Review
Biochemistry & Molecular Biology
Rossella Paolini, Rosa Molfetta
Summary: CD155, also known as the poliovirus receptor, is often overexpressed in tumors and promotes cell migration and proliferation. It plays an immunomodulatory role by binding to receptors on immune cells. DNAM-1 is involved in anti-tumor immune surveillance, while TIGIT acts as an immune checkpoint receptor, counterbalancing DNAM-1. Targeting CD155 and enhancing DNAM-1 function are promising therapeutic approaches, and clinical trials for anti-TIGIT treatment are already underway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ruijia Zhou, Shiyin Chen, Qiwen Wu, Lingyun Liu, Yian Wang, Yongzhen Mo, Zhaoyang Zeng, Xuyu Zu, Wei Xiong, Fuyan Wang
Summary: This review focuses on the structure and function of CD155 and its receptors, as well as their role in immune escape, tumor therapy, and immunotherapy research. It also discusses the future direction of checkpoint immunotherapy.
Article
Immunology
Chang Jiang, Xiaodie Qu, Li Ma, Ling Yi, Xu Cheng, Xiang Gao, Jinghui Wang, Nanying Che, Hongtao Zhang, Shucai Zhang
Summary: CD155 expression in non-small cell lung cancer patients affects the response to anti-PD1 therapy, with CD155-positive patients showing a worse therapeutic effect. CD155 is also associated with poor responses in PD-L1 positive patients, across different stages of PD1 therapy.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su Thandar Hlaing, Potjanee Srimanote, Pongsri Tongtawe, Onruedee Khantisitthiporn, Kittirat Glab-ampai, Monrat Chulanetra, Jeeraphong Thanongsaksrikul
Summary: In this study, specific regions of the EV-A71 IRES were identified and used to select a single-chain antibody that binds specifically to the IRES. Molecular docking analysis revealed the specific amino acid residues involved in the interaction between the antibody and the IRES. This antibody has the potential to be used as a tool to study the biology of the EV-A71 RNA genome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Kohei Mori, Kazumasa Matsumoto, Noriyuki Amano, Dai Koguchi, Soichiro Shimura, Masahiro Hagiwara, Yuriko Shimizu, Masaomi Ikeda, Yuichi Sato, Masatsugu Iwamura
Summary: This study investigates the relationship between the expression of membranous CD155 (mCD155) or cytoplasmic CD155 (cCD155) and clinicopathological findings in bladder cancer (BC). The results show that BC cases with mCD155-positive expression are associated with high-grade tumors, nodal status, and pT stage. Additionally, mCD155-positive cases have shorter periods of recurrence-free survival and cancer-specific survival. Overall, mCD155 expression may serve as a marker for an aggressive phenotype and a poor prognosis in patients with BC.
Article
Oncology
Cong Luo, Wenrui Ye, Jiao Hu, Belaydi Othmane, Huihuang Li, Jinbo Chen, Xiongbing Zu
Summary: The study revealed that poliovirus receptor (PVR) was overexpressed and associated with poor prognosis in bladder cancer. A risk signature and nomogram model based on PVR-related genes could predict patient prognosis and therapeutic efficacy, and were also correlated with immune infiltration in bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fabrice Tolle, Viktor Umansky, Jochen Utikal, Stephanie Kreis, Sabrina Brechard
Summary: Neutrophils, once underestimated in cancer research, now are recognized for their dual roles in tumorigenesis. While they can promote tumor progression, they also possess anti-tumorigenic properties, highlighting the importance of understanding their functions for developing effective therapeutic strategies in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Yu-Siang Su, Lih-Hwa Hwang, Chi-Ju Chen
Summary: The study demonstrated the integral role of HSPA6 in EV-A71 infection as a positive regulator, showcasing its impact on viral protein production and virion assembly, specifically through the regulation of IRES-mediated translation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Duygu Ozmadenci, Jayanth S. Shankara Narayanan, Jacob Andrew, Marjaana Ojalill, Allison M. Barrie, Shulin Jiang, Samhita Iyer, Xiao Lei Chen, Michael Rose, Valeria Estrada, Alfredo Molinolo, Thomas Bertotto, Zbigniew Mikulski, Michael C. McHale, Rebekah R. White, Denise C. Connolly, Jonathan A. Pachter, Vijay K. Kuchroo, Dwayne G. Stupack, David D. Schlaepfer
Summary: High-grade serous ovarian cancer (HGSOC) is a lethal malignancy with immunosuppressive tumor microenvironment. This study reveals the association between elevated active focal adhesion kinase (FAK) and TIGIT checkpoint ligands in HGSOC tumors. Inhibition of FAK activity reduces tumor burden and increases tumor infiltrating lymphocytes (TILs), while combination treatment with FAK inhibitor and TIGIT antibody prolongs host survival and promotes lymphoid structure formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo, Youzhong Zhang
