期刊
EXPERT REVIEW OF PROTEOMICS
卷 12, 期 1, 页码 37-60出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.2015.1000870
关键词
interactomics; network analysis; network hubs; protein-protein interactions; proteomics
资金
- National 973 Basic Research Program of China [2013CB911300]
- Chinese NSFC [J1103518]
- Research Program of Science and Technology Department of Sichuan Provence, China [2014JY0043]
Protein-protein interactions are central to all cellular processes. Understanding of protein-protein interactions is therefore fundamental for many areas of biochemical and biomedical research and will facilitate an understanding of the cell process-regulating machinery, disease causative mechanisms, biomarkers, drug target discovery and drug development. In this review, we summarize methods for populating and analyzing the interactome, highlighting their advantages and disadvantages. Applications of interactomics in both the biochemical and clinical arenas are presented, illustrating important recent advances in the field.
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