetics & Heredity
Abudureyimu Shajidan, Abulaiti Palida, Hui Li, Zhi Xing, Shasha Liu, Wen Li, Ying Gao
Summary: The study evaluated the roles of endothelial lipase gene (LIPG) related SNPs in patients with coronary artery disease (CAD), finding that the CC + AC genotype in rs3813082 was protective for CAD, while rs3744843, rs3744841, and rs2000813 variants were associated with lipid parameters and vascular stenosis in CAD patients. The results provide a promising reference for preventing CAD.
Article
Health Care Sciences & Services
In-Jai Kim, Jeong-Yong Lee, Hyeon-Woo Park, Han-Sung Park, Eun-Ju Ko, Jung-Hoon Sung, Nam-Keun Kim
Summary: The study suggests that HOTAIR gene polymorphisms may serve as novel biomarkers for diagnosing coronary artery disease (CAD) and are closely associated with CAD susceptibility. Variations in genetic polymorphisms, genotype combinations, and haplotype analysis of HOTAIR are linked to disease occurrence and clinical factors contributing to disease susceptibility.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Maria Ganopoulou, Theodoros Moysiadis, Anastasios Gounaris, Nikolaos Mittas, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Georgios Sianos, Ioannis S. Vizirianakis, Lefteris Angelis
Summary: Due to recent technological progress, a large amount of accumulated data has emerged in various scientific fields, posing new challenges in leveraging this data for valuable insights. Causal models are effective tools for revealing the causal relationships between variables, enabling experts to better understand these relationships and potentially uncover new knowledge. A study on 963 patients with coronary artery disease examined the robustness of the causal structure of single nucleotide polymorphisms, taking into account the Syntax Score, which evaluates the complexity of the disease. The study found that the causal structure was more robust under milder interventions, but the impact increased with stronger interventions, and the local causal structure around the Syntax Score remained resilient even under strong interventions.
Review
Cardiac & Cardiovascular Systems
Konstantinos Agiannitopoulos, Pinelopi Samara, Miranta Papadopoulou, Astradeni Efthymiadou, Eirini Papadopoulou, Georgios N. Tsaousis, George Mertzanos, Dimitrios Babalis, Klea Lamnissou
Summary: The study found that miR196a2 C>T (rs11614913) and miR499 A>G (rs3746444) polymorphisms, as well as the miR146C-miR149C-miR196T-miR499G allele combination, are closely associated with the risk for developing CAD and MI in the Greek population.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Tomasz Iwanicki, Joanna Iwanicka, Anna Balcerzyk-Matic, Tomasz Nowak, Katarzyna Mizia-Stec, Pawel Banka, Artur Filipecki, Jolanta Krauze, Alicja Jarosz, Sylwia Gorczynska-Kosiorz, Anna Ochalska-Tyka, Iwona Zak, Pawel Niemiec
Summary: The rs1729410 polymorphism at the 11q23.3 locus increases the risk of coronary artery disease in synergy with traditional risk factors, while the rs10750097 polymorphism at the 11q23.3 locus affects the risk of death in patients with coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Soudeh Ghafouri-Fard, Mahdi Gholipour, Mohammad Taheri
Summary: miRNAs play a crucial role in the pathophysiological process of CAD, with up-regulated and down-regulated miRNAs associated with the development of CAD, which can be utilized for diagnostic and prognostic evaluation of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medical Laboratory Technology
Susu Jin, Xiujing Liu, Yingying Wang, Jian Yu, Minghua Jiang
Summary: The study identified the association between IL-32 and coronary artery disease, the independent correlation between IL-32 levels and CAD susceptibility, and suggested the potential of using IL-32 levels to indicate coronary artery stenosis and the efficacy of PCI.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Neurosciences
Soraya Herrera-Espejo, Borja Santos-Zorrozua, Paula Alvarez-Gonzalez, Idoia Martin-Guerrero, Marian M. de Pancorbo, Africa Garcia-Orad, Elixabet Lopez-Lopez
Summary: This study identified four SNPs in miRNAs associated with LOAD risk, with in silico analyses supporting a potential functional effect of these SNPs on miRNA levels and regulation of pathways relevant to LOAD development. Additional studies are needed to validate these findings.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yongyan Song, Shujin Li, Chuan He
Summary: Activated by ligands, PPAR gamma plays a role in enhancing insulin sensitivity, promoting adipocyte differentiation, and possessing anti-atherosclerosis, anti-inflammation, and anti-oxidation properties. Polymorphisms in the PPARG gene have been associated with coronary artery disease, possibly through affecting PPARG gene expression and PPAR gamma protein function, leading to metabolic disorders and increased susceptibility to CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Anna Kablak-Ziembicka, Rafal Badacz, Tadeusz Przewlocki
Summary: MicroRNAs (miRs) play important roles in the diagnosis, prognosis and treatment of atherosclerotic cardiovascular disease, a globally significant condition affecting a wide range of clinical cases. Studying the expression of miRs in CAD and ACS can provide clinicians with vital information.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Maria Bergami, Natalia Fabin, Edina Cenko, Raffaele Bugiardini, Olivia Manfrini
Summary: Coronary artery disease (CAD) is a major cause of global mortality, and there is a need for novel diagnostic biomarkers and therapeutic targets. Recent evidence suggests a link between dysregulated miRNAs and cardiovascular diseases, including CAD. miRNAs have potential as diagnostic and prognostic biomarkers, and are involved in regulating multiple pathways that contribute to atherosclerotic plaque development. miRNAs are stable and easily detectable, making them attractive as biomarkers for cardiovascular disease diagnosis and prognosis.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Moomal Sarosh, Syed Muhammad Nurulain, Syed Tahir Abbas Shah, Muhammad Jadoon Khan, Zahid Muneer, Nazia Bibi, Syed Fawad Ali Shah, Sabir Hussain
Summary: This study reveals a significant association between ATG7 gene polymorphisms and coronary artery disease in the Pakistani population, highlighting novel risk factors for the disease.
Article
Medicine, General & Internal
Xingzhu Liu, Yanfei Chen, Yanfei Yang, Zhongjian Su, Feng Wang, Chenghao Zhanghuang, Yuqin Wu, Xing Zhang
Summary: This study investigated the correlation between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease. The concentrations of serum MMPs and FG-α were significantly higher in KD patients, suggesting that FGA gene polymorphisms affect coronary artery lesion in children with KD.
FRONTIERS IN MEDICINE
(2023)
Article
Genetics & Heredity
Qi Liu, Danyan Li, Yunkai Dai, Yunzhan Zhang, Shaoyang Lan, Qi Luo, Jintong Ye, Xu Chen, Peiwu Li, Weijing Chen, Ruliu Li, Ling Hu
Summary: This study aimed to investigate the relationship between miR-146a, miR-196a2, miR-149, miR-499, and miR-27a gene single nucleotide polymorphisms (SNPs) and their expressions with pathological changes in gastric mucosa, and to further analyze the interactions between SNPs and Hp. The results showed that miR-196a2 rs11614913 and miR-27a rs895819 may affect the genetic susceptibility to gastric precancerous lesions (GPL) or gastric cancer (GC). The up-regulation of miR-499, miR-196a2, and miR-27a expression caused by Hp infection may be an important mechanism of gastric carcinogenesis.
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Aybike Sena Ozuynuk, Aycan Fahri Erkan, Nazli Dogan, Berkay Ekici, Nihan Erginel-Unaltuna, Ozge Kurmus, Neslihan Coban
Summary: The study found that APOE and CLU gene polymorphisms have a significant impact on the prevalence of CAD and T2DM, as well as lipid and glucose metabolism. The 82 and 84 isoforms of apoE were associated with serum lipid levels, while CLU T allele carriers showed lower glycosylated hemoglobin levels in non-CAD subjects. Additionally, carriers of the 82 isoform had a lower risk for CAD combined with T2DM, and the combination of APOE 82 and CLU T allele carriers had decreased risk for CAD complexed with T2DM compared to non-carriers.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Silvia Pulignani, Cecilia Vecoli, Andrea Borghini, Ilenia Foffa, Lamia Ait-Ali, Maria Grazia Andreassi
PEDIATRIC CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Cecilia Vecoli, Andrea Borghini, Silvia Pulignani, Antonella Mercuri, Stefano Turchi, Clara Carpeggiani, Eugenio Picano, Maria Grazia Andreassi
Editorial Material
Cardiac & Cardiovascular Systems
Silvia Pulignani, Maria Grazia Andreassi
REVISTA ESPANOLA DE CARDIOLOGIA
(2019)
Article
Biology
Maurizio Portaluri, Maria Fonte Petruzzelli, Francesco Tramacere, Maria Grazia Andreassi
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Environmental Sciences
Maria Grazia Andreassi, Andrea Borghini, Cecilia Vecoli, Emanuela Piccaluga, Giulio Guagliumi, Maurizio Del Greco, Fiorenzo Gaita, Eugenio Picano
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2020)
Article
Biotechnology & Applied Microbiology
Michael Fenech, Siegfried Knasmueller, Lisbeth E. Knudsen, Micheline Kirsch-Volders, Permal Deo, Bernhard Franzke, Helga Stopper, Maria-Grazia Andreassi, Claudia Bolognesi, Varinderpal S. Dhillon, Blanca Laffon, Karl-Heinz Wagner, Stefano Bonassi
Summary: The purpose of the Micronuclei and Disease special issue is to investigate the association of micronuclei with various diseases in humans, define mechanisms of this association, and identify gaps in knowledge for translating micronuclei assays into clinical practice. The issue includes 14 papers covering topics such as mechanisms of micronuclei formation, associations with different diseases, effects of interventions on micronuclei frequency, and a roadmap for clinical application. Most studies reviewed were case-control studies, with meta-analyses showing different mean ratios for micronuclei frequencies in non-cancer diseases and cancers, indicating the potential of micronuclei assays in identifying high-risk patients for preventive therapy.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ivana Barravecchia, Chiara De Cesari, Mattia Forcato, Francesca Scebba, Olga Pyankova, Joanna M. Bridger, Helen A. Foster, Giovanni Signore, Andrea Borghini, Mariagrazia Andreassi, Massimiliano Andreazzoli, Silvio Bicciato, Mario Enrico Pe, Debora Angeloni
Summary: Microgravity and space radiation have distinct effects on human endothelial cells in space flight, triggering different molecular pathways and leading to specific changes in cell structure and function. Tailored countermeasures should be developed separately for microgravity and space radiation to protect astronauts' health effectively.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Biancamaria Pierri, Carlo Buonerba, Andrea Pierri, Antonio Pizzolante, Amedeo Ferro, Anna Crispo, Valentina Bollati, Tiffany R. Sanchez, Maria Grazia Andreassi, Mauro Esposito, Pellegrino Cerino
Summary: This study proposes a new biomonitoring model based on a whole systemic analytical evaluation of environmental context, aiming to evaluate the risk of exposure to environmental pollutants, predict potential correlated clinical outcomes, and support public health interventions. It combines healthy human subjects in the cohort to identify potential risks of exposure and predict possible correlated clinical outcomes, particularly focusing on areas with high levels of pollution like the Campania region.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Maria Grazia Andreassi, Nadia Haddy, Mats Harms-Ringdahl, Jonica Campolo, Andrea Borghini, Francois Chevalier, Jochen M. Schwenk, Brice Fresneau, Stephanie Bolle, Manuel Fuentes, Siamak Haghdoost
Summary: The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission with the aim of improving understanding of long-term ionizing radiation risks for pediatric patients. This paper provides a detailed overview of the project's rationale, design, and methods for the biological aspect, with objectives to understand the molecular pathways and identify potential biomarkers involved in long-term health risks. Biological samples will be collected at three time points, and state-of-the-art analytical methods will be used to assess biomarker levels and explore proteomics and miRNA transcriptomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maria Grazia Andreassi
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Borghini, Antonella Mercuri, Jonica Campolo, Marina Parolini, Rudina Ndreu, Stefano Turchi, Maria Grazia Andreassi
Summary: A strong relationship between Chr9p21 rs1333049 variant and LTL was identified, and they interactively affect the risk of poor prognosis in CAD patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jonica Campolo, Andrea Borghini, Marina Parolini, Antonella Mercuri, Stefano Turchi, Maria Grazia Andreassi
Summary: Clinical and epidemiological evidence suggests a link between coronary artery disease (CAD) and cancer. This study aimed to identify risk factors and biomarkers that could predict cancer incidence and death in CAD patients. The study found that age, smoking, obesity, and systemic inflammatory indexes were associated with cancer incidence, while age was a predictor of cancer death. Lung and gastrointestinal cancer patients had higher levels of a specific biomarker. The study suggests that reducing risk factors and suppressing chronic inflammation may help prevent cancer in CAD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Maria Fonte Petruzzelli, Maria Pia Vasti, Angelo Errico, Rosa D'Agostino, Francesco Tramacere, Emilio A. L. Gianicolo, Santa Bambace, Maria Grazia Andreassi, Eugenio Picano, Maurizio Portaluri
ANNALI DELL ISTITUTO SUPERIORE DI SANITA
(2018)
Article
Cardiac & Cardiovascular Systems
Silvia Pulignani, Andrea Borghini, Cecilia Vecoli, Ilenia Foffa, Lamia Ait-Ali, Maria Grazia Andreassi
CARDIOVASCULAR TOXICOLOGY
(2018)
