Article
Obstetrics & Gynecology
R. A. Thompson, J. M. D. Thompson, J. Wilson, R. S. Cronin, E. A. Mitchell, C. H. Raynes-Greenow, M. Li, T. Stacey, A. E. P. Heazell, L. M. O'Brien, L. M. E. McCowan, N. H. Anderson
Summary: Through analyzing data from previous studies, independent and novel risk factors for late-preterm (28-36 weeks) and term (≥37 weeks) stillbirth were identified, and the development of a risk-prediction model was explored. The results showed that fetal movement changes, poor antenatal care utilization, and the adequacy of care were associated with stillbirth. These findings are valuable in the risk assessment of late-stillbirth.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Health Care Sciences & Services
Darsy Darssan, Gita D. Mishra, Darren C. Greenwood, Sven Sandin, Eric J. Brunner, Sybil L. Crawford, Samar R. El Khoudary, Maria Mori Brooks, Ellen B. Gold, Mette Kildevaeld Simonsen, Hsin-Fang Chung, Elisabete Weiderpass, Annette J. Dobson
Summary: Methods for meta-analysis of studies with individual participant data and continuous exposure variables are demonstrated in this study. A two-stage process is used to estimate response curves for each study and average them pointwise over all studies at each value of the exposure. Real data samples and code are provided for result replication.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Oncology
Emma Copland, Dexter Canoy, Milad Nazarzadeh, Zeinab Bidel, Rema Ramakrishnan, Mark Woodward, John Chalmers, Koon K. Teo, Carl J. Pepine, Barry R. Davis, Sverre Kjeldsen, Johan Sundstrom, Kazem Rahimi
Summary: This study found no consistent evidence linking antihypertensive medication use to cancer risk, providing reassurance to clinical practice. However, evidence for some comparisons was insufficient to entirely rule out excess risk, particularly for calcium channel blockers.
Article
Psychiatry
Lamprini Syrogiannouli, Lea Wildisen, Christiaan Meuwese, Douglas C. Bauer, Anne R. Cappola, Jacobijn Gussekloo, Wendy P. J. den Elzen, Stella Trompet, Rudi G. J. Westendorp, J. Wouter Jukema, Luigi Ferrucci, Graziano Ceresini, Bjorn O. Asvold, Layal Chaker, Robin P. Peeters, Misa Imaizumi, Waka Ohishi, Bert Vaes, Henry Voelzke, Jose A. Sgarbi, John P. Walsh, Robin P. F. Dullaart, Stephan J. L. Bakker, Massimo Iacoviello, Nicolas Rodondi, Cinzia Del Giovane
Summary: In non-randomized studies, imbalance of baseline values may introduce bias to the study and meta-analysis estimates. This study compared different methods to account for baseline values of outcome variables in IPD-MA of NRSs. The results showed that ANCOVA provided the most precise estimates, and ANCOVA and change score methods were similar when groups were well-balanced at baseline.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Stevan Nikolin, Adriano Moffa, Lais Razza, Donel Martin, Andre R. Brunoni, Ulrich Palm, Frank Padberg, Djamila Bennabi, Emmanuel Haffen, Daniel M. Blumberger, Mohammad Ali Salehinejad, Colleen K. Loo
Summary: Prefrontal transcranial direct current stimulation (tDCS) shows promise as an effective treatment for depression. Factors influencing treatment and the time-course of symptom improvements were explored using data from ten randomised controlled trials of tDCS in depression. The study found that tDCS effect sizes peaked at approximately 6 weeks and continued to diverge from sham up to 10 weeks, with significant predictors associated with treatment response being baseline depression severity and bipolar disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Microbiology
David T. J. Broderick, David W. Waite, Robyn L. Marsh, Carlos A. Camargo, Paul Cardenas, Anne B. Chang, William O. C. Cookson, Leah Cuthbertson, Wenkui Dai, Mark L. Everard, Alain Gervaix, J. Kirk Harris, Kohei Hasegawa, Lucas R. Hoffman, Soo-Jong Hong, Laurence Josset, Matthew S. Kelly, Bong-Soo Kim, Yong Kong, Shuai C. Li, Jonathan M. Mansbach, Asuncion Mejias, George A. O'Toole, Laura Paalanen, Marcos Perez-Losada, Melinda M. Pettigrew, Maxime Pichon, Octavio Ramilo, Lasse Ruokolainen, Olga Sakwinska, Patrick C. Seed, Christopher J. van der Gast, Brandie D. Wagner, Hana Yi, Edith T. Zemanick, Yuejie Zheng, Naveen Pillarisetti, Michael W. Taylor
Summary: In this study, a meta-analysis of individual participant data from 20 studies involving 2624 children revealed that respiratory diseases were associated with decreased bacterial diversity in nasal and lower airway samples, as well as higher abundance of specific nasal taxa including Streptococcus and Haemophilus. Machine learning showed varying success rates in assigning samples to diagnostic groupings depending on the anatomical site, with positive predictive value ranging from 43 to 100 and sensitivity ranging from 8 to 99%.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Health Care Sciences & Services
Yin Wu, Ying Sun, Yi Liu, Brooke Levis, Ankur Krishnan, Chen He, Dipika Neupane, Scott B. Patten, Pim Cuijpers, Roy C. Ziegelstein, Andrea Benedetti, Brett D. Thombs
Summary: By analyzing the data sets from the DEPRESsion Screening Data project, this study identified factors associated with data contribution, which can help promote data contribution to IPDMAs in the future.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Andrew Clegg, Karen Bandeen-Roche, Amanda Farrin, Anne Forster, Thomas M. Gill, John Gladman, Ngaire Kerse, Richard Lindley, Richard J. McManus, Rene Melis, Ruben Mujica-Mota, Parminder Raina, Kenneth Rockwood, Ruth Teh, Danielle van der Windt, Miles Witham
Summary: Meta-analyses based on individual participant data have the potential to provide more comprehensive insights into the effectiveness of interventions in aging research. However, the challenges lie in the complexity and resources needed for data collection and management. Establishing an international collaboration among trialists in aging research could facilitate the use of individual participant data meta-analysis and contribute to evidence-based care for older people.
Article
Oncology
Lonneke A. van Tuijl, Maartje Basten, Kuan-Yu Pan, Roel Vermeulen, Luetzen Portengen, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Femke Lamers, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Trynke R. de Jong, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W. J. H. Penninx, Ina Rissanen, Annelieke M. Roest, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W. M. Monique Verschuren, Kimberly D. van der Willik, Judith G. M. Rosmalen, Adelita V. Ranchor
Summary: A meta-analysis of individual participant data from 18 cohorts found no associations between depression or anxiety and most types of cancer, except for lung cancer and smoking-related cancers. The associations with lung and smoking-related cancers were attenuated when adjusting for known risk factors.
Article
Clinical Neurology
Areti Angeliki Veroniki, Georgios Seitidis, Georgios Tsivgoulis, Aristeidis H. Katsanos, Dimitris Mavridis
Summary: Meta-analysis, using individual participant data (IPD-MA) from randomized controlled trials (RCTs), is considered the gold standard approach that strengthens evidence for decision making. This study highlights the importance, properties, and main approaches of conducting an IPD-MA, with examples illustrating its benefits over traditional aggregate data (AD) meta-analysis. IPD-MA allows for standardization, reanalysis, accounting for missing data, detecting outliers, exploring intervention-by-covariate interactions, and tailoring effects to participant characteristics. However, retrieval of IPD from original RCTs is a key limitation that requires careful planning of time and resources.
Article
Allergy
Eleanor Van Vogt, Suzie Cro, Victoria R. Cornelius, Hywel C. Williams, Lisa M. Askie, Rachel Phillips, Maeve M. Kelleher, Robert J. Boyle
Summary: Using individual participant data (IPD) meta-analysis can improve the certainty of evidence, safety outcomes, subgroup analysis, and adherence analysis compared to aggregate data meta-analysis.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Review
Endocrinology & Metabolism
Fengze Nie, Jiaan He, Hui Cao, Xinhua Hu
Summary: This meta-analysis found that abnormal ankle brachial index (ABI) is associated with a higher risk of cardiovascular or all-cause mortality and major adverse cardiovascular events (MACEs) in patients with diabetes. The predictive role of abnormal ABI is largely dominated by the low ABI rather than the high ABI.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Psychiatry
Wilson Baldin Depress Med Students Res Grp, Wilson Baldin Zatt, Kenneth Lo, Wilson Tam
Summary: This study aimed to improve the precision of previous research on the prevalence of depressive symptoms among medical students by gathering individual participant data (IPD). The findings showed that the pooled prevalence obtained from IPD meta-analysis was lower compared to previous meta-analyses using aggregated data. Age, sex, and year of study were significantly associated with the depression z-score.
Article
Mathematical & Computational Biology
Balint Tamasi, Michael Crowther, Milo Alan Puhan, Ewout W. Steyerberg, Torsten Hothorn
Summary: This study introduces a new model class for meta-analysis of individual participant data (IPD) that incorporates general normally distributed random effects into linear transformation models and can handle data with arbitrary random censoring patterns. The proposed method shows efficiency in predicting the survival of patients with chronic obstructive pulmonary disease, compared to alternative approaches. Simulation study confirms the correctness of the implementation and highlights the efficiency of the proposed method.
Article
Cardiac & Cardiovascular Systems
Engelbert A. Nonterah, Nigel J. Crowther, Kerstin Klipstein-Grobusch, Abraham R. Oduro, Maryam Kavousi, Godfred Agongo, Todd J. Anderson, Gershim Asiki, Palwende R. Boua, Solomon S. R. Choma, David J. Couper, Gunnar Engstrom, Jacqueline de Graaf, Jussi Kauhanen, Eva M. Lonn, Ellisiv B. Mathiesen, Lisa K. Micklesfield, Shuhei Okazaki, Joseph F. Polak, Tatjana Rundek, Jukka T. Salonen, Stephen M. Tollman, Tomi-Pekka Tuomainen, Diederick E. Grobbee, Michele Ramsay, Michiel L. Bots
Summary: The association between established cardiovascular risk factors and carotid-intima media thickness (CIMT) differs across racial or ethnic groups, which may be due to lifestyle risk factors and genetics. These differences have implications for developing race-ethnicity-specific primary prevention strategies and understanding the pathogenesis of cardiovascular disease. Further investigations are needed to explore the burden of subclinical atherosclerosis in African American individuals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Mari S. Oba, Yoshitaka Murakami, Michihiro Satoh, Takahisa Murakami, Mami Ishikuro, Taku Obara, Kazuhiko Hoshi, Yutaka Imai, Takayoshi Ohkubo, Hiroto Metoki
Summary: The study investigated the trimester-specific direct effects of low gestational weight gain (GWG) in Japanese women on birthweight, identifying that insufficient weight gain in the second and third trimesters had a negative impact on birthweight.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Peripheral Vascular Disease
Jesus D. Melgarejo, Wen-Yi Yang, Lutgarde Thijs, Yan Li, Kei Asayama, Tine W. Hansen, Fang-Fei Wei, Masahiro Kikuya, Takayoshi Ohkubo, Eamon Dolan, Katarzyna Stolarz-Skrzypek, Qi-Fang Huang, Valerie Tikhonoff, Sofia Malyutina, Edoardo Casiglia, Lars Lind, Edgardo Sandoya, Jan Filipovsky, Natasza Gilis-Malinowska, Krzysztof Narkiewicz, Kalina Kawecka-Jaszcz, Jose Boggia, Ji-Guang Wang, Yutaka Imai, Thomas Vanassche, Peter Verhamme, Stefan Janssens, Eoin O'Brien, Gladys E. Maestre, Jan A. Staessen, Zhen-Yu Zhang
Summary: This study found a close association between 24-hour mean arterial pressure and major adverse cardiovascular events, with higher 24-hour systolic blood pressure increasing risk and higher 24-hour diastolic blood pressure reducing risk. Using thresholds for 24-hour mean arterial pressure in conjunction with systolic and diastolic blood pressure can refine risk estimates.
Article
Public, Environmental & Occupational Health
Megumi Tsubota-Utsugi, Jun Watanabe, Jun Takebayashi, Tomoyuki Oki, Yoshitaka Tsubono, Takayoshi Ohkubo
Summary: This study constructed an AOC database of foods representative of the typical Japanese diet, clarifying rice and seafood as the main contributors to AOC intake in the overall Japanese diet. Further research is expected to shed light on the association between food-derived AOC and its role in preventing or ameliorating lifestyle-related diseases.
JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Physiology
Sundararajan Venkatesh, Erdene Baljinnyam, Mingming Tong, Toshihide Kashihara, Lin Yan, Tong Liu, Hong Li, Lai-Hua Xie, Michinari Nakamura, Shin-ichi Oka, Carolyn K. Suzuki, Diego Fraidenraich, Junichi Sadoshima
Summary: The study found that in human induced pluripotent stem cell-derived cardiomyocytes differentiated from human heart cells, an increase in mitochondrial proteins regulates metabolic pathways such as fatty acid oxidation, potentially through regulators like LonP1, IR, and Rb1. These findings may help optimize the maturation of iPSC-CMs.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Review
Peripheral Vascular Disease
Kei Asayama, Takayoshi Ohkubo, Yutaka Imai
Summary: Accurate blood pressure measurement is essential for the diagnosis and treatment of hypertension. Validation of blood pressure measurement devices is crucial, and clinical guidelines should be region-specific. Out-of-office blood pressure measurements are widely recommended in global guidelines to ensure timely and accurate evidence for hypertension.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Shingo Nakayama, Michihiro Satoh, Yukako Tatsumi, Takahisa Murakami, Tomoko Muroya, Takuo Hirose, Takayoshi Ohkubo, Takefumi Mori, Atsushi Hozawa, Hirohito Metoki
Summary: The study found that both high and low levels of serum uric acid were identified as risk factors for chronic kidney disease incidence in middle-aged men and women. The association between serum uric acid levels and the increase in the risk of chronic kidney disease incidence differed by sex, and the range of serum uric acid levels associated with an increase in the risk of chronic kidney disease incidence varied by sex.