Summary: Objective TIGIT/CD155 has been identified as a potential therapeutic target in cervical cancer. This study demonstrated that high expression of TIGIT promotes the exhaustion of CD8(+) T lymphocytes and inhibits cytokine production. Blocking TIGIT/CD155 restores the function of CD8(+) T cells and inhibits tumor growth. Therefore, TIGIT/CD155 is considered a promising therapeutic target for cervical cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Helena Jaramillo-Mesa, Emma Fischer, Aurelie M. Rakotondrafara
Summary: Diverse elements within the 5' untranslated region of mRNA can affect translation efficiency. This study reveals the cooperative role of multiple CU-rich segments flanking the TriMV YX-AUG motif in internal initiation of translation. These auxiliary domains may enhance ribosome capacity and delivery to the correct initiation site.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Jingxuan Xia, Zhiyuan Zhang, Yijin Huang, Yufei Wang, Guangwei Liu
Summary: This article summarizes the formation process of neutrophil extracellular traps (NETs), their regulatory role in tumor development, and treatment methods based on NETs. NETs have the ability to awaken latent tumor cells and promote their proliferation and development, while also inhibiting tumor growth. These advancements provide a theoretical basis for the development of NET-targeted drugs.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Riai Okamoto, Nobumasa Ito, Yutaro Ide, Bouchra Kitab, Yoshihiro Sakoda, Kyoko Tsukiyama-Kohara
Summary: This study designed siRNAs targeting CSFV-IRES activity and constructed lentiviral vectors expressing shRNA. The results showed that lentiviral vector expressing sh198 significantly suppressed CSFV infection.
Article
Oncology
Xiyang Tang, Jie Yang, Anping Shi, Yanlu Xiong, Miaomiao Wen, Zhonglin Luo, Huanhuan Tian, Kaifu Zheng, Yujian Liu, Chen Shu, Nan Ma, Rui Wang, Jinbo Zhao
Summary: CD155, a new immune checkpoint, is found to be highly expressed in esophageal squamous cell cancer (ESCA) and positively associated with PD-1/PD-L1 expression. It can support ESCA proliferation by regulating the cell cycle and inducing cell apoptosis through the PI3K/Akt and MAPK signaling pathways. Inhibition of CD155 may enhance the therapeutic effect of anti-PD-1 immunotherapies in ESCA.
Article
Engineering, Biomedical
Chuanrong Chen, Qianqian Guo, Hao Fu, Jian Yu, Liting Wang, Ying Sun, Jiali Zhang, Yourong Duan
Summary: PD-L1/PD-1 blockade therapy offers durable responses to triple-negative breast cancer (TNBC) with a low response rate. The coexpression of PD-L1 and CD155 on TNBC cells was verified and the use of P/PEALsiCD155 nanoparticles showed promising results in enhancing immune surveillance and preventing immune escape of TNBC tumors. This combination therapy also induced immunogenic cell death (ICD) and effectively inhibited TNBC progression and metastasis with superior safety in a preclinical model.
Article
Engineering, Biomedical
Ibtehaj Naqvi, Nicholas Giroux, Lyra Olson, Telmo Llanga, Tolu O. Akinade, Yuefei Zhu, Yiling Zhong, Shree Bose, Stephanie Arvai, Karen Abramson, Lingye Chen, Loretta Que, Bryan Kraft, Xiling Shen, Jaewoo Lee, Kam W. Leong, Smita K. Nair, Bruce Sullenger, Sarah Anh Morrison
Summary: It has been found that severely ill COVID-19 patients in the ICU display a hyper-stimulation of TLR signaling, with nucleic acid-sensing TLR agonists present in their blood and lungs. CD16+ monocytes from deceased ICU patients show a TLR-tolerant phenotype and a deficient anti-viral response. Treatment with MnO nanoparticles effectively neutralizes TLR activation by nucleic acid-containing DAMPs/PAMPs in the lungs and blood.
Article
Biotechnology & Applied Microbiology
Linsley Kelly, Lyra B. Olson, Rachel E. Rempel, Jeffrey Everitt, Dana Levine, Smita K. Nair, Mark E. Davis, Bruce A. Sullenger
Summary: The study investigates a novel anti-inflammatory agent, a linear beta-cyclodextrin-containing polymer (CDP), which effectively inhibits NA-containing DAMP-mediated activation of Toll-like receptors and improves healing in lupus mice while enhancing survival in animals infected with influenza.
Article
Chemistry, Multidisciplinary
Imran Ozer, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, Joel H. Collier, Michael S. Hershfield, Angus M. Hucknall, Ashutosh Chilkoti
Summary: Protein therapeutics, especially those with PEG decoration, face challenges of short half-life and immunogenicity. The authors developed a poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) conjugate to improve the stability and immunogenicity of PEGylated proteins. The uricase-POEGMA conjugate demonstrated enhanced pharmacokinetics and reduced immunogenicity compared to traditional PEGylated proteins.
Article
Anesthesiology
Kristin M. Corey, Lyra B. Olson, Ibtehaj A. Naqvi, Sarah A. Morrison, Connor Davis, Shahid M. Nimjee, Loretta G. Que, Robin E. Bachelder, Bryan D. Kraft, Lingye Chen, Smita K. Nair, Jerrold H. Levy, Bruce A. Sullenger
Summary: This study confirms the association between coagulopathy and hypoxemia in critically ill COVID-19 patients. It identifies several coagulation and inflammatory biomarkers that are associated with severe hypoxemia and major thrombotic events in these patients.
Letter
Oncology
Justin T. Low, Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, Rebecca Fuller, Zachary J. Reitman, Andrea M. Muscat, Seethalakshmi Hariharan, Janell Hostettler, Sarah Danehower, Ali Baker, Mustafa Khasraw, Nicholas C. Wong, Simon Gregory, Smita K. Nair, Amy Heimberger, Matthias Gromeier, Darell D. Bigner, David M. Ashley
Letter
Pediatrics
Rajeev Kumar Thapar, Smita Nair
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Corrine A. Nief, Alana Gonzales, Erika Chelales, Julia Sroda Agudogo, Brian T. Crouch, Smita K. Nair, Nirmala Ramanujam
Summary: In the study, it was found that pre-treating tumors with sodium bicarbonate and low-dose cyclophosphamide, followed by tumor ablation, can elicit an anti-tumor immune response in TNBC models. The treatment showed significant therapeutic effects and induced immune memory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Ericka Chorniak, Yang Liu, Ren Odion, Wiguins Etienne, Aidan Canning, Smita K. Nair, Paolo Maccarini, Gregory M. Palmer, Brant A. Inman, Tuan Vo-Dinh
Summary: Bladder cancer is a common cancer with a high proportion of late stage diagnoses. This study developed a novel treatment for bladder cancer using a combination of gold nanostar-mediated photothermal therapy and checkpoint inhibitor immunotherapy. The results showed that this combined therapy was more effective than individual treatments. The study also used intravital optical imaging to investigate immune responses and immune cell accumulation in distant tumors following the treatment. The findings suggest that intravital optical imaging is an efficient tool for studying the mechanisms of photoimmunotherapy.
Article
Immunology
Aaron D. Therien, Georgia M. Beasley, Kristen E. Rhodin, Norma E. Farrow, Douglas S. Tyler, David Boczkowski, Rami N. Al-Rohil, Eda K. Holl, Smita K. Nair
Summary: This study aimed to explore the differences in the histologic location and activation status of B cell follicles in sentinel lymph nodes of melanoma patients. The findings suggest that B cell follicles play a role in coordinating effective adaptive immune responses in melanoma when low volume metastatic disease is present in tumor draining lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Georgia M. Beasley, Michael C. Brown, Norma E. Farrow, Karenia Landa, Rami N. Al-Rohil, Maria Angelica Selim, Aaron D. Therien, Sin-Ho Jung, Junheng Gao, David Boczkowski, Eda K. Holl, April K. S. Salama, Darell D. Bigner, Matthias Gromeier, Smita K. Nair
Summary: In patients with melanoma, those who had intratumoral inflammation and immune cell infiltrates after anti-PD-1 therapy and lerapolturev treatment had a longer progression-free survival, and they also exhibited stronger immune responses in peripheral blood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Oncology
Austin Eckhoff, Ashley Fletcher, Matthew Iyer, Chanjuan Shi, Daniel Nussbaum, Smita Nair, Peter Allen
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Kristen E. Rhodin, Danielle Bello, Norma Farrow, Paul Mosca, April K. Salama, Smita Nair, Douglas Tyler, Charlotte Ariyan, Georgia Beasley
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Aaron D. Therien, Eda K. Holl, Rami Al-Rohil, Kristen E. Rhodin, Douglas Tyler, Smita Nair, Georgia Beasley
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Critical Care Medicine
Aditya Mohan, Lyra Olson, Ibtehaj Naqvi, Sarah Morrison, Bryan Kraft, Lingye Chen, Smita Nair, Bruce Sullenger, George Kasotakis
CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Camille Robinson, Maria M. Xu, Smita K. Nair, Georgia M. Beasley, Kristen E. Rhodin
Summary: Malignant melanoma recurrence can present in various ways, requiring personalized management. Oncolytic viruses can stimulate local immune response and potentially overcome anti-PD-1 therapy resistance. Currently, one oncolytic virus is FDA-approved for this population, with other viruses under investigation.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)