Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine

A Single In-Vial Dual Extraction Strategy for the Simultaneous Lipidomics and Proteomics Analysis of HDL and LDL Fractions

(2016) Joanna Godzien et al.   JOURNAL OF PROTEOME RESEARCH

In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization

(2016) C. D. Shaw et al.   MOLECULAR MICROBIOLOGY

Dynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form

(2016) Chaoqun Yao et al.   Parasites & Vectors

Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasiteLeishmania

(2016) Élodie Gazanion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms

(2016) Christopher Fernandez-Prada et al.   PLoS Neglected Tropical Diseases

An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion

(2016) Adele Goldman-Pinkovich et al.   PLoS Pathogens

Capillary electrophoresis reveals polyamine metabolism modulation inLeishmania (Leishmania) amazonensiswild-type and arginase-knockout mutants under arginine starvation

(2015) Emerson A. Castilho-Martins et al.   ELECTROPHORESIS

In-source fragmentation and correlation analysis as tools for metabolite identification exemplified with CE-TOF untargeted metabolomics

(2015) Joanna Godzien et al.   ELECTROPHORESIS

What role can metabolomics play in the discovery and development of new medicines for infectious diseases?

(2015) Dong-Hyun Kim et al.   Bioanalysis

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Differential Gene Expression and Infection Profiles of Cutaneous and Mucosal Leishmania braziliensis Isolates from the Same Patient

(2015) Eliza V. C. Alves-Ferreira et al.   PLoS Neglected Tropical Diseases

Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism

(2015) Gareth D. Westrop et al.   PLoS One

A Multiplatform Metabolomic Approach to the Basis of Antimonial Action and Resistance in Leishmania infantum

(2015) David Rojo et al.   PLoS One

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania

(2014) Gisele A. B. Canuto et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Controlling the quality of metabolomics data: new strategies to get the best out of the QC sample

(2014) Joanna Godzien et al.   Metabolomics

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

(2014) Eleanor C. Saunders et al.   PLoS Pathogens

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

(2013) Manu De Rycker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism

(2013) Isabel M. Vincent et al.   International Journal for Parasitology-Drugs and Drug Resistance

The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment

(2013) Belen Pedrique et al.   Lancet Global Health

CE-ESI-MS metabolic fingerprinting of Leishmania resistance to antimony treatment

(2012) Gisele A. B. Canuto et al.   ELECTROPHORESIS

Cell death in parasitic protozoa: regulated or incidental?

(2012) William R. Proto et al.   NATURE REVIEWS MICROBIOLOGY

Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS, and multivariate data analysis

(2011) L. Imbert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Isotopomer Profiling ofLeishmania mexicanaPromastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

(2011) Eleanor C. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axenic Leishmania amazonensis Promastigotes Sense both the External and Internal Arginine Pool Distinctly Regulating the Two Transporter-Coding Genes

(2011) Emerson A. Castilho-Martins et al.   PLoS One

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

(2011) W Moreira et al.   Cell Death & Disease

Metabolic Variation during Development in Culture of Leishmania donovani Promastigotes

(2011) Ana Marta Silva et al.   PLoS Neglected Tropical Diseases

Lysine transporters in human trypanosomatid pathogens

(2010) Ehud Inbar et al.   AMINO ACIDS

The potential of metabolomics for Leishmania research in the post-genomics era

(2010) RICHARD A. SCHELTEMA et al.   PARASITOLOGY

Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry

(2010) Liang Zheng et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations

(2010) Ruben t'Kindt et al.   PLoS Neglected Tropical Diseases

Membrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes

(2009) M. Saint-Pierre-Chazalet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Arginine Homeostasis and Transport in the Human PathogenLeishmania donovani

(2009) Ilona Darlyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid and sphingolipid metabolism in Leishmania

(2009) Kai Zhang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

(2009) Ou Zhang et al.   PLoS Pathogens

Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis inTrypanosoma brucei

(2008) Alina Fridberg et al.   JOURNAL OF CELL SCIENCE