Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection

Interference with Ubiquitination in CFTR Modifies Stability of Core Glycosylated and Cell Surface Pools

(2014) S. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

(2014) Hanna Renk et al.   PLoS One

Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity

(2013) James D. Londino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Influenza A virus (H1N1) increases airway epithelial cell secretion by up-regulation of potassium channel KCNN4

(2013) Taryn Waugh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The silent codon change I507-ATC→ATT contributes to the severity of the ΔF508 CFTR channel dysfunction

(2013) Ahmed Lazrak et al.   FASEB JOURNAL

Heterozygosity for the F508del Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Attenuates Influenza Severity

(2013) Famke Aeffner et al.   JOURNAL OF INFECTIOUS DISEASES

Normal CFTR Inhibits Epidermal Growth Factor Receptor-Dependent Pro-Inflammatory Chemokine Production in Human Airway Epithelial Cells

(2013) Suil Kim et al.   PLoS One

Early Host Responses of Seasonal and Pandemic Influenza A Viruses in Primary Well-Differentiated Human Lung Epithelial Cells

(2013) Rachael L. Gerlach et al.   PLoS One

Chloride secretion across adult alveolar epithelial cells contributes to cardiogenic edema

(2013) J. D. Londino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin

(2013) S Tripathi et al.   Cell Death & Disease

The CFTR and ENaC debate: how important is ENaC in CF lung disease?

(2012) James F. Collawn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung

(2012) Neal S. Gould et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of CFTR Folding at the Endoplasmic Reticulum

(2012) Soo Jung Kim et al.   Frontiers in Pharmacology

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs

(2011) L. S. Ostedgaard et al.   Science Translational Medicine

Cation trapping by cellular acidic compartments: Beyond the concept of lysosomotropic drugs

(2011) François Marceau et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers

(2010) Pierre LeSimple et al.   JOURNAL OF PHYSIOLOGY-LONDON

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

(2009) Ahmed Lazrak et al.   FASEB JOURNAL

Nanomolar Potency Pyrimido-pyrrolo-quinoxalinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model

(2009) Lukmanee Tradtrantip et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Interfering RNA Targeting M2 Gene Induces Effective and Long Term Inhibition of Influenza A Virus Replication

(2009) Hong-Yan Sui et al.   PLoS One

Inhibition of Na+Transport in Lung Epithelial Cells by Respiratory Syncytial Virus Infection

(2008) Lan Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL