Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry

(2015) Carolina Doerrier et al.   LIFE SCIENCES

The p65 subunit of NF-κB involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes

(2014) Luankun Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit

(2014) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

(2013) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Mitochondrial DNA and inflammatory diseases

(2011) Germaine Escames et al.   HUMAN GENETICS

Intracellular sensing of microbes and danger signals by the inflammasomes

(2011) Gabor L. Horvath et al.   IMMUNOLOGICAL REVIEWS

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: A pleiotropic molecule regulating inflammation

(2010) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice

(2010) Hiroko Tsutsui et al.   Gastroenterology Research and Practice

Sepsis and the heart

(2009) J.D. Hunter et al.   BRITISH JOURNAL OF ANAESTHESIA

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Autoregulatory feedback loops terminating the NF-κB response

(2009) Florian Renner et al.   TRENDS IN BIOCHEMICAL SCIENCES

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE