Article
Environmental Sciences
Huiyang Fu, Feng Gao, Xiaoxu Wang, Peng Tan, Shengnan Qiu, Baoming Shi, Anshan Shan
Summary: Glyphosate is the most widely produced and used herbicide globally, with concerns rising over its toxic effects on animals and plants. Experimental results showed that adding glyphosate to the feed of weaned piglets can affect the tissue morphology of the uterus and ovaries, increase antioxidant enzyme activity, and alter hormone balance.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Preechaya Tajai, Dumnoensun Pruksakorn, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: Glyphosate-based herbicides, containing glyphosate as the active component, may pose potential risks to human health by affecting the endocrine system and reproductive system, leading to changes in sex hormone levels and pathological changes. Prenatal exposure may have transgenerational effects on offspring.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Christelle Simasotchi, Audrey Chissey, Gerald Jungers, Thierry Fournier, Gilles-Eric Seralini, Sophie Gil
Summary: Glyphosate-based herbicidal formulations, such as Roundup, consist of glyphosate as the active principle and other undisclosed formulants. Studies show that these formulants are more toxic than glyphosate, affecting placental permeability and fetal blood flow. Formulants may disrupt fetal-placental circulation and integrity, potentially leading to adverse pregnancy outcomes.
Article
Endocrinology & Metabolism
Mingjun Cao, Yufeng Wang, Fan Yang, Jizhou Li, Xunsi Qin
Summary: The study revealed that low-dose glyphosate has adverse effects on oocyte maturation and early embryo cleavage, while melatonin may play a protective role against GBH-induced oocyte deterioration.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Environmental Sciences
Lei Qi, Yupeng Li, Yanmei Dong, Shuli Ma, Gang Li
Summary: This study investigated the reproductive toxicity of glyphosate-based herbicide (GBH) on mice. The results showed that GBH exposure damaged the mitochondrial pyknosis and nuclear membrane of spermatogonia, and caused significant increase in sperm malformations in the high-dose group. Omics analysis revealed that GBH disrupted various metabolic pathways. These findings provide comprehensive evidence of the adverse effects of GBH exposure and contribute to understanding the reproductive toxicity of organophosphorus pesticides.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Environmental Sciences
Karem Zuniga, Georgette Rebollar, Mayra Avelar, Jose Campos-Teran, Eduardo Torres
Summary: This review presents the recent advances in developing nanomaterial-based sensors for glyphosate detection. It emphasizes the advantages of nanosensors over traditional methods and reviews the characteristics and potential applications of different types of nanomaterials.
Article
Marine & Freshwater Biology
Jessy Le Du-Carree, Thierry Morin, Morgane Danion
Summary: The study found that exposure of rainbow trout to a concentration of 1 mu g L-1 of glyphosate for 10 months did not significantly impact their overall health, including during the spawning period, regardless of whether the pure active substance or two GBH formulations were used. However, immunological disturbances observed may require further investigation as they could have a significant impact in response to infectious stress.
AQUATIC TOXICOLOGY
(2021)
Article
Agronomy
Arthur Arrobas Martins Barroso, Thomas Bruno Michelon, Pedro Luis da Costa Aguiar Alves, Heping Han, Qin Yu, Stephen B. Powles, Martin M. Vila-Aiub
Summary: Goosegrass (Eleusine indica) with double Thr-102-Ile + Pro-106-Ser (TIPS) EPSPS mutations shows high resistance to glyphosate, but also incurs a substantial fitness cost. Soybean competition further increases this fitness cost, resulting in 95%, 95%, and 96% reductions in vegetative growth, seed mass, and seed number, respectively. Glyphosate treatment enhances growth in TIPS plants compared to untreated plants. Conversely, moderate glyphosate resistance mutation P106S shows decreased survival rate, vegetative growth, aboveground biomass (34%), seed mass (48%), and number (52%) when treated with glyphosate alone. However, under the combined effects of soybean competition and field-recommended glyphosate dose, both P106S and TIPS plants have significantly limited vegetative growth, aboveground biomass, seed mass, and number (≤99%).
PEST MANAGEMENT SCIENCE
(2022)
Article
Environmental Sciences
Paola I. Ingaramo, Ramiro Alarcon, Maria L. Caglieris, Jorgelina Varayoud, Enrique H. Luque, Monica Munoz-de-Toro
Summary: This study demonstrates that neonatal exposure to glyphosate-based herbicides can result in adverse effects on uterine angiogenesis in rats, potentially leading to increased post-implantation losses.
ENVIRONMENTAL POLLUTION
(2022)
Article
Plant Sciences
Benjamin Fuchs, Miika Laihonen, Anne Muola, Kari Saikkonen, Petre I. Dobrev, Radomira Vankova, Marjo Helander
Summary: Glyphosate residues have multifaceted consequences on plant hormonal equilibrium, which can have cascading effects on plant performance and herbivore damage.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Austin Eide, Yu Zhang, Cengiz Koparan, John Stenger, Michael Ostlie, Kirk Howatt, Sreekala Bajwa, Xin Sun
Summary: Studies in mid-western states have shown that herbicide-resistant weed management has increased weed control costs by $20-$40 per acre. Greenhouse research found that glyphosate-resistant horseweed was reliably classified as the only resistant biotype, with 89% accuracy. More reliable identification of glyphosate-resistant weed species may require evaluation of additional multispectral sensing technologies or analysis models.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2021)
Review
Endocrinology & Metabolism
Anderson Tadeu de Araujo-Ramos, Marcella Tapias Passoni, Marco Aurelio Romano, Renata Marino Romano, Anderson Joel Martino-Andrade
Summary: Glyphosate-based herbicides are widely used but controversial for their potential impacts on human health. While regulatory guideline studies suggest glyphosate lacks endocrine disrupting properties, in vivo and in vitro studies indicate GBHs may disrupt hormonal pathways.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agronomy
S. Ramula, S. A. Mathew, A. Kalske, R. Nissinen, K. Saikkonen, M. Helander
Summary: The study found that soil phosphorus level rather than glyphosate treatment influenced the richness of plant endophytic microbial communities. While the composition of plant bacterial communities differed between glyphosate-treated and control soils across plant tissue types, no difference was observed for fungi. Plant bacterial communities in glyphosate-treated soils were dominated by potential nitrogen-fixing bacteria belonging to the family Bradyrhizobiaceae.
Article
Pharmacology & Pharmacy
Ryota Ojiro, Hiromu Okano, Yasunori Takahashi, Kazumi Takashima, Qian Tang, Shunsuke Ozawa, Xinyu Zou, Gye-Hyeong Woo, Makoto Shibutani
Summary: Increasing evidence suggests that glyphosate-based herbicides (GBHs) can induce developmental neurotoxicity. This study investigated the effects of glyphosate (GlyP) and GBH exposure on hippocampal neurogenesis in rats. The results showed that both GlyP and GBH suppressed neural progenitor cell proliferation, altered the number of granule cells, and increased synaptic plasticity in the hippocampus. These effects were associated with increased sensitivity to oxidative stress and disruption of neurogenesis. GBH had a stronger impact on adult age, suggesting that surfactants in GBH may enhance the neurotoxicity of GlyP.
Article
Environmental Sciences
Catalina Lopez-Florez, Monica Andrea Ortiz Ruiz, Edwin Gomez-Ramirez
Summary: This study determined the effects of glyphosate on the skin of D. molitor tadpoles. The results showed that sublethal concentrations of glyphosate caused histopathological, ultrastructural, and morphometric alterations, which may affect the survival of the species in the natural environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Correction
Toxicology
Maria M. Milesi, Virginia Lorenz, Pablo M. Beldomenico, Stella Vaira, Jorgelina Varayoud, Enrique H. Luque
ARCHIVES OF TOXICOLOGY
(2020)
Article
Biodiversity Conservation
Andrea S. Rossi, Noelia Fanton, Melina P. Michlig, Maria R. Repetti, Jimena Cazenave
ECOLOGICAL INDICATORS
(2020)
Article
Environmental Sciences
German Hugo Galoppo, Yamil Ezequiel Tavalieri, Gonzalo Schierano-Marotti, Mario Raul Osti, Enrique Hugo Luque, Monica Milagros Munoz-de-Toro
ENVIRONMENTAL RESEARCH
(2020)
Review
Cell Biology
Paola Ingaramo, Ramiro Alarcon, Monica Munoz-de-Toro, Enrique H. Luque
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Engineering, Chemical
Carla Jose, L. E. Briand, Nicolas Michlig, M. Rosa Repetti, Carla Benedetich, Laura M. Cornaglia, M. Laura Bosko
Summary: The study successfully established the best conditions for separating ibuprofen from ethyl esters through a combination of electrodialysis and enzymatic esterification, allowing for high efficiency extraction of ibuprofen.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Environmental Sciences
Andres Maximiliano Attademo, Rafael Carlos Lajmanovich, Paola Mariela Peltzer, Ana Paula Cuzziol Boccioni, Candela Martinuzzi, Fernanda Simonielo, Maria Rosa Repetti
Summary: Exposure to herbicide Dicamba had lethal and sublethal effects on tadpoles, affecting enzyme activities and hormone levels. Urgent reevaluation of Dicamba toxicity in native species is needed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemical Research Methods
Nicolas Michlig, Steven J. Lehotay, Alan R. Lightfield, Horacio Beldomenico, Maria Rosa Repetti
Summary: The study aimed to evaluate and validate the QuEChERSER method for pesticide residue analysis in hemp, using UHPLC-MS/MS and ITSP+LPGC-MS/MS. The results showed that the method is effective for detecting pesticide residues in different matrices of hemp.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Environmental Sciences
Victoria Soledad Andrade, Maria Florencia Gutierrez, Luciana Regaldo, Aldo Raul Paira, Maria Rosa Repetti, Ana Maria Gagneten
Summary: Climate change is expected to increase spatial variability in rainfall, leading to higher rainfall rates in the Pampas region during spring and summer, which may result in more pesticides and nutrients being carried into surface water systems. The growth stage of crops can also impact pesticide and nutrient runoff. In this study, the influence of rainfall and seasonal crop practices on water quality was assessed, with significant effects observed on pesticide concentrations and water quality.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Marine & Freshwater Biology
Y. E. Tavalieri, R. Alarcon, M. V. Tschopp, G. Canesini, E. H. Luque, M. Munoz-de-Toro, G. H. Galoppo
Summary: Endocrine disrupting compounds (EDCs) can alter the oviduct differentiation in Caiman latirostris, potentially leading to impaired reproduction. Exposure to BPA and E2 during early postnatal stages affects the levels of Wnt-7a, Wnt-5a, β-catenin, and FoxA2, contributing to altered histological features and protein expressions in the oviduct.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Andres M. Attademo, Juan C. Sanchez-Hernandez, Rafael C. Lajmanovich, Maria Rosa Repetti, Paola M. Peltzer
Summary: Soil enzyme activities are often used as indicators of soil contamination. This study analyzed the responses of specific soil enzymes to different land uses in soybean and rice crops, finding that enzyme activities were generally lower in both crops compared to a reference site. The results showed that enzyme activities decreased at the start of crop cycles and were lower at the end in soybean and rice crops, suggesting the potential use of enzyme activities as indicators of pesticide impact in agricultural soils of Argentina.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Environmental Sciences
Noelia Fanton, Jimena Cazenave, Melina P. Michlig, Maria R. Repetti, Andrea Rossi
Summary: Fish cultivation in rice fields serves as a valuable resource for protein and income in rural areas, but the use of pesticides raises concerns for fish and consumer health. This study assessed the impact of pesticides on native fish in a rice field, indicating biological responses to cope with stressful environments without showing significant oxidative or neurotoxic effects throughout the production cycle.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Rafael C. Lajmanovich, Andres M. Attademo, German Lener, Ana P. Cuzziol Boccioni, Paola M. Peltzer, Candela S. Martinuzzi, Luisina D. Demonte, Maria R. Repetti
Summary: The study found that glyphosate (GLY) and glufosinate ammonium (GA) herbicides, when used alone or in combination with polyethylene microplastic particles (PEMPs), have an impact on the toxicity of Scinax squalirostris tadpoles, with the combination increasing toxicity effects. Exposure to GLY and GA herbicides alone, as well as in combination with PEMPs, affects enzyme activities and leads to an increase in GST, and a decrease in AChE and CbE.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Paola I. Ingaramo, Ramiro Alarcon, Maria L. Caglieris, Jorgelina Varayoud, Enrique H. Luque, Monica Munoz-de-Toro
Summary: This study demonstrates that neonatal exposure to glyphosate-based herbicides can result in adverse effects on uterine angiogenesis in rats, potentially leading to increased post-implantation losses.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Gabriela A. Altamirano, Eduardo Masat, Oscar Rivera, Ramiro Alarcon, Gisela Dioguardi, Monica Munoz-de-Toro, Enrique H. Luque, Laura Kass
Summary: The aim of this study was to assess the effects of early postnatal exposure to a glyphosate-based herbicide (GBH) on pre-pubertal mammary development in Friesian lambs. GBH-exposed lambs exhibited larger mammary ducts and decreased area occupied by terminal duct lobular units, accompanied by an increase in adipocyte area in the mammary stroma. The expression of estrogen receptor alpha and progesterone receptor was altered in the GBH-exposed lambs, as well as decreased epithelial cell proliferation and changes in the IGF-1 system.
Article
Environmental Sciences
Guillermina Canesini, German H. Galoppo, Yamil E. Tavalieri, Gisela P. Lazzarino, Cora Stoker, Enrique H. Luque, Jorge G. Ramos, Monica Munoz-de-Toro
Summary: Environmental exposure to agrochemicals during early development can lead to permanent alterations in normal physiology. This study investigated the effects of atrazine exposure on gonadal development in caiman embryos, and found that it disrupts the expression of biomarkers and genes involved in sex determination and gonadal differentiation. The results suggest that atrazine can interfere with gonadal developmental programming and the observed effects may be present in other vertebrate species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)