Article
Biotechnology & Applied Microbiology
Vladimir Heredia, Luc Marchal, Olivier Goncalves, Jeremy Pruvost
Summary: This study investigates the optimization of TAG production in microalgae by continuous nitrogen-limited culture, focusing on mechanical resistance of strains and optimal harvesting time. The study compared continuous nitrogen addition to pulsed addition, with continuous addition resulting in the highest released TAG.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Fisheries
Daniel P. Killeen, Jeremy S. Rooney, Asli Card, Liam B. Hegarty, Warren W. Fantham, Keith C. Gordon, Damian Moran
Summary: The authors investigated the potential of portable Raman spectroscopy as a faster and more efficient method for quantifying the fatty acid composition of rotifers in aquaculture. They found that the portable instrument could accurately measure total fatty acids (TFA) and total polyunsaturated fatty acids (PUFA) and significantly reduced analysis time compared to the traditional FT-Raman system. Portable Raman spectroscopy is a promising tool for high throughput screening of rotifer lipid composition in aquaculture.
AQUACULTURE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Serena Lima, Alberto Brucato, Giuseppe Caputo, Luca Schembri, Francesca Scargiali
Summary: By developing a model, researchers were able to predict the growth of microalgae in reactors with different configurations. Furthermore, they found that biomass and lipid content of the microalgae changed under different light intensities and reactor configurations.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
David Tichy, Zdenek Slouka
Summary: The article introduces an electrodialysis method for ion separation using an electric field-mediated process. Through a microfluidic system and experiments with a model KCl solution, the system's working principle and performance are demonstrated, showing the flexibility to select different operating modes based on the needs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agricultural Engineering
Sang-Il Han, Min Seo Jeon, Yun Hwan Park, Sok Kim, Yoon-E Choi
Summary: Semi-continuous immobilized cultivation of Porphyridium cruentum with calcium alginate beads increased cell biomass and daily SPs productivity, and combining blue wavelength illumination further enhanced phycobiliproteins content. Nutrient deficiencies in conjunction with immobilization doubled the daily SPs productivity compared to the control. The chemical composition and biological activity of the extracellular polymeric substances produced through immobilization were similar to those of the control, suggesting the potential application of calcium alginate beads-based immobilization for continuous and high-efficiency SPs production.
BIORESOURCE TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Fiddy S. Prasetiya, Martin Foret, Jean-Sebastien Deschenes, Romain Gastineau, Jean-Luc Mouget, Rejean Tremblay
Summary: The feasibility of culturing different species and strains of blue Haslea in photobioreactors was studied, focusing on sustained blue pigment production. Factors such as mixing, silicate concentration, and type of light were examined to maximize marennine or marennine-like pigment production. It was found that mixing negatively affected marennine production, while higher silicate concentrations and LED lights were more beneficial. Different Haslea species showed varying levels of pigment yields, with Haslea sp. having the lowest, and preservation of marennine was successful at low temperatures and without light. Further studies are needed to optimize production and reduce costs for industrial applications.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Agricultural Engineering
Andrey A. Kovalev, Dmitriy A. Kovalev, Elena A. Zhuravleva, Alexandra A. Laikova, Svetlana V. Shekhurdina, Vivekanand Vivekanand, Yuriy V. Litti
Summary: The performance and kinetics of thermophilic semi-continuous dark fermentation of complex carbohydrate-rich waste were studied at different hydraulic retention times (HRT) and compared with biochemical hydrogen potential assay (BHP) data. Thermoanaerobacterium thermosaccharolyticum dominated both BHP and the reactor. The modified Gompertz and first-order models described the fermentation kinetics well. The HRT of 2.5 d was found to be optimal in terms of maximum hydrogen production rate and hydrogen potential, surpassing BHP significantly.
BIORESOURCE TECHNOLOGY
(2023)
Article
Engineering, Environmental
Sebastian O. N. Topalian, Pedram Ramin, Kasper Kjellberg, Christian Kazadi Mbamba, Damien J. Batstone, Krist V. Gernaey, Xavier Flores-Alsina
Summary: In this study, a dynamic polymer dosing strategy is developed for an industrial centrifuge system that receives highly variable rates and quality of feed solids from a wastewater treatment plant. The strategy includes data extraction, data wrangling, model development, and model analysis, using partial least squares and random forest models to predict polymer dosages. The approach has the potential to save operators a significant amount of time and improve efficiency.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Engineering, Chemical
T. R. Geoffroy, J. Thibodeau, M. Faucher, M. E. Langevin, F. Lutin, L. Bazinet
Summary: Electrodialysis with ultrafiltration membrane (EDUF) is a promising industrial technology for the recovery of bioactive peptides. This study focused on the impact of initial whey protein hydrolysate (WPH) concentration and current intensity. The results showed that there is a proportional relationship between the initial WPH concentration and the quantity of peptides recovered. The selectivity of the cationic recovery fraction was improved, and the working parameters used allowed for a high peptide yield in a short period of time. Based on the bioactivity values, using the cationic recovery fractions as an antidiabetic product seems to be the most promising avenue. Preliminary results at higher current intensity also showed encouraging results with higher peptide yield and preserved bioactivities. Overall, EDUF has great potential in the recovery of bioactive peptides.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Agricultural Engineering
Zhiwei Huang, Qiuya Niu, Wenkai Nie, Yan Lin, Shaohua Wu, Xiang Li, Jay J. Cheng, Chunping Yang
Summary: The high concentrations of antibiotics in swine wastewater may have potential adverse effects on anaerobic digestion (AD). Previous studies focused on the effects of antibiotic concentrations but did not consider the fluctuation of swine wastewater quality and reactor operating conditions in practical engineering applications. This study found that continuous addition of oxytetracycline for 30 days had no effect on AD performance in systems with COD of 3300 mg/L and HRT of 4.4 days. However, when COD and HRT were changed to 4950 mg/L and 1.5 days respectively, oxytetracycline at different concentrations had varying effects on methane yield and cell membrane.
BIORESOURCE TECHNOLOGY
(2023)
Article
Agricultural Engineering
Yeadam Jo, Chaeyoung Rhee, Hyungmin Choi, Juhee Shin, Seung Gu Shin, Changsoo Lee
Summary: The study found that bioaugmentation with rumen culture can enhance the performance and stability of reactors co-digesting food waste with kimchi waste, especially under high ammonia conditions. Increasing microbial diversity can improve the resilience of microbial communities, with some augmented microorganisms likely playing a significant role. This bioaugmentation strategy may effectively treat and valorize kimchi waste, as well as other seasonal lignocellulosic wastes, by co-digesting with food waste.
BIORESOURCE TECHNOLOGY
(2021)
Article
Engineering, Environmental
Bruno C. Marreiros, Monica Carvalheira, Claudia Henriques, Daniela Pequito, Yen Nguyen, Runar G. Solstad, J. Johannes Eksteen, Maria A. M. Reis
Summary: This study explores the potential of converting the proteinaceous fraction of fish silage into biodegradable polyhydroxyalkanoates (PHA), a more economically valuable product. The researchers conducted acidogenic fermentation of salmon peptone (SP) in a continuous reactor and obtained a fermentate rich in acetate and butyrate. The enriched mixed microbial culture with PHA-accumulating organisms achieved a good overall PHA yield and global volumetric PHA productivity, despite high ammonia concentration and constant nutrient availability.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Microbiology
Putu Virgina Partha Devanthi, Ferren Pratama, Katherine Kho, Mohammad J. Taherzadeh, Solmaz Aslanzadeh
Summary: This study investigated the bacterial cellulose (BC) production and biochemical changes in the co-culture system of Komagataeibacter intermedius and Dekkera bruxellensis. The results showed that the concentration and inoculation time of D. bruxellensis had crucial impacts on the species interactions and product yield in the co-culture system.
Article
Multidisciplinary Sciences
Suneerat Ruangsomboon, Duenrut Chonudomkul
Summary: This study found that CO2 supplementation can increase the biomass and production of high-value biomolecules in Nannochloropsis oculata, making it an ideal source for dietary supplements and biodiesel production.
CHIANG MAI JOURNAL OF SCIENCE
(2022)
Article
Biochemical Research Methods
Ye Tao, Weiyu Liu, Chunlei Song, Zhenyou Ge, Zhaokai Li, Yanbo Li, Yukun Ren
Summary: This study introduces an effective method for continuous delivery and position-switchable trapping of nanoparticles through field-effect control on hybrid electrokinetics (HEK). By combining linear and nonlinear electroosmosis, the proposed microfluidic nanoparticle concentrator enables the precise manipulation of nanoparticles.
Review
Dentistry, Oral Surgery & Medicine
Andrea Muras, Natalia Mallo, Paz Otero-Casal, Jose M. Pose-Rodriguez, Ana Otero
Summary: This study summarizes the role of bacterial extracellular signaling systems, namely quorum sensing (QS), in oral biofilm formation, and explores the potential of blocking these communication systems as a new approach to prevent and treat oral infectious diseases. Current evidence suggests that QS molecules play an important role in the oral microbial ecosystem. Targeting the mechanisms that regulate gene expression through bacterial communication systems shows promise in controlling oral biofilm formation. However, there is still limited knowledge about microbial interactions and signaling processes within multispecies biofilms in the oral cavity.
Article
Pharmacology & Pharmacy
Maria Vivero-Lopez, Andrea Muras, Diana Silva, Ana Paula Serro, Ana Otero, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study evaluated the use of MPC and resveratrol to endow contact lenses with antibiofilm features, showing that resveratrol can decrease biofilm formation and preserve antioxidant activity.
Article
Biotechnology & Applied Microbiology
Mariana Carneiro, Graziella Chini Zittelli, Bernardo Cicchi, Eleftherios Touloupakis, Cecilia Faraloni, Ines B. Maia, Hugo Pereira, Tamara Santos, Francisco X. Malcata, Ana Otero, Joao Varela, Giuseppe Torzillo
Summary: In the study, in situ chlorophyll a fluorescence measurements were used to monitor changes in photochemical variables of Nannochloropsis oceanica cultures under nitrogen-deplete and nitrogen-replete conditions. Changes in lipid content and de-epoxidation state of xanthophyll cycle pigments were the first biochemical variables triggered by the change in nutrient status, showing a good correlation with the in situ effective quantum yield of PSII (Delta F'/F-m').
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Fairouz El Aichar, Andrea Muras, Ana Parga, Ana Otero, Farida Nateche
Summary: The study aimed to screen Bacillus strains with broad-spectrum quorum quenching (QQ) activity against N-acyl-L-homoserine lactones (AHLs) from Algeria. A total of 94 halotolerant strains were tested for QQ, antibacterial, and anti-biofilm activities. Strains DZ16 and DZ17 exhibited interesting properties with potential applications in probiotics and infectious disease control.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ines B. Maia, Mariana Carneiro, Tania Magina, F. Xavier Malcata, Ana Otero, Joao Navalho, Joao Varela, Hugo Pereira
Summary: The growth patterns, photosystem II performance, and accumulation of target metabolites of two commercially relevant diatoms, Phaeodactylum tricornutum and Skeletonema costatum, were investigated. S. costatum exhibited higher growth rate, biomass productivity, photosynthetic efficiency, and temperature tolerance compared to P. tricornutum.
JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Microbiology
Manuel Romero, Celia Mayer, Stephan Heeb, Krittanont Wattanavaekin, Miguel Camara, Ana Otero, Paul Williams
Summary: This study introduces a novel biofilm culture system, the rolling biofilm bioreactor (RBB), which allows for the investigation of bacterial biofilm architecture and biology. Using this system, the researchers discovered mushroom-shaped structures in mature Acinetobacter baumannii biofilms that had not been observed in other models. They also showed the impact of quorum sensing on biofilm differentiation, composition, and antibiotic tolerance. The study highlights the importance of understanding the mechanisms of mature biofilm development for developing new strategies to eradicate and remove biofilms.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Aly Castillo, Simon Pereira, Ana Otero, Carmen Garcia-Jares, Marta Lores
Summary: This study introduces an efficient alternative method for extracting bioactive compounds from wet Haematococcus pluvialis using matrix solid-phase dispersion (MSPD), with ethanol identified as the best solvent for overall recovery of carotenoids and fatty acids. The study also reveals previously uncharacterized phenolic compounds in red stage H. pluvialis, showing the method's positive feasibility and effectiveness compared to traditional extraction methods.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
M. Carneiro, I. B. Maia, P. Cunha, I Guerra, T. Magina, T. Santos, P. S. C. Schulze, H. Pereira, F. X. Malcata, J. Navalho, J. Silva, A. Otero, J. Varela
Summary: The study found that using LED lighting can significantly increase the biomass and nighttime productivity of microalgae under low light conditions, especially when the sunlight is weak. However, the use of LED lighting in outdoor raceway ponds should only be considered for high-value metabolites.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Pharmacology & Pharmacy
Maria Vivero-Lopez, Chiara Sparacino, Ana Quelle-Regaldie, Laura Sanchez, Eva Candal, Anton Barreiro-Iglesias, Fernando Huete-Toral, Gonzalo Carracedo, Ana Otero, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: This study successfully addressed the limitations of resveratrol, an antioxidant agent, by preparing single and mixed micelles of Pluronic (R) F127 and casein. These micelles significantly increased the solubility of resveratrol, remained stable, and exhibited potent antioxidant properties. They also showed antimicrobial activity. However, mixed micelles displayed lower permeability through the sclera compared to single micelles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Giulia Bernabe, Giovanni Marzaro, Giuseppe Di Pietra, Ana Otero, Massimo Bellato, Anthony Pauletto, Melania Scarpa, Stefania Sut, Adriana Chilin, Stefano Dall'Acqua, Paola Brun, Ignazio Castagliuolo
Summary: In this study, a novel inhibitor of acyl-homoserine lactone (AHL)-mediated signaling in P. aeruginosa, GM-50, was identified. GM-50 reduced virulence factors, enhanced the anti-biofilm activity of aztreonam, and protected Galleria mellonella larvae from damage induced by P. aeruginosa. It also showed activity against clinical strains, highlighting its potential as a starting point for the development of new phenolic derivatives as QS inhibitors in P. aeruginosa infections.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Maria Vivero-Lopez, Ana F. Pereira-da-Mota, Gonzalo Carracedo, Fernando Huete-Toral, Ana Parga, Ana Otero, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: This study developed advanced contact lenses with antibacterial phosphorylcholine and antioxidant prebiotic resveratrol as integral components. These lenses can protect eye microbiota, prevent eye diseases, and release drugs.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xian Farto-Vaamonde, Luis Diaz-Gomez, Ana Parga, Ana Otero, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: In this work, Carvacrol-loaded PLA scaffolds were fabricated by 3D printing to achieve antibacterial and antibiofilm effects without affecting angiogenesis, showing great potential.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Ana Parga, Andrea Muras, Paz Otero-Casal, Alexandre Arredondo, Agnes Soler-Olle, Gerard alvarez, Luis D. Alcaraz, Alex Mira, Vanessa Blanc, Ana Otero
Summary: The AHL-targeting QQ enzyme Aii20J can effectively modulate oral biofilm formation without altering the microbiome structure. This study highlights the potential of AHL-targeting enzymes in improving oral health and emphasizes the importance of personalized approaches to oral biofilm control.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Ana Parga, Daniel Manoil, Malin Brundin, Ana Otero, Georgios N. Belibasakis
Summary: This study assessed the effect of AHLs on biofilm formation and transcriptional regulations in Enterococcus faecalis and found that AHLs promote biofilm formation and up-regulate a transcriptional network involved in virulence and stress tolerance.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Vanesa Garcia, Luz Leston, Ana Parga, Isidro Garcia-Menino, Javier Fernandez, Ana Otero, John E. Olsen, Ana Herrero-Fresno, Azucena Mora
Summary: This study investigated 31 strains of Escherichia coli from different sources using genomic comparison, bladder-cell, and biofilm formation assays. It found that animal-derived and human extraintestinal infection strains had high genomic similarity and exhibited similar pathogenic characteristics in cell and biofilm assays. These results highlight the potential role of food-producing animals as a source of urinary tract infections.
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.