Article
Rheumatology
Hideyo Tsutsui, Hirotoshi Kikuchi, Hiroko Oguchi, Hajime Kono, Takayoshi Ohkubo
Summary: This study confirmed the validity and reliability of the BD-checklist 92. The number of problem categories in the BD-checklist 92 correlated significantly with all dimensions of the SF-36 questionnaire. Construct validity showed that the number of manifestations experienced and specific lesions contributed to an increased number of problems associated with BD.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mingming Tong, Toshiro Saito, Peiyong Zhai, Shin-Ichi Oka, Wataru Mizushima, Michinari Nakamura, Shohei Ikeda, Akihiro Shirakabe, Junichi Sadoshima
Summary: The study found that during the chronic phase of obesity-associated cardiomyopathy, mitophagy is activated even after conventional autophagy is downregulated, serving as an essential mitochondrial quality control mechanism to protect the heart.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Lisa C. Heather, Anne D. Hafstad, Ganesh V. Halade, Romain Harmancey, Kimberley M. Mellor, Paras K. Mishra, Erin E. Mulvihill, Miranda Nabben, Michinari Nakamura, Oliver J. Rider, Matthieu Ruiz, Adam R. Wende, John R. Ussher
Summary: Diabetes is a significant risk factor for cardiovascular diseases, and various models have been used to study its mechanisms and impacts. This review aims to provide information on the accuracy of different models in reproducing cardiovascular disease in diabetic individuals, highlighting their advantages, disadvantages, practical challenges, and technical considerations.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Aya Hirata, Tomonori Okamura, Takumi Hirata, Daisuke Sugiyama, Takayoshi Ohkubo, Nagako Okuda, Yoshikuni Kita, Takehito Hayakawa, Aya Kadota, Keiko Kondo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
Summary: There is a U-shaped association between non-fasting triglycerides and fatal cardiovascular disease events in the general population in Japan.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Erina Eto, Yasutaka Maeda, Noriyuki Sonoda, Naoki Nakashima, Kunihisa Kobayashi, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguchi
Summary: This study found an association between serum total bilirubin levels and the progression of diabetic nephropathy and end-stage kidney disease. Patients with lower bilirubin levels were more likely to experience progressive renal decline and end-stage kidney disease. Serum total bilirubin levels may be useful in identifying high-risk patients for end-stage kidney disease.
Article
Multidisciplinary Sciences
Yukihiro Inoguchi, Toyoshi Inoguchi, Tomoaki Eto, Mitsunori Masakado, Satoru Suehiro, Teruaki Yamauchi, Fumio Umeda
Summary: The study suggests that serum indirect bilirubin levels may be associated with decreased skeletal muscle mass in older male patients with type 2 diabetes.
Article
Public, Environmental & Occupational Health
Yiwei Liu, Aya Hirata, Tomonori Okamura, Daisuke Sugiyama, Takumi Hirata, Aya Kadota, Keiko Kondo, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
Summary: The impact of resting heart rate on cardiovascular disease mortality varies according to serum albumin levels in the general Japanese population.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mariko Aoyagi Keller, Chun-yang Huang, Andreas Ivessa, Sukhwinder Singh, Peter J. Romanienko, Michinari Nakamura
Summary: This study investigates the functional impact of the Bcl-xS gene in mice, showing that knockout mice develop cardiac hypertrophy and splenomegaly, suggesting that Bcl-xS plays a crucial role in maintaining the homeostasis of multiple organs.
Article
Public, Environmental & Occupational Health
Yiwei Liu, Tomonori Okamura, Aya Hirata, Yasunori Sato, Takehito Hayakawa, Aya Kadota, Keiko Kondo, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
Summary: This study found that smoking is associated with worse quality of life in long-term follow-up.
JOURNAL OF EPIDEMIOLOGY
(2023)