Article
Multidisciplinary Sciences
Conall Sauvey, Ittipat Meewan, Gretchen Ehrenkaufer, Jonathan Blevitt, Paul Jackson, Ruben Abagyan
Summary: Entamoeba histolytica, a disease-causing parasitic amoeba, affects an estimated 50 million people worldwide and can lead to serious symptoms, including colitis and dysentery. Current drugs for this parasite have limitations, such as adverse effects and potential resistance. In this study, a compound library was screened and a highly potent inhibitor, JNJ001, was identified, showing better activity than the current approved treatment. Further experiments confirmed the compound's effectiveness and its inhibition of related organisms. This discovery may lead to improved therapy against this parasite.
Article
Microbiology
Giulia Dal Canto, Tawaddud Hassan Eisa Artaiga, Abdulrahman Ibrahiem Mohamed, Hayat Amin Makki Hassan, Doaa Mahmoud Adam, Moram Awadalla Ibrahiem Ahmed, Jihad Motwali, Manuela Valenti, Susanna Esposito
Summary: Diarrheal disease is a leading cause of death in children under five in developing countries, causing approximately 500,000 deaths annually. Due to the lack of diagnostic tests, empirical therapy is often used to treat diarrheal disease. This case study highlights the life-threatening complications of amoebiasis in children with severe acute malnutrition, emphasizing the need for a rapid and inexpensive diagnostic test and further research on antimicrobial resistance patterns.
Article
Chemistry, Medicinal
Maritza Velasquez-Torres, Jose Guadalupe Trujillo-Ferrara, Marycarmen Godinez-Victoria, Rosa Adriana Jarillo-Luna, Victor Tsutsumi, Virginia Sanchez-Monroy, Araceli Posadas-Mondragon, Roberto Issac Cuevas-Hernandez, Jose Angel Santiago-Cruz, Judith Pacheco-Yepez
Summary: This study demonstrates for the first time the in vitro and in silico anti-amoebic activity of riluzole, showing that it reduces the viability of Entamoeba histolytica and induces cell death. It also suggests that riluzole has a higher affinity than metronidazole for the antioxidant enzymes of the parasite. Further research should be conducted to confirm the anti-amoebic effects of riluzole in vivo.
Review
Chemistry, Medicinal
Clemente Capasso, Claudiu T. Supuran
Summary: This article discusses 12 protozoan genera that cause zoonotic diseases in humans and animals, with a focus on Babesia spp and Entamoeba histolytica, and mentions Toxoplasma gondii, Trypanosoma cruzi, and Leishmania spp. Despite a deep understanding of the complex life cycles of pathogenic protozoa, this has not led to the discovery of new drugs. The current clinical armamentarium for treating protozoan diseases is limited and often ineffective, necessitating innovative approaches to address these challenges.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2023)
Review
Biochemistry & Molecular Biology
Eyra Ortiz-Perez, Lenci K. Vazquez-Jimenez, Alma D. Paz-Gonzalez, Timoteo Delgado-Maldonado, Alonzo Gonzalez-Gonzalez, Carlos Gaona-Lopez, Antonio Moreno-Herrera, Karina Vazquez, Gildardo Rivera
Summary: Despite the existence of drugs for the treatment of parasitic diseases, they remain a public health issue with varying efficacy and potential serious adverse effects. Over the past two decades, there has been interest in the enzyme carbonic anhydrase (CA) due to its essential role in the life cycle of various parasites. Advances in discovering compounds with potent inhibitory activity suggest that CA is a promising candidate for the development of new antiprotozoal agents.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biology
Jesus Perez-Hernandez, Clarisa Retana-Gonzalez, Espiridion Ramos-Martinez, Jose Cruz-Colin, Andres Saralegui-Amaro, Gabriela Baltazar-Rosario, Concepcion Gutierrez-Ruiz, Gerardo Aristi-Urista, Rosario Lopez-Vancell
Summary: Amoebiasis in humans is caused by the protozoan parasite Entamoeba histolytica, which interacts with the c-Met receptor on the surface of HepG2 cells through its Gal/GalNAc lectin, leading to cytotoxic effects.
