IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation

(2014) Graham A. Tynan et al.   DIABETES

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

(2013) Lee S. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monosodium Urate Activates Src/Pyk2/PI3 Kinase and Cathepsin Dependent Unconventional Protein Secretion From Human Primary Macrophages

(2013) Elina Välimäki et al.   MOLECULAR & CELLULAR PROTEOMICS

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

The IL-1-Dependent Sterile Inflammatory Response Has a Substantial Caspase-1-Independent Component That Requires Cathepsin C

(2012) H. Kono et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

(2011) A. Seubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59

(2011) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells

(2011) M. K. L. MacLeod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Quantifying Cathepsin S Activity in Antigen Presenting Cells Using a Novel Specific Substrate

(2008) Nicolas Lützner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA