期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 62, 期 5, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02642-17
关键词
heavy metal resistance; bla(NDM-1); bla(CTX-M-15); plasmids; coresistance
资金
- CSC
- HEFC
- MRC grant DETER-XDR-China [MR/P007295/1]
- BBSRC [BB/R012776/1] Funding Source: UKRI
- MRC [MR/N028317/1, MR/P007295/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/R012776/1] Funding Source: researchfish
- Medical Research Council [MR/N028317/1, MR/P007295/1] Funding Source: researchfish
The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla(NDM-1) or bla(CTX-M-15) genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in bla(NDM-1)-positive (48.8% to 71.8%) and bla(CTX-M-15)-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.
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