Effect of an 88-amino-acid deletion in nsp2 of porcine reproductive and respiratory syndrome virus on virus replication and cytokine responses in vitro

Effect of amino acids residues 323–433 and 628–747 in Nsp2 of representative porcine reproductive and respiratory syndrome virus strains on inflammatory response in vitro

(2015) Xing Liu et al.   VIRUS RESEARCH

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Genetic manipulation of a transcription-regulating sequence of porcine reproductive and respiratory syndrome virus reveals key nucleotides determining its activity

(2014) Haihong Zheng et al.   ARCHIVES OF VIROLOGY

Cytokines transcript levels in lung and lymphoid organs during genotype 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection

(2014) Obdulio García-Nicolás et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Genomic analysis and pathogenic characteristics of Type 2 porcine reproductive and respiratory syndrome virus nsp2 deletion strains isolated in Korea

(2014) Hwan-Won Choi et al.   VETERINARY MICROBIOLOGY

Comparative expression of Toll-like receptors and inflammatory cytokines in pigs infected with different virulent porcine reproductive and respiratory syndrome virus isolates

(2013) Lili Zhang et al.   Virology Journal

Evaluation of the Efficacy of an Attenuated Live Vaccine against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus in Young Pigs

(2012) Xue Leng et al.   Clinical and Vaccine Immunology

Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-κB and p38 MAPK pathways in porcine alveolar macrophages

(2012) Shuang Song et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

N-Linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus ReplicationIn Vivo

(2012) Zuzhang Wei et al.   JOURNAL OF VIROLOGY

Cytokine production in immortalized porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus

(2012) Yoo Jin Lee et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Stable expression of foreign gene in nonessential region of nonstructural protein 2 (nsp2) of porcine reproductive and respiratory syndrome virus: Applications for marker vaccine design

(2012) Yan-Zhao Xu et al.   VETERINARY MICROBIOLOGY

Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway

(2012) Jun Hou et al.   VIRUS RESEARCH

Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains

(2012) Susan L. Brockmeier et al.   VIRUS RESEARCH

Development of a differentiable virus via a spontaneous deletion in the nsp2 region associated with cell adaptation of porcine reproductive and respiratory syndrome virus

(2012) Xiaomin Wang et al.   VIRUS RESEARCH

Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production

(2011) A. E. Firth et al.   JOURNAL OF GENERAL VIROLOGY

Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses

(2011) C. R. Johnson et al.   JOURNAL OF GENERAL VIROLOGY

Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus

(2011) Gang Wang et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation

(2011) Xue Leng et al.   VETERINARY MICROBIOLOGY

Chimeric porcine reproductive and respiratory syndrome viruses reveal full function of genotype 1 envelope proteins in the backbone of genotype 2

(2011) Debin Tian et al.   VIROLOGY

Establishment of a DNA-launched infectious clone for a highly pneumovirulent strain of type 2 porcine reproductive and respiratory syndrome virus: Identification and in vitro and in vivo characterization of a large spontaneous deletion in the nsp2 region

(2011) Yan-Yan Ni et al.   VIRUS RESEARCH

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

NSP2 gene variation of the North American genotype of the Thai PRRSV in central Thailand

(2010) Roongtham Kedkovid et al.   Virology Journal

The PRRSV replicase: Exploring the multifunctionality of an intriguing set of nonstructural proteins

(2010) Ying Fang et al.   VIRUS RESEARCH

In vivo growth of porcine reproductive and respiratory syndrome virus engineered nsp2 deletion mutants

(2010) Kay S. Faaberg et al.   VIRUS RESEARCH

Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response

(2009) Z. Chen et al.   JOURNAL OF GENERAL VIROLOGY

The 30-Amino-Acid Deletion in the Nsp2 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China Is Not Related to Its Virulence

(2009) L. Zhou et al.   JOURNAL OF VIROLOGY

An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS

(2009) Zhi-Jun Tian et al.   VETERINARY MICROBIOLOGY

Molecular mutations associated with the in vitro passage of virulent porcine reproductive and respiratory syndrome virus

(2009) Wei Han et al.   VIRUS GENES

Genetic polymorphism of the nsp2 gene in North American type-Porcine reproductive and respiratory syndrome virus

(2008) Masaaki Yoshii et al.   ARCHIVES OF VIROLOGY

Development of genetic markers in the non-structural protein 2 region of a US type 1 porcine reproductive and respiratory syndrome virus: implications for future recombinant marker vaccine development

(2008) Y. Fang et al.   JOURNAL OF GENERAL VIROLOGY

Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus

(2008) S. Genini et al.   JOURNAL OF GENERAL VIROLOGY

An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome

(2008) J. Lv et al.   JOURNAL OF GENERAL VIROLOGY

Development of a porcine reproductive and respiratory syndrome virus differentiable (DIVA) strain through deletion of specific immunodominant epitopes

(2008) Marcelo de Lima et al.   VACCINE

Reverse genetic manipulation of the overlapping coding regions for structural proteins of the type II porcine reproductive and respiratory syndrome virus

(2008) Dandan Yu et al.   VIROLOGY

Insertion and deletion in a non-essential region of the nonstructural protein 2 (nsp2) of porcine reproductive and respiratory syndrome (PRRS) virus: effects on virulence and immunogenicity

(2008) Dal-Young Kim et al.   VIRUS GENES