Review
Biochemistry & Molecular Biology
Antonio Moreno-Herrera, Sandra Cortez-Maya, Virgilio Bocanegra-Garcia, Bimal Krishna Banik, Gildardo Rivera
Summary: Parasitic infections caused by various protozoa affect millions of people worldwide annually, with limited pharmacological treatments. Developing new and more effective drugs could be crucial in improving therapy outcomes for parasitic diseases.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Infectious Diseases
Andrea L. Maricuto, Viledy L. Velasquez, Jacinto Pineda, David M. Flora-Noda, Isaac Rodriguez, Crismar A. Rodriguez-Ines, Oscar O. Noya-Gonzalez, Rosa Contreras, Oscar D. Omana-Avila, Ivan A. Escalante-Perez, Natasha A. Camejo-Avila, Nicolle A. Kuffaty-Akkou, Fhabian S. Carrion-Nessi, Martin Carballo, Maria E. Landaeta, David A. Forero-Pena
Summary: This study presents a case of a patient with COVID-19 co-presenting with ALA. The case suggests that coinfection with SARS-CoV-2 and Entamoeba histolytica could impact the patient's clinical course, but larger studies are needed to fully understand the interaction between these pathogens.
BMC INFECTIOUS DISEASES
(2021)
Article
Plant Sciences
Julio Cesar Carrero, Violeta Curay-Herrera, Lysette Chacon-Nino, Felix Krengel, Silvia-Laura Guzman-Gutierrez, Mayra Silva-Miranda, Luisa-Carolina Gonzalez-Ramirez, Raul J. Bobes, Clara Espitia, Ricardo Reyes-Chilpa, Juan-Pedro Laclette
Summary: This study evaluated the pharmacological activities of Tabernaemontana plant species on Entamoeba histolytica. The alkaloid fraction of T. arborea root bark showed potent anti-amoebic activity, but its effect decreased over time and was unable to limit abscess formation. This research provides a new potential alternative for amoebiasis control.
Article
Medicine, General & Internal
Ravikanth Reddy
Summary: Intestinal amoebiasis and its sequelae, such as amoebic liver abscess, are rarely reported in the modern medical era. Atypical presentation of amoebic liver abscess, with high false-positive results on serology in endemic regions, presents major diagnostic challenges in developing countries. The case study discussed illustrates the importance of detailed medical history and serological testing in the diagnosis and treatment of amoebic liver abscess, with successful management evident in the patient's three-month follow-up.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Kushagra Khanna, Rajika Khanna, Sourya Acharya, Sunil Kumar
Summary: Tropical countries have a higher incidence of amoebic liver abscess (ALA) due to the prevalence and severity of the parasite Entamoeba histolytica. However, the increasing number of immigrants from these areas has made it necessary to study the global impact of the disease. Patients usually present with common symptoms such as right upper quadrant pain, hepatomegaly, jaundice, and vomiting, but the condition can have various manifestations that do not respond to standard treatment. Therefore, it is important to consider new approaches to reduce morbidity and mortality and improve patient outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Daisuke Usuda, Shiho Tsuge, Riki Sakurai, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Hayabusa Takano, Shintaro Shimozawa, Yuta Hotchi, Shungo Tokunaga, Ippei Osugi, Risa Katou, Sakurako Ito, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Jiro Oba, Tomohisa Nomura, Manabu Sugita
Summary: Amebic liver abscesses (ALAs) are a common extraintestinal manifestation of human invasive amebiasis caused by Entamoeba histolytica. ALAs result from the invasion of the intestinal mucosa, and diagnosis requires liver imaging and antibody detection. ALAs can be treated with medication, and the prognosis is generally good.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Infectious Diseases
Aya Kitaoka, Kazuya Tanimura, Yuto Yasuda, Kensuke Nishioka, Yutaka Hirayama, Kiyoshi Uemasu, Daisuke Iwashima, Sou Arita, Toshiyuki Kitai, Susumu Hoshi, Emi Date, Norishige Iizuka, Ken-Ichi Takahashi
Summary: This case study reports a 64-year-old male patient with advanced small-cell lung cancer who developed fulminant amoebic colitis during cytotoxic chemotherapy. After treatment with metronidazole and paromomycin, the amoebiasis improved and there was a partial response to small-cell lung cancer. This case suggests paromomycin as an additional option for amoebiasis during cytotoxic chemotherapy, and clinicians should be alert to the development of amoebiasis in cases of persistent diarrhea during cytotoxic chemotherapy.
Article
Materials Science, Ceramics
Syed Khasim, Syed G. Dastager, Mohammed Issa Alahmdi, Taymour A. Hamdalla, Chellasamy Panneerselvam, Mohammad Basha Makandar
Summary: A green synthesis approach using rice husk biomass was used for the fabrication of a Pd/TiO@BC nanocomposite, which showed crystalline structure and successful biosynthesis. The nanocomposite exhibited high efficiency in the removal of Congo red dye from wastewater and showed potential for applications in various fields such as electrochemistry, catalysis sensors, and wastewater treatment.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Mohammed Issa Alahmdi
Summary: A new phenothiazine derivative (PTZ-c) fluorophore was synthesized via the Knoevenagel condensation reaction between phenothiazine-3,7-dicarbaldehyde and isophorone. PTZ-c exhibited exceptional solvatochromic and pH-sensing abilities. Multiple spectroscopic techniques were used to characterize the synthesized PTZ-c sensor, and its fluorescence and absorption spectra were found to be highly solvent-dependent.
Article
Chemistry, Multidisciplinary
Adeniyi T. T. Adewumi, Wande M. M. Oluyemi, Yemi A. A. Adekunle, Nonhlanhla Adewumi, Mohamed Issa Alahmdi, Mahmoud E. S. Soliman, Nader E. E. Abo-Dya
Summary: This study identifies six novel inhibitors of the KasA enzyme, a critical target in TB drug design. The compounds JFX, M1, M2, and M5 show stronger interactions with KasA and have good predicted inhibitory constants, drug-likeness, ADME, and synthetic accessibility. The findings provide potential lead-like molecules for future TB drugs.
Article
Chemistry, Organic
Mohd Waheed, Meshari A. Alsharif, Mohammed Issa Alahmdi, Sayeed Mukhtar, Humaira Parveen
Summary: An efficient, environmentally benign and one-pot approach for the synthesis of 2-arylimino-2H-chromenes from 2-hydroxybenzyl alcohols and beta-ketothioamides at room temperature under visible light has been developed. The reported reaction conditions were favorable for a wide range of beta-ketothioamides afforded good to excellent yields of the respective products. The low cost and air stable Knolker iron catalyst has been employed for the dehydrogenation of 2-hydroxybenzyl alcohols under photolysis that would usually require a higher temperature.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemical Research Methods
Salman A. Khan, Md. Zafer Alam, Md. Mohasin, Suhail Ahmad, Umme Salma, Humaira Parveen, Sayeed Mukhtar, Menier Al-Anazi, Fatimah A. Alotaibi, Mahmoud A. Abdelaziz
Summary: In this study, the chalcone compound DHPO was synthesized through a chemical reaction and ultrasound irradiation. The fluorescence behavior of DHPO compound interacting with metal ions, especially Fe3+, was investigated, demonstrating its potential as a switchable fluorescence sensor. The fluorescence quenching and complexation between DHPO and Fe3+ ion were further examined using various methods.
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Physical
Mohammed A. I. Elbastawesy, Fatma A. M. Mohamed, Islam Zaki, Mohammed Issa Alahmdi, Seham S. Alzahrani, Hayat Ali Alzahrani, Hesham A. M. Gomaa, Bahaa G. M. Youssif
Summary: A new series of quinoline-2-one Schiff-base hybrids were synthesized and characterized. The compounds were screened for antimicrobial activity and compound 6c showed significant inhibitory effects against B. subtilis, E. coli, and S. aureus. It also exhibited inhibitory activity against E. coli topoisomerase IV and DNA gyrase.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Analytical
Mohammed Issa Alahmdi
Summary: New fluorescent iodobiphenyl ethers with para-alkyloxy functional groups of different alkyl tail lengths were synthesized simply by reacting aliphatic alcohols with hydroxyl-substituted iodobiphenyls under alkali assistance. The molecular structures of the synthesized compounds were characterized using FTIR spectroscopy, elemental analysis, and NMR spectroscopy. Both absorption and fluorescence spectra demonstrated solvatochromic activity. The synthesized compounds showed antioxidant effectiveness, with the analogues containing the longest hydrocarbon chain exhibiting the highest efficacy with an IC50 value of 21.26 +/- 0.36 μg/ml. Docking operations on the 5IKQ protein were also performed for the alkyloxy-substituted iodobiphenyl analogues.
Article
Chemistry, Organic
Mohd Waheed, Meshari A. Alsharif, Mohammed Issa Alahmdi, Sayeed Mukhtar, Humaira Parveen
Summary: An environmentally friendly and mild method for the synthesis of C-3 alkylated indoles, bisindolylmethanes, and flavanones using alcohols under visible light at room temperature has been developed. The reported reaction conditions showed good yields for a wide range of alcohols. The reaction system was also successfully extended to the synthesis of flavanones from 2-hydroxyacetophenone. A low-cost and air-stable Knolker iron catalyst was used for the dehydrogenation of alcohols under photolysis, which typically requires higher temperatures.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Organic
Mohd Waheed, Meshari A. Alsharif, Mohammed Issa Alahmdi, Sayeed Mukhtar, Humaira Parveen
Summary: An efficient and environmentally friendly method for synthesizing indoles from o-nitrostyrenes has been developed. The process utilizes a stable and inexpensive Knolker complex as a catalyst and employs photoirradiation at room temperature for the intramolecular reductive cyclization, resulting in high yields of the desired products.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Organic
Sayeed Mukhtar, Meshari A. Alsharif, Mohammed Issa Alahmdi, Humaira Parveen, Mohd Waheed
Summary: An effective, simple, green, and metal-free iodine catalyzed approach has been developed for the production of isoxazoles from primary alcohols and 3-O-propargyl flavones using DMSO as the oxidant. This methodology shows promise for a wide range of primary alcohols and 3-O-propargyl flavones, with isoxazoles being generated within 10 hours.
TETRAHEDRON LETTERS
(2023)
Article
Multidisciplinary Sciences
Md. Abdur Rashid Mia, Qamar Uddin Ahmed, Sahena Ferdosh, Abul Bashar Mohammed Helaluddin, Syed Najmul Hejaz Azmi, Fatimah Ammar Al-Otaibi, Humaira Parveen, Sayeed Mukhtar, Mohammad Z. Ahmed, Md. Zaidul Islam Sarker
Summary: This study evaluated the anti-obesity and antihyperlipidemic effects of Phaleria macrocarpa fruit using in vitro, computational, and in vivo assays. The results confirmed that the fruit possesses lipase and HMG-CoA reductase inhibitors, indicating its potential as a lipid-lowering and anti-obesity herbal medicine.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Medicine, General & Internal
Syed Kashif Ali, Hafiz A. Makeen, Gulrana Khuwaja, Hassan A. Alhazmi, Mukul Sharma, Afraim Koty, Islam Mazahirul, Humaira Parveen, Asaduddin Mohammed, Sayeed Mukhtar, Mohammad Firoz Alam
Summary: This study investigates the phytochemical profile, antioxidant capacity, and hepatoprotective effect of Andrographis paniculata, finding that it has potential as a natural remedy for liver-related ailments.
MEDICINA-LITHUANIA
(2023)
Article
Chemistry, Multidisciplinary
Karam Ahmed El-Sharkawy, Rafat Milad Mohareb, Sayeed Mukhtar, Humaira Parveen, Mahmoud Ali Abdelaziz
Summary: This study synthesized benzo[d]thiazole derivatives and used them to synthesize thiophene derivatives, which further formed thiazole derivatives. The synthesized products were evaluated for their anticancer activity and further evaluated against different types of cancer cell lines. Among them, compounds 13c and 13h showed excellent morphological changes in the A549 cell line.
ACTA CHIMICA SLOVENICA
(2023)
