Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Divergent Role of Sphingosine 1-Phosphate on Insulin Resistance

(2014) Susann Fayyaz et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Regulation of glucose and lipid homeostasis by adiponectin: Effects on hepatocytes, pancreatic β cells and adipocytes

(2013) Caroline Tao et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response

(2013) Dietlind Sommerweiss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In Vivo JNK Activation in Pancreatic  -Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas

(2013) J. Lanuza-Masdeu et al.   DIABETES

Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype

(2013) Susann Fayyaz et al.   DIABETOLOGIA

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice

(2013) Yanfei Qi et al.   FASEB JOURNAL

Role of ceramide in diabetes mellitus: evidence and mechanisms

(2013) Sehamuddin Galadari et al.   Lipids in Health and Disease

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival

(2012) Julien Véret et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

FTY720 preserved isletβ-cell mass by inhibiting apoptosis and increasing survival ofβ-cells in db/db mice

(2012) Hosik Moon et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Sphingosine 1-Phosphate (S1P) Regulates Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells

(2012) Jamie Cantrell Stanford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Saturated Nonesterified Fatty Acid Palmitate in Beta Cell Dysfunction

(2012) Michael Maris et al.   JOURNAL OF PROTEOME RESEARCH

Sphingosine 1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P2 Receptor Subtype

(2012) Lukasz Japtok et al.   PLoS One

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction

(2012) Ebru Boslem et al.   Islets

FTY720 Normalizes Hyperglycemia by Stimulating β-Cellin VivoRegeneration indb/dbMice through Regulation of Cyclin D3 and p57KIP2

(2011) Zhengshan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

(2010) Adria Giacca et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic β-cells

(2010) Toshiyuki Imasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

(2010) O. Kluth et al.   DIABETOLOGIA

ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets

(2010) L. D. Mastrandrea et al.   JOURNAL OF LIPID RESEARCH

Circulating sphingolipid biomarkers in models of type 1 diabetes

(2010) Todd E. Fox et al.   JOURNAL OF LIPID RESEARCH

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Low- and High-Density Lipoproteins Modulate Function, Apoptosis, and Proliferation of Primary Human and Murine Pancreatic β-Cells

(2009) Sabine Rütti et al.   ENDOCRINOLOGY

Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells

(2009) Qun Zhu et al.   FEBS LETTERS

Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

(2009) A. Assmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Sphingosine 1-Phosphate Restrains Insulin-Mediated Keratinocyte Proliferation via Inhibition of Akt through the S1P2 Receptor Subtype

(2008) Melanie Schüppel